Preparation And Evaluation Of Directly Compressible Tablets Of Ketoprofen Crystals

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2020-01-01 DOI:10.35652/igjps.2020.10303

Pooja D. Vaghela, H. M. Tank

{"title":"Preparation And Evaluation Of Directly Compressible Tablets Of Ketoprofen Crystals","authors":"Pooja D. Vaghela, H. M. Tank","doi":"10.35652/igjps.2020.10303","DOIUrl":null,"url":null,"abstract":"Purpose: The aim of present investigation was to prepare the directly compressible tablets of Ketoprofen loaded crystals and the prepared tablets were evaluated for the improvement in drug release of Ketoprofen as compared to the pure drug. Methods: Ketoprofen crystals were prepared by solvent evaporation, a conventional method, with an excipient, saccharin sodium dihydrate at room temperature. Control batch of Ketoprofen was prepared by excluding the excipient in the preparation. The prepared crystals were converted to directly compressible tablet dosage form. Results: The crystal formation of Ketoprofen lead to improve the compressibility, mechanical properties, and tensile strength of the drug which enable to prepare directly compressible tablet dosage form. The In-vitro study demonstrated 2.71 fold increase in the drug release rate from tablets of Ketoprofen crystals compared to the pure drug after one hour. The characterization was done by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) study of Ketoprofen treated crystals illustrated the improvement in physicochemical, manufacturability, and pharmacotechnical parameters of Ketoprofen. Conclusions: The crystal engineering approach can be used to improve the physicomechanical and pharmacotechnical parameters of BCS Class-II drugs which enable to prepare directly compressible tablet dosage form. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Vaghela, P.D.; Tank, H.M. Preparation and evaluation of directly compressible tablets of ketoprofen crystals. Indo Global J. Pharm. Sci., 2020; 10(3): 21-34. DOI: http://doi.org/10.35652/IGJPS.2020.10303 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(3): 21-34 22 Dissolution Study 1. In-Vitro drug release study of directly compressible tablets of pure drug, its control batch, and Ketoprofen","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indo Global Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35652/igjps.2020.10303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The aim of present investigation was to prepare the directly compressible tablets of Ketoprofen loaded crystals and the prepared tablets were evaluated for the improvement in drug release of Ketoprofen as compared to the pure drug. Methods: Ketoprofen crystals were prepared by solvent evaporation, a conventional method, with an excipient, saccharin sodium dihydrate at room temperature. Control batch of Ketoprofen was prepared by excluding the excipient in the preparation. The prepared crystals were converted to directly compressible tablet dosage form. Results: The crystal formation of Ketoprofen lead to improve the compressibility, mechanical properties, and tensile strength of the drug which enable to prepare directly compressible tablet dosage form. The In-vitro study demonstrated 2.71 fold increase in the drug release rate from tablets of Ketoprofen crystals compared to the pure drug after one hour. The characterization was done by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) study of Ketoprofen treated crystals illustrated the improvement in physicochemical, manufacturability, and pharmacotechnical parameters of Ketoprofen. Conclusions: The crystal engineering approach can be used to improve the physicomechanical and pharmacotechnical parameters of BCS Class-II drugs which enable to prepare directly compressible tablet dosage form. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Vaghela, P.D.; Tank, H.M. Preparation and evaluation of directly compressible tablets of ketoprofen crystals. Indo Global J. Pharm. Sci., 2020; 10(3): 21-34. DOI: http://doi.org/10.35652/IGJPS.2020.10303 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(3): 21-34 22 Dissolution Study 1. In-Vitro drug release study of directly compressible tablets of pure drug, its control batch, and Ketoprofen

查看原文本刊更多论文

酮洛芬晶体直接可压片的制备及评价

目的:制备酮洛芬晶体直接可压片，并评价其与纯药相比对酮洛芬释药的改善作用。方法:以二水合糖精钠为辅料，采用常规溶剂蒸发法制备酮洛芬结晶。采用不含辅料的方法制备酮洛芬对照批。将制备的晶体转化为可直接压缩片剂剂型。结果:酮洛芬晶体的形成改善了药物的可压缩性、力学性能和抗拉强度，可直接制备可压缩片剂剂型。体外研究表明，酮洛芬晶体片剂在1小时后的药物释放率比纯药物增加2.71倍。通过扫描电镜(SEM)、差示扫描量热法(DSC)、粉末x射线衍射(pXRD)和顶空气相色谱(HSGC)对酮洛芬处理后的晶体进行了表征，表明酮洛芬在物理化学、可制造性和药物技术参数方面得到了改善。结论:晶体工程方法可改善BCSⅱ类药物的物理力学参数和药物技术参数，使其可直接制备可压缩片剂剂型。©2020全球研究与出版基金会。版权所有。引用这篇文章:Vaghela, P.D.;酮洛芬晶体直接可压片的制备与评价。印度国际制药公司。科学。, 2020;10(3):还是。DOI: http://doi.org/10.35652/IGJPS.2020.10303。印度全球药物科学杂志，2020;22溶解度研究纯药直接可压片、对照批及酮洛芬的体外释放研究

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indo Global Journal of Pharmaceutical Sciences

自引率

0.00%

发文量