In vivo最新文献

{"title":"Risk Factors Associated With Thrombocytopenia Induced by Intravenous Immunoglobulin Formulations: An Analysis Using the JADER database.","authors":"Yoshihiro Nishita, Natsuko Ishida, Hirofumi Nagai, Togen Masauji, Junko Ishizaki","doi":"10.21873/invivo.14028","DOIUrl":"10.21873/invivo.14028","url":null,"abstract":"<p><strong>Background/aim: </strong>Thrombocytopenia is a serious adverse event observed with intravenous immunoglobulin formulations (IVIg). There have been some individual case reports of such events, but to our knowledge, no epidemiological studies have been reported. In this study, the risk of IVIg-induced thrombocytopenia and factors associated with IVIg-induced thrombocytopenia were examined using the Japanese Adverse Drug Event Report database.</p><p><strong>Patients and methods: </strong>Data spanning from April 2004 to August 2024 were used. The association between IVIg and thrombocytopenia was evaluated using the reporting odds ratio (ROR). The reports of IVIg-induced thrombocytopenia events were evaluated by disease and aggregated by disease group. Factors associated with IVIg-induced thrombocytopenia were detected using multiple logistic regression with age, sex, formulation method, and disease group as explanatory variables and adjusted RORs were calculated.</p><p><strong>Results: </strong>The IVIgs examined were significantly associated with thrombocytopenia. Pemphigoid was the most frequently reported disease, followed by Kawasaki disease and polymyositis/dermatomyositis. Immune-mediated skin diseases were the most frequently reported disease group, followed by Kawasaki disease, immune-mediated neurological diseases, and immune-mediated muscular diseases. Multiple logistic regression analysis showed that at age 60 years or older, immune-mediated skin diseases and immune-mediated muscular diseases were independently associated with significantly increased RORs.</p><p><strong>Conclusion: </strong>This study suggests that IVIg can induce thrombocytopenia and that thrombocytopenia should be assessed in patients with immune-mediated skin diseases, immune-mediated muscular diseases and in the elderly.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2320-2327"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Usefulness of the Modified Advanced Lung Cancer Inflammation Index (mALI) as a Prognostic Factor in Patients With Esophageal Cancer who Have Undergone Curative Resection.","authors":"Sosuke Yamamoto, Toru Aoyama, Yukio Maezawa, Itaru Hashimoto, Ryuki Esashi, Kazuki Otani, Suguru Nukada, Tetsushi Ishiguro, Kiyoko Shimada, Keisuke Kazama, Koji Numata, Mamoru Uchiyama, Rei Hatayama, Ayako Tamagawa, Aya Saito, Norio Yukawa","doi":"10.21873/invivo.14013","DOIUrl":"10.21873/invivo.14013","url":null,"abstract":"<p><strong>Background/aim: </strong>In several previous studies, the modified advanced lung cancer inflammation index (mALI) has been reported to be a useful prognostic factor in non-small cell lung cancer. This study aimed to demonstrate the relationship between mALI and the oncological prognosis of patients with esophageal cancer (EC) who underwent curative treatment and to clarify the underlying mechanism.</p><p><strong>Patients and methods: </strong>We retrospectively followed up patients who underwent curative resection of esophageal cancer at Yokohama City University between 2000 and 2020 and extracted clinical data from their medical records. mALI was defined as follows: mALI=[L3 muscle index (L3MI) (cm²/m²)×albumin (g/l)]/neutrophil-to-lymphocyte ratio (NLR) [neutrophil count÷lymphocyte count].</p><p><strong>Results: </strong>A total of 196 patients were selected for this study, and the cutoff value for mALI was set separately for male and females. When the cutoff value was set at 10 for males and 12 for females, 84 patients were assigned to the mALI-low group and 112 patients were assigned to the mALI-high group. A survival analysis revealed that the 5-year overall survival (OS) rate was 50.3% in the mALI-low group and 62.5% in the mALI-high group (<i>p</i>=0.014). A multivariate analysis of OS revealed that mALI was an independent prognostic factor. The 5-year recurrence-free survival (RFS) rates were 33.0% in the mALI-low group and 44.9% in the mALI-high group (<i>p</i>=0.044). The multivariate analysis of RFS revealed that mALI was an independent prognostic factor. In addition, the mALI-low group had a higher rate of hematogenous metastasis than the mALI-high group.</p><p><strong>Conclusion: </strong>mALI is associated with the oncological prognosis of patients with EC who have undergone radical resection <i>via</i> several mechanisms and is a useful prognostic factor.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2176-2185"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Glucose Metabolism Disorders and Acne in Women With Polycystic Ovary Syndrome (PCOS).","authors":"Eftichia Damoulaki, Dimos Sioutis, Eleni P Georgiadi, Eftichios Trakakis, Georgios Mastorakos, Alexander Katoulis, Konstantinos Louis, Dimitrios Panagiotopoulos, Nikolaos Machairiotis, Vasilios Pergaliotis, Periklis Panagopoulos, Chrysi Christodoulaki","doi":"10.21873/invivo.14017","DOIUrl":"10.21873/invivo.14017","url":null,"abstract":"<p><strong>Background/aim: </strong>Acne is a common dermatological manifestation of polycystic ovary syndrome (PCOS), a prevalent endocrinological disorder among women of reproductive age. A growing body of evidence highlights glucose metabolism disorders, including insulin resistance, in the context of PCOS. This study aimed to investigate the association of acne and its severity with insulin resistance in a population of women with PCOS.</p><p><strong>Patients and methods: </strong>A total of 305 women with PCOS aged between 17-35 years were included in this retrospective observational study. Anthropometric, hormonal, biochemical, and ultrasonographic markers of PCOS were analyzed in relation to insulin resistance indices, including HOMA-IR and QUICKI.</p><p><strong>Results: </strong>Acne was present in 56.4% of participants, with 52.1% exhibiting mild and 4.3% severe cases. Younger age (<i>p</i>=0.006), higher DHEAS levels (<i>p</i>=0.001), and glucose metabolism disorders, including fasting glucose >100 mg/dl, <i>p</i>=0.026 and 2-h glucose higher than 140 mg/dl (<i>p</i>=0.019), were significantly associated with acne. Multivariate analysis indicated younger age (OR=0.94, <i>p</i>=0.012), elevated DHEAS levels (OR=1.03; <i>p</i>=0.006), and 2-h glucose levels >140 mg/dl (OR=3.25, <i>p</i>=0.029) as independent predictors of acne severity.</p><p><strong>Conclusion: </strong>This study indicates the association between insulin resistance and hyperandrogonemia with both the presence and severity of acne in PCOS. These findings align with contemporary literature and underscore the importance of addressing the hormonal and metabolic factors in the etiological management of acne in PCOS.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2219-2227"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and Risk Factors of Inappropriate Bladder Filling in Patients Irradiated for High-risk Prostate Cancer.","authors":"Dirk Rades, Laura Doehring, Jan-Dirk Küter, Justus Domschikowski, Jon Cacicedo, Stefan Janssen","doi":"10.21873/invivo.14030","DOIUrl":"10.21873/invivo.14030","url":null,"abstract":"<p><strong>Background/aim: </strong>Many patients with high-risk prostate cancer receive normo-fractionated irradiation. Previously, high-risk cancer and pre-treatment bladder volumes <200 ml were associated with inappropriate bladder filling during the radiotherapy course. A prospective trial will investigate the value of an app reminding patients to drink water before each radiotherapy session. This study provides information regarding magnitude of inappropriate bladder filling and risk factors required for the prospective trial.</p><p><strong>Patients and methods: </strong>In 23 patients with high-risk prostate cancer and inappropriate pre-treatment bladder filling, mean and median numbers of radiation fractions with bladder volumes less than 200 ml and potential risk factors were retrospectively investigated.</p><p><strong>Results: </strong>Mean and median numbers of fractions with volumes less than 200 ml were 29.2±6.6 and 32.0 (interquartile range=24.0-35.0) of 35 fractions. Higher numbers were significantly associated with a lower performance score (<i>p</i> <0.029).</p><p><strong>Conclusion: </strong>Bladder filling was inappropriate during most radiotherapy fractions and, therefore, must be considered a significant problem. Our results are relevant for a subsequent prospective trial.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2333-2339"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Challenges and Advancements in the Management of Pivotal Porcine/Swine Viral Diseases.","authors":"Taeho Kwon, Gyu-Seo Bae, Eunsu Jeon, Philyong Kang, Hee Chang Son, You Jung An, Bon-Sang Koo, Sun-Uk Kim, Kyung-Seob Lim","doi":"10.21873/invivo.13982","DOIUrl":"10.21873/invivo.13982","url":null,"abstract":"<p><p>Porcine/swine viral diseases pose substantial challenges to the global pig industry by affecting animal health and economic stability. This comprehensive review examines four major viral diseases impacting swine populations worldwide: Porcine reproductive and respiratory syndrome (PRRS), African swine fever (ASF), classical swine fever (CSF), and porcine circovirus type 2 (PCV2). We investigated the etiology, epidemiology, clinical signs, and diagnostic methods for each disease, thereby providing an in-depth understanding of their complexities. Additionally, we assessed their global distribution, transmission dynamics, and the economic repercussions they entail. We also discuss current management and control strategies, including vaccination, biosecurity measures, and regulatory policies. Special attention is given to the evolving nature of these diseases, with a focus on emerging strains, new insights into their pathogenesis, and the latest advancements in vaccine development. This review intends to be a valuable resource for veterinarians, researchers, and policymakers, presenting a thorough and current overview of the challenges and developments in managing these swine viral diseases at the international level.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"1810-1832"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Safety Pharmacology and Musculoskeletal Changes of HMGB1 Box A Gene Therapy in Middle-aged Monkeys.","authors":"Sukanya Jaroenporn, Tayanee Chundee, Sakawdaurn Yasom, Lalitta Suriya-Arunroj, Motee Chimngam, Nutchanat Suttisan, Suchinda Malaivijitnond, Apiwat Mutirangura","doi":"10.21873/invivo.13994","DOIUrl":"10.21873/invivo.13994","url":null,"abstract":"<p><strong>Background/aim: </strong>HMGB1 Box A gene therapy is a promising therapeutic approach for age-associated diseases, based on evidence from <i>in vitro</i> and <i>in vivo</i> studies in rodents. This study aimed to evaluate long-term safety and musculoskeletal change of the Box A gene in non-human primates.</p><p><strong>Materials and methods: </strong>Perimenopausal monkeys were intravenously injected with a control plasmid (PC group) or Box A plasmid (Box A group) once a week for eight weeks, and were observed for one year. The safety pharmacology, blood biochemistry and hematology, bone mineral density, bone geometry, and muscle density were assessed and compared between the groups.</p><p><strong>Results: </strong>The safety pharmacological tests, general clinical observations, and evaluation of the central nervous, cardiovascular, and respiratory systems revealed no safety concerns. The response of the musculoskeletal system to Box A showed that the radius and tibia exhibited opposing bone density and size changes between the PC and Box A groups. Box A attenuated the age-related increase in bone mass and decrease in bone size at the radial metaphysis. Box A promoted cortical bone accumulation in the tibial diaphysis. The PC group, but not the Box A group, showed elevated blood glucose levels starting from the 48^th week of the experiment. Box A group trended to gain less weight than the PC group, without experiencing muscle loss.</p><p><strong>Conclusion: </strong>This study indicated that Box A was safe over a 56-week observation period, causing no adverse clinical symptoms. Notably, it mitigated age-associated phenotypes, including improved bone health, lowered blood glucose, and reduced weight gain in perimenopausal monkeys. These results suggest Box A as a safe rejuvenation medicine.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"1965-1983"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular Damage in the Deep Mucosal <i>Lamina Propria</i> Triggers the Onset of Colitis in Dextran Sulfate Sodium-induced Colitis in Mice.","authors":"Hiroki Saijo, Hisashi Hashimoto, Seiji Arihiro, Moriaki Kusakabe, Masataka Okabe","doi":"10.21873/invivo.13986","DOIUrl":"10.21873/invivo.13986","url":null,"abstract":"<p><strong>Background/aim: </strong>Dextran sulfate sodium (DSS) is employed to induce colitis in mice for studying ulcerative colitis (UC), an inflammatory bowel disease. However, the precise mechanism underlying its action remains unclear. Microcirculatory issues in the colonic mucosa contribute to DSS-induced colitis; however, early structural changes in the local vascular system have not been thoroughly investigated. Therefore, we aimed to explore the circulatory system and mucosal circulation in the mouse colon and identify the early causes of bleeding in DSS-induced colitis.</p><p><strong>Materials and methods: </strong>A 2% DSS solution was administered to C57BL/6J mice, and on days 3, 4, and 5 of administration, colonic circulation was examined through histological analysis of the mucosa, vascular casting, and differential staining of arteries and veins by sequential infusion of a fluorescent isothiocyanate-labeled gelatin solution and a small amount of a rhodamine isothiocyanate-labeled gelatin solution.</p><p><strong>Results: </strong>By day 4, we observed increased vascular leakage, with significant changes in the mucosal vascular networks evident on day 5. Differential staining of the superior mesenteric artery and inferior mesenteric artery elucidated the boundary regions of their perfusion areas in the middle colon. DSS primarily caused vascular injury in this border zone, extending to the mid- and distal colon. Further exploration of the mucosal circulation revealed bleeding originating from the deep mucosal arteriolar plexus.</p><p><strong>Conclusion: </strong>Early vascular impairment, particularly in the deep mucosal arteriolar plexus, precedes DSS-induced colitis in mice. Understanding these vascular disturbances may provide insights into pathogenesis of inflammatory bowel disease and aid in developing early detection and intervention strategies for UC in humans.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"1864-1878"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerotherapy With Polidocanol Is Highly Effective for Treating Oral Cavernous Hemangiomas in Children.","authors":"Li-Na Han, Yu-Bo Wang, Rong-Xiang Tian, Wen-Ya Huang, Ralf Smeets, Martin Gosau, Lan Kluwe, Ming Yan, Rico Rutkowski, Reinhard E Friedrich","doi":"10.21873/invivo.14006","DOIUrl":"10.21873/invivo.14006","url":null,"abstract":"<p><strong>Background/aim: </strong>Cavernous hemangiomas in children older than 2 years will unlikely resolute and therefore, frequently require treatment. The aim of the study was to comparatively evaluated the outcome of the sclerotherapy with polidocanol and the conventional pingyangmycin therapy for thick cavernous hemangiomas in the oral cavity in children.</p><p><strong>Patients and methods: </strong>We treated a total of 21 cavernous hemangiomas in the oral cavity (majority on the tongue) of children aged 2-11 years by means of a sclerotherapy using an anesthetic agent polidocanol under ultra-sound monitoring.</p><p><strong>Results: </strong>Total regression of the tumors was achieved in 20 cases, corresponding to a success rate of 95%, significantly (<i>p</i>=0.0005) higher than that achieved by the conventional pingyangmycin therapy, which was <50%. No severe complication was observed, while mild and transit ones such as local swelling, pain, and ulceration were reported by both groups at similar frequency (10-20%).</p><p><strong>Conclusion: </strong>Sclerotherapy using polidocanol provides an effective, safe, and relatively simple treatment for hemangiomas in the oral cavity of children and may be recommended to replace the conventional pingyangmicine treatment.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2109-2114"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Preoperative Dry Eye Disease on the Outcome of Second (Visumax 800) Generation Keratorefractive Lenticule Extraction Surgery.","authors":"Chia-Yi Lee, Shun-Fa Yang, Ie-Bin Lian, Hung-Chi Chen, Jing-Yang Huang, Chao-Kai Chang","doi":"10.21873/invivo.14010","DOIUrl":"10.21873/invivo.14010","url":null,"abstract":"<p><strong>Background/aim: </strong>To evaluate the influence of preoperative dry eye disease (DED) on the postoperative outcome of second generation keratorefractive lenticule extraction (KLEx) surgery.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was performed and patients who received second generation KLEx surgery were enrolled. After the categorization, a total of 76, 59, and 65 eyes were put into the non-DED, DED without artificial tear (AT), and DED with AT groups, respectively. The primary outcomes were the uncorrected distance visual acuity (UDVA), spherical equivalent (SE), and postoperative complications. The one-way ANOVA was applied for the statistical analysis.</p><p><strong>Results: </strong>One day postoperatively, the DED without AT group demonstrated a significantly worse UDVA compared to the other two groups (<i>p</i>=0.002). At the final visit, the UDVA in this group was not significantly lower from that in the non-DED and DED with AT groups (<i>p</i>=0.129). The SE was significantly higher in the DED without AT group than the other two groups from postoperatively day one through three months (all <i>p</i><0.05). Moreover, the change in UDVA over time was significantly greater in the DED without AT group than in the other two groups (<i>p</i>=0.007). Regarding the vector analysis, the difference vector (DV), correction index (CoI), and angle of error (AE) was significantly higher in the DED without AT group compared to the other two groups (all <i>p</i><0.05). The rate of postoperative superficial keratitis and DED was significantly higher in the DED without AT group compared to the other two groups (both <i>p</i><0.05).</p><p><strong>Conclusion: </strong>The presence of preoperative DED is associated with worse postoperative UDVA recovery and refraction of second generation KLEx surgery, which can be prevented by preoperative AT application.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2144-2153"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of Proteinuria and Nephrotic Syndrome Using the Japanese Adverse Drug Event Reporting Database.","authors":"Sho Masago, Kenta Yamaoka, Mayako Uchida, Yoshihiro Uesawa, Kennosuke Yorifuji, Tadashi Shimizu","doi":"10.21873/invivo.14002","DOIUrl":"10.21873/invivo.14002","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to identify potential drug associations between proteinuria and nephrotic syndrome (NS) using the Japanese Adverse Drug Event Report (JADER) database.</p><p><strong>Patients and methods: </strong>We extracted data reported in JADER between April 2004 and May 2023, and conducted a comprehensive disproportionality analysis of spontaneous adverse event reports to identify drugs potentially linked to proteinuria and NS.</p><p><strong>Results: </strong>Our analysis identified 20 and 32 drugs associated with proteinuria and NS, respectively. Notably, anti-vascular endothelial growth factor (anti-VEGF) agents represented 45% (9/20) of proteinuria-associated drugs and 34% (11/32) of NS-associated drugs. Furthermore, the association between anti-VEGF agents and these adverse events appeared to be independent of the route of administration, sex, or clinical background.</p><p><strong>Conclusion: </strong>These findings suggest that anti-VEGF agents play a significant role in the development of proteinuria and NS. Given the widespread use of anti-VEGF therapy, heightened vigilance, routine monitoring, and timely interventions are crucial to mitigate these risks and improve patient outcomes.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2073-2084"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}