IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13686

Noriaki Hamatani, Masashi Yagi, Shinichi Shimizu, Naoki Ishino, Masaki Shimizu, Yoshiaki Kuwana, Toshiro Tsubouchi, Masaaki Takashina, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Masumi Umezawa, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai

{"title":"Investigation of Ionization Chamber Characteristics for Ultrahigh-dose-rate Scanned Carbon-ion Beams.","authors":"Noriaki Hamatani, Masashi Yagi, Shinichi Shimizu, Naoki Ishino, Masaki Shimizu, Yoshiaki Kuwana, Toshiro Tsubouchi, Masaaki Takashina, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Masumi Umezawa, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai","doi":"10.21873/invivo.13686","DOIUrl":"10.21873/invivo.13686","url":null,"abstract":"Background/aim: There are only a few studies on dosimetry with ultrahigh-dose-rate (uHDR) scanned carbon-ion beams. This study investigated the characteristics of four types of ionization chambers for the uHDR beam.Materials and methods: We employed a newly developed large-plane parallel chamber to monitor a 208.3-MeV/u uHDR scanned carbon-ion beam with a 110-Gy/s average dose rate. The ionization chambers used were the Advanced Markus chamber (AMC), PinPoint 3D chamber (PPC), Farmer chamber (FC), and large-plane parallel chamber (StingRay). The AMC and StingRay surfaces and the PPC and FC geometric centers were aligned to the radiation isocenter using treatment room lasers. Using the voltage range stated in the instruction manuals, we obtained the saturation curves of the chambers. From these curves, we obtained the ion recombination correction factors using the two-voltage and three-voltage linear methods. The dose linearity was evaluated using five measurement points, and the chamber repeatability was verified by conducting repeated measurements for different dose values.Results: Although all chambers, except for AMC, reached saturation when specified voltages were applied, they exhibited excellent linearity for different dose values. The ion recombination correction factors of the AMC obtained using the aforementioned linear methods were nearly 1. Additionally, all chambers exhibited excellent repeatability. Although the standard deviation of the PPC for the lowest dose was ~1.5%, those of all the other chambers were <1.0%.Conclusion: All ionization chambers can be used for measuring the relative dose, and absolute dose can be conveniently measured using the AMC with an uHDR carbon-ion scanned beam.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of RAMP1 Signaling Suppresses Liver Regeneration and Angiogenesis Following Partial Hepatectomy in Mice. 小鼠部分肝切除术后，缺乏 RAMP1 信号传导会抑制肝脏再生和血管生成。

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13691

Shuji Nakamoto, Yoshiya Ito, Nobuyuki Nishizawa, Y U Kuroda, Kanako Hosono, Mariko Kamata, Kazutake Tsujikawa, Yusuke Kumamoto, Hideki Amano

{"title":"Lack of RAMP1 Signaling Suppresses Liver Regeneration and Angiogenesis Following Partial Hepatectomy in Mice.","authors":"Shuji Nakamoto, Yoshiya Ito, Nobuyuki Nishizawa, Y U Kuroda, Kanako Hosono, Mariko Kamata, Kazutake Tsujikawa, Yusuke Kumamoto, Hideki Amano","doi":"10.21873/invivo.13691","DOIUrl":"10.21873/invivo.13691","url":null,"abstract":"Background/aim: The liver effectively restores both size and function following partial hepatectomy (PHx). Angiogenesis is crucial for the repair and regeneration of liver tissue post-PHx. Calcitonin gene-related peptide (CGRP) released from sensory nerves and its receptor-receptor activity-modifying protein 1 (RAMP1) are involved in angiogenesis. This study aimed to assess the role of RAMP1 signaling in angiogenesis during liver regeneration following PHx.Materials and methods: RAMP1 deficient (RAMP1-/-) and wild-type (WT) mice were subjected to PHx.Results: RAMP1-/- mice demonstrated delayed liver regeneration, indicated by lower liver-to-body weight ratios compared to WT mice. This was associated with lower levels of Ki67+ hepatocytes and hepatic trophic growth factors. Additionally, RAMP1-/- mice exhibited lower levels of endothelial cell markers, including CD31, compared to WT mice. This reduction was associated with reduced levels of vascular endothelial growth factor (VEGF)-C, VEGF-D, and VEGF receptor 3 (VEGFR3). In WT mice with PHx, the administration of a VEGFR3 inhibitor reduced the liver-to-body weight ratio, Ki67+ hepatocytes, and VEGF-C/VEGFR3 expression levels in the liver compared to those in the vehicle-treated group.Conclusion: The deletion of RAMP1 signaling suppresses liver regeneration and angiogenesis through VEGFR3. Specific activation of RAMP1 signaling may represent a potential therapeutic strategy for liver regeneration following PHx.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipopolysaccharide Derived from Pantoea agglomerans Directly Promotes the Migration of Human Keratinocytes. 盘尾丝菌产生的脂多糖直接促进人类角质形成细胞的迁移

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13680

Hiroyuki Inagawa, Takashi Nishizawa, Chie Kohchi, Gen-Ichiro Soma

{"title":"Lipopolysaccharide Derived from Pantoea agglomerans Directly Promotes the Migration of Human Keratinocytes.","authors":"Hiroyuki Inagawa, Takashi Nishizawa, Chie Kohchi, Gen-Ichiro Soma","doi":"10.21873/invivo.13680","DOIUrl":"10.21873/invivo.13680","url":null,"abstract":"Background/aim: Because the skin is exposed to the external environment, it is important that wound healing processes proceed and terminate rapidly to minimize the risk of infection. A previous case report described the promotion of wound healing by transdermal administration of lipopolysaccharide derived from Pantoea agglomerans (LPSp). However, whether the wound healing-promoting effect of LPSp was due to direct activity on skin cells or indirect effects involving macrophages remained unclear. Therefore, this study investigated the wound healing-promoting effect of LPSp, particularly the promotion of keratinocyte migration.Materials and methods: The migration of HaCaT human keratinocytes over time with and without LPSp was assayed using a cell migration assay kit. Migration was also analyzed using HaCaT cells treated with LPSp and an antibody against Toll-like receptor (TLR) 4, a receptor for LPS.Results: Addition of LPSp significantly enhanced cell migration compared to no LPSp addition. Migration was inhibited by the addition of anti-TLR4 antibody.Conclusion: LPSp acts directly on epidermal cells to promote migration and may be one mechanism by which LPSp promotes wound healing.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenic Detection by Metagenomic Next-generation Sequencing in Skin and Soft Tissue Infection. 通过元基因组下一代测序检测皮肤和软组织感染中的病原体。

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13703

Ting-Kuang Yeh, Yao-Ting Huang, Po-Yu Liu, Yan-Chiao Mao, Chih-Sheng Lai, Kuo-Lung Lai, Chien-Hao Tseng, Chia-Wei Liu, Wei-Hsuan Huang, Hsien-Po Huang, Kuan-Pei Lin

{"title":"Pathogenic Detection by Metagenomic Next-generation Sequencing in Skin and Soft Tissue Infection.","authors":"Ting-Kuang Yeh, Yao-Ting Huang, Po-Yu Liu, Yan-Chiao Mao, Chih-Sheng Lai, Kuo-Lung Lai, Chien-Hao Tseng, Chia-Wei Liu, Wei-Hsuan Huang, Hsien-Po Huang, Kuan-Pei Lin","doi":"10.21873/invivo.13703","DOIUrl":"10.21873/invivo.13703","url":null,"abstract":"Background/aim: Skin and soft tissue infections (SSTIs) can be life-threatening, but the conventional bacterial cultures have low sensitivity and are time-consuming. Metagenomic next-generation sequencing (mNGS) is widely used as a diagnostic tool for detecting pathogens from infection sites. However, the use of mNGS for pathogen detection in SSTIs and related research is still relatively limited.Patients and methods: From January 2020 to October 2021, 19 SSTI samples from 16 patients were collected in a single center (Taichung Veterans General Hospital, Taichung, Taiwan). The clinical samples were simultaneously subjected to mNGS and conventional bacterial culture methods to detect pathogens. Clinical characteristics were prospectively collected through electronic chart review. The microbiological findings from conventional bacterial culture and mNGS were analyzed and compared.Results: The mNGS method detected a higher proportion of multiple pathogens in SSTIs compared to conventional bacterial culture methods. Pseudomonas spp. was among the most commonly identified Gram-negative bacilli using mNGS. Additionally, the mNGS method identified several rare pathogens in patients with SSTIs, including Granulicatella adiacens, Bacillus thuringiensis, and Bacteroides fragilis. Antimicrobial resistance genes were detected in 10 samples (52.6%) using the mNGS method, including genes for extended-spectrum beta-lactamase, Ambler class C β-lactamases, and carbapenemase.Conclusion: mNGS not only plays an important role in the detection of pathogens in soft tissue infections, but also informs clinical professionals about the presence of additional microbes that may be important for treatment decisions. Further studies comparing conventional pathogen culture with the mNGS method in SSTIs are required.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propofol Versus Dexmedetomidine for Conscious Sedation During Vaginal Hysterectomy With Pre-emptive Local Anesthesia: A Prospective Cohort Study. 在阴道子宫切除术中使用丙泊酚与右美托咪定进行意识镇静，并预先进行局部麻醉：一项前瞻性队列研究。

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13711

Sofia Hadzilia, Themos Grigoriadis, Anastasia Prodromidou, Emmanouil Stamatakis, Dimitra Papadopoulou, Dimitrios Zacharakis, Stavros Athanasiou, Dimitrios Valsamidis

{"title":"Propofol Versus Dexmedetomidine for Conscious Sedation During Vaginal Hysterectomy With Pre-emptive Local Anesthesia: A Prospective Cohort Study.","authors":"Sofia Hadzilia, Themos Grigoriadis, Anastasia Prodromidou, Emmanouil Stamatakis, Dimitra Papadopoulou, Dimitrios Zacharakis, Stavros Athanasiou, Dimitrios Valsamidis","doi":"10.21873/invivo.13711","DOIUrl":"10.21873/invivo.13711","url":null,"abstract":"Background/aim: Hysterectomy is the most frequent gynecological surgery. Vaginal hysterectomy (VH) seems to be related to favorable perioperative outcomes compared to abdominal or laparoscopic approaches. As the population ages, anesthesia that is safer for the elderly, such as local anesthesia (LA) with conscious sedation, is gaining popularity and is related to favorable outcomes in patients' recovery compared to general or regional anesthesia. We aimed to evaluate the efficacy of dexmedetomidine versus propofol for women undergoing VH for uterine prolapse under LA and conscious sedation.Patients and methods: A prospective study on 40 women with uterine prolapse stage ≥3 who had VH under LA with conscious sedation under either dexmedetomidine (n=20) or propofol (n=20) was performed. A standardized surgical approach with continuous hemodynamic monitoring and sedation assessment using the Ramsay Sedation Scale (RSS) was conducted. The primary endpoint of the study was to determine the percentage of patients receiving intraoperative fentanyl.Results: Analysis of outcomes demonstrated a significant reduction in the proportion of patients requiring intraoperative rescue fentanyl (35% vs. 5%, respectively, p=0.04) and in postoperative pain scores, with more patients achieving an optimal RSS score of 3 in the dexmedetomidine group.Conclusion: Based on the findings of the present study, dexmedetomidine offered superior analgesia and patient comfort compared to propofol, suggesting a favorable anesthetic profile for VH under LA.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) Help Predict Outcomes of Patients With Recurrent Glioblastoma? 血小板淋巴细胞比值（PLR）和中性粒细胞淋巴细胞比值（NLR）能否帮助预测复发性胶质母细胞瘤患者的预后？

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13700

Oksana Zemskova, Nathan Y Yu, Jan Leppert, Anastassia Löser, Dirk Rades

{"title":"Can Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) Help Predict Outcomes of Patients With Recurrent Glioblastoma?","authors":"Oksana Zemskova, Nathan Y Yu, Jan Leppert, Anastassia Löser, Dirk Rades","doi":"10.21873/invivo.13700","DOIUrl":"10.21873/invivo.13700","url":null,"abstract":"Background/aim: In patients with recurrent glioblastoma, very little data are available regarding the prognostic value of platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte (NLR) ratios. This study investigated potential associations between PLR or NLR and treatment outcomes.Patients and methods: PLR and NLR at diagnosis of recurrence plus 10 additional characteristics were retrospectively analyzed for associations with progression-free survival (PFS) and overall survival (OS) in 75 patients with recurrent glioblastoma.Results: On multivariate analyses, maximal cumulative diameter of recurrent lesion(s) <40 mm (p=0.015) and systemic therapy (p<0.001) were associated with improved PFS. On multivariate analysis of OS, improved outcomes were significantly associated with PLR ≤150 (p=0.029), maximal cumulative diameter <40 mm (p=0.030), and systemic therapy (p=0.010).Conclusion: In addition to other characteristics, PLR at the time of recurrence was identified as an independent predictor of OS in patients with recurrent glioblastoma. PLR may be useful when designing personalized treatment approaches or clinical trials.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Misoprostol for Labor Induction: Vaginal Insert Versus Oral Application Concerning Efficiency and Safety. 比较米索前列醇引产：阴道插入与口服应用在效率和安全性方面的比较。

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13701

Dominik Ratiu, Mirka Hunke, Jessika Ratiu, Nina Mallmann-Gottschalk, Peter Mallmann, Sunhwa Baek, Berthold Grüttner, Katherina Hide-Moser

{"title":"Comparison of Misoprostol for Labor Induction: Vaginal Insert Versus Oral Application Concerning Efficiency and Safety.","authors":"Dominik Ratiu, Mirka Hunke, Jessika Ratiu, Nina Mallmann-Gottschalk, Peter Mallmann, Sunhwa Baek, Berthold Grüttner, Katherina Hide-Moser","doi":"10.21873/invivo.13701","DOIUrl":"10.21873/invivo.13701","url":null,"abstract":"Background/aim: The aim of the present retrospective study was to examine the efficiency and safety of the induction of labor with Misoprostol, administered either vaginally or orally.Patients and methods: This retrospective cohort study included pregnant women with a gestational age of ≥36 +0 weeks and a singleton pregnancy who underwent induction of labor with Misoprostol as vaginal insert or as tablet (oral) between January 2014 and January 2019 at the Department of Obstetrics and Gynecology of the University Hospital of Cologne. The objective of this study was to analyze the time until delivery and the maternal and neonatal outcomes.Results: A total of 1,511 patients were included in this retrospective analysis, of whom 1,035 patients (68.5%) underwent induction of labor with a misoprostol vaginal insert (MVI) and 476 (31.5%) with tablets (oral misoprostol: OM). MVI significantly shortened the time from application to delivery (p<0.001) in comparison to OM, reduced the need for epidural anesthesia (EA) (p=0.018) without an increase in caesarean sections (CS) (p=1), ventouse deliveries (VD) (p=0.715), maternal birth injuries or a reduced neonatal outcome (APGAR-Score, umbilical cord pH).Conclusion: MVI is superior to OM in terms of efficiency (primary outcome: time from application to delivery) and is equally safe (primary outcome: CS rate). Our study, along with existing literature, highlights the need for further research, particularly regarding neonatal outcomes. Additionally, it underscores the importance of careful consideration when inducing labor and ensuring informed consent.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of Survival of Ablation Treatment for Portal Vein Tumor Thrombus in Patients With Hepatocellular Carcinoma. 肝细胞癌患者门静脉瘤栓消融治疗存活率的决定因素

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13721

Toru Ishikawa, Ryo Sato, Ryo Jimbo, Yuji Kobayashi, Toshifumi Sato, Akito Iwanaga, Tomoe Sano, Junji Yokoyama, Terasu Honma

{"title":"Determinants of Survival of Ablation Treatment for Portal Vein Tumor Thrombus in Patients With Hepatocellular Carcinoma.","authors":"Toru Ishikawa, Ryo Sato, Ryo Jimbo, Yuji Kobayashi, Toshifumi Sato, Akito Iwanaga, Tomoe Sano, Junji Yokoyama, Terasu Honma","doi":"10.21873/invivo.13721","DOIUrl":"10.21873/invivo.13721","url":null,"abstract":"Background/aim: The prognosis of hepatocellular carcinoma (HCC) complicated with portal vein tumor thrombus (PVTT) is extremely poor. This study investigated whether local ablation-a curative treatment similar to resection-could improve the prognosis of patients with Child-Pugh B/C PVTT.Patients and methods: Between January 2020 and December 2023, 25 patients with Child-Pugh B/C PVTT HCC were enrolled, and their overall survival with radiofrequency ablation treatment and the associated drivers were investigated.Results: Overall survival (median 282 days) differed between the group treated with transarterial chemoembolization (TACE, 285 days) and the group without it (159 days, p=0.0151). The median survival in the esophagogastric variceal exacerbation group (120.5 days) was shorter than that in the non-exacerbation group (284.0 days, p=0.00964). In multivariate analysis, concomitant TACE had a hazard ratio (HR) of 0.121 (p=0.0097), and the exacerbation of esophagogastric varices had a HR of 6.761 (p=0.01).Conclusion: Local ablation for PVTT may promote patient survival specifically by inhibiting the exacerbation of portal hypertension in patients with hepatocellular carcinoma.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid Diseases After Total Knee Replacement: A Multi-center, Propensity-score-matched Cohort Study. 全膝关节置换术后的甲状腺疾病：一项多中心、倾向分数匹配队列研究

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13714

Chen-Pi Li, Shao-Wei Lo, Christine Hsu, Yun-Feng Li, Ru-Yin Tsai, Hui-Chin Chang, Shuo-Yan Gau

{"title":"Thyroid Diseases After Total Knee Replacement: A Multi-center, Propensity-score-matched Cohort Study.","authors":"Chen-Pi Li, Shao-Wei Lo, Christine Hsu, Yun-Feng Li, Ru-Yin Tsai, Hui-Chin Chang, Shuo-Yan Gau","doi":"10.21873/invivo.13714","DOIUrl":"10.21873/invivo.13714","url":null,"abstract":"Background/aim: Thyroid diseases are prevalent endocrine disorders that significantly affect overall health. Although the impact of pre-existing thyroid dysfunction on total knee replacement (TKR) outcomes has been studied, the potential for TKR to increase the risk of developing thyroid disorders remains unexplored.Patients and methods: We examined electronic medical records from a large U.S. research network in the TriNetX research network. The study focused on patients with osteoarthritis, comparing those who had total knee replacement surgery (TKR) between 2005 and 2018 to a non-TKR group who did not have the surgery. Propensity score matching was employed to control for critical confounders. The hazard ratios (HRs) for the risk of thyroid diseases in TKR patients versus non-TKR controls were assessed.Results: Post-matching, the TKR cohort demonstrated a significantly higher risk of developing thyroid diseases compared to the non-TKR cohort (unadjusted HR=1.218, 95%CI=1.169-1.269). This elevated risk persisted after adjusting for confounders (adjusted HR=1.126, 95%CI=1.061-1.196). Stratification analysis indicated that female TKR patients and those aged ≥65 years were at higher risk of developing thyroid diseases than their respective control groups.Conclusion: This study suggests a potential link between TKR and an increased risk of thyroid diseases, particularly among older adults and females. Potential mechanisms include inflammatory processes, surgical stress, autoimmune responses, and pharmacological effects. Healthcare providers should be vigilant in monitoring and managing thyroid dysfunction in TKR patients. Further research is necessary to elucidate the underlying mechanisms and develop preventive strategies.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Robot-assisted Adrenalectomy for a Giant Adrenal Hemangioma: A Case Report. 机器人辅助肾上腺切除术治疗巨大肾上腺血管瘤的效果：病例报告

IF 1.8 4区医学

In vivo Pub Date : 2024-09-01 DOI: 10.21873/invivo.13728

Nanaka Katsurayama, Yuki Kobari, Y U Kizima, Hironori Fukuda, Kazuhiko Yoshida, Sekiko Taneda, Junpei Iizuka, Hideki Ishida, Yoji Nagashima, Toshio Takagi

{"title":"Effectiveness of Robot-assisted Adrenalectomy for a Giant Adrenal Hemangioma: A Case Report.","authors":"Nanaka Katsurayama, Yuki Kobari, Y U Kizima, Hironori Fukuda, Kazuhiko Yoshida, Sekiko Taneda, Junpei Iizuka, Hideki Ishida, Yoji Nagashima, Toshio Takagi","doi":"10.21873/invivo.13728","DOIUrl":"10.21873/invivo.13728","url":null,"abstract":"Background: Adrenal hemangiomas are extremely rare benign tumors that often need to be distinguished from malignancies. Adrenal tumors >4 cm in size are treated surgically because the possibility of malignancy cannot be ruled out. Traditionally, open surgery has been the mainstay of treatment; however, in recent years, robot-assisted surgery has been increasingly used for tumors of larger size and suspected malignancy. Here, we report a case of robot-assisted adrenalectomy for an 11 cm adrenal hemangioma.Case report: A 62-year-old male with lateral abdominal pain was referred to our hospital for further examination and treatment. His medical history was significant for hypertension, diabetes, and dyslipidemia. Computed tomography revealed an 11 cm left adrenal tumor, and all endocrinological screening tests were negative. Because the possibility of malignancy could not be ruled out, a robot-assisted adrenalectomy was performed. The operation time was 129 min, and the estimated blood loss was 7 ml. Pathological findings revealed an adrenal hemangioma. The postoperative course was uneventful, and patient's condition subsequently improved postoperatively.Conclusion: Robot-assisted adrenalectomy was performed for a giant adrenal hemangioma without any complications. Robotic surgery is useful for resecting adrenal hemangiomas even exceeding 11 cm in diameter.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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