Indian Journal of Nephrology最新文献_第4页

Association of LDLR Gene Polymorphism with the Risk of Cardiovascular Disease in End-Stage Kidney Disease Patients on Maintenance Hemodialysis LDLR 基因多态性与维持性血液透析的终末期肾病患者罹患心血管疾病风险的关系

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_33_2024

Enas Ahmed Osman, Hanan Shawky, Rania Mohammed Abbas, A. Metwaly, Anas Hassan Ibrahim, Farida M. Khanany

{"title":"Association of LDLR Gene Polymorphism with the Risk of Cardiovascular Disease in End-Stage Kidney Disease Patients on Maintenance Hemodialysis","authors":"Enas Ahmed Osman, Hanan Shawky, Rania Mohammed Abbas, A. Metwaly, Anas Hassan Ibrahim, Farida M. Khanany","doi":"10.25259/ijn_33_2024","DOIUrl":"https://doi.org/10.25259/ijn_33_2024","url":null,"abstract":"\u0000\u0000The low-density lipoprotein receptor (LDLR) is essential for regulating intracellular cholesterol levels. Mutations in the LDLR gene can cause a increase in LDL cholesterol levels in the blood, elevating the vulnerability to cardiovascular disease (CVD). This study evaluated the correlation between the LDLR rs688 polymorphism and CVD risk in chronic kidney disease (CKD).\u0000\u0000\u0000\u0000Polymorphism in this case-control study was genotyped using the TaqMan real-time polymerase chain reaction in a cohort of 100 CKD patients (Group I) and 100 healthy controls (Group II). We examined the LDLR rs688 allele and genotype distribution in 50 CKD cases with CVD and 50 cases without CVD.\u0000\u0000\u0000\u0000There was a significantly greater frequency of CT variant of LDL SNP rs688 in Group I than in Group II (p = 0.006). CT and TT genotypes were significantly higher in CKD patients with CVD, with odds ratios (ORs) (95% CI) of 4.3 (1.6–11.8, p = 0.004) and 7.6 (2.3–24.8, p = 0.001), respectively.\u0000\u0000\u0000\u0000SNP rs688 C>T detection in the LDLR gene showed that CT and TT genotypes are associated with elevated CVD risk in CKD.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Transplant Renal Vein Stenosis (TRVS) Managed with Percutaneous Endovascular Stenting: A Case Report 经皮血管内支架置入术治疗移植肾静脉狭窄 (TRVS)：病例报告

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_193_23

Preeti Chaudhary, Rajesh Tarachandani, Ranjeet Kumar Nath, H. Mahapatra

引用次数: 0

Clinical, Microbiological Profile, and Treatment Outcomes of Carbapenem-Resistant Urinary Tract Infections in a Tertiary Care Hospital 一家三级医院中耐药碳青霉烯类抗生素尿路感染的临床、微生物学特征和治疗结果

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_530_23

M. Eshwarappa, Rahul Sai Gangula, R. Rajashekar, Pooja Prakash Prabhu, V. Hamsa, M. Yousuff, Gireesh Mathihally, G. Konana, Lia Sara Anish

{"title":"Clinical, Microbiological Profile, and Treatment Outcomes of Carbapenem-Resistant Urinary Tract Infections in a Tertiary Care Hospital","authors":"M. Eshwarappa, Rahul Sai Gangula, R. Rajashekar, Pooja Prakash Prabhu, V. Hamsa, M. Yousuff, Gireesh Mathihally, G. Konana, Lia Sara Anish","doi":"10.25259/ijn_530_23","DOIUrl":"https://doi.org/10.25259/ijn_530_23","url":null,"abstract":"\u0000\u0000Carbapenem-resistant urinary tract infections (CR-UTIs) are a major global health threat. Many factors contribute to the increasing incidence of CR-UTI. Owing to the limited availability of treatment options, CR-UTIs are highly challenging to treat.\u0000\u0000\u0000\u0000This was a single-center, hospital-based, observational, retrospective cohort study. We investigated the treatment results, microbiological profiles, and clinical manifestations of CR-UTI at our institution between January 2017 and December 2021. All patients exhibiting clinical signs and symptoms of urinary tract infection (UTI) and a urine culture that showed growth of a single organism greater than 105 colony-forming units/ml were included. All patients were considered for a 1-year follow-up.\u0000\u0000\u0000\u0000From January 2017 to December 2022, 3016 (31%) CR-UTI episodes were noted. Approximately, 75% of CR-UTI episodes were caused by the most prevalent urinary pathogens, Escherichia coli and Klebsiella pneumoniae. Within 28 days, 308 patients (12.59%) died. Enterobacteriaceae treated for a minimum of 7–10 days showed a greater response to Aminoglycosides, Fosfomycin, Ceftizoxime, Colistin with Carbapenem, Tigecycline with Carbapenem, and Ceftazidime/avibactam. Within a year, 994 CR-UTI episodes were identified in patients who were available for follow-up; and 38% of these episodes were the result of relapse. Three-quarters of the remaining incidents were recurrent, accounting for a higher mortality rate (14.2%) within a year.\u0000\u0000\u0000\u0000Despite effective antibiotic treatment, CR-UTIs are associated with early relapse and recurrence. Newer effective treatment and preventive strategies are required to address this pandemic.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Outcomes of Covid-19 Vaccine-Associated Glomerular Diseases (CVAGD) – A Case Series from India Covid-19 疫苗相关肾小球疾病 (CVAGD) 的治疗结果--印度的一个病例系列

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_479_23

V. Rajarathinam, Jayalakshmi Seshadri, G. Senthilkumaran, V. Jibia, Vinoj Murugesan, P. Devaraju, C. M. Balasubramanian, Dinesh Kumar, T. Lamech, Natarajan Gopalakrishnan

{"title":"Outcomes of Covid-19 Vaccine-Associated Glomerular Diseases (CVAGD) – A Case Series from India","authors":"V. Rajarathinam, Jayalakshmi Seshadri, G. Senthilkumaran, V. Jibia, Vinoj Murugesan, P. Devaraju, C. M. Balasubramanian, Dinesh Kumar, T. Lamech, Natarajan Gopalakrishnan","doi":"10.25259/ijn_479_23","DOIUrl":"https://doi.org/10.25259/ijn_479_23","url":null,"abstract":"\u0000\u0000Several cases of glomerular diseases following Covid-19 vaccination, especially mRNA vaccines, have been reported. However, there is little data on glomerular diseases associated with the two vaccines widely available in India (Covaxin and Covishield) and their long-term outcomes.\u0000\u0000\u0000This was a prospective observational study conducted between May 2021 and May 2023. Patients with new-onset or relapse of proteinuria, hematuria, or renal failure within 30 days of Covid-19 vaccination were included. Data on pre-existing renal disease, vaccine type, symptomatology, laboratory reports, kidney biopsy findings, and treatment details were collected. The clinical course and long-term renal outcomes were studied.\u0000\u0000\u0000Sixteen patients with Covid-19 vaccine associated glomerular disease (CVAGD) were studied. The median age was 28 years (IQR 20.5–40) and median time of symptom onset was 14 days (IQR 10–16.5) after vaccination. Renal syndromes at presentation were nephrotic syndrome in seven patients (43.75%), nephritic syndrome in seven patients (43.75%), and rapidly progressive renal failure in two patients (12.5%). Kidney biopsy revealed minimal change disease in five patients (31.2%); IgA nephropathy in four patients (25%); C3 glomerulopathy, lupus nephritis, and focal segmental glomerulosclerosis in two patients each (12.5%); and pauci-immune glomerulonephritis (ANCA-associated vasculitis) in one patient (6.25%). Eleven patients were treated with immunosuppressive drugs. Median duration of follow-up was 20 months (IQR 18–21). At last follow-up, 11 patients had complete recovery of renal failure and proteinuria and 4 patients had partial recovery.\u0000\u0000\u0000The most common lesions in this series were minimal change disease and IgA nephropathy. The overall long-term outcome of CVAGD appears good.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunneled Dialysis Catheter Insertion in External Jugular Vein by Nephrologists 肾脏科医生在颈外静脉插入隧道式透析导管

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Indian Journal of Nephrology Pub Date : 2024-07-08 DOI: 10.25259/ijn_511_23

Vineet Behera, Shahbaj Ahmad, Smriti Sinha, Gireesh Reddy G, K. Srikanth, Indranil Ghosh, P. Chauhan, Ananthakrishnan Ramamoorthy, Vivek Hande

{"title":"Tunneled Dialysis Catheter Insertion in External Jugular Vein by Nephrologists","authors":"Vineet Behera, Shahbaj Ahmad, Smriti Sinha, Gireesh Reddy G, K. Srikanth, Indranil Ghosh, P. Chauhan, Ananthakrishnan Ramamoorthy, Vivek Hande","doi":"10.25259/ijn_511_23","DOIUrl":"https://doi.org/10.25259/ijn_511_23","url":null,"abstract":"\u0000\u0000External jugular vein (EJV) is used to insert tunneled dialysis catheter (TDC) in patients with no AVF and exhausted right internal jugular veins (IJV). There is scarce data on TDC insertion in EJV by nephrologists with fluoroscopy guidance.\u0000\u0000\u0000\u0000This was a prospective observational study that included hemodialysis patients with exhausted right IJV access who underwent EJV TDC insertion, and excluded occluded ipsilateral brachiocephalic vein or superior vena cava, EJV < 5 mm diameter, or patients with existing EJV TDC. All patients underwent evaluation of central veins. TDC insertions were performed by a nephrologist using ultrasound and fluoroscopic guidance. The primary outcome was the successful insertion of EJV TDC and catheter removal within 6 months due to major catheter dysfunction or complications.\u0000\u0000\u0000\u0000EJV TDC was successfully inserted in 23/23 cases (100% success), of which 17 (73.9%) were in right side, and 21 (91.3%) were denovo insertions. Catheter dysfunction needing removal occurred in seven cases (30.4%) with subclavian vein thrombosis in five cases (21.7%) and infectious complications in two cases (8.6%). The censored catheter survival was 23/23 (100%) at 1 month, 22/23 (95.6%) at 3 months, and 13/20 (65%) at 6 months. Cases of EJV catheter removal had a significant association with drainage of EJV into subclavian vein as compared to other anatomical variants (p = 0.005).\u0000\u0000\u0000\u0000EJV TDC insertion has a good technical success rate when performed under fluoroscopy. It is associated with an acceptable rate of catheter dysfunction, especially thrombosis, which is more common in EJV opening into subclavian veins.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Women in Nephrology—India: A Vision for the Future 印度肾脏病学界的女性：未来愿景

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Indian Journal of Nephrology Pub Date : 2024-07-08 DOI: 10.25259/ijn_447_23

Urmila Anandh, M. Sahay, Priti Meena, Divya Bajpai, M. Swarnalatha, Arpita Ray, Arpana Iyengar, Manjusha Yadla

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A Unique Case of Joubert Syndrome with Concurrent IgA Nephropathy and Nephronophthisis in an Adult Patient 一名成年患者并发 IgA 肾病和肾炎的朱伯特综合征独特病例

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Indian Journal of Nephrology Pub Date : 2024-07-08 DOI: 10.25259/ijn_86_2024

Mythri Shankar, V. Anusha, Aditya Shetty, CG Sreedhara, KS Vinay, Kishan Aralapuram, G. G. Reddy

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Multifocal Cryptococcus Neoformans Osteomyelitis in a Kidney Transplant Recipient 肾移植受者的多灶性隐球菌骨髓炎