S Vignesh, T Mukuntharajan, Krishnaswamy Sampathkumar
{"title":"Outcomes of Endovascular Treatment for Salvaging Failed Hemodialysis Arteriovenous Fistula - Role of Balloon Angioplasty as Initial Therapy.","authors":"S Vignesh, T Mukuntharajan, Krishnaswamy Sampathkumar","doi":"10.25259/ijn_539_23","DOIUrl":"10.25259/ijn_539_23","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the technical and clinical outcomes of endovascular treatment for failed native hemodialysis fistulas, mainly the role of balloon angioplasty in salvaging thrombosed and stenosed arteriovenous fistulas.</p><p><strong>Materials and methods: </strong>This retrospective study was done on 23 patients who had presented with non-functioning dialysis fistulas. The mean age of the patients was 58.7 ± 2.3 years. The cause of failure was thrombosis in 14 cases (61%) and stenosis in 9 cases (39%). All patients initially underwent percutaneous transluminal angioplasty (PTA), followed by thromboaspiration depending on the thrombus load and extent.</p><p><strong>Results: </strong>A total of 27 salvage procedures were performed on 23 patients. Technical success was achieved in 24 procedures (88.8%), and clinical success was 81.5%. Patients were followed up for mean duration of 9.5 months (range: 1-19 months). Eight out of 23 accesses initially revised failed again due to repeat thrombosis, of which four patients underwent repeat procedures. The mean duration to re-intervention was 5.5 ± 1.3 months. The primary patency rates were 79% at 3 months and 60% at 6, 12, and 18 months. The cumulative (secondary) patency rates were 73% at 6 months and 66% at 12 and 18 months. Minor complications were seen in three procedures (11%), which included venous extravasation in two cases and prolonged bleeding from puncture site in one case.</p><p><strong>Conclusion: </strong>Percutaneous balloon angioplasty can be used as first-line procedure in failed hemodialysis fistulas, in both cases of stenosis and/or thrombosis, followed by thromboaspiration if required.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"34 6","pages":"583-588"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Onu Ugochi Chika, Prabhjot Kaur, Nidhi Singh, Raja Ramachandran, Krishan Lal Gupta, Vivek Kumar
{"title":"Outcomes after Severe AKI Managed Outside ICU in Resource-Constrained Settings: A Prospective Cohort Study.","authors":"Onu Ugochi Chika, Prabhjot Kaur, Nidhi Singh, Raja Ramachandran, Krishan Lal Gupta, Vivek Kumar","doi":"10.25259/ijn_168_23","DOIUrl":"10.25259/ijn_168_23","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"34 6","pages":"646-648"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transplant Professionals and Transplant Commercialism in India: The Difficulty of Being Good.","authors":"Sanjay Nagral","doi":"10.25259/IJN_558_2024","DOIUrl":"10.25259/IJN_558_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"34 6","pages":"549-551"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endogenous Endophthalmitis in the Setting of Kidney Disease: A Case Series.","authors":"Ramakrishnan Santanaraman, Ramprasad Ramalingam, Dilip Rangarajan, Kiran Chandra Patro, Nikhil John Elenjickal","doi":"10.25259/IJN_271_2024","DOIUrl":"10.25259/IJN_271_2024","url":null,"abstract":"<p><p>Blood stream infections (BSI) are common in patients with kidney disease. Metastatic foci of infections are one of the known complications of BSI. Endophthalmitis which is defined as infection and inflammation of the inner coats of the eye ball and intraocular fluids (aqueous and vitreous), is one such focus. We discuss the clinical profile of five patients who had endogenous endophthalmitis in the setting of kidney disease and their management and outcome. All five had diabetes mellitus; the source was central venous catheter in two and urinary tract infection in two. Microbial cause was <i>Staphylococcus aureus</i> in two, <i>Pseudomonas aeruginosa</i> in one, <i>Klebsiella pneumoniae</i> in one and <i>Candida albicans</i> in one. All five required dialysis. Recovery of vision was poor with partial recovery only in two patients. A vision-threatening emergency, this condition requires early identification and management for better recovery of vision.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"34 6","pages":"652-654"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Urgent Dialysis as a Bridge to Palliative Care in Advanced Cancer Patients.","authors":"Devina Juneja","doi":"10.25259/IJN_243_2024","DOIUrl":"10.25259/IJN_243_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"34 6","pages":"676"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashok Kumar Yadav, Arpita Ghosh, Vivek Kumar, Sreejith Parameswaran, Sitanshu Sekhar Kar, Jarnail Singh Thakur, Harbir Singh Kohli, Neil R Dalton, Tazeen H Jafar, Andrew S Levey, Vivekanand Jha
{"title":"Development and Validation of an Accurate Creatinine-Based Equation to Estimate Glomerular Filtration Rate for the Adult Indian Population: Design and Methods.","authors":"Ashok Kumar Yadav, Arpita Ghosh, Vivek Kumar, Sreejith Parameswaran, Sitanshu Sekhar Kar, Jarnail Singh Thakur, Harbir Singh Kohli, Neil R Dalton, Tazeen H Jafar, Andrew S Levey, Vivekanand Jha","doi":"10.25259/IJN_221_2024","DOIUrl":"10.25259/IJN_221_2024","url":null,"abstract":"<p><strong>Background: </strong>Existing creatinine-based equations to estimate glomerular filtration rate (GFR), developed primarily in populations of European and African American ancestry, do not accurately reflect the GFR in the Indian population due to differences in body composition, diet, and other factors. This manuscript describes the rationale and methodology for developing a creatinine-based equation for more accurate GFR estimation in Indian subjects.</p><p><strong>Materials and methods: </strong>This cross-sectional study will be conducted in India's two geographically and demographically diverse locations: Chandigarh (north) and Puducherry (south). Participants will include a representative sample from the general population and subjects with chronic kidney disease (CKD), with the latter being recruited from outpatient clinics. A total of 1558 subjects will be enrolled in the discovery and cross-validation cohort and 620 subjects in the external validation cohort. The reference standard for measured GFR (mGFR) will be the plasma clearance of iohexol. Stepwise multiple regression on log-transformed data will determine a set of variables that jointly predict mGFR and identify factors influencing mGFR and estimated (eGFR) in the study population. This study will also explore the performance of mGFR by iohexol measurement from dried blood spots against mGFR from plasma clearance of iohexol.</p><p><strong>Conclusion: </strong>Developing a more reliable and accurate creatinine-based GFR estimating equation will improve CKD diagnosis, classification, and management. The findings will have substantial implications for CKD research in India and other regions with similar populations.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":" ","pages":"1-8"},"PeriodicalIF":0.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Characteristics and Outcomes of COVID-Positive Maintenance Hemodialysis Patients: A Study from India.","authors":"Manjusha Yadla, Anupama Kankokkaran Vadakkeveetil","doi":"10.25259/ijn_288_21","DOIUrl":"10.25259/ijn_288_21","url":null,"abstract":"<p><strong>Background: </strong>This study describes to the clinical features and outcomes of patients on maintenance hemodialysis infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant.</p><p><strong>Materials and methods: </strong>This was a retrospective analysis of case records of patients on maintenance hemodialysis admitted for management of coronavirus disease (COVID) infection. Our teaching hospital, being a state-designated referral center, had COVID admissions from March 2020 till December 2020. Epidemiological and clinical data were collected and analyzed. Factors influencing survival and the survival curve analysis were assessed.</p><p><strong>Results: </strong>Of a total of 21,228 admissions during the period, 400 patients were referred for nephrology services. Of the 400 referrals, 226 were maintenance hemodialysis patients. Mean age of the group was 50 years, and fever was the most common presenting symptom. On multivariate analysis, factors influencing mortality were found to be older age, presence of diabetes, leukopenia, thrombocytopenia, hypoxemia, need for support, and a higher qSOFA score. The probability of survival of dialysis patients at the end of 19 days was 60%.</p><p><strong>Conclusion: </strong>During the pandemic by SARS-CoV-2 delta variant, majority of the nephrology referrals were for maintenance hemodialysis patients. Mortality was 38% in the study group, and the factors associated with mortality with a significant hazard ratio were older age and diabetes.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"34 5","pages":"448-452"},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of Urinary Tract Infections and Vesicoureteric Reflux: Key Updates from Revised Indian Society of Pediatric Nephrology Guidelines 2023.","authors":"Jitendra Meena, Arvind Bagga, Pankaj Hari","doi":"10.25259/ijn_546_23","DOIUrl":"10.25259/ijn_546_23","url":null,"abstract":"<p><p>Non-specific symptoms and difficulty in collecting urine specimens make diagnosis of urinary tract infection (UTI) challenging in young children. However, timely diagnosis and initiation of therapy are essential to prevent complications. Children with recurrent UTIs require detailed evaluation and follow-up for optimal management. We report key updates from revised evidence-based practice guidelines of the Indian Society of Pediatric Nephrology for urinary tract infections and primary vesicoureteric reflux.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"34 5","pages":"442-447"},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}