Fever of Unknown Origin in a Renal Transplant Recipient.

IF 0.8 Q4 UROLOGY & NEPHROLOGY
Indian Journal of Nephrology Pub Date : 2025-07-01 Epub Date: 2024-08-22 DOI:10.25259/IJN_10_2024
Subashri Mohanasundaram, N D Srinivasaprasad, Edwin Fernando, K Thirumalvalavan, Sujit Surendran, Poongodi Annadurai
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引用次数: 0

Abstract

A syndrome of exaggerated lymphocytic proliferation and activation, called hemophagocytic lymphohistiocytosis (HLH) can occur primarily due to genetic mutation, in children and secondary to infection, malignancy or autoimmunity in adults. It is characterized by a misdirected activation of immune system, which causes cytokine release from macrophages and cytotoxic cells, in an uncontrolled fashion. Most treatment protocols are formulated for primary hemophagocytic histiocytosis, which occurs in children, whereas awareness and therapeutic guidelines for the secondary form of the disease which affects predominantly the adults is limited. We present a 29 year old renal transplant recipient presenting with fever of unknown origin found to have HLH secondary to tuberculosis, who responded to anti-tuberculous treatment.

Abstract Image

肾移植受者不明原因发热。
一种淋巴细胞增殖和活化过度的综合征,称为噬血细胞性淋巴组织细胞增多症(HLH),在儿童中主要由基因突变引起,在成人中继发于感染、恶性肿瘤或自身免疫。它的特点是免疫系统的错误激活,导致巨噬细胞和细胞毒性细胞以不受控制的方式释放细胞因子。大多数治疗方案是针对发生在儿童中的原发性噬血细胞组织细胞增多症制定的,而对主要影响成人的继发性疾病的认识和治疗指南有限。我们报告一位29岁的肾移植受者,出现不明原因的发热,发现有继发于结核病的HLH,他对抗结核治疗有反应。
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来源期刊
Indian Journal of Nephrology
Indian Journal of Nephrology UROLOGY & NEPHROLOGY-
CiteScore
1.40
自引率
0.00%
发文量
128
审稿时长
24 weeks
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