Indian Journal of Nephrology最新文献

{"title":"Mycophenolate-Induced Dysphagia in a Kidney Transplant Recipient.","authors":"Kalathil K Sureshkumar, Robert Ryhal, Khaled Nashar, Reem Daloul","doi":"10.25259/IJN_680_2024","DOIUrl":"https://doi.org/10.25259/IJN_680_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"446-447"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature's Cure or Kidney Curse? The Nephrotoxic Potential of Indigenous Remedies.","authors":"Jasmine Sethi, Urmila Anandh, Vivekanand Jha","doi":"10.25259/IJN_321_2024","DOIUrl":"https://doi.org/10.25259/IJN_321_2024","url":null,"abstract":"<p><p>Traditional medicine refers to a diverse range of health and healing practices used by Indigenous peoples that incorporate plants, animals, and the spiritual realm for the diagnosis and treatment of illness or maintenance of health and well-being. While these practices hold significant cultural value, there is growing evidence of potential nephrotoxicity associated with some traditional indigenous medicines (TIMs). In this review, we explore the various clinical manifestations of nephrotoxicity induced by TIMs. Nephrotoxicity can result from various factors, including the intrinsic toxicity of certain herbs, contamination with heavy metals, inappropriate dosages, and interaction with conventional medications. This review highlights the importance of monitoring kidney function in patients using TIMs and calls for increased awareness and regulation to ensure the safe use of these traditional therapies.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"335-342"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obinutuzumab as a Promising Treatment for Membranous Nephropathy.","authors":"Priti Meena, Raja Ramachandran","doi":"10.25259/IJN_391_2024","DOIUrl":"https://doi.org/10.25259/IJN_391_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"322-323"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Considerations in Metformin Use for ADPKD: A Commentary on Recent Findings.","authors":"Amol N Patil, Mahendra Pratap Singh, Pramod Rawat, Sanjit Sah, Prakasini Satapathy","doi":"10.25259/IJN_513_2024","DOIUrl":"https://doi.org/10.25259/IJN_513_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"443"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Telemedicine in Nephrology: The Role Beyond COVID-19.","authors":"Hari Shankar Meshram, Sanjeev Gulati","doi":"10.25259/IJN_745_2024","DOIUrl":"https://doi.org/10.25259/IJN_745_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"421-423"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Anticomplement Factor H Antibody Positive Versus Negative Atypical Hemolytic Uremic Syndrome.","authors":"Vamsidhar Veeranki, Jeyakumar Meyyappan, Arpit Srivastava, Ravi Shanker Kushwaha, Manas Behera, Manas Ranjan Patel, Anupma Kaul, Dharmendra Singh Bhadauria, Monika Yachha, Manoj Jain, Jai Kishun, Narayan Prasad","doi":"10.25259/IJN_106_2024","DOIUrl":"https://doi.org/10.25259/IJN_106_2024","url":null,"abstract":"<p><strong>Background: </strong>Atypical hemolytic uremic syndrome (aHUS) is a severe thrombotic microangiopathy predominantly affecting the kidneys, often associated with complement dysregulation. This study is aimed to analyze the clinical characteristics, treatment outcomes, and long-term implications of aHUS in a resource-limited setting.</p><p><strong>Materials and methods: </strong>A retrospective observational study conducted at an institute between January 2016 and December 2022 included all patients with aHUS, excluding secondary causes and renal transplant recipients. Demographic profiles, clinical features, laboratory parameters, treatment modalities (immunosuppression and plasma exchange), and outcomes were collected. Anticomplement Factor H (anti-CFH) antibody, complement levels, and genetic mutation analysis were performed to ascertain etiological factors. The patient and renal outcomes of anti-CFH positive and negative patients on long-term follow-up were compared.</p><p><strong>Results: </strong>Fifty-seven patients (mean age: 12.5 ± 4.9 years; 63% males) were analyzed. Among them, 33 (57.9%) tested positive for anti-CFH antibodies and eight presented postpartum. Initial remission was achieved in 42 (73.6%) patients, with 13 (22.8%) partial and 29 (50.9%) complete remission. The median follow-up duration was 24 months [interquartile range (IQR) 8.5-84]; 12 (21%) patients died, with two deaths during the index admission, six among nonresponders, and 4 among responders. Dialysis-free renal survival was superior in anti-CFH seropositive patients (81.2%) compared to seronegative counterparts (55.9%), while patient survival was statistically similar between the two groups. Elevated anti-CFH titers (>4000 AU/ml), age ≥16 years, female gender, and seizures predicted nonresponsiveness.</p><p><strong>Conclusion: </strong>Anti-CFH antibody associated aHUS had better kidney outcomes than the seronegative counterparts. In resource limited settings, a combination of plasma exchange and immunosuppression showed promising results in the short and long term.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"402-409"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Versus Standard of Care in Patients with Autosomal Dominant Polycystic Kidney Disease - A Randomized Control Trial.","authors":"Vaishnavi Venkatasubramanian, Jasmine Sethi, Vivek Kumar, Ashok Kumar Yadav, Anupam Lal, Harbir Singh Kohli","doi":"10.25259/IJN_100_2024","DOIUrl":"https://doi.org/10.25259/IJN_100_2024","url":null,"abstract":"<p><strong>Background: </strong>Autosomal dominant kidney disease (ADPKD) is the most common monogenic disorder leading to renal failure with limited therapeutic options. We aimed to assess the efficacy and safety of metformin in nondiabetic ADPKD patients and its role in slowing disease progression.</p><p><strong>Materials and methods: </strong>We conducted a prospective, randomized controlled, open labelled clinical trial and enrolled 52 nondiabetic adults aged 18-60 years with typical ADPKD, estimated glomerular filtration rate (eGFR) > 45 mL/min/m², and no risk factors of rapid disease progression. Participants were randomized in a 1:1 ratio by a computer-generated random number table into metformin + standard of care group (metformin arm) and standard of care group (Control arm). Primary outcome of the study was to evaluate the effects of metformin versus control arm on the percentage and absolute change in eGFR over a 6-month period.</p><p><strong>Results: </strong>Mean (SD) age of the cohort was 37.15 (10.16) years with half of them being females. The mean (SD) baseline htTKV and eGFR were 335.67 (153.3) mL/m and 100.23 (25.95) mL/min/m², respectively. Clinical exome sequencing was available in nine (17.3%) patients of which two-thirds had PKD1 mutation. Baseline characteristics were distributed equally across randomized groups. Baseline proteinuria was significantly higher in the metformin arm (p = 0.014). The eGFR difference and percentage change in eGFR was not different between the groups at 6 months (p = 0.53 and 0.48, respectively). There was no statistically significant difference in htTKV and percentage change in htTKV at 6 months between the groups, although an increase in htTKV was numerically smaller in the metformin group (p = 0.769, 0.805). Blood pressure, body weight, body mass index (BMI), and proteinuria also did not differ between the two groups. Only half of the cohort tolerated the maximum dose of metformin. Around two-thirds of patients reported adverse effects, most commonly asthenia.</p><p><strong>Conclusion: </strong>Metformin appears to be safe and well tolerated in nondiabetic patients with ADPKD.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"410-416"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Methicillin Resistant <i>Staphylococcus Aureus</i> Colonisation and the Incidence of Invasive Staphylococcal Infection in Patients Undergoing Hemodialysis.","authors":"Navya Mathew, Shweta Ann Suresh, Lisha Pallivalappil, Kundoly Velayudhan Suseela","doi":"10.25259/IJN_418_2024","DOIUrl":"https://doi.org/10.25259/IJN_418_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"419-421"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Maggot Infestation in a Tunneled Hemodialysis Catheter: An Unusual Presentation.","authors":"Majibullah Ansari, Manoj Anant Dhanorkar, Namrata S Rao, Abhilash Chandra","doi":"10.25259/IJN_651_2024","DOIUrl":"https://doi.org/10.25259/IJN_651_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"439"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Factor H Antibody Hemolytic Uremic Syndrome: A Disease in Need of \"Make in India\" Management.","authors":"Valentine Lobo","doi":"10.25259/IJN_539_2024","DOIUrl":"https://doi.org/10.25259/IJN_539_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"326-328"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}