Indian Journal of Nephrology最新文献

Antibody Response to Covishield and Covaxin in Kidney Transplant Recipients.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-08-01 DOI: 10.25259/ijn_549_23

Neha Manhas, Shyam Bihari Bansal, Amit Kumar Mahapatra, Abhyudaysingh Rana, Sidharth Kumar Sethi, Manish Jain, Dinesh Kumar Yadav

{"title":"Antibody Response to Covishield and Covaxin in Kidney Transplant Recipients.","authors":"Neha Manhas, Shyam Bihari Bansal, Amit Kumar Mahapatra, Abhyudaysingh Rana, Sidharth Kumar Sethi, Manish Jain, Dinesh Kumar Yadav","doi":"10.25259/ijn_549_23","DOIUrl":"10.25259/ijn_549_23","url":null,"abstract":"Background: The COVID-19 pandemic had a major impact on solid organ transplant recipients. COVID-19 vaccination plays a crucial role in pandemic management.There is limited data on replication-defective viral vectors [ChAdOx1-nCOV (COVISHIELDTM)] and whole inactivated one BBV-152 (COVAXINTM) in kidney transplant recipients (KTRs). This study aims to assess the humoral immune response and adverse effects of these vaccines in KTRs after the first and second doses of vaccination.Materials and methods: Anti-SARS-CoV-2 anti-spike antibody titers were measured in 285 KTRs recipients prior to vaccination, 3 weeks ± 3 days after first dose and 3 weeks ± 3 days after second dose of the COVISHIELD (n = 232) and COVAXIN (n = 55) vaccines. Anti-spike antibodies were measured by the chemiluminescence immunoassay method. The primary outcome was seroconversion after two doses of COVAXIN and COVISHIELD and secondary outcome was the incidence of adverse events to COVID-19 vaccines within one week of vaccination.Results: At baseline, 25 (39.7%) and 67 (30.2%) of KTRs were found to be seropositive before receiving COVAXINTM and COVISHIELDTM, respectively. After first dose of vaccination, 46 (73.0%) and 158 (71.2%) were seropositive and after second dose, 51 (81.0%) and 177 (79.7%) were seropositive, respectively. Common adverse effects were fever, chills, myalgia, and headache which settled in 1-2 days. There was no episode of rejection.Conclusion: Both ChAdOx1-nCOV and BBV-152 were well tolerated and induced robust antibody formation in KTRs in the Indian population.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"277-282"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tenofovir-Induced Fanconi Syndrome Associated with a Fragility Fracture of the Right Femoral Neck.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-09-12 DOI: 10.25259/IJN_454_2024

Lakhan Singh, Shivendu Bharadwaj, Gursimran Singh, Isha Gupta

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Diphallia with Duplicated Urethra and Urinary Bladder: A Rare Congenital Genitourinary Tract Anomaly.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-24 DOI: 10.25259/IJN_499_2024

Swaroop G Hegde, Anmol Bhatia, Nitin James Peters, Akshay Kumar Saxena, Kushaljit Singh Sodhi

引用次数: 0

Extensive Tumoral Calcinosis and Acral Osteolysis.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-11-13 DOI: 10.25259/IJN_512_2024

Sriram Sriperumbuduri, Mohammad Atari, Mohamed Hassanein

引用次数: 0

GALNT3 Mutation in Hyperphosphatemic Familial Tumoral Calcinosis - Novel Etiology of Secondary Amyloidosis.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-06-24 DOI: 10.25259/ijn_534_23

Sourabh Sharma, Sahil Arora, Renju Binoy, Anupam Agarwal, Pallavi Prasad, Himanshu Verma

引用次数: 0

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors for Anemia in Non-Dialysis Dependent Chronic Kidney Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.25259/ijn_382_23

Jyoti Tyagi, Manveen Kaur, Sandeep Moola, Raja Ramachandran, Priti Meena, Divya Bajpai, Soumyadeep Bhaumik

{"title":"Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors for Anemia in Non-Dialysis Dependent Chronic Kidney Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Jyoti Tyagi, Manveen Kaur, Sandeep Moola, Raja Ramachandran, Priti Meena, Divya Bajpai, Soumyadeep Bhaumik","doi":"10.25259/ijn_382_23","DOIUrl":"10.25259/ijn_382_23","url":null,"abstract":"Background: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) is a new therapy option for anemia in chronic kidney disease (CKD) patients. We aimed to evaluate evidence from randomized controlled trials (RCTs) on HIF-PHIs for anemia in non-dialysis dependent (NDD)-CKD patients.Materials and methods: We searched three electronic databases (PubMed, CINAHL, Cochrane Central Register of Controlled Trials databases), trial registries, and manually screened reference list. Two authors independently conducted screening, data extraction, and assessed risk of bias. We used RevMan 5.3 for meta-analysis using standard methods. Certainty of evidence was assessed by Grading of Recommendations, Assessment, Development, and Evaluations.Results: We included 12 RCTs involving 8611 patients with anemia of kidney disease. The studies included roxadustat (n = 2), daprodustat (n = 3), molidustat (n = 3), vadadustat (n = 2), enarodustat (n = 1), and desidustat (n = 1). Desidustat and daprodustat reported no difference in the hemoglobin levels from baseline up to 24-52 weeks as compared to darbepoetin alpha [Mean Difference (MD): 0.09 g/dL (CI 95% 0.15-0.33); p = 0.46; 529 participants; low certainty evidence; and MD: 0.08 g/dL (CI 95% 0.08-0.08); p < 0.00001; two studies; 4089 participants; low certainty evidence, respectively]. Broadly, HIF-PHI molecules exhibited little difference when compared to other alternatives like erythropoietin stimulating agents (ESAs), but the evidence is not of high certainty.Conclusion: Our meta-analysis provides evidence on the use of HIF-PHIs as an alternative to ESAs for anemia in NDD-CKDs.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"217-233"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition Profile and Quality of Life of Chronic Kidney Disease Patients on Maintenance Hemodialysis in India.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-09-26 DOI: 10.25259/IJN_390_2024

Umesh Khanna, Neil Saldanha, Chintan Paresh Gandhi

引用次数: 0

Nutritional Advice for Dialysis Patients: A Patient's Perspective.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-11-22 DOI: 10.25259/IJN_588_2024

Kamal Shah

引用次数: 0

Poisoning and Envenomation Induced Acute Kidney Injury: A Hospital-Based Study.

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-08-14 DOI: 10.25259/IJN_3_2024

Arham Khan, Saif Quaiser, Ruhi Khan, Neha Agrawal

{"title":"Poisoning and Envenomation Induced Acute Kidney Injury: A Hospital-Based Study.","authors":"Arham Khan, Saif Quaiser, Ruhi Khan, Neha Agrawal","doi":"10.25259/IJN_3_2024","DOIUrl":"10.25259/IJN_3_2024","url":null,"abstract":"Background: Most cases of acute kidney injury (AKI) in the Indian subcontinent are community-acquired. Some causes of AKI like poisonings are unique to the local demographics. This study examined the clinical features, spectrum, and outcomes of AKI in patients with poisoning and evaluated the predictors of mortality.Materials and methods: This was a prospective observational study conducted in patients admitted to Jawaharlal Nehru Medical College, Aligarh with an alleged history of poisoning orsnake bite. Relevant history, laboratory tests, mode of treatment, and outcome were recorded for all patients who were followed up after 3 months post discharge.Results: During the study period, 394 patients were admitted with a provisional diagnosis of poisoning/snake bite analyzed, of whom 56 (14.2%) developed AKI. Final data analysis was done for 51 patients as 5 patients were lost to follow up. Paraquat poisoning was the most common cause of AKI, seen in 12 patients, followed by methanol in 9 patients. Hemodialysis was required in 29 (56.8%) patients. Complete recovery was seen in 33 (64.7%) patients, and 14 patients (27.5%) died during the acute phase of the illness. Late presentation to the hospital and presence of shock (mean arterial pressure <65 mmHg) on presentation were found to be associated with adverse outcomes (mortality/failure of return of renal function at 3 months). The most common cause of death was septic shock seen in 8 patients.Conclusion: This study, which is probably the first from North India, highlights the fact that cases of poisoning/envenomation-related AKI contribute to a sizeable amount of morbidity/mortality.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"283-289"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life of Children with Idiopathic Nephrotic Syndrome.

IF 0.8

Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-08-22 DOI: 10.25259/IJN_5_2024

Jyoti Shukla, Anita Gupta, Raminder Kalra

{"title":"Quality of Life of Children with Idiopathic Nephrotic Syndrome.","authors":"Jyoti Shukla, Anita Gupta, Raminder Kalra","doi":"10.25259/IJN_5_2024","DOIUrl":"10.25259/IJN_5_2024","url":null,"abstract":"Background: Nephrotic syndrome (NS) is relapsing-remitting illness affecting children and characterized by proteinuria, edema, and hypoalbuminemia. The disease involves the significant formative years of a child's life and profoundly impacts their physical and psychosocial well-being. There is a scarcity of literature exploring the quality of life (QoL) of children with NS and the factors influencing them. The study aimed to discuss the QoL of children with NS and the factors influencing it.Materials and methods: A systematic search of electronic databases, including PubMed, Google Scholar, and Embase, was carried out from 2004 to August 2023. Nineteen original articles in English language that focused on evaluating the QoL of children with NS were included. Articles in languages other than English, letters, and editorial reviews, studies involving populations other than children, were excluded.Results: Children with NS tend to have a better QoL as compared to those with other chronic diseases (p = <0.001), but it remains lower than that of healthy children (p<0.05). School functioning was the most affected domain. Recurrent relapses, prolonged illness, high steroid dosages, and multiple medications are significant contributors to impaired QoL. Children with steroid-resistant nephrotic syndrome (SRNS) had poorer QoL among the clinical subtypes.Conclusion: Children with NS face various challenges that impact their QoL. Comprehensive care strategies to enhance QoL are the need of the hour.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"234-242"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0