Indian Journal of Nephrology最新文献_第10页

Radiation-induced Renal Artery Stenosis 辐射导致的肾动脉狭窄

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Indian Journal of Nephrology Pub Date : 2024-05-22 DOI: 10.25259/ijn_485_23

Kosha Patel, Sishir Gang, Umapati Hegde, Abhijit Konnur, Hardik Patel

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Nerve Epidermal Growth Factor-Like 1 Protein (NELL-1) Expression in Mercury-Related Membranous Nephropathy: Is It a True Association or a Chance Occurrence? 汞相关膜性肾病中神经表皮生长因子样 1 蛋白（NELL-1）的表达：是真实关联还是偶然发生？

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Indian Journal of Nephrology Pub Date : 2024-05-20 DOI: 10.25259/ijn_109_2024

B. Srinivas, Norton S. Stephen, P. Priyamvada, RajeshNachiappa Ganesh, Sreejith Parameswaran, D. Gochhait

{"title":"Nerve Epidermal Growth Factor-Like 1 Protein (NELL-1) Expression in Mercury-Related Membranous Nephropathy: Is It a True Association or a Chance Occurrence?","authors":"B. Srinivas, Norton S. Stephen, P. Priyamvada, RajeshNachiappa Ganesh, Sreejith Parameswaran, D. Gochhait","doi":"10.25259/ijn_109_2024","DOIUrl":"https://doi.org/10.25259/ijn_109_2024","url":null,"abstract":"\u0000\u0000Neural epidermal-like growth factor-like 1 (NELL-1) is a protein kinase C binding protein expressed in osteoblasts and renal tubules. It is expressed in 5%–25% glomerular cells at the mRNA level. Membranous Nephropathy (MN) is characterized by the presence of antibodies against certain types of antigens on the glomerular basement membrane. The most common one implicated in primary MN is an antibody against PLA2R. Many newer antigens have been discovered in the recent past, which are proven to cause secondary MN, one of which is NELL-1. NELL-1 has been associated with malignancy-associated MN and also recently associated with traditional indigenous medications containing mercury. In this study, we study the expression of NELL-1 in mercury-associated MN.\u0000\u0000\u0000\u0000Records of ten cases of Mercury -associated MN were retrieved from the Institute medical archives and NELL-1 Immunohistochemistry was performed in all ten cases.\u0000\u0000\u0000\u0000NELL-1 was found to be positive in 50% of the cases of Mercury associated MN. In addition, mass spectrometric studies was performed, which revealed the common Mercuric compound associated to be ‘Swaskalpa’, Sudarshana Melugu’ and Rasagandhi Mezhugu’.\u0000\u0000\u0000\u0000This study highlights why it is important to diagnose mercury-associated MN by a pathologist by picking up the finer histopathological clues and by using NELL-1 immunohistochemistry, especially in PLA2R-negative patients. The former is true as most of the time a history of mercuric compound intake is missed out.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141119554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Physical Activity and Quality of Sleep Among Patient with Chronic Kidney Disease on Hemodialysis: A Cross-Sectional Study 血液透析慢性肾病患者的体育锻炼和睡眠质量：一项横断面研究

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Indian Journal of Nephrology Pub Date : 2024-05-20 DOI: 10.25259/ijn_56_23

Srishti Choudhary, N. Rana, Ashok Kumar, N. Bajpai, P. Gangadevi

{"title":"Physical Activity and Quality of Sleep Among Patient with Chronic Kidney Disease on Hemodialysis: A Cross-Sectional Study","authors":"Srishti Choudhary, N. Rana, Ashok Kumar, N. Bajpai, P. Gangadevi","doi":"10.25259/ijn_56_23","DOIUrl":"https://doi.org/10.25259/ijn_56_23","url":null,"abstract":"\u0000\u0000Chronic kidney disease (CKD) patients on hemodialysis face issues like poor quality of sleep and reduced physical activity, which can impair their quality of life. This study aimed to assess the physical activity and quality of sleep among CKD patients on hemodialysis.\u0000\u0000\u0000\u0000This cross-sectional study was conducted at All India Institute of Medical Sciences (AIIMS), Jodhpur. Data from 66 participants selected consecutively using self-reported standardized tools, namely, Global Physical Activity Questionnaire (GPAQ) and Pittsburgh Sleep Quality Index (PSQI), were collected, along with sociodemographic variables. After receiving written informed consent, questionnaires were administered through face-to-face interviews.\u0000\u0000\u0000\u0000The majority of the individuals, 45 (68.2%), were found to be physically active with a mean score of 2280.8 metabolic equivalents (MET)-min/week. The average PSQI score was 9.24 ± 4, and 49 (74.2%) participants had a PSQI score as higher than 5, suggesting poor quality of sleep. Physical activity and quality of sleep were found to have a significant relationship (P = 0.03). Physical activity was found to have a significant relationship with age (P = 0.01), whereas quality of sleep was associated with smoking status (P = 0.04), alcohol consumption (P < 0.01), and body mass index (BMI; P = 0.03).\u0000\u0000\u0000\u0000Contrary to many studies where CKD patients on hemodialysis were found to be physically inactive, the present study showed a substantial portion of them to be physically active. Poor quality of sleep was common; hence, interventions to promote sleep quality recommended.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tunneled Hemodialysis Catheter Making Its Way into the Spinal Canal: An Unusual Complication 隧道式血液透析导管进入椎管：非同寻常的并发症

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Indian Journal of Nephrology Pub Date : 2024-05-18 DOI: 10.25259/ijn_53_2024

A. Saha, N. Bodhey, Nitin Kumar Kashyap, Vinay Rathore, Rohit Badge, Jyoti Aggarwal, N. Pathak

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Hidden in Plain Sight—A Rare Presentation of Cystic Fibrosis with Pseudo-Bartter Syndrome 隐藏在众目睽睽之下--囊性纤维化伴假巴特综合征的罕见表现

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Indian Journal of Nephrology Pub Date : 2024-05-18 DOI: 10.25259/ijn_53_23

Ratnapriya Chowdhry, R. Vaswani, Jane David

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A Rare Case of Apparent Mineralocorticoid Excess Presenting as Endocrine Hypertension 一个表现为内分泌性高血压的明显矿皮质激素过多的罕见病例

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Indian Journal of Nephrology Pub Date : 2024-05-18 DOI: 10.25259/ijn_83_2024

Vishnu Vijayakumar, Nitish Kumar, Devesh Kumar, Abhishek Abhinay, Ankur Singh, R. Prasad

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The Ups and Downs of Live Posting in Nephrology Conferences 肾脏病学会议现场发帖的起起落落

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Indian Journal of Nephrology Pub Date : 2024-05-18 DOI: 10.25259/ijn_427_23

Jasmine Sethi

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Acute Kidney Injury in Chronic Liver Disease in Northwest India: Still a Battle to Conquer 印度西北部慢性肝病患者的急性肾损伤：仍是一场有待征服的战争

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Indian Journal of Nephrology Pub Date : 2024-05-14 DOI: 10.25259/ijn_286_23

Disha Saxena, Manoj Yadav, Tarun Kumar, Sanjeev Sharma, P. Beniwal, V. Malhotra, D. Agarwal, Sandeep Nijhawan

{"title":"Acute Kidney Injury in Chronic Liver Disease in Northwest India: Still a Battle to Conquer","authors":"Disha Saxena, Manoj Yadav, Tarun Kumar, Sanjeev Sharma, P. Beniwal, V. Malhotra, D. Agarwal, Sandeep Nijhawan","doi":"10.25259/ijn_286_23","DOIUrl":"https://doi.org/10.25259/ijn_286_23","url":null,"abstract":"Background: Patients with cirrhosis are susceptible to development of acute kidney injury (AKI), which leads to poor outcome. We conducted a study to evaluate the spectrum of AKI in patients with cirrhosis. Materials and Methods: This study was conducted in consecutive cirrhotic patients with AKI admitted in a tertiary care center of India from April 2020 to December 2022. Details including history, examination findings, and results of laboratory investigations were recorded. Results: A total of 243 patients were enrolled in this study. The majority (91.3%) of the patients were males. The most common etiology of cirrhosis was alcohol in 58.4% (n = 142) followed by hepatitis B in 10.3% (n = 25) of patients. Pre-renal form of AKI was present in 54.4% (n = 132) of patients and hepatorenal syndrome (HRS) in 21.8% (n = 53) of patients. IgA nephropathy was the commonest (n = 6) glomerular pathology in nonresponders with intrinsic renal disease. Majority of the patients belonged to stage II (46.9%) and stage I AKI (37%), while only 16.1% had stage III AKI. Various stages of AKI showed a significant correlation (P < 0.05) with Child–Turcotte–Pugh (CTP) score and Model for End-stage Liver Disease (MELD)-Na score. The overall in-hospital mortality rate was found to be 18.5% (n = 45). Conclusion: Renal dysfunction is a frequent complication among cirrhotic patients. Pre-renal factors were the most common cause of AKI in cirrhotics. Stages of AKI showed significant correlation with liver prognostic scores. Renal biopsy should be considered in patients not responding to treatment, to guide further management.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Clinical Audit of Assisting Renal Biopsy Procedure Performed in Nephrology Unit of a Tertiary Care Hospital with a View to Develop Standard Nursing Procedure Protocol 对一家三甲医院肾内科进行的辅助肾活检程序进行临床审计，以期制定标准护理程序规程

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Indian Journal of Nephrology Pub Date : 2024-05-14 DOI: 10.25259/ijn_415_23

Mamta Thakur, S. Mawar, L. Murry, D.K. Sharma

{"title":"Clinical Audit of Assisting Renal Biopsy Procedure Performed in Nephrology Unit of a Tertiary Care Hospital with a View to Develop Standard Nursing Procedure Protocol","authors":"Mamta Thakur, S. Mawar, L. Murry, D.K. Sharma","doi":"10.25259/ijn_415_23","DOIUrl":"https://doi.org/10.25259/ijn_415_23","url":null,"abstract":"Background: Renal biopsy is one of the most commonly performed diagnostic procedures in the nephrology unit. Nurses play a very important role in pre-biopsy preparation, assisting during procedure and post-biopsy care. Nursing care provided during or after renal biopsy is of utmost importance in reducing complications. The study aims to perform a clinical audit of nursing practices to find the gaps in existing practices for the procedure of assisting renal biopsy and to develop standard protocol. Materials and Methods: This descriptive observational study was conducted on 19 nurses who were working in the nephrology unit of the tertiary care center. They were enrolled through total enumerative sampling. Sociodemographic profile and clinical profile were collected. The observation checklist was formed based on standard nursing practices, which included three dimensions for the procedure of assisting renal biopsy. Based on the gaps identified, a standard protocol was developed. Nurses were observed during two shifts and each nurse was observed once. Scoring of items was done in each dimension and for acceptable practices, nurses have to score ≥80% in each dimension. Data were analyzed using descriptive statistics. Results: The majority of nurses (73.7%) have not undergone any special training in nephrology. None (100%) showed an acceptable level of nursing practices for all the dimensions of assisting renal biopsy procedure. Standard protocol was developed by the researcher following a rigorous process. Conclusion: The clinical audit found that there were gaps in the existing nursing practices for the procedure of assisting renal biopsy and these gaps have been addressed by the development of a standard protocol.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Dysfunction Screening in Peritoneal Dialysis Patients: A Cross-Sectional Study 腹膜透析患者认知功能障碍筛查：横断面研究

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Indian Journal of Nephrology Pub Date : 2024-05-14 DOI: 10.25259/ijn_378_23

Ana C. Brás, Joana Marques, V. Fernandes, Ana C. Ferreira

{"title":"Cognitive Dysfunction Screening in Peritoneal Dialysis Patients: A Cross-Sectional Study","authors":"Ana C. Brás, Joana Marques, V. Fernandes, Ana C. Ferreira","doi":"10.25259/ijn_378_23","DOIUrl":"https://doi.org/10.25259/ijn_378_23","url":null,"abstract":"Background: Mild cognitive impairment (MCI) in peritoneal dialysis (PD) patients has been described as a risk factor for worse outcomes such as peritonitis, technique failure, and mortality. In this study, we aimed to determine the prevalence of MCI in a population of PD patients and identify the possible risk factors associated with MCI. Materials and Methods: We performed an observational, cross-sectional study to evaluate cognitive function using the Montreal Cognitive Assessment (MOCA) test and the Mini Mental State Examination (MMSE) test in PD patients. Patients with diagnosis of dementia or severe neurologic impairment, active cancer, or infection were excluded. Results: We evaluated 66 patients (mean age 60 years); 53% were male. Prevalence of MCI assessed by MOCA test and MMSE test was 65% and 33%, respectively. Predictors of MCI with MOCA test were higher age (P = 0.0001), lower education level (P = 0.005), need of a helper (P = 0.009), and continuous ambulatory PD modality (P = 0.019). Higher Charlson comorbidity index (P = 0.002), coronary artery disease (P = 0.006), and peripheral artery disease (P = 0.033) were also associated with MCI. Lower Kt/V (P = 0.012) and lower levels of normalized protein catabolic rate (nPCR; P < 0.000) were related to MCI. MCI patients had more episodes of peritonitis (P = 0.047). Multivariable analysis showed that lower education, Kt/V, and nPCR were the most relevant factors connected to MCI (P = 0.029, P = 0.037, and P = 0.019, respectively). Conclusion: In our PD population, MCI was detected in more than half of the patients. Patients with MCI were older, had lower education level, more disease burden, and higher risk for developing peritonitis. Lower Kt/V and nPCR levels were associated with MCI.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0