Indian Journal of Nephrology最新文献_第10页

MicroRNA Expression and Target Prediction in Children with Nephrotic Syndrome. 儿童肾病综合征的MicroRNA表达及靶标预测。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-06-17 DOI: 10.25259/ijn_47_23

Pricilla Charmine, Vettriselvi Venkatesan, Sangeetha Geminiganesan, Bollam Rangaswamy Nammalwar, Mohanapriya Chinambedu Dandapani

{"title":"MicroRNA Expression and Target Prediction in Children with Nephrotic Syndrome.","authors":"Pricilla Charmine, Vettriselvi Venkatesan, Sangeetha Geminiganesan, Bollam Rangaswamy Nammalwar, Mohanapriya Chinambedu Dandapani","doi":"10.25259/ijn_47_23","DOIUrl":"10.25259/ijn_47_23","url":null,"abstract":"Background: Nephrotic syndrome is a common cause of kidney diseases in children. Many studies have examined the association of microRNAs playing potential roles in many pathophysiological functions. We investigated the expression pattern of the microRNAs miR-17-5P, miR-155p, miR-424-5p in children with steroid sensitive nephrotic syndrome (SSNS) and steroid resistance nephrotic syndrome (SRNS), along with the healthy subjects.Materials and methods: Total RNA was isolated from the urine samples from the three groups (SSNS n = 100, SRNS n = 100, and healthy control group n = 100). Bioinformatics tools such as miRWalk and miR-Tar link were used in predicting targets for the microRNAs. Online database and g profiler software are used to evaluate the targets based on the biological functions. The expression pattern for the candidate microRNAs was carried out using quantitative real time polymerase chain reaction (RT-PCR) equipment.Results: miR-424 and miR-155 were upregulated in SRNS group while miR-17 was downregulated in SRNS group. miR-424-5p and miR-155p was up regulated in SRNS group while miR-17-5p was downregulated.Conclusion: Combined analysis of gene expression along with studied candidate microRNAs can give better understanding of the pathogenesis of childhood nephrotic syndrome.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"59-63"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Histologic Coexistence of Infection-Related Glomerulonephritis and Thrombotic Microangiopathy. 感染相关性肾小球肾炎和血栓性微血管病罕见的组织学共存。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-08-29 DOI: 10.25259/IJN_304_2024

C V Malathi, Jansi Prema K S, Kishan Aralapuram, Venkataramanan Krishnamoorthy, Anila Abraham Kurien

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Insights into Therapeutic Strategies and Longitudinal Outcomes: A Retrospective Analysis of NELL1 Positive Membranous Nephropathy Cohort. 对治疗策略和纵向结果的见解：NELL1阳性膜性肾病队列回顾性分析。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-10-17 DOI: 10.25259/IJN_443_2024

Gurjot Singh, Harsha Makhija, Pankaj Beniwal, Vinay Malhotra

引用次数: 0

Viral Infection Associated Membranous Nephropathy: Clinical Presentation and Outcomes. 病毒性感染相关膜性肾病：临床表现和结果。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-08-01 DOI: 10.25259/IJN_57_2024

Prabhjot Kaur, Arun Prabhahar, Anitha Vijayakumar Niranjan, Vinod Kumar, Deeksha Pal, Manish Rathi, Harbir Singh Kohli, Aravind Sekar, Ritambhra Nada, Sunil Taneja, Raja Ramachandran

{"title":"Viral Infection Associated Membranous Nephropathy: Clinical Presentation and Outcomes.","authors":"Prabhjot Kaur, Arun Prabhahar, Anitha Vijayakumar Niranjan, Vinod Kumar, Deeksha Pal, Manish Rathi, Harbir Singh Kohli, Aravind Sekar, Ritambhra Nada, Sunil Taneja, Raja Ramachandran","doi":"10.25259/IJN_57_2024","DOIUrl":"10.25259/IJN_57_2024","url":null,"abstract":"Background: Viral infections can increase the likelihood of an individual developing membranous nephropathy (MN). Limited information is available regarding the treatment approaches for such cases. We conducted a review focusing on hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV)-associated MN.Materials and methods: Our investigation encompassed patient records and cases documented in the literature, utilizing various search engines (PubMed, Scopus, Embase, and Web of Science). We aimed to identify all reported instances of MN associated with HBV, HCV, or HIV infections between 2010 and February 2023 in individuals aged 18 years and above, who underwent PLA2R testing in their serum or kidney biopsy.Results: We analyzed 63 patients with MN associated with viral infections, comprising 7 patients from our center and 57 from the review, consisting of 43% with HIV, 28.5% with HBV, 17.5% with HCV, and 11% with mixed infections. The average age of these patients was 47 years. Their mean proteinuria, serum albumin, and creatinine levels were 7.5 g/day, 2.3 g/dl, and 1.4 mg/dl, respectively. Two-thirds of these cases were PLA2R-related. Notably, 24% of patients achieved remission solely through antiviral treatment, while nearly 40% attained remission with a combination of antiviral and immunosuppression therapies. Eight patients did not achieve remission despite receiving immunosuppressive therapy and antiviral agents.Conclusion: The review suggests that using antiviral medications alone or combined with immunosuppressive therapy can lead to substantial remission in patients with viral-associated MN.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"70-76"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor V Leiden Heterozygous Mutation and Hyperhomocysteinemia Presenting with Vascular Rejection and Renal Allograft Infarction. 因子V Leiden杂合突变和高同型半胱氨酸血症表现为血管排斥和同种异体肾移植梗死。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-06-12 DOI: 10.25259/IJN_330_2024

Taruna Pahuja, Sukhwinder Singh Sangha, Akash Sarkar, Raj Kanwar Yadav

引用次数: 0

Sapovirus-Associated Diarrhea in Renal Transplant Patient Treated Without Altering Immunosuppression. 在未改变免疫抑制的情况下治疗肾移植患者的腺病毒相关性腹泻。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-06-29 DOI: 10.25259/ijn_507_23

Ravi Andrews, Mohammed Sajid Abdul Samad, Teja Chimtalapudi, Venkat Ramesh, Muna Ather Ali

引用次数: 0

Oral Anticoagulant-Related Nephropathy: A New Cause for an Old Entity. 口服抗凝剂相关肾病：一个旧实体的新原因。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.25259/IJN_528_20

Patrícia Valério, Elsa Soares, Catarina Abrantes, Mário Góis, Helena Sousa, Ana Farinha, Ana Azevedo

引用次数: 0

Spontaneous Intravascular Cephalad Migration of Tunneled Cuffed Catheter - An Unusual Late Complication and Role of Re-Imaging. 管状套管头侧血管内自发性移位——一种罕见的晚期并发症及重新成像的作用。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-08-22 DOI: 10.25259/IJN_264_2024

Ajay Jaryal, Sanjay Vikrant, Varun Bansal, Akanksha, Sajal Sharma, Riya Aneja

引用次数: 0

Silent Hearing Loss in Kidney Transplant Patients Receiving Tacrolimus: A Fact or a Myth? 接受他克莫司肾移植患者的无声性听力损失：事实还是神话？

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-06-24 DOI: 10.25259/ijn_503_23

Ahmed ElSaeed Abdulgalil, Ola H Elnagdy, Noha H Elnagdy, Eman Nagy

{"title":"Silent Hearing Loss in Kidney Transplant Patients Receiving Tacrolimus: A Fact or a Myth?","authors":"Ahmed ElSaeed Abdulgalil, Ola H Elnagdy, Noha H Elnagdy, Eman Nagy","doi":"10.25259/ijn_503_23","DOIUrl":"10.25259/ijn_503_23","url":null,"abstract":"Background: It has been claimed that tacrolimus may have harmful effects on the auditory system, where it has been linked to ototoxicity and sensorineural hearing loss (SNHL). We evaluated silent SNHL in kidney transplant recipients (KTRs) receiving tacrolimus and the different factors affecting it compared to healthy controls.Materials and methods: In this case control study, hearing functions were studied in 42 KTRs receiving tacrolimus as maintenance immunosuppressive therapy for more than 3 months in comparison to 27 age- and gender-matched healthy subjects using tympanometry, pure-tone audiometry (PTA), extended high frequency audiometry (EHFA), and transient evoked oto-acoustic emissions (TEOAEs). Also, different factors were studied in relation to SNHL.Results: PTA showed that 23.8%, 21.4%, and 4.8% had mild, moderate, and severe SNHL, respectively. One-fifth of KTRs had severe SNHL, according to EHFA. According to TEOAEs, 28.6% of KTRs had abnormal hearing. There was a significant positive correlation between the tacrolimus trough levels and the results of both the PTA (P = 0.002) and EHFA (P = 0.035) tests.Conclusion: SNHL was detected in about half of the studied KTRs. Silent SNHL in KTRs might be associated with higher tacrolimus trough levels.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"64-69"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Belimumab for Glucocorticoid Discontinuation in Juvenile-Onset Lupus Nephritis. 贝利单抗对青少年狼疮性肾炎患者停用糖皮质激素的疗效。

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Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.25259/IJN_444_2024

Tomoo Kise, Masatsugu Uehara

{"title":"Effectiveness of Belimumab for Glucocorticoid Discontinuation in Juvenile-Onset Lupus Nephritis.","authors":"Tomoo Kise, Masatsugu Uehara","doi":"10.25259/IJN_444_2024","DOIUrl":"10.25259/IJN_444_2024","url":null,"abstract":"Lupus nephritis (LN) is an important complication of systemic lupus erythematosus, for which glucocorticoids (GCs) are the primary treatment. Due to the side effects associated with GCs, their long-term use should ideally be tapered and discontinued. At present, no such possibility exists without problematic flares after discontinuation. We administered belimumab, a human monoclonal antibody that binds to a soluble B lymphocyte stimulator to reduce the number of activated B cells, to six patients with Type IV LN to discontinue GCs. The six patients were 10-15 years old when LN developed and 15-24 years old when belimumab treatment was initiated. Prednisolone was tapered from 6 to 20 mg by 2.5-5 mg every month until the dosage reached 5 mg, at which point the dosage was further reduced by 1 mg every 6 months. One patient was transferred to another hospital midway and five patients discontinued GCs. No flares occurred 8-38 months post discontinuation. No adverse effects were observed following belimumab treatment. In conclusion, belimumab was effective in the successful discontinuation of GCs.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"85-87"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0