{"title":"Anti-Glomerular Basement Membrane Antibody Disease: Clinicopathologic Profile and Outcomes.","authors":"Manoj Kumar, Varadharajan Jayaprakash, Natarajan Gopalakrishnan, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, Jeyachandran Dhanapriya","doi":"10.25259/IJN_110_2024","DOIUrl":"10.25259/IJN_110_2024","url":null,"abstract":"<p><strong>Background: </strong>Anti-glomerular basement membrane antibody disease is a rare autoimmune disease caused by antibodies to α3 chain of type 4 collagen. Patients presenting with severe renal involvement requiring dialysis have poor response to treatment.</p><p><strong>Materials and methods: </strong>We conducted a retrospective and prospective study at Institute of Nephrology, Madras Medical College, Chennai, India by analyzing the data of patients with biopsy-proven anti-GBM antibody disease treated from January 2013 to December 2019.</p><p><strong>Results: </strong>There were 2,949 kidney biopsies in the study period and 92 showed crescentic glomerulonephritis (GN). Of those, 20 patients (10 males) had anti-GBM antibody disease. Mean age was 40.75 ± 14.75 years. Rapidly progressive renal failure was the most common mode of presentation (95%); five (25%) patients had diffuse alveolar hemorrhage (DAH) and nineteen patients (95%) required dialysis at presentation. Seven patients (35%) were positive for anti-neutrophil cytoplasmic antibody (anti-myeloperoxidase in six and anti-proteinase 3 in one). Of the twelve patients (60%) who received immunosuppression (cyclophosphamide, steroids, and plasma exchange), two patients (10%) attained remission, and two patients (10%) expired due to sepsis. Crescentic GN was the predominant pathology in kidney biopsy in 19 patients (95%). Mesangial hypercellularity with deposition of IgA and C3 in mesangium was present in one patient.</p><p><strong>Conclusion: </strong>In our study, anti-GBM antibody disease accounted for 21.7% of crescentic GN. Majority of patients presented late, requiring dialysis. Patient survival was 90%, while renal survival was only 10%. One patient had co-occurrence of IgA nephropathy with anti-GBM antibody disease.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"265-269"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lia Sarah Anish, Aishwarya P Lakshmi, S Mathini, R Ram
{"title":"\"Jogger's Nephritis\" After Pilgrimage.","authors":"Lia Sarah Anish, Aishwarya P Lakshmi, S Mathini, R Ram","doi":"10.25259/IJN_480_2024","DOIUrl":"10.25259/IJN_480_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"313-314"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intravascular Hemolysis During Therapeutic Plasma Exchange Using 5% Human Albumin: What is Missed?","authors":"Abhilasha Soni, Manish Chaturvedy, Rajesh Jhorawat, Nitin Bajpai","doi":"10.25259/IJN_437_2024","DOIUrl":"10.25259/IJN_437_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"312-313"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Turning Challenges into Opportunities: A Conversation with Patient Living with Dialysis and His Path to Entrepreneurship.","authors":"Aditya S Pawar, Kamal D Shah","doi":"10.25259/IJN_459_2024","DOIUrl":"10.25259/IJN_459_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"315-318"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabina Yusuf, Suceena Alexander, Sanjeet Roy, Grace Rebekah, Elenjickal Elias John, Athul Thomas, Jeethu Joseph Eapen, Vinoi George David, Santosh Varughese
{"title":"Glomerulonephritis After Renal Transplatation in South Asia - Single Center Experience Over 5 Decades.","authors":"Sabina Yusuf, Suceena Alexander, Sanjeet Roy, Grace Rebekah, Elenjickal Elias John, Athul Thomas, Jeethu Joseph Eapen, Vinoi George David, Santosh Varughese","doi":"10.25259/IJN_39_2024","DOIUrl":"10.25259/IJN_39_2024","url":null,"abstract":"<p><strong>Background: </strong>With significant advances in the understanding of transplant immunology and a reduction in rejection rates, significant improvements in kidney allograft survival have been seen. The problem of recurrent and denovo glomerular diseases after transplantation affecting graft outcomes remains and is poorly characterized. This study aimed to analyze the incidence, characteristics, and outcomes of glomerulonephritis (GN) after kidney transplant in the Indian subcontinent.</p><p><strong>Materials and methods: </strong>Data on patients who underwent kidney transplants in our hospital from 1971 to 2018 was analyzed. Patients who had biopsy proven glomerulonephritis after transplant were included in the study. Demographic factors, characteristics of glomerulonephritis after transplant, and patient and graft outcomes were studied.</p><p><strong>Results: </strong>Post-transplant glomerulonephritis was seen in 177 out of 3630 (4.8%) patients. IgA nephropathy (IgAN) was the most common type, followed by focal segmental glomerulosclerosis (FSGS) and thrombotic microangiopathy (TMA). Patients with IgAN and FSGS were younger, and native kidney disease was unknown in the majority (70% in IgAN and 40% in FSGS). Glomerulonephritis was the most common cause of graft loss. A serum creatinine level of ≥2 mg/dL at 1 year post-transplant was significantly associated with the risk of death and graft loss. In addition, the occurrence of glomerulonephritis within a year of transplant and cytomegalovirus (CMV) infection were found to be significant risk factors for death and graft loss, respectively.</p><p><strong>Conclusion: </strong>Post transplant glomerulonephritis can significantly impact patient and graft outcomes. Understanding its etiology and pathogenesis is crucial to enabling its prevention and management and improving the outcomes of kidney transplantation.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"270-276"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriele Gaggero, Katia Mazzocco, Barbara Cafferata, Andrea Angeletti
{"title":"Mesangial C1q Deposition in IgA Nephropathy: Does the Classical Complement Pathway Play an Independent Role?","authors":"Gabriele Gaggero, Katia Mazzocco, Barbara Cafferata, Andrea Angeletti","doi":"10.25259/IJN_424_2024","DOIUrl":"10.25259/IJN_424_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"116-117"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concomitant Parvovirus B19 and CMV Infection in a Child with Kidney Transplant.","authors":"Soodeh Shamsadini Moghadam, Hamid Eshaghi, Mastaneh Moghtaderi","doi":"10.25259/ijn_418_23","DOIUrl":"10.25259/ijn_418_23","url":null,"abstract":"<p><p>Parvovirus B19 is a common human infection worldwide and is typically self-limiting in healthy persons but immunocompromised patients require specific treatments. Pretransplant B19 screening doesn't seem to be important or have any impact on the transplantation process but cytomegalovirus (CMV) study is crucial. We present a kidney-transplanted child infected by parvovirus B19 and cytomegalovirus presented with intractable anemia and raised creatinine.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"97-98"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2024 - A Year in Review.","authors":"Vivekanand Jha","doi":"10.25259/IJN_821_2024","DOIUrl":"10.25259/IJN_821_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"1-2"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pancake Kidney: A Rare Case of Renal Ectopia.","authors":"Abhishek Pratap Singh, Pankaj Beniwal, Vinay Malhotra","doi":"10.25259/IJN_401_2024","DOIUrl":"10.25259/IJN_401_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 1","pages":"111-112"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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