Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors for Treatment of Anemia in Chronic Kidney Disease: Guidelines for South Asia.

IF 0.8 Q4 UROLOGY & NEPHROLOGY

Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI:10.25259/ijn_389_23

Abi Abraham, Alan Almeida, Anil Kumar Bhalla, Arpita Ray Chaudury, Arup Ratan Dutta, Ashwani Gupta, Bharat Shah, Biswajeet Roy, Budithi Subbarao, Chula Herath, Cynthia Amrutha, Dibya Singh Shah, Dilip Kumar Pahari, Dinesh Khullar, Divya Bajpai, Guruvulu Venkata Simaladinne, Jatin Kothari, Jyoti Tyagi, Inika Sharma, Kamal Shah, Manish Malik, Manisha Sahay, Manjuri Sharma, Manoj Gumber, Melemadathil Sreelatha, Mangesh Tiwaskar, Manveen Kaur, Muhammed Rafiqul Alam, Natarajan Gopalakrishnan, Narayan Prasad, Nivedita Kamath, Priti Meena, Prem Prakash Varma, Pratik Das, Raja Ramachandran, Raj Kumar Sharma, Reena George, Salil Jain, Samiksha Ingale, Sandeep Moola, Sandip Kumar Bhattacharya, Sanjay D'Cruz, Sanjeev Gulati, Sanjiv Saxena, Sankaran Sundar, Shivnarayan Acharya, Shyam Bihari Bansal, Siddini Vishwanath, Sishir Gang, Sree Bhushan Raju, Sreejith Parameswaran, Soumyadeep Bhaumik, Sri Venkata Madhu, Suceena Alexander, Tarun Jeloka, Tarun Kumar Saha, Tonmoy Das, Urmila Anandh, Umesh Khanna, Virat Bhatia, Vishal Saxena, Vijay Kher, Vasundhara Raghavan, Vivekanand Jha

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Abstract

This guideline addresses the use of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in patients >18 years with chronic kidney disease (CKD) and anemia in South Asia (Bangladesh, Bhutan, Nepal, India, Pakistan, Sri Lanka). It also summarizes recommendations for anemia treatment for individual HIF-PHI molecules under two categories: dialysis-dependent and non-dialysis-dependent CKD patients. The recommendations do not apply to pediatric (≤12 years) and adolescent (12 to 18) patients or those with primary anemia or anemia secondary to other causes such as blood loss, cancer (any type), polycystic kidney disease and infectious diseases.

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