Ashwini Gadde, Shyam B Bansal, Swapnil Dhampalwar, Narendra Singh Choudhary, Pranaw Jha, Abhyuday K Rana, Neeraj Saraf
{"title":"Outcome of Kidney Alone Transplantation in Patients with End Stage Kidney Disease with Compensated Cirrhosis.","authors":"Ashwini Gadde, Shyam B Bansal, Swapnil Dhampalwar, Narendra Singh Choudhary, Pranaw Jha, Abhyuday K Rana, Neeraj Saraf","doi":"10.25259/IJN_28_2024","DOIUrl":"https://doi.org/10.25259/IJN_28_2024","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of data regarding the need for liver transplantation in end-stage kidney disease (ESKD) patients with compensated cirrhosis. Overall outcomes of isolated kidney transplants in these patients in terms of renal graft outcome, hepatic decompensation, and survival are less clear.</p><p><strong>Materials and methods: </strong>This is the retrospective analysis of patients treated at a single center. Patients with cirrhosis with evidence of portal hypertension who underwent kidney transplantation were compared with a matched control group without chronic liver disease (CLD) who underwent kidney transplantation during the same period.</p><p><strong>Results: </strong>Nineteen CLD patients with evidence of portal hypertension confirmed by endoscopy showing varices (8/19), hepatic venous pressure gradient (HVPG) >5 (12/19), or portosystemic collaterals on imaging (8/19) underwent kidney transplantation and were compared with 38 patients without liver disease transplanted during the same period. The discharge of creatinine was similar in both groups. The median follow-up was approximately 4 years in both groups, with the last mean serum creatinine of 1.3 and 1.37 mg/dl (unit for creatinine) in the patient and control groups (P = 0.382). Biopsy-proven acute rejections were similar [3 (15.8%) vs. 7 (18.4%), p = 1]. Two patients died in the CLD group, one due to hepatic decompensation with sepsis and the other due to cardiac cause. Four patients died in the control group (3 with sepsis and 1 with cardiac cause). Two patients had liver decompensation post-transplant (1-month post-transplant with ascites, 4 years post-transplant with ascites and hepatic encephalopathy).</p><p><strong>Conclusion: </strong>Kidney-alone transplantation in a carefully selected population with CLD and portal hypertension has comparable outcomes to those without liver disease.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"385-389"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majibullah Ansari, Manoj Anant Dhanorkar, Namrata S Rao, Abhilash Chandra
{"title":"A Case of Maggot Infestation in a Tunneled Hemodialysis Catheter: An Unusual Presentation.","authors":"Majibullah Ansari, Manoj Anant Dhanorkar, Namrata S Rao, Abhilash Chandra","doi":"10.25259/IJN_651_2024","DOIUrl":"https://doi.org/10.25259/IJN_651_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"439"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sriya Machiraju, K V V Satya Sridevi, Nageswara Rao Boddapati, Machiraju Sai Ravishankar
{"title":"Severe Osteomalacia in an Adult HIV Patient on Tenofovir Disoproxil Fumarate.","authors":"Sriya Machiraju, K V V Satya Sridevi, Nageswara Rao Boddapati, Machiraju Sai Ravishankar","doi":"10.25259/IJN_430_2024","DOIUrl":"https://doi.org/10.25259/IJN_430_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"441-442"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling Complexity: Nesidioblastosis in the Nexus of Diabetes and Chronic Kidney Disease.","authors":"Niranjana Rekha Paladugu, Muralinath Vukkadala, Anshuman Das, Anuradha Sekaran, Chandhana Merugu","doi":"10.25259/IJN_90_2024","DOIUrl":"https://doi.org/10.25259/IJN_90_2024","url":null,"abstract":"<p><p>We report a rare and intricate case of nesidioblastosis, marked by hyperinsulinemic hypoglycemia, in a patient with diabetes and chronic kidney disease (CKD). PET-CT imaging and histopathology confirmed the condition, culminating in a comprehensive treatment strategy comprising subtotal pancreatectomy and pharmacotherapy. This case marks the first documented occurrence of nesidioblastosis in a patient with CKD and diabetes. The presence of CKD further complicated the clinical picture, influencing hypoglycemic risk, drug efficacy, insulin clearance, and counter-regulatory mechanisms.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"433-434"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Observational Study on the Clinicopathologic Features of Renal Monoclonal Immunoglobulin Deposition Disease.","authors":"C V Malathi, Ks Jansi Prema, Anila Abraham Kurien","doi":"10.25259/IJN_708_2024","DOIUrl":"https://doi.org/10.25259/IJN_708_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"417-419"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dissecting the Delicate Dynamics of Donation in Dysglycemia.","authors":"Nisha Jose, Santosh Varughese","doi":"10.25259/IJN_623_2024","DOIUrl":"https://doi.org/10.25259/IJN_623_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"319-321"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Regional Citrate versus Heparin Anticoagulation in Continuous Renal Replacement Therapy.","authors":"Gaurav Bhandari, Debarun Choudhury, Anil Kumar Bhalla, Manish Malik, Anurag Gupta, Vinant Bhargava, Vaibhav Tiwari, Shiv Chadha, Ashwani Gupta, Devinder Singh Rana","doi":"10.25259/ijn_195_23","DOIUrl":"https://doi.org/10.25259/ijn_195_23","url":null,"abstract":"<p><strong>Background: </strong>Continuous renal replacement therapy (CRRT) is used in hemodynamically unstable patients with acute kidney injury (AKI). Heparin, the most commonly used anticoagulant, has a significant bleeding risk and is associated with heparin-induced thrombocytopenia. Regional citrate anticoagulation is an alternative anticoagulation strategy in CRRT.</p><p><strong>Materials and methods: </strong>A randomized controlled trial was conducted in the Intensive Care Unit over one year, from October 2020 to September 2021, in patients with AKI requiring CRRT. Fifty-two patients were randomized into two groups: group 1 received regional citrate anticoagulation, and group 2 received heparin anticoagulation.</p><p><strong>Results: </strong>The mean age in group 1 was 50.46 years, while it was 49.35 years in group 2. The mean filter lifespan in group 1 was 45.11 hours, while in group 2, it was 26.11 hours and was statistically significant (P < 0.001). The mean effective delivered RRT dose was higher in group 1 (26 ml/kg/hour) compared to group 2 (24.23 ml/kg/hour), which was statistically significant (P < 0.001). Bleeding episodes were higher in group 2 than in group 1 (42.3% vs 11.5%), which was statistically significant (P = 0.027). The RCA group had various electrolyte and metabolic complications, but these were not statistically significant.</p><p><strong>Conclusion: </strong>Regional citrate anticoagulation is better than heparin anticoagulation in terms of filter lifespan, effective delivered RRT dose, bleeding episodes, and metabolic complications.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"380-384"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utility of POCUS (Point of Care Ultrasound) in Renal Transplantation.","authors":"Edwin M Fernando, Suhasini Balasubramaniam","doi":"10.25259/IJN_245_2024","DOIUrl":"https://doi.org/10.25259/IJN_245_2024","url":null,"abstract":"<p><p>Point of care ultrasound (POCUS) is gaining wide recognition in its bedside applications. The day-to-day practice of nephrology requires several ultrasonographic parameters for diagnosis. Hence, familiarity with basics of renal ultrasound imaging is becoming a necessary skill for every nephrologist. This review provides an overview of the normal and abnormal findings in a graft kidney and its environment throughout graft survival and after its failure. The correlative understanding of the clinical features with image findings provides the greatest advantage in applying POCUS at the bedside.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"329-334"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}