揭示复杂性：Nesidioblastosis与糖尿病和慢性肾脏疾病的关系。

IF 0.8 Q4 UROLOGY & NEPHROLOGY

Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-06-24 DOI:10.25259/IJN_90_2024

Niranjana Rekha Paladugu, Muralinath Vukkadala, Anshuman Das, Anuradha Sekaran, Chandhana Merugu

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引用次数: 0

摘要

我们报告一例罕见和复杂的nesidioblastosis病例，以高胰岛素性低血糖为特征，患者患有糖尿病和慢性肾脏疾病（CKD）。PET-CT成像和组织病理学证实了这种情况，最终采取了包括次全胰切除术和药物治疗在内的综合治疗策略。本病例是CKD合并糖尿病患者中第一例有文献记载的nesidioblastosis。CKD的存在进一步使临床情况复杂化，影响低血糖风险、药物疗效、胰岛素清除率和反调节机制。

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Unveiling Complexity: Nesidioblastosis in the Nexus of Diabetes and Chronic Kidney Disease.

We report a rare and intricate case of nesidioblastosis, marked by hyperinsulinemic hypoglycemia, in a patient with diabetes and chronic kidney disease (CKD). PET-CT imaging and histopathology confirmed the condition, culminating in a comprehensive treatment strategy comprising subtotal pancreatectomy and pharmacotherapy. This case marks the first documented occurrence of nesidioblastosis in a patient with CKD and diabetes. The presence of CKD further complicated the clinical picture, influencing hypoglycemic risk, drug efficacy, insulin clearance, and counter-regulatory mechanisms.

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