Indian Journal of Nephrology最新文献_第3页

Reassessing Metformin's Potential in Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Call for Further Research. 重新评估二甲双胍在常染色体显性多囊肾病（ADPKD）中的潜力：进一步研究的呼吁。

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-11-06 DOI: 10.25259/IJN_542_2024

Jasmine Sethi

引用次数: 0

Clinical Application of Genetic Testing in Nephrology. 基因检测在肾病学中的临床应用。

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI: 10.25259/IJN_802_2024

Gladwin Jeemon, J K Jayram, Kartik Ganesh, Jithin S Kumar, Sunita Simon, M Abi Abraham

引用次数: 0

Genetic Rarity: The First Case Report of TMPRSS3 Mutation Coinciding with Multicystic Dysplastic Kidney. 遗传罕见：TMPRSS3突变合并多囊性发育不良肾首例报道。

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-10-29 DOI: 10.25259/IJN_462_2024

Abhishek Abhinay, Nitish Kumar, Satyabrata Panda, Ankur Singh

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Diagnosis (by p-RIFLE and KDIGO) and Risk Factors of Acute Kidney Injury in Pediatric Diabetic Ketoacidosis: A Retrospective Study. 儿童糖尿病酮症酸中毒急性肾损伤的诊断（p-RIFLE和KDIGO）和危险因素：回顾性研究。

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-08-01 DOI: 10.25259/IJN_79_2024

Siddarajaiah Likhitha, Ramachandran Rameshkumar, Chinnaiah Govindhareddy Delhikumar, Tamil Selvan

{"title":"Diagnosis (by p-RIFLE and KDIGO) and Risk Factors of Acute Kidney Injury in Pediatric Diabetic Ketoacidosis: A Retrospective Study.","authors":"Siddarajaiah Likhitha, Ramachandran Rameshkumar, Chinnaiah Govindhareddy Delhikumar, Tamil Selvan","doi":"10.25259/IJN_79_2024","DOIUrl":"https://doi.org/10.25259/IJN_79_2024","url":null,"abstract":"Background: There are two criteria to diagnose and stage acute kidney injury (AKI) in children: pediatric-Risk, Injury, Failure, Loss (p-RIFLE) and Kidney Disease Improving Global Outcomes (KDIGO). This study aims to find out the extent of agreement in diagnosis (by p-RIFLE and KDIGO) and risk factors of AKI in pediatric diabetic ketoacidosis (DKA).Materials and methods: A retrospective cohort study involving children aged ≤15 years with DKA was conducted between January 2014 and December 2022. Those with inborn errors of metabolism, septic shock, and urinary tract disease were excluded. The primary outcome was the extent of agreement in diagnosis of AKI by p-RIFLE and KDIGO. The secondary outcomes were staging agreement, risk factors, complications (hypoglycemia, hypokalemia, and cerebral edema), time to resolution of DKA, and hospital and pediatric intensive care units (PICU) stay.Results: Data from 161 patients were collected. Mean (SD) age was 8.6 (3.7) years. Good agreement between p-RIFLE and KDIGO criteria for diagnosis of AKI was noted at admission (Kappa = 0.71, p ≤ 0.001), at 24 hours (Kappa = 0.73, p ≤ 0.001) and discharge (Kappa = 0.60, p ≤ 0.001), and for the staging of AKI at admission (Kappa = 0.81, p ≤ 0.001) at 24 hours (Kappa = 0.75, p ≤ 0.001) and discharge (Kappa = 0.48, p ≤ 0.001). On multivariate analysis, age (≤5 years: aOR = 3.03, 95% CI 1.04-8.79) is an independent risk factor for AKI at discharge by KDIGO. Cerebral edema (n = 6, 3.7%), hypoglycemia (n = 66, 41%), and hypokalemia (n = 59, 36.6%) were noted. Resolution and stay in PICU and hospitals were longer for patients with AKI.Conclusion: p-RIFLE and KDIGO criteria showed good agreement in diagnosis and staging of AKI in pediatric DKA.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"373-379"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence and Outcomes of BK Polyoma Virus Nephropathy in Living Donor Kidney Transplant Recipients. 活体肾移植受者BK多瘤病毒肾病的患病率和预后

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-08-01 DOI: 10.25259/ijn_87_23

Abhyudaysingh Rana, Shyam Bihari Bansal, Camille Nelson Kotton, Amit Kumar Mahapatra, Alka Rana, Sidharth Kumar Sethi, Pranaw Kumar Jha, Ashwini B Gadde, Manish Jain, Dinesh Kumar Yadav, Dinesh Bansal, Vijay Kher

{"title":"The Prevalence and Outcomes of BK Polyoma Virus Nephropathy in Living Donor Kidney Transplant Recipients.","authors":"Abhyudaysingh Rana, Shyam Bihari Bansal, Camille Nelson Kotton, Amit Kumar Mahapatra, Alka Rana, Sidharth Kumar Sethi, Pranaw Kumar Jha, Ashwini B Gadde, Manish Jain, Dinesh Kumar Yadav, Dinesh Bansal, Vijay Kher","doi":"10.25259/ijn_87_23","DOIUrl":"https://doi.org/10.25259/ijn_87_23","url":null,"abstract":"Background: BK polyomavirus nephropathy (BKPyVN) remains an important cause of allograft dysfunction and loss. There is little data about prevalence and outcome of BKPyVN infection from India in living donor kidney transplant recipients.Materials and methods: This is a retrospective analysis of all biopsy-proven BKPyVN among kidney transplant recipients at our center from January 2010 to January 2022. We compared them to age, sex, and type of immunosuppression received matched (1:2) non-BKPyVN-infected recipients transplanted during the same period.Results: During the study period, 2465 patients underwent kidney transplants at our center, of which 26 (1.05%) developed biopsy-proven BKPyVN. Four recipients (16%) lost their graft over a median period of 65 (IQR, 57-83) months from the time of diagnosis. The mean serum creatinine at the recent follow-up was higher in the BKPyVN arm as compared to controls (2.05 ± 1.39 vs 1.35 ± 0.46, p = 0.001.) Both BKPyVN and control arms had similar death-censored graft survival (82% vs 94%, p = 0.09) and patient survival (88% vs 96%, p = 0.184).Conclusion: BKPyVN was uncommon in our kidney transplant recipients. Most patients were able to maintain their kidney function for many years, albeit at a somewhat reduced level compared with the controls, and about a fifth of our patients lost their graft.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 3","pages":"343-348"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid-Hemodialysis Levetiracetam as Rescue Therapy in Patients Having Seizures During Hemodialysis Session. 左乙拉西坦在血液透析期间癫痫发作患者中的抢救作用。

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-01-31 DOI: 10.25259/IJN_649_2024

Pulak Azad, Yasir Sultan Rizvi

引用次数: 0

H5N1 Infection and Kidney Pathology: Is There a Link? H5N1感染与肾脏病理：有联系吗？

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-11 DOI: 10.25259/IJN_684_2024

Henry H L Wu, Rajkumar Chinnadurai

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Optimizing the Immunosuppression: Role of Early BK Polyomavirus Surveillance and Evolving a Cost-Effective Strategy. 优化免疫抑制：早期BK多瘤病毒监测的作用和发展一个具有成本效益的策略。

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Indian Journal of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-10-11 DOI: 10.25259/IJN_528_2024

Arun Kumar Subbiah, Sandeep Mahajan

引用次数: 0

Antibody Response to Covishield and Covaxin in Kidney Transplant Recipients. 肾移植受者对Covishield和Covaxin的抗体反应。

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-08-01 DOI: 10.25259/ijn_549_23

Neha Manhas, Shyam Bihari Bansal, Amit Kumar Mahapatra, Abhyudaysingh Rana, Sidharth Kumar Sethi, Manish Jain, Dinesh Kumar Yadav

{"title":"Antibody Response to Covishield and Covaxin in Kidney Transplant Recipients.","authors":"Neha Manhas, Shyam Bihari Bansal, Amit Kumar Mahapatra, Abhyudaysingh Rana, Sidharth Kumar Sethi, Manish Jain, Dinesh Kumar Yadav","doi":"10.25259/ijn_549_23","DOIUrl":"10.25259/ijn_549_23","url":null,"abstract":"Background: The COVID-19 pandemic had a major impact on solid organ transplant recipients. COVID-19 vaccination plays a crucial role in pandemic management.There is limited data on replication-defective viral vectors [ChAdOx1-nCOV (COVISHIELDTM)] and whole inactivated one BBV-152 (COVAXINTM) in kidney transplant recipients (KTRs). This study aims to assess the humoral immune response and adverse effects of these vaccines in KTRs after the first and second doses of vaccination.Materials and methods: Anti-SARS-CoV-2 anti-spike antibody titers were measured in 285 KTRs recipients prior to vaccination, 3 weeks ± 3 days after first dose and 3 weeks ± 3 days after second dose of the COVISHIELD (n = 232) and COVAXIN (n = 55) vaccines. Anti-spike antibodies were measured by the chemiluminescence immunoassay method. The primary outcome was seroconversion after two doses of COVAXIN and COVISHIELD and secondary outcome was the incidence of adverse events to COVID-19 vaccines within one week of vaccination.Results: At baseline, 25 (39.7%) and 67 (30.2%) of KTRs were found to be seropositive before receiving COVAXINTM and COVISHIELDTM, respectively. After first dose of vaccination, 46 (73.0%) and 158 (71.2%) were seropositive and after second dose, 51 (81.0%) and 177 (79.7%) were seropositive, respectively. Common adverse effects were fever, chills, myalgia, and headache which settled in 1-2 days. There was no episode of rejection.Conclusion: Both ChAdOx1-nCOV and BBV-152 were well tolerated and induced robust antibody formation in KTRs in the Indian population.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":"35 2","pages":"277-282"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Diphallia with Duplicated Urethra and Urinary Bladder: A Rare Congenital Genitourinary Tract Anomaly. 双咽伴重复尿道和膀胱：一种罕见的先天性泌尿生殖系统异常。

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Indian Journal of Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-24 DOI: 10.25259/IJN_499_2024

Swaroop G Hegde, Anmol Bhatia, Nitin James Peters, Akshay Kumar Saxena, Kushaljit Singh Sodhi

引用次数: 0