Indian Journal of Nephrology最新文献_第3页

Clinical, Biochemical, and Histological Manifestations and Long-Term Outcomes of Renal Sarcoidosis - A Single Center Study 肾肉样瘤病的临床、生化和组织学表现及长期疗效--一项单中心研究

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Indian Journal of Nephrology Pub Date : 2024-07-22 DOI: 10.25259/ijn_222_23

Harshita Sharma, N. Prasad, A. Kaul, D. Bhaduria, M. Patel, M. Behera, M. Yaccha, Ravi Shankar Kushawaha, Vinita Agarwal, M. Jain

{"title":"Clinical, Biochemical, and Histological Manifestations and Long-Term Outcomes of Renal Sarcoidosis - A Single Center Study","authors":"Harshita Sharma, N. Prasad, A. Kaul, D. Bhaduria, M. Patel, M. Behera, M. Yaccha, Ravi Shankar Kushawaha, Vinita Agarwal, M. Jain","doi":"10.25259/ijn_222_23","DOIUrl":"https://doi.org/10.25259/ijn_222_23","url":null,"abstract":"\u0000\u0000Renal involvement in sarcoidosis is rare. We evaluated the pattern of renal involvement in sarcoidosis, its clinical course, renal histology, and response to treatment.\u0000\u0000\u0000\u0000We retrospectively analyzed the data of all cases with sarcoidosis exhibiting renal involvement referred to our department between January 2010 and December 2021.\u0000\u0000\u0000\u0000A total of 33 patients (age: 50.6 ± 12.6 years, males: 57.6%) were analyzed. Common presenting symptoms were weight loss (81.8%; n = 27), fever (75.8%; n = 25), and vomiting (63.6%; n = 21). A total of 14 (42.4%) patients had granulomatous interstitial nephritis (GIN), 13 (39.4%) had isolated hypercalcemia, and six (18.2%) had GIN along with hypercalcemia. Renal biopsy was performed in 20 (60.6%) patients, and all showed GIN, with concomitant glomerular disease in four (12.1%) patients. Mean serum creatinine and 24-h urine protein at presentation were 4.3 ± 2.1 mg/dL and 2.5 ± 0.9 g/day, respectively. All patients received oral prednisolone 1 mg/kg/day with subsequent tapering, concomitantly with azathioprine. Mycophenolate mofetil was used in three (9.1%) patients who developed azathioprine-induced hepatoxicity. After a median follow-up of 24 months (8–120 months), mean serum creatinine and 24-h urine protein improved to 1.9 ± 1.5 mg/dL and 1.1 ± 0.6 g/day, respectively, (P = 0.005). On follow-up, two patients (6.1%) became dialysis-dependent, and three (9.1%) succumbed: one due to a cardiovascular event and two to sepsis and septic shock.\u0000\u0000\u0000\u0000Granulomatous interstitial nephritis was the most common diagnosis in sarcoidosis patients with kidney failure. Early steroid treatment improves kidney function.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141815366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathology of Allograft Nephrectomies – A Ten Year Observational Study 同种异体肾切除术的组织病理学--十年观察研究

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Indian Journal of Nephrology Pub Date : 2024-07-22 DOI: 10.25259/ijn_73_2024

C.V Malathi, K. Jansi Prema, A. Kurien

{"title":"Histopathology of Allograft Nephrectomies – A Ten Year Observational Study","authors":"C.V Malathi, K. Jansi Prema, A. Kurien","doi":"10.25259/ijn_73_2024","DOIUrl":"https://doi.org/10.25259/ijn_73_2024","url":null,"abstract":"\u0000\u0000Though infrequent, allograft nephrectomies are performed for early and late graft loss. The study aims to analyze the histopathologic characteristics of allograft nephrectomy specimens.\u0000\u0000\u0000\u0000We conducted an observational study of 103 cases of allograft nephrectomies from 21 centers from 2013 to 2023. All the pathology slides, including hematoxylin and eosin-stained sections, masson trichrome, jones methenamine silver, PAS, GMS, AFB, and immunohistochemistry (C4d, SV40) were reviewed. Pathologic findings were analyzed based on the transplant to nephrectomy interval (0–3 months, > 3 months) and type of donor (deceased, live donor).\u0000\u0000\u0000\u0000Of the total 103 cases, 77 were male. The mean age at the time of nephrectomy was 36.4 (range 5–64) years. The allografts were obtained from deceased (57) donors and live related (46) donors. Graft tenderness, oliguria/anuria, and fever were common clinical presentations. The majority (71.8%) of the nephrectomies were performed within the first 3 months of renal transplant. Renal vessel thrombosis (32.03%) was the most common pathologic finding. Infections were more common in the first 3 months after the transplant. Fungal infection had a significant association with deceased donor transplantation (p = 0.029).\u0000\u0000\u0000\u0000Histopathological study of allograft nephrectomy specimens aids understanding of graft loss causes. The study also provides opportunities to prevent complications and implement measures to prolong graft survival in a subsequent transplant.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudomonas UTI Masquerading as Neonatal Jaundice: A Case Report 伪装成新生儿黄疸的尿道假单胞菌感染：病例报告

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Indian Journal of Nephrology Pub Date : 2024-07-22 DOI: 10.25259/ijn_209_2024

Aditi Das, Rimjhim Sonowal, Subhankar Sarkar, Rohit Bhowmick, Niladri Sekhar Bhunia, Nihar Ranjan Mishra

引用次数: 0

Prevalence and Association of Insulin Resistance in Non-Diabetic Hemodialysis Patients: A Descriptive-Analytic Cross-Sectional Study in Vietnam 非糖尿病血液透析患者胰岛素抵抗的患病率和相关性：越南一项描述性分析横断面研究

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Indian Journal of Nephrology Pub Date : 2024-07-22 DOI: 10.25259/ijn_31_2024

Bui Bao Hoang, Khoa Ngoc Van Nguyen, Trang Thi Khanh Ngo

{"title":"Prevalence and Association of Insulin Resistance in Non-Diabetic Hemodialysis Patients: A Descriptive-Analytic Cross-Sectional Study in Vietnam","authors":"Bui Bao Hoang, Khoa Ngoc Van Nguyen, Trang Thi Khanh Ngo","doi":"10.25259/ijn_31_2024","DOIUrl":"https://doi.org/10.25259/ijn_31_2024","url":null,"abstract":"\u0000\u0000Patients with chronic kidney disease (CKD) experience high mortality rates from cardiovascular disease (CVD). Insulin resistance (IR) is a frequent complication of CKD and is associated with poorer cardiovascular outcomes. This study investigates the prevalence and associations of IR in hemodialysis (HD) patients.\u0000\u0000\u0000\u0000A descriptive-analytic cross-sectional study was conducted on 103 HD patients. We used the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and the Quantitative Insulin Sensitivity Check Index (QUICKI) to measure IR. We examined potential associations between IR and the following factors: age, gender, etiology of kidney failure, BMI, waist circumference, blood lipids, hemoglobin concentration, uric acid, and duration of HD.\u0000\u0000\u0000\u0000The prevalence of IR, as measured by HOMA-IR, was 61.2%, and by QUICKI, it was 48.5%. Age, gender, etiology of kidney failure and increased waist circumference did not significantly influence IR. A significant associations were observed between IR and higher BMI, anemia, dyslipidemia, and longer duration of HD therapy. Interestingly, the HOMA-IR and QUICKI indices correlated for most factors except total cholesterol, LDL-C, and uric acid.\u0000\u0000\u0000\u0000This study found a high prevalence of IR in HD patients, with 61.2% identified by HOMA-IR and 48.5% by QUICKI. We confirmed significant associations between IR and BMI, anemia, dyslipidemia, and duration of HD therapy in this population.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhinocerebral Mucormycosis in Patients with Kidney Disease Following Covid 19 Infection 肾病患者感染 Covid 19 后发生的犀脑粘液瘤病

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Indian Journal of Nephrology Pub Date : 2024-07-20 DOI: 10.25259/ijn_233_21

Manjusha Yadla, Manu, Tauseef Ahmed, Sreekanth Burri, Shivam Yadav, Shoban, Shabana Nazneen, Harsh Gupta

引用次数: 0

Association of Acute Kidney Injury with Ammonia Poisoning: A Case Report 急性肾损伤与氨中毒的关联：病例报告

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Indian Journal of Nephrology Pub Date : 2024-07-20 DOI: 10.25259/ijn_9_21

Vishal Pooniya, Abhilash Chandra, N. Rao S, Amit K. Singh, K. P. Malhotra

引用次数: 0

Concomitant Histological Features of Membranous Nephropathy and Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis 膜性肾病和抗中性粒细胞胞浆抗体相关性血管炎的共同组织学特征

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_140_2024

C. Rajesh, Utkarash Mishra, Sanjeet Roy, R. Alam, S. Mani, J. Eapen, Athul Thomas, S. Alexander, S. Varughese, V. David

引用次数: 0

Unusual Late Onset Recurrent Venous Thrombosis in Two Young Post Renal Transplant Recipients – Challenges in Diagnosis and Management with Review of Literature 两名年轻的肾移植术后受者罕见的晚期复发性静脉血栓 - 诊断和处理的挑战与文献综述

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_207_2024

A. Jha, Ambati K. Rakesh, Ratan Jha, Koraddi Avinash

引用次数: 0

Approach to Glomerular Disease in Pregnancy 治疗妊娠期肾小球疾病的方法

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_26_2024

Priti Meena, S. Jesudason, Cristina Adriana Popa, Namrata S. Rao, P. Priyamvada

引用次数: 0

Clinical Profile and Predictors Affecting Outcome in Community-Acquired Acute Kidney Injury: A 3 Months Follow-Up Study 社区获得性急性肾损伤的临床概况和影响预后的因素：三个月随访研究

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Indian Journal of Nephrology Pub Date : 2024-07-15 DOI: 10.25259/ijn_352_23

Rajesh Tarachandani, L. Pursnani, M. Balakrishnan, H. Mahapatra, Sutanay Bhattacharyya, Preeti Chaudhary, Vipul Gupta

{"title":"Clinical Profile and Predictors Affecting Outcome in Community-Acquired Acute Kidney Injury: A 3 Months Follow-Up Study","authors":"Rajesh Tarachandani, L. Pursnani, M. Balakrishnan, H. Mahapatra, Sutanay Bhattacharyya, Preeti Chaudhary, Vipul Gupta","doi":"10.25259/ijn_352_23","DOIUrl":"https://doi.org/10.25259/ijn_352_23","url":null,"abstract":"\u0000\u0000Community-Acquired Acute Kidney Injury (CA-AKI) is often a devastating clinical syndrome allied with high hospital mortality. Moreover, only limited prospective data exist on the outcomes of CA-AKI. Hence, this follow-up study was conducted to assess clinical profiles and the factors affecting outcomes in CA-AKI.\u0000\u0000\u0000\u0000A prospective study enrolling 283 participants was conducted from the year 2021 to 2022. AKI patients defined as per Kidney Disease Improving Global Outcomes (KDIGO) criteria were included. Data were collected on demographics, clinical features, and etiological factors. Patients were followed for three months. Univariate and multinomial analyses were done to predict outcomes. The Cox regression model was fitted to identify predictors of mortality.\u0000\u0000\u0000\u0000The mean age of patients was 41.67±16.21 years with male predominance. Most of the patients required non-ICU (81.9%) care. Around 36% and 39.6 % of AKI patients were oliguric and required dialysis, respectively. Most patients had a single etiology, with sepsis being the most common cause. Most patients were in KDIGO stage 3, followed by stage 2. At three months of follow-up, 40.6%, 12.3%, and 4.2% had complete, partial, and non-recovery, respectively, and 30.4% died. Age, single etiology, hepatorenal syndrome, sepsis, requirement of mechanical ventilation and vasopressors, comorbidities and glomerulonephritis were significantly associated with mortality.\u0000\u0000\u0000\u0000CA-AKI is significantly associated with higher mortality, even for those patients who require non-ICU care on presentation. This highlights the pressing need for AKI prevention, early detection, and intervention to mitigate reversible risk factors and optimize clinical outcomes.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0