Indian Journal of Medical Research最新文献

{"title":"Evolutionary analysis and immunoinformatic-based epitope prediction of dengue virus serotype 2 strains from Sri Lanka.","authors":"Dilara Sesadi Gunawardane, Amani Navarathna, Pasindu Akash Kulasinghe, Thaksala Chamod Jayakanth, Pavithra Dilakshini Dayananda","doi":"10.25259/IJMR_2990_2025","DOIUrl":"10.25259/IJMR_2990_2025","url":null,"abstract":"<p><p>Background and objectives To investigate the phylogenetic and evolutionary relationships of dengue virus 2 (DENV-2) strains in Sri Lanka and identify probable antigenic B and T cell epitopes in the envelope gene region. Methods Phylogenetic analysis was conducted on the envelope gene region of Sri Lankan DENV-2 strains alongside globally homologous sequences. Selection pressure analysis identified codons under diversifying and purifying selection. Epitope prediction was performed to detect probable antigenic B and T cell epitopes. Results The sequences belonged to two major lineages of the cosmopolitan genotype: major lineage A and F from various geographical regions. Phylogenetic analysis showed segregation into distinct clades, with close sub-clustering of Sri Lankan strains with those from China, Malaysia, Myanmar, Taiwan, and Reunion Island. Selection pressure analysis revealed two sites under diversifying selection, with numerous sites under purifying selection. Epitope prediction detected several linear B and T cell epitopes with probable antigenicity within the envelope gene region. Interpretation and conclusions This study highlights the widespread dominance of the cosmopolitan genotype in Sri Lanka and underscores the role of air travel and human migration in viral transmission and global strain introduction. The presence of diversifying selection at two E gene sites alongside widespread purifying selection suggests evolutionary pressures on viral fitness. The identified B and T cell epitopes represent potential targets for universal vaccine development and therapeutic interventions.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"282-289"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procedures to implement the Supreme Court of India directives to withdraw/withhold life-sustaining medical treatment.","authors":"Nandini Vallath, V Parvathy, Pratyasa Padhi, Angelin Johny T, Mathangi Krishnakumar, P S Varghese","doi":"10.25259/IJMR_3005_2025","DOIUrl":"10.25259/IJMR_3005_2025","url":null,"abstract":"<p><p>In 2018, the Supreme Court of India legally recognised the rights of patients with terminal illness through the judgement in Common Cause (A Registered Society) v. Union of India and Another, (2018) 5 SCC 1. The processes prescribed to withhold or withdraw artificial life-support medical treatments became practical after the 2023 amendment. The law aimed to ensure the dignified dying of sick individuals whose condition was deemed terminal and irreversible. Healthcare institutions can comply with the Court's guidelines in their entirety only after the concerned State Governments activate specific processes. Karnataka state activated the legal mandates by early 2025. Using an implementation case study, we describe the institutional processes to uphold the ethical and legal mandates when withholding/withdrawing life-support treatment (WH/WD-LST) in a mentally incompetent, terminally ill elderly patient, admitted to a tertiary care hospital in Karnataka. It aims to clarify, (i) validation of 'Advance-Medical-Directive', or the living will; (ii) sequential institutional processes for WH/WD-LST as per ethical and legal mandates; (iii) constitution of the primary, secondary medical boards (PMB, SMB); (iv) reporting formats for PMB, SMB evaluations, and (v) the templates relevant to institutional administrators to convey the mandated details of WH/WD-LST to their jurisdictional judiciary magistrate of first class. The impressions and impact of activating the living will and WH/WD-LST on the family, on patient care, for the professionals, and for the institution are described in brief.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"319-326"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of GCKR and GLIS3 gene polymorphisms with gestational diabetes mellitus: A case-control study.","authors":"Jethendra Kumar Muruganantham, Vijayalakshmi Kandasamy, Ramakrishnan Veerabathiran","doi":"10.25259/IJMR_3385_2025","DOIUrl":"10.25259/IJMR_3385_2025","url":null,"abstract":"<p><p>Background and objectives Gestational diabetes mellitus (GDM) increases the chances of negative consequences for both the mother and the foetus. It shares genetic and physiological characteristics with type 2 diabetes mellitus (T2DM), particularly insulin resistance and impaired insulin secretion. While gene variants involved in glucose metabolism, such as those in glucokinase receptor (GCKR) and GLI similar 3 (GLIS3), have been linked to diabetes risk, their association with GDM in South Indian populations remains underexplored. Methods This study comprised 195 patients with GDM and 195 normoglycemic pregnant women of South Indian ethnicity. GDM diagnosis was recognised using an oral glucose tolerance test. Genotyping of GCKR (rs780094) and GLIS3 (rs701847, rs7020673, rs10814916) were performed using Tetra-ARMS PCR and validated through Sanger sequencing. Associations between genotypes and the risk of GDM were assessed using logistic regression. Results Women with GDM exhibited significantly higher age, body mass index, blood pressure, and adverse metabolic profiles. There was a strong genotype-specific correlation between GDM and the GCKR rs780094 CT genotype. When dominant models and the AG genotype were used, rs701847 exhibited the strongest correlation with GLIS3. rs10814916 was linked through the AC genotype, whereas rs7020673 only demonstrated a connection under the recessive model. In women with GDM, HOMA-IR was significantly higher (P<0.001). Interpretation and conclusion This study highlights significant associations between GCKR and GLIS3 polymorphisms and the risk of GDM in South Indian women, supporting the role of ethnicity-specific genetic screening in predicting GDM risk.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"273-281"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression levels of miRNA 22-5p and miRNA 337-5p in bladder cancer.","authors":"Mehmet Aydin Dagdeviren, Sibel Bayil Oguzkan, Mehmet Ozaslan, Mehmet Sakip Erturhan","doi":"10.25259/IJMR_2226_2025","DOIUrl":"10.25259/IJMR_2226_2025","url":null,"abstract":"<p><p>Background and objectives MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play critical roles in tumour development and progression. Bladder cancer requires reliable molecular biomarkers for diagnosis and prognosis; the roles of certain miRNAs remain insufficiently explored. This study aimed to investigate the expression profiles of miR-22-5p and miR-337-5p in bladder cancer and to evaluate their associations with clinicopathological characteristics. Methods Paired tumour and adjacent non-tumorous bladder tissue samples were collected from 50 patients undergoing transurethral resection of bladder tumour. Quantitative PCR was performed using RNA U6 as the reference gene. Expression differences were analysed, and correlations with clinicopathological features were assessed. Results Both miR-22-5p and miR-337-5p were downregulated in tumour tissues compared to normal tissues. miR-22-5p expression showed a marked reduction in bladder cancer, while miR-337-5p downregulation reached borderline statistical significance. Correlation analyses revealed no association between miR-22-5p expression and clinical variables; however, miR-337-5p expression was significantly correlated with patient age and disease duration. Interpretation and conclusions Altered expression of miR-22-5p and miR-337-5p may contribute to bladder cancer pathogenesis. miR-22-5p appears as a potential tumour suppressor, while miR-337-5p expression is influenced by clinical parameters such as age and disease duration, highlighting their potential roles as prognostic and therapeutic biomarkers.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"290-294"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance and assessment of medical device-associated adverse events in a tertiary care hospital: An observational study.","authors":"Vithya T, Supraja Bollineni, Tasleem F, Prabhuswami Ganachari, Md Sohail Ahmad Khan, Shankar Prasad","doi":"10.25259/IJMR_1988_2025","DOIUrl":"10.25259/IJMR_1988_2025","url":null,"abstract":"<p><p>Background and objectives Medical devices are essential in hospitals for diagnosis and treatment but may also cause unintended adverse events. Materiovigilance plays a crucial role in detecting, reporting, and preventing such events to safeguard patients. This study aimed to monitor, assess, and report medical device-associated adverse events (MDAEs) in a tertiary care hospital and to identify the devices most frequently implicated. Methods A prospective observational study was conducted at a tertiary care hospital in Bengaluru, India, from May 2023 to January 2024. Daily ward rounds were carried out in collaboration with the biomedical team to identify device-related issues. Confirmed MDAEs were documented using the standard reporting forms of the Materiovigilance Programme of India (MvPI). Results Among 1,100 medical devices in use, 31 (2.81%) were associated with adverse events. Most affected patients were females, with an average age of 61 years. Frequently implicated devices included disposable syringes and intravenous (IV) cannulas. The common events included thrombophlebitis, blocked or damaged needles, and elevated serum creatinine following contrast use. Most adverse events involved Class B devices. Causality assessment classified the majority as probable or possible. Interpretation and conclusions The overall frequency medical device associated of adverse events associated was low. However, the findings underscore the importance of continuous device surveillance. Strengthening awareness and structured reporting under MvPI can improve early detection, timely intervention, and long-term patient safety in clinical practice.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"304-308"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis: So much accomplished and so much more to be done.","authors":"Amita Gupta","doi":"10.25259/IJMR_924_2026","DOIUrl":"10.25259/IJMR_924_2026","url":null,"abstract":"","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"269-271"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum uric acid and its association with intrauterine insemination outcomes in women with polycystic ovarian syndrome.","authors":"Xiaohui Zhang, Qianqian Qin, Haochen Yang, Lu Yu, Yixuan Li, Ronghao Sun, Shilei Wang, Xinyang Wei, Fei Chen, Yehao Dong","doi":"10.25259/IJMR_1973_2025","DOIUrl":"10.25259/IJMR_1973_2025","url":null,"abstract":"<p><p>Background and objectives Uric acid is associated with many systemic diseases. Recent evidence demonstrated that high serum uric acid levels in polycystic ovary syndrome (PCOS) could lead to a poor prognosis of in-vitro fertilisation. The objective of this study was to explore the association between serum uric acid levels and reproductive outcomes in women with PCOS undergoing intrauterine insemination (IUI) treatment. Methods We included 682 patients with PCOS who underwent IUI treatment between 2015 and 2024. They were stratified into three groups according to the level of serum uric acid: normal (251-360 µmol/L), low (≤250 µmol/L), and high (>360 µmol/L). Pregnancy and obstetric outcomes of patients were evaluated and linked to serum uric acid levels. The primary outcome measures of this study were the clinical pregnancy rate and live birth rate. Secondary outcome measures included the rates of biochemical pregnancy, ectopic pregnancy, miscarriage, and low birth weight. Results There was no significant difference between the three groups with respect to clinical pregnancy rate (23.3% vs. 26.2% vs. 30.4%) and live birth rate (86.2% vs. 81.5% vs. 93.6%). Biochemical pregnancy rate (25.1% vs. 28.2% vs. 35.3%), ectopic pregnancy rate (3.5% vs. 1.9% vs. 3.2%), miscarriage rate (10.4% vs. 16.7% vs. 3.2%), and low-birth-weight rate (14.6% vs. 12.5% vs. 19.4%) were comparable among the three groups.In terms of birth weight, the three study groups showed comparable values (3122.8±81.10 vs. 3095.6±68.96 vs. 3099.5±162.09 g), and no significant difference was observed. These results remained the same after adjusting for baseline clinical characteristics and in-hospital treatment. Interpretation and conclusions Our findings demonstrated that maternal pre-pregnancy serum uric acid level was not significantly related to pregnancy and obstetric outcomes following IUI treatment in women with PCOS.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"406-414"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' response.","authors":"Rupsa Banerjee, Pijush Kanti Khan, Bidhan Goswami, Smita Mahapatra, Nagamani Kammilli, Rinku Saini, Shauli Sengupta, Mamata Jena, Shalini Rathore, Madhavi Latha Manolla, Winnie Thomas, Madhusmita Hembram, Bharti Malhotra, Suparna Sutradhar, Thrilok Chander Bingi, Goli Mahalakshmi, Deepak Behera, Kirtirekha Mohapatra, Jnanindra Nath Behera, Amarjeet Mehta, Sudhir Bhandari, Ashoo Grover, Sutapa Bandyopadhyay Neogi","doi":"10.25259/IJMR_1089_2026","DOIUrl":"10.25259/IJMR_1089_2026","url":null,"abstract":"","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"421-422"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early biochemical muscle injury and one-year clinical and imaging outcomes following microsurgical versus endoscopic lumbar discectomy: A prospective comparative study.","authors":"Venkata Ramesh Chandra Vemula, Silpa Thota, Chandra Sekhar Chigurupalli, Anil Kumar Reddy Papasani, Chandramouliswara Prasad Bodapati, Mahesh Middina","doi":"10.25259/IJMR_3114_2025","DOIUrl":"10.25259/IJMR_3114_2025","url":null,"abstract":"<p><p>Background and objectives Minimally invasive spinal techniques aim to reduce tissue trauma while maintaining surgical efficacy. Comparative evidence integrating early biochemical muscle injury markers with long-term clinical and imaging outcomes remains limited. This study evaluated postoperative day 3 biochemical responses, and one-year clinical and MRI-based imaging changes between microsurgical lumbar discectomy (MLD) and percutaneous endoscopic lumbar discectomy (PELD). Methods 192 patients with single-level lumbar disc herniation (L4-L5 or L5-S1) underwent MLD (n=97) or PELD (n=95) between January 2022 and October 2024. Pain and disability were assessed using the visual analogue scale (VAS) and oswestry disability index (ODI) preoperatively and at one year. Serum creatine phosphokinase (CPK), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) were measured preoperatively and on postoperative days (POD) 1 and 3. MRI was performed preoperatively and at one year to assess paraspinal muscle cross-sectional area (CSA), fatty infiltration (Goutallier grading), and disc height index. Results Both groups showed significant improvement in VAS and ODI at one year (P<0.05). PELD demonstrated lower POD 1 and 3 CPK, IL-6, and hs-CRP levels (P<0.05), and shorter operative duration (66.3±12 vs. 86±14 min). MRI followup revealed better preservation of muscle CSA and less fatty infiltration in PELD (P<0.05), with comparable disc height maintenance. Interpretation and conclusions While both MLD and PELD achieved similar one-year functional outcomes, PELD demonstrated lower early biochemical markers and superior radiological muscle preservation.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"399-405"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy and safety of Cy-Tb for detection of tuberculosis infection: A multicentric study from India.","authors":"Manjula Singh, Tahziba Hussain, Bhavesh Modi, Sanjeev Nair, Sunil Kumar, Yasir Alvi, Karma Doma Bhutia, Sindhu Joshi, Pranav Patel, Jaydip Oza, Richa Gautam, Hardik Solanki, Chinmay Divyadarshi Kar, Prashanta Kumar Hota, Sarada Devi K L, Arshad Kalliath, Rinchenla Bhutia, Aruna Pradhan, Shilpa Vinod Pantula, Vijaya L Valluri, Kirankumar Rade, Rajendra Prasad Joshi, Sanjay Kumar Mattoo, Manjeet Singh Chalga, Abdul Mabood Khan, Rajni Rani, Sanghamitra Pati","doi":"10.25259/IJMR_1794_2025","DOIUrl":"10.25259/IJMR_1794_2025","url":null,"abstract":"<p><p>Background and objectives Only 10% of the individuals infected with Mycobacterium tuberculosis (MTB) manifest active tuberculosis. Interferon-γ release assay (IGRA) and tuberculin skin test using purified protein derivative (PPD) are used to identify tuberculosis (TB) infection. We aimed to study the comparative performance of Cy-Tb (the SIILTIBCY skin test) and PPD with IGRA as the reference standard. Methods In step-I, 30 TB patients and 32 IGRA-negative health controls; in step-II, 2651 participants aged 1 to 85 yr; and in step- III, 647 household contacts of TB patients aged 1-18 years old were enrolled. Blood for IGRA was drawn immediately prior to intra-dermal administration of Cy-Tb (the SIILTIBCY skin test) or PPD. The size of induration of Cy-Tb ≥5 mm or PPD ≥ 10mm after 48 to 72 h were considered positive. Combined Data from step II and step III were analysed for sensitivity, specificity, agreement, and kappa-coefficient with IGRA as the reference standard using Stata version 14.2. Results The step-I results for Cy-Tb showed 90% specificity, 93.8% specificity, and an agreement of 91.9% with IGRA and a Cohen's kappa coefficient of 0.83. Combined analysis of step-II and step-III data revealed sensitivity of 82.6% (95% CI 79.1-85.8), specificity of 71.1% (95% CI 68.2-73.8), agreement of 74.8%, and kappa of 0.5 for Cy-Tb. PPD showed sensitivity and specificity of 71.0% (95% CI 66.7-75.0) and 71.9% (95% CI 69.0-74·6), respectively with 71.6% agreement and kappa of 0.4 with IGRA. Interpretation and conclusions Performance of Cy-Tb was comparable to that of PPD with IGRA as reference standard. Cy-Tb skin test can be used for diagnosis of TB infection.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"163 3","pages":"309-318"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}