Indian Dermatology Online Journal最新文献

{"title":"Uncommon and Unusual Variants of Autoimmune Bullous Diseases.","authors":"Kiran, Raghavendra Rao","doi":"10.4103/idoj.idoj_755_23","DOIUrl":"10.4103/idoj.idoj_755_23","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune blistering diseases (AIBDs) are a type of dermatosis with antibodies produced against various structural proteins of the epidermis or dermoepidermal junction. AIBDs are broadly divided into intraepidermal and subepidermal types. Apart from the common AIBDs, there is an array of uncommon AIBDs.</p><p><strong>Objective: </strong>To discuss uncommon variants of AIBDs so that the readers are updated about them.</p><p><strong>Methods: </strong>In this review, we have discussed uncommon and unusual variants like pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus, induced pemphigus, IgG/IgA pemphigus, oral lichenoid pigmentation in pemphigus, pemphigus acanthoma, and follicular pemphigus. Rarer variants of the pemphigoid group of disorders include anti-laminin 332 pemphigoid, mixed linear IgA/IgG pemphigoid, anti-p200 pemphigoid, Brunsting-Perry pemphigoid, IgM pemphigoid, granular C3 pemphigoid, anti-p105 pemphigoid, ORF-induced anti-laminin 332 pemphigoid, and acral purpura in dermatitis herpetiformis.</p><p><strong>Conclusion: </strong>This review will help in early diagnosis and treatment of uncommon and unusual variants of AIBDs.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"739-748"},"PeriodicalIF":1.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Study to Evaluate the Efficacy of Oral Tranexamic Acid, Modified Kligman's Formula, and Placebo Cream in Melasma.","authors":"S Prathyoosha, K Ananditha, T Narayana Rao, K V T Gopal, P V Krishnam Raju","doi":"10.4103/idoj.idoj_797_23","DOIUrl":"10.4103/idoj.idoj_797_23","url":null,"abstract":"<p><strong>Background: </strong>Despite the availability of various treatment modalities, the treatment of melasma is often incomplete, with a high recurrence rate. The present study was undertaken to assess the efficacy and safety of oral tranexamic acid (TXA), modified Kligman's formula (MKF), and a placebo cream in melasma.</p><p><strong>Materials and methods: </strong>Ninety cases of melasma of both sexes were enrolled, and divided into three groups of 30 patients each. The baseline severity of melasma was graded by Melasma Area Severity Index (MASI) score. Group A, B, and C patients were treated with oral TXA 250 mg twice daily, daily MKF cream at night, and daily placebo cream at night, respectively, for 12 weeks. Improvement in MASI score was calculated after 4, 8, and 12 weeks. At each visit, adverse effects, if any, were noted. Statistical analysis was done using Chi-square test.</p><p><strong>Results: </strong>Based on intention to treat analysis, at the end of 12 weeks, the reduction in MASI score in oral TXA, MKF, and placebo groups was 9.94(65.91%), 6.12(54.78%), and 2.07(17.22%), respectively (<i>P</i> = 0.00). The difference in reduction of mean MASI scores after 12 weeks between oral TXA group and MKF group was not significant (<i>P</i> = 0.29). The efficacy of oral TXA and MKB was significantly higher than that of the placebo group (<i>P</i> = 0.01 and <i>P</i> = 0.03, respectively). Adverse effects in all groups were mild and self-limiting.</p><p><strong>Limitations: </strong>A limited sample size, non-blinded design, and absence of dermoscopic evaluation were the study limitations.</p><p><strong>Conclusion: </strong>In view of its excellent safety profile, oral TXA may be considered as a better option for moderate to severe melasma.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"787-793"},"PeriodicalIF":1.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verruca Vulgaris Atop Naevus Sebaceous of Jadassohn.","authors":"Sukhdeep Singh, Kittu Malhi, Debajyoti Chatterjee, Tarun Narang","doi":"10.4103/idoj.idoj_851_23","DOIUrl":"10.4103/idoj.idoj_851_23","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"900-901"},"PeriodicalIF":1.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Hidradenitis Suppurativa Responsive to Testosterone Replacement Therapy.","authors":"Corey Stone, Dedee F Murrell","doi":"10.4103/idoj.idoj_653_23","DOIUrl":"10.4103/idoj.idoj_653_23","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"854-855"},"PeriodicalIF":1.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoring Criteria for Autoimmune Bullous Diseases: Utility, Merits, and Demerits.","authors":"Henry Tseng, Corey Stone, Dédée F Murrell","doi":"10.4103/idoj.idoj_611_23","DOIUrl":"10.4103/idoj.idoj_611_23","url":null,"abstract":"<p><strong>Background: </strong>Scoring systems play a crucial role in dermatology by providing objective measurements of disease severity, treatment efficacy, and outcome comparisons. In autoimmune blistering diseases (AIBDs), standardized scoring systems are essential for accurate evaluations; however, there is currently a lack of consensus on scoring methods.</p><p><strong>Objective: </strong>This literature review explores scoring systems in AIBDs by tracing their development, addressing challenges, and highlighting their role in defining endpoints, regulatory considerations, and clinical trials.</p><p><strong>Materials and methods: </strong>Existing scoring systems for AIBDs, such as the Pemphigus Disease Area Index, Autoimmune Bullous Skin Disorder Intensity Score, Pemphigus Oral Lesions Intensity Score, Oral Disease Severity Score, and Pemphigus Vulgaris Activity Score, are examined for their validity, reliability, and responsiveness. The Bullous Pemphigoid Disease Area Index for bullous pemphigoid is also discussed. The concept of minimal clinically important differences is explored to determine clinically significant improvements in disease severity.</p><p><strong>Conclusion: </strong>This review provides a comprehensive understanding of the central role of scoring systems in dermatology and their implications for research and clinical practice in AIBDs.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"732-738"},"PeriodicalIF":1.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of the Efficacy of Intralesional Measles Mumps Rubella (MMR) Vaccine and Auto Implantation for the Treatment of Periungual and Palmoplantar Warts: A Randomized Controlled Trial.","authors":"Ravindra Abusaria, Chinmai Yadav, Vinod Jain, Dilip Kachhawa, Pankaj Rao, Anand Lamoria","doi":"10.4103/idoj.idoj_394_23","DOIUrl":"10.4103/idoj.idoj_394_23","url":null,"abstract":"<p><strong>Background: </strong>Warts are benign epidermal proliferations, caused by infection of keratinocytes with human papillomavirus (HPV). Auto implantation and intralesional mumps, measles, and rubella (MMR) vaccine are novel methods of immunotherapy for treating periungual and palmoplantar warts. They act by stimulating the patient's immune system; this clears not only the local warts but also distant warts with lesser side effects.</p><p><strong>Objective: </strong>We conducted this study to compare the efficacy and safety of both methods in treating periungual and palmoplantar warts.</p><p><strong>Materials and methods: </strong>A total of 160 patients were randomly allocated into two groups of 80 patients. Group A was treated with 0.3 mL of intralesional MMR vaccine at an interval of 3 weeks or for a maximum of three sittings, and Group B was treated with auto implantation.</p><p><strong>Results: </strong>At the end of therapy, the result was better in group A (MMR vaccine) as 86% of cases yielded an excellent response as compared to 71% in group B (auto implantation). The recurrence rate was 5% in group A and 4% in group B. There were no serious side effects in both groups with pain during injection (70%) in group A and swelling at the recipient site (8%) in group B being the most common side effect.</p><p><strong>Conclusion: </strong>Both MMR and auto implantation had significant response rates. But MMR was faster and better.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"812-816"},"PeriodicalIF":1.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acral Ulcerated Nodule in a Young Female.","authors":"Keshavmurthy A Adya, Ajit B Janagond, Arun C Inamadar","doi":"10.4103/idoj.idoj_160_24","DOIUrl":"10.4103/idoj.idoj_160_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 6","pages":"1074-1075"},"PeriodicalIF":1.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of the Histopathological Spectrum of Erythema Nodosum Leprosum.","authors":"Varniraj Patel, Rhea Ahuja, Sudheer K Arava, Sujay Khandpur, Neetu Bhari, Vishal Gupta, M Ramam","doi":"10.4103/idoj.idoj_952_23","DOIUrl":"10.4103/idoj.idoj_952_23","url":null,"abstract":"<p><strong>Background: </strong>There are no recent studies with a focus on the histopathology of erythema nodosum leprosum (ENL).</p><p><strong>Objectives: </strong>To describe the histopathological spectrum of ENL.</p><p><strong>Materials and methods: </strong>Digital records from the pathology department were searched, and 125 slides were included. The histopathologic findings were recorded using a pre-designed proforma.</p><p><strong>Results: </strong>Several patterns were noted with the most common being a superficial and deep, perivascular and peri-appendageal, well-circumscribed dermal infiltrate that was seen in 70 (56.0%) biopsies. Other dermal patterns included a similar but loose infiltrate in 19 (15.2%) biopsies, diffuse dermal involvement in 9 (7.2%), top-heavy in 9 (7.2%), and bottom-heavy infiltrates in 12 (9.6%). Subcutaneous tissue was included in 107 biopsies. Extension of dermal infiltrates to the subcutis was noted in 71 (66.4%) biopsies and predominant involvement of the subcutis was noted in 6 (4.8%) biopsies, with lobular involvement in 60 (56.1%), septal involvement in 3 (2.8%), and septo-lobular involvement in 14 (13.1%). In 30 (28.0%) biopsies, the subcutaneous fat was uninvolved. The infiltrates contained neutrophils and foamy histiocytes in variable proportions, along with lymphocytes and plasma cells. Eosinophils were noted occasionally. Medium and/or small vessel vasculitis was noted in 11 (8.8%) biopsies. Fite-Faraco staining was available for 112 biopsies and revealed mainly fragmented and granular acid-fast bacilli (AFB) in 29 (25%) biopsies.</p><p><strong>Limitations: </strong>Our study had a retrospective design; we could not compare the lesional age and clinical characteristics of patients with the histological features.</p><p><strong>Conclusion: </strong>ENL is characterized by dermal infiltrates composed of foamy histiocytes and neutrophils in varying proportions arrayed in different dermal patterns. Extension of dermal infiltrates into the subcutis was frequent but absent in some. Predominant or exclusive involvement of the subcutis was rare. Vasculitis was noted in a small minority, while AFB were demonstrated in about a quarter of cases.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"779-786"},"PeriodicalIF":1.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blaschkoidal Lesion Over the Buttock in a Young Woman.","authors":"Hitaishi Mehta, Anish Thind, Debajyoti Chatterjee, Anuradha Bishnoi","doi":"10.4103/idoj.idoj_953_23","DOIUrl":"10.4103/idoj.idoj_953_23","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"906-908"},"PeriodicalIF":1.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intertriginous Xanthomas: Clues to Homozygous Familial Hypercholesterolemia.","authors":"Nikhil Mehta, Gouri Anand, Anamika Choudhary, Somesh Gupta","doi":"10.4103/idoj.idoj_60_24","DOIUrl":"10.4103/idoj.idoj_60_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 5","pages":"902-903"},"PeriodicalIF":1.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}