Indian Dermatology Online Journal最新文献

{"title":"Psoriasis Comorbidities: Obesity, Diet, and Metabolic Syndrome.","authors":"Abir Saraswat","doi":"10.4103/idoj.idoj_420_25","DOIUrl":"10.4103/idoj.idoj_420_25","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"367-369"},"PeriodicalIF":1.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Adiposity in Patients with Psoriasis and its Correlation with Disease Severity: A Case-Control Study.","authors":"Seerat Fatima, Seema Qayoom, Majid Jehangir","doi":"10.4103/idoj.idoj_510_24","DOIUrl":"10.4103/idoj.idoj_510_24","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis and obesity are known to share many mediators of inflammation with each other such as TNF-<i>α</i> and IL-6. Obesity, being a low-grade inflammatory state, is known to affect the disease course, severity, predisposition, and response to therapy in psoriatic patients. Whole-body dual-energy X-ray absorptiometry (DEXA) is a proven method to estimate total, abdominal, and extremity fat mass.</p><p><strong>Objectives: </strong>The present study aimed to assess the correlation of the severity of psoriasis with adiposity using regional fat mass DEXA indices.</p><p><strong>Patients and methods: </strong>This was a case-control study involving 153 cases followed through till the completion of the study. A total of 153 age and gender-matched controls were included in the study after ruling out confounding factors. DEXA scans were conducted on both cases and controls; the following indices, including total body fat percentage, android-gynoid ratio, and trunk/limb fat mass ratio, were analyzed.</p><p><strong>Results: </strong>The total fat percentage, as assessed by DEXA scan, had a mean of 29.13 ± 9.66 (32.12 ± 9.51 for cases and 26.13 ± 8.87 for controls) with a significant <i>P</i> value of <0.001. The android/gynoid ratio had a mean of 1.01 ± 0.22 (1.09 ± 0.21 for cases and 0.93 ± 0.21 for controls). Percentage fat trunk/percentage fat limbs (central/peripheral fat) had a mean of 1.05 ± 0.16 (1.08 ± 0.15 for cases and 1.03 ± 0.16 for controls) with a significant <i>P</i> value of <0.001. The correlation of DEXA adiposity grading with the severity of psoriasis was found to be significant, with a <i>P</i> value of <0.001.</p><p><strong>Limitations: </strong>The cross-sectional design restricts assessment to associations rather than causality. Although major confounding factors were ruled out during recruitment, variables such as lifestyle and dietary habits, physical activity levels, and treatment history were not the primary focus and hence not extensively analyzed. The sample size analyses, such as stratification by gender or treatment modalities, may benefit from larger cohorts in future research.</p><p><strong>Conclusion: </strong>DEXA is a useful indicator of adiposity, with greater total fat percentage, android/gynoid ratio, and trunk/limb fat mass ratio in cases compared to controls and it was positively correlated with the severity of psoriasis in our study.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"402-406"},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Roles and Visibility for Women in Dermatology.","authors":"Anukriti Yadav, Rashmi Sarkar, Mona Gohara, Amy Paller","doi":"10.4103/idoj.idoj_1010_24","DOIUrl":"10.4103/idoj.idoj_1010_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"533-535"},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear Erythematous Streaks in Neonates - Diagnostic Dilemma in Four Cases.","authors":"Tulasi Jarang, Bhumesh K Katakam, Pavani Kusuma, Deepika Meda","doi":"10.4103/idoj.idoj_970_23","DOIUrl":"10.4103/idoj.idoj_970_23","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"480-483"},"PeriodicalIF":1.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterned Acquired Dermal Macular Hyperpigmentation - A Novel Presentation of Chest Guard-Induced Hyperpigmentation on the Back.","authors":"Vibhu Mendiratta, Twinkle Yadav, Priti Chatterjee","doi":"10.4103/idoj.idoj_895_23","DOIUrl":"10.4103/idoj.idoj_895_23","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"447-449"},"PeriodicalIF":1.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Insensitivity to Pain and Anhidrosis: Dermoscopy of a Rare Genetic Disorder.","authors":"Balachandra S Ankad, Shashank Devani, Sourab Dhananjaya, Ramesh Pol","doi":"10.4103/idoj.idoj_193_24","DOIUrl":"10.4103/idoj.idoj_193_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"475-477"},"PeriodicalIF":1.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Cryotherapy Resistant Verruca Vulgaris with 18% Aluminum Chloride Solution: A Report of 4 Cases.","authors":"Kübra Pınar Hararcı Yıldırım, Sabir Hasanbeyzade, Efsun Tanaçan, Didem Dinçer Rota","doi":"10.4103/idoj.idoj_894_24","DOIUrl":"10.4103/idoj.idoj_894_24","url":null,"abstract":"<p><p>Warts are benign intraepidermal proliferations commonly seen in children and adults caused by Papillomavirus. Invasive and non-invasive methods such as salicylic acid, cryotherapy, imiquimod, intralesional 5-fluorouracil, and electrocauterization take part in the treatment. In this study, we present 4 cryotherapy-resistant verruca cases treated successfully with 18% aluminum chloride solution. It is thought that the aluminum chloride solution acts by desquamation of the epidermis with its intraepidermal keratinolytic effect in the virus-infected epidermis. As a result of treatment, clinical improvement was seen in all cases. This treatment option can be used because it is painless, leaves no scarring, the frequency of hospital admission is low and the results are fast.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"432-434"},"PeriodicalIF":1.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study Comparing 0.025% Topical Tretinoin Versus 4% Retinol Peel and 10% Retinol Peel in the Management of Acanthosis Nigricans.","authors":"Shreya Srinivasan, C Balakumaran, G Sukanya, N Ashok Kumar, A Sakthi Megalai, Aswin Senthilvel","doi":"10.4103/idoj.idoj_506_24","DOIUrl":"10.4103/idoj.idoj_506_24","url":null,"abstract":"<p><strong>Background: </strong>Acanthosis nigricans (AN) presents a significant challenge for dermatologists, as it is a common condition yet often proves resistant to treatment.</p><p><strong>Aim and objective: </strong>To compare the effects of 0.025% topical tretinoin, 4% retinol peel, and 10% retinol peel, in the management of AN of neck using Acanthosis Nigricans Area Severity Index (ANASI) score.</p><p><strong>Patients and methods: </strong>Patients with AN of neck were recruited to the study with due consideration to the inclusion criteria and were divided into 3 groups based on the treatment administered which was either 0.025% topical tretinoin, 4% retinol peel, or 10% retinol peel. The patients were followed-up every 2 weeks up to 8 weeks with ANASI score and Likert scale.</p><p><strong>Results: </strong>All the groups demonstrated statistically significant improvement but participants in the topical group achieved a slightly better reduction, with a mean ANASI score of 10 at final follow-up, followed by 10% retinol and 4% retinol peel with a mean ANASI score of 12 and 11, respectively. Overall, though 4% retinol peel group had the least reported side effects, patient satisfaction score was found to be higher among the participants in the topical group.</p><p><strong>Limitations: </strong>Small sample size and allocation of patients to different treatment groups was not randomized.</p><p><strong>Conclusion: </strong>Among the three groups, topical tretinoin group showed better response when compared to 4% and 10% retinol peels and, as such, can be a preferred mode of treatment since it is also cost effective over the more expensive chemical peels. Thus, in the era of chemical peels and lasers, topical treatment with retinoids still holds good.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"414-419"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Morbidity in Chronic Dermatological Disorders: A Review.","authors":"Narayanan Baskaran, Aarushi Arunima, Shikha Shah, Tarun Narang, Muthu Sendhil Kumaran","doi":"10.4103/idoj.idoj_458_24","DOIUrl":"10.4103/idoj.idoj_458_24","url":null,"abstract":"<p><p>Skin diseases not only manifest physically but also significantly impact mental and emotional well-being due to the close biological connection between the skin and brain. Psychodermatology, a field that bridges dermatology and psychiatry, addresses the psychological aspects of dermatological disorders, which can profoundly affect quality of life. This review explores the psychological morbidity associated with common dermatological conditions, including acne vulgaris, alopecia areata, atopic dermatitis, hidradenitis suppurativa, leprosy, melasma, psoriasis, urticaria, and vitiligo. A comprehensive literature search was performed and studies assessing quality of life in common chronic dermatological disorders were analyzed. Patients with chronic skin conditions often experience anxiety, depression, social withdrawal, and stigmatization, which can impair their personal and professional lives. Psychometric tools like the Dermatology Life Quality Index (DLQI) and Patient Health Questionnaire-9 (PHQ-9) are essential for assessing the impact on quality of life and identifying psychiatric comorbidities. Despite the recognized link between dermatological conditions and mental health, these aspects often receive insufficient attention in clinical practice. This review highlights the need for a multidisciplinary approach that integrates psychological support with dermatological treatment. Effective management strategies, including cognitive behavioral therapy, psychotropic medications, and habit reversal therapy, are discussed as crucial components of patient care.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"381-388"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Intermittent Fasting in the Management of Chronic Plaque Psoriasis: A Phase IIb Clinical Trial.","authors":"Shekhar Neema, Biju Vausdevan, Pratibha Misra, Senkadhir Vendhan, M K Sibin, Seema Patrikar","doi":"10.4103/idoj.idoj_635_24","DOIUrl":"10.4103/idoj.idoj_635_24","url":null,"abstract":"<p><strong>Background: </strong>Dietary measures have been used as an adjunctive therapy in the management of psoriasis. Intermittent fasting (IF) is an eating pattern in which energy is not consumed for a fixed duration, resulting in metabolic switch from liver-derived glucose to adipose-derived ketones. The data regarding effectiveness of IF in psoriasis are limited.</p><p><strong>Aim and objectives: </strong>The aim of this study was to assess efficacy of IF in patients with chronic plaque psoriasis. The primary outcome of the study was change in psoriasis severity as measured by psoriasis area and severity index (PASI) at 28 weeks. The secondary outcome measures were change in metabolic parameters and biomarkers for atherosclerosis in each group.</p><p><strong>Patients and methods: </strong>The study was designed as a randomized parallel group trial. Clinical parameters, psoriasis severity, fasting and postprandial blood sugar, lipid profile, high sensitivity C-reactive protein (hsCRP), vascular endothelial growth factor (VEGF), and interleukin 6 (IL-6), were measured using standard methods at baseline, 16 weeks, and 28 weeks. Patients were randomized to receive methotrexate in the dose of 0.3 mg/Kg/week with or without intermittent fasting.</p><p><strong>Results: </strong>A total of 120 patients were randomized in two groups of 60 each: group 1 (methotrexate) and group 2 (methotrexate and intermittent fasting). The mean age, mean duration of disease, PASI, and dermatology life quality index (DLQI) in group 1 were 45.5 (±12.9) years, 5.06 (±5.5) years, 17.1 (±6.7), and 12.33 (±5), respectively. The mean age, mean duration of disease, PASI, and DLQI in group 2 were and 42.9 (±14.6) years, 6.91 (±6.2) years, 16 (±4.3), and 11.9 (±4.3), respectively. There was no statistically significant difference in baseline parameters in two groups. In both the groups, there was a statistically significant difference in PASI, DLQI, VEGF, and hsCRP from baseline to 16 and 28 weeks. At week 16, 44 (73.3%) patients in group 1 and 47 (78.3%) in group 2 achieved PASI50 (<i>P</i> = 0.8). At week 28, 16 (36%) in group 1 and 27 (54.4%) patients in group 2 maintained PASI50 (<i>P</i> = 0.054). There was a statistically significant weight and waist circumference reduction at 16 weeks and 28 weeks in group 2. There was a statistically significant reduction in VEGF, IL6, and hsCRP at 28 weeks in group 2 as compared to group 1.</p><p><strong>Limitations: </strong>The small sample size and loss to follow-up are major limitations of the study.</p><p><strong>Conclusion: </strong>Intermittent fasting using 16: 8 protocol is easy to perform and a safe and effective adjuvant for managing severe chronic plaque psoriasis. It helps in maintaining remission and results in improvement in metabolic parameters and markers of vascular inflammation.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"389-396"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}