Indian Dermatology Online Journal最新文献

{"title":"Polarized Light for Rapidly Examining Large Areas of the Skin.","authors":"Nithya Satish, Chakravarthi R Srinivas, C K Shashidharan Nair, Surendranath Lal","doi":"10.4103/idoj.idoj_107_24","DOIUrl":"10.4103/idoj.idoj_107_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"445-446"},"PeriodicalIF":1.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leonine Facies in Dermatology.","authors":"Debopriya Paul, Akash Mustari, Suvesh Singh","doi":"10.4103/idoj.idoj_553_24","DOIUrl":"10.4103/idoj.idoj_553_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"440-444"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Study to Evaluate the Efficacy and Adverse Effects of Cryotherapy Combined with Intralesional Steroids, Intralesional Bleomycin Combined with Steroids and Fractional CO₂ Laser in Keloids.","authors":"P Sravya Krishna, K V T Gopal, K Ananditha, V Sai Teja Reddy, T Narayana Rao","doi":"10.4103/idoj.idoj_789_24","DOIUrl":"10.4103/idoj.idoj_789_24","url":null,"abstract":"<p><strong>Background: </strong>Despite the availability of various treatment modalities, the treatment of keloids is often incomplete, with a high recurrence rate. The present study was undertaken to assess the efficacy and safety of cryotherapy combined with intralesional steroid injections (Cy + ILS), intralesional combined bleomycin and steroids (ILB + S), and fractional carbon dioxide laser (Fr CO₂) in keloid management.</p><p><strong>Patients and methods: </strong>Ninety cases with keloids were enrolled and randomly divided into three groups of 30 patients each. The baseline severity of keloids was graded using the Vancouver scar scale (VSS) and high-frequency ultrasonography (HFUS). Group A, B, and C patients were treated with Cy + ILS, ILB + S, and Fr CO₂, respectively for four sittings at 4-week intervals. Improvement in VSS score was calculated after 4, 8, 12, and 16 weeks, and with HFUS after 16 weeks. At each visit, adverse effects, if any, were noted. Statistical analysis was done using Chi-square test and ANOVA.</p><p><strong>Results: </strong>At the end of 16 weeks, the reductions in VSS in Cy + ILS, ILB + S, and Fr CO₂ groups were 5.12 (60.09%), 5.84 (69.30%), and 3.06 (38.3%), respectively (<i>P</i> = 0.00). The difference in mean VSS reduction after 16 weeks between ILB + S and Cy + ILS was not significant (<i>P</i> = 0.28), whereas ILB + S and Cy + ILS were more efficacious than Fr CO₂ (<i>P</i> = 0.01 and <i>P</i> = 0.02, respectively). The incidence of adverse effects was comparable between ILB + S and Fr CO₂ (<i>P</i> = 0.11) but higher with Cy + ILS (<i>P</i> = 0.04).</p><p><strong>Limitations: </strong>Small sample size, non-blinded design, and short follow-up period.</p><p><strong>Conclusion: </strong>ILB + S may be considered as the first-line treatment option for keloids in view of its satisfactory efficacy, and excellent safety profile.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"407-413"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-epidemiological Characteristics and Long-term Surgical Outcomes in Patients with Glomus Tumor: A Retrospective Study.","authors":"Keshavamurthy Vinay, Tarun Narang, N Roshini, Narayanan Baskaran, Ashwini Reddy, Sandeep Patel, Sunil Dogra","doi":"10.4103/idoj.idoj_786_24","DOIUrl":"10.4103/idoj.idoj_786_24","url":null,"abstract":"<p><strong>Background: </strong>Glomus tumors are painful neoplasms arising from the glomus bodies generally over fingertips. Being rare tumors, data on long-term surgical outcomes is scarce.</p><p><strong>Aim and objective: </strong>This study aimed to describe the clinico-epidemiological characteristics, and surgical outcomes, assess patient satisfaction, rates of recurrence, and surgical complications of glomus tumor.</p><p><strong>Patients and methods: </strong>This was a retrospective study of patients with glomus tumors of nail apparatus who attended the dermatosurgery clinic and underwent surgery in the last 10 years (2013-2023). The demographic details, presenting symptoms, investigations, surgical procedures, and follow-up were analyzed.</p><p><strong>Results: </strong>There were 25 patients with glomus tumor with a female preponderance, and fingers were affected (23/25) in the majority. The most common symptom was pain present in all patients. Reddish-blue discoloration of the nail bed was seen in 17 (68%) patients and nail plate changes in the form of dystrophic nails and longitudinal splitting at presentation were noted in five (20%) patients. All patients were treated surgically by transungual excision. The commonest immediate complication was pain, present in all patients. Incomplete nail plate formation and longitudinal split post-surgery were noted in six patients (24%). The median duration of follow-up was 5 years post-surgery. All the patients were satisfied after surgery having complete pain relief without any recurrence during the follow-up period.</p><p><strong>Limitations: </strong>Small sample size, retrospective study design, and unavailability of onychoscopy and imaging studies (ultrasonography and/or magnetic resonance imaging) in all cases.</p><p><strong>Conclusion: </strong>Surgical excision of glomus tumors was curative with minimal risk of recurrence. Patients were contended with pain relief and improved quality of life.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"426-431"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avian-Inspired Analogies in Dermatology.","authors":"Mira Tharani Srinivasan, Tanigassalame Pavithran, Ramamoorthy Logamoorthy, Kaliaperumal Karthikeyan","doi":"10.4103/idoj.idoj_1039_24","DOIUrl":"10.4103/idoj.idoj_1039_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"435-439"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Tumors Unraveling a Rare Genetic Disorder.","authors":"Seema Negi, Anubha Dev, Muthu Sendhil Kumaran","doi":"10.4103/idoj.idoj_1287_24","DOIUrl":"10.4103/idoj.idoj_1287_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"531-532"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Real-World Study of Tofacitinib in Indian Patients with Refractory Moderate-to-Severe Atopic Dermatitis, its Economic Considerations and Immunological Rationale.","authors":"Kabir Sardana, Savitha Sharath, Sumitra Kumari Meena, Ananta Khurana, Bhawuk Dhir","doi":"10.4103/idoj.idoj_665_24","DOIUrl":"10.4103/idoj.idoj_665_24","url":null,"abstract":"<p><strong>Background: </strong>The response of atopic dermatitis (AD) to different biologics and JAK inhibitors (JAKibs) is variable due to the varied immunological endotypes of AD.</p><p><strong>Aim and objectives: </strong>To assess the effectiveness and adverse effect profile of tofacitinib in recalcitrant, moderate-to-severe AD patients and to compare the cost of therapy of tofacitinib with dupilumab.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed records of moderate to severe AD treated with tofacitinib monotherapy. The response to tofacitinib was assessed using clinical scores including Numerical Rating Scale (NRS), Scoring Atopic Dermatitis (SCORAD), and Eczema Area and Severity Index (EASI) at 4 weeks and 8 weeks of treatment. We also analyzed the duration of remission and time after which recurrences were seen after stopping tofacitinib. The cost of tofacitinib was compared with dupilumab.</p><p><strong>Results: </strong>Twelve cases of recalcitrant moderate-severe AD who had failed systemic agents [oral corticosteroids (n = 7), cyclosporine (n = 4), and azathioprine (n = 2)] were treated with tofacitinib monotherapy. There was a statistically significant reduction in SCORAD, EASI, and NRS scores at 4 weeks and 8 weeks of tofacitinib therapy [mean at baseline: 4 weeks: 8 weeks = SCORAD- 43.54: 22.74: 11.87 (<i>P</i> = 0.002); EASI-19.5: 6.45: 1.6 (<i>P</i> = 0.002); NRS-5.75: 3.25: 1.08 (<i>P</i> = 0.002)]. EASI 90 was achieved by 66% of patients in 8 weeks with treatment failure in one patient. The mean time to achieve complete/near complete resolution (n = 8) of the disease was 6.1 weeks (3-8 weeks). Relapse of the disease was noted in 4/11 (36.3%) patients. Side effects were observed in 5/12 (41.6%) patients (herpes zoster, dyslipidemia, anemia, impetigo, and thrombocytosis). The cost of therapy with dupilumab is 122 times higher than that of tofacitinib therapy (8 weeks treatment).</p><p><strong>Limitations: </strong>Small sample size and lack of tissue cytokines analysis pre- and post-treatment.</p><p><strong>Conclusion: </strong>Tofacitinib (pan JAK inhibitor) inhibits T helper 2 (Th2), Th1, Th17, and Th22 cell lines, and thus has potential for refractory AD. There is a need to generate tissue-based cytokine expression data in Indian patients with AD.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"420-425"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bull's Eye Rash in Lyme Disease.","authors":"Vijayasankar Palaniappan, Aravind Baskar Murthy, Kaliaperumal Karthikeyan","doi":"10.4103/idoj.idoj_691_24","DOIUrl":"https://doi.org/10.4103/idoj.idoj_691_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"525"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome.","authors":"Essam M Akl, Nehad A Fouad, Maram S Mahmoud, Karem T Khalil","doi":"10.4103/idoj.idoj_546_24","DOIUrl":"10.4103/idoj.idoj_546_24","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a chronic inflammatory condition of the skin that can be related to a variety of other conditions, including cardiovascular disease and metabolic syndrome. Growth differentiation factor-15 (GDF-15) is a cytokine that reacts to cellular stress. GDF-15 serum levels may have clinical uses in a variety of inflammatory and cardiovascular conditions.</p><p><strong>Objectives: </strong>To determine the levels of GDF-15 in the serum of patients with generalized plaque psoriasis (GPP) and its correlation with the metabolic syndrome.</p><p><strong>Patients and methods: </strong>This case-control study included 50 patients with GPP and 50 age- and sex-matched healthy volunteers as controls. A general examination was performed, with a particular emphasis on measurements of body mass index, circumference of the waist, and blood pressure. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI) score. In addition, laboratory tests, including fasting blood sugar, lipid profile, and serum GDF-15 level measurement, were made.</p><p><strong>Results: </strong>Patients had significantly higher median GDF-15 levels compared to controls (<i>P</i> < 0.001). GDF-15 showed a substantial correlation with both disease duration and PASI score (<i>P</i> < 0.001 for each). GDF-15 levels were considerably greater in participants with metabolic syndrome compared with those without (<i>P</i> = 0.01).</p><p><strong>Limitation: </strong>The relatively small sample size could be a disadvantage and drawback of the study.</p><p><strong>Conclusion: </strong>Serum GDF-15 levels are linked to the severity of psoriasis and the associated metabolic disorders.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"397-401"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Presentation of Verrucous Porokeratosis on Face.","authors":"C Navya Suvidha, C Karishni, B Anil Kumar, C Sudharani","doi":"10.4103/idoj.idoj_429_24","DOIUrl":"10.4103/idoj.idoj_429_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 3","pages":"510-511"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}