Indian Journal of Microbiology最新文献_第7页

Cloning, Overexpression and Application of Lipase from Thermotolerant Bacillus subtilis TTP-06 in the Degradation of Polyhydroxyalkanoate 耐热枯草芽孢杆菌 TTP-06 脂肪酶的克隆、过表达及其在降解聚羟基烷酸酯中的应用

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-20 DOI: 10.1007/s12088-024-01329-z

Manpreet Kaur, Sudha Batta, Rutika Sehgal, Reena Gupta

{"title":"Cloning, Overexpression and Application of Lipase from Thermotolerant Bacillus subtilis TTP-06 in the Degradation of Polyhydroxyalkanoate","authors":"Manpreet Kaur, Sudha Batta, Rutika Sehgal, Reena Gupta","doi":"10.1007/s12088-024-01329-z","DOIUrl":"https://doi.org/10.1007/s12088-024-01329-z","url":null,"abstract":"Polyhydroxyalkanoates (PHAs) constitute a principal group of bio-degradable polymers that are produced by certain microbes under limited supply of nutrients. PHA is a linear polyester that comprises of 3-hydroxy fatty acid monomers. Triacylglycerol acylhydrolases are known to catalyze the hydrolysis of ester linkages and in turn they are beneficial in the degradation of PHA. In present study, lipase-catalyzed degradation of PHA synthesized by Priestia megatarium POD1 was monitored. A gene from thermotolerant Bacillus subtilis TTP-06 that was capable of expressing lipase enzyme was amplified by PCR, cloned into a pTZ57R/T-vector, transferred to an expression vector pET-23a (+) and expressed in Escherichia coli BL21 (DE3) cells. The recombinant enzyme purified to 19.37-fold had a molecular weight of 30 kDa (SDS-PAGE analysis). Scanning Electron Microscopy (SEM) revealed changes in the surface morphology of native and treated PHA films. Further, changes in molecular vibrations were confirmed by Fourier Transform Infrared Spectroscopy.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"146 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold Nanoparticles as a Tool to Detect Biomarkers in Osteoarthritis: New Insights 纳米金颗粒作为骨关节炎生物标记物的检测工具：新见解

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-20 DOI: 10.1007/s12088-024-01331-5

Atul Mourya, Shristi Arya, Ayush Singh, Gopal Bajad, Soham Loharkar, Shubhra, Pawan Devangan, Neelesh Kumar Mehra, Rahul Shukla, Ramesh Chandra, Jitender Madan

{"title":"Gold Nanoparticles as a Tool to Detect Biomarkers in Osteoarthritis: New Insights","authors":"Atul Mourya, Shristi Arya, Ayush Singh, Gopal Bajad, Soham Loharkar, Shubhra, Pawan Devangan, Neelesh Kumar Mehra, Rahul Shukla, Ramesh Chandra, Jitender Madan","doi":"10.1007/s12088-024-01331-5","DOIUrl":"https://doi.org/10.1007/s12088-024-01331-5","url":null,"abstract":"Extensive research over the years has revealed the remarkable potential of gold nanoparticles (AuNPs) for detecting biomarkers in osteoarthritis (OA). AuNPs are a promising class of nanomaterials offering a wide range of diagnostic and clinical applications. It provides an effective and robust framework for qualitative and quantitative analysis of biomarkers present in the biological fluids of OA patients. AuNPs as theranostics have gained significant attention due to their discrete physical and optical characteristics, including localized surface plasmon resonance (LSPR), fluorescence, surface-enhanced Raman scattering, and quantized charging effect. These unique properties provide AuNPs as an excellent scaffold for ligand multiplexing, allowing accrued sensitivity for biomarker detection. Several reports have delved into the LSPR properties of the kinetics of biological interactions between the ligand and analyte. Tuneable radiative properties of AuNPs coupled with surface engineering allow facile detection of biomarkers in biological fluids. Herein, we have presented a comprehensive summary of distinct biomarkers generated from different molecular pathological processes in OA. An armamentarium of diagnostic methodologies such as aptamer conjugation, antibody coupling, ligand anchoring, and peptide decoration on the surface of AuNPs facilitates the identification and quantification of biomarkers. Additionally, a diverse range of sensing strategies for biomarker spotting, along with current challenges and future perspectives, have also been well delineated in the present manuscript.<h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"36 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141530152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopriming with EPS-producing Bacteria of Sub-Himalayan-Soil Origin Recovers the Cold-Induced Vigor Loss in Seedlings 利用喜马拉雅山下土壤中产生 EPS 的细菌进行生物修复，可恢复寒冷导致的幼苗活力损失

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-20 DOI: 10.1007/s12088-024-01342-2

Priyanka Maity, Dipankar Roy, Bratati Chowdhury, Binayak Chakraborty, Navya Anand, Bidhan Roy, Ashok Choudhury, Nipa Biswas, Kapudeep Karmakar

{"title":"Biopriming with EPS-producing Bacteria of Sub-Himalayan-Soil Origin Recovers the Cold-Induced Vigor Loss in Seedlings","authors":"Priyanka Maity, Dipankar Roy, Bratati Chowdhury, Binayak Chakraborty, Navya Anand, Bidhan Roy, Ashok Choudhury, Nipa Biswas, Kapudeep Karmakar","doi":"10.1007/s12088-024-01342-2","DOIUrl":"https://doi.org/10.1007/s12088-024-01342-2","url":null,"abstract":"The eastern sub-Himalayan region of India (which belongs to the Cwa zone in Koppen’s classification) experiences severe cold waves during winter which causes a loss in seed vigor. Though most of the studies on cold stress deal with atmospheric temperatures, the seed vigor is majorly affected by the temperature of the soil. Therefore, the vigor loss of tomato and green gram were investigated under low-temperature stress. The analysis of locally available soil temperature showed a median value of 20.3 ± 0.1 °C. When the seeds were subjected to this temperature in vitro, a loss in vigor (70–75%) was observed. This was due to the reduced fluidity of the membrane which caused electrolyte leakage. In this regard, the indigenous polysaccharides-producing microbes act as an eco-friendly priming agent to recover the lost vigor. However, seed treatment with Bacillus and Pseudomonas strains didn’t affect the germination-related factors but aided in recovering 30–70% of the lost vigor by enhancing the growth of seedlings. The mode of vigor recovery was the production of indole-acetic acid. This approach can be used to quicken the nursery period of tomato and green gram exposed to low soil temperatures prevalent in the sub-Himalyan terai region.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"50 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141530269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Gen Nano Biosensor Technologies to Monitor Carbapenem Resistance for Personalized Medicine 下一代纳米生物传感器技术监测碳青霉烯耐药性，实现个性化医疗

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-20 DOI: 10.1007/s12088-024-01337-z

Rahul Harikumar Lathakumari, Leela Kakithakara Vajravelu, Jayaprakash Thulukanam, Ashwin Kumar Narasimhan

{"title":"Next-Gen Nano Biosensor Technologies to Monitor Carbapenem Resistance for Personalized Medicine","authors":"Rahul Harikumar Lathakumari, Leela Kakithakara Vajravelu, Jayaprakash Thulukanam, Ashwin Kumar Narasimhan","doi":"10.1007/s12088-024-01337-z","DOIUrl":"https://doi.org/10.1007/s12088-024-01337-z","url":null,"abstract":"Carbapenem resistance represents a pressing public health concern, posing significant challenges due to limited treatment options and escalating mortality rates. In India, the prevalence of carbapenem resistance among Enterobacteriaceae ranges between 18 to 31%, causing severe infections such as bloodstream infections, pneumonia, urinary tract infections, and intra-abdominal infections. Accurate and timely diagnosis, particularly for Enterobacteriaceae producing carbapenemase, is crucial for effective clinical prophylaxis of critical care patients as they are considered as a last resort of therapy. Various genotypic and non-genotypic detection methods have been developed over the past decade, their limitations in terms of sensitivity and specificity have led the exploration of innovative technologies. Advanced opportunities for carbapenem resistance detection using microfluidic-based biosensors have miniaturized various biomedical devices. This enables the use of less sample and reagents, cheap pricing, automation, screening, and improved detection. Despite ongoing research and development, the adoption of these biosensors in healthcare settings is limited due to the lack of awareness and understanding of their efficiency. Therefore, this review primarily focuses on the advantages and limitations of all biosensor-based devices over existing methods for the detection of carbapenem resistance in gram negative bacilli. These biosensors represent substantial advancements in combating carbapenem resistance, providing promise for more reliable and accurate diagnostic techniques that may eventually improve patient care and infection control.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"26 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Characteristics and Risk Factors of Cytomegalovirus Infection in Dermatomyositis 皮肌炎患者巨细胞病毒感染的特征和风险因素

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-20 DOI: 10.1007/s12088-024-01333-3

Min Zhang, Bing Yan

{"title":"The Characteristics and Risk Factors of Cytomegalovirus Infection in Dermatomyositis","authors":"Min Zhang, Bing Yan","doi":"10.1007/s12088-024-01333-3","DOIUrl":"https://doi.org/10.1007/s12088-024-01333-3","url":null,"abstract":"To investigate the characteristics and risk factors of cytomegalovirus (CMV) infection in patients with dermatomyositis (DM) and explore whether CMV infection plays a role in the prognosis of patients with DM. The retrospective reviewed patients with DM admitted to the hospital from October 2017 to June 2022 and the enrolled patients who were assessed for CMV infection. The clinical characteristics and prognosis of the patients with CMV infection were compared to those without CMV. Of the 181 patients with DM, 53 (29.2%) suffered from CMV infection. The prevalence of CMV infection in the anti-MDA5( +) DM group was higher than it was in the anti-MDA5(-) DM group (38.7% vs. 16.0%, P = 0.001). Multivariate analyses demonstrated that the ILD (OR 5.11, 95% CI 1.74–15.26, P = 0.003), other infections (OR 6.24, 95% CI 1.63–23.89, P = 0.007), the cumulative dose of glucocorticoids (OR 5.19, 95% CI 2.44–11.02, P < 0.001), usage of CTX (OR 8.49, 95% CI 2.28–31.54, P = 0.001), ALB ≦ 30 g/L (OR 3.19, 95% CI 1.03–9.85, P = 0.043) were independent risk factors for CMV infection in patients with DM. Patients in the CMV-infection group showed significantly higher incidences of other infections than those in the CMV-infection-negative group. Higher mortality was observed in the CMV infection group than in the without CMV infection group. CMV infection occurred in patients with DM frequently and was found to be relevant to death. The cumulative dose of glucocorticoids, ILD, useage of CTX, hypoproteinemia, and other infections were contributing factors in the development of CMV infection in patieents with DM.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"8 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimisation of Aspergilus flavus-Mediated Biosorption Process for Removal of Cr (VI) and Mn (II) Ions by Response Surface Methodology Approach 通过响应面方法优化黄曲霉介导的生物吸附过程以去除铬 (VI) 和锰 (II) 离子

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-20 DOI: 10.1007/s12088-024-01328-0

Fitsum Dejene, Fitsum Wubishet, R. S. Suresh Kumar, Aseer Manilal, Aweke Mamo, Thanigaivel Sundaram

{"title":"Optimisation of Aspergilus flavus-Mediated Biosorption Process for Removal of Cr (VI) and Mn (II) Ions by Response Surface Methodology Approach","authors":"Fitsum Dejene, Fitsum Wubishet, R. S. Suresh Kumar, Aseer Manilal, Aweke Mamo, Thanigaivel Sundaram","doi":"10.1007/s12088-024-01328-0","DOIUrl":"https://doi.org/10.1007/s12088-024-01328-0","url":null,"abstract":"In this study, soil samples from textile industries located in the Arba Minch region were collected and screened for the presence of heavy-metal-resistant fungi. Among the three isolates identified during the screening process, Aspergillus flavus exhibited the highest resistance to heavy metals such as Cr (VI) and Mn (II). Our results showed that A. flavus biosorbed Mn and Cr at concentrations of 80.5% and 68.4%, respectively, making it a promising biosorbing agent. Furthermore, our study demonstrated that pretreatment of A. flavus fungal biomass with NaOH enhanced the biosorption of Mn and Cr. To optimize the biosorption process, a study was conducted using A. flavus biomass with three independent variables: pH (2–10), biomass dosage (1–5 g/mL), and contact time (40–150 min). The Box-Behnken experimental design was used to determine the optimal biosorption values. Maximum biosorption was achieved at pH 10, biomass dosage (5 g/mL), and contact time of 150 min. These conditions resulted in 88 and 80.29% sorption efficiency for manganese and chromium ions, respectively, by A. flavus biomass. The scanning electron microscopic analysis of A. flavus biomass indicated the presence of large porosities on the microbial surface due to NaOH treatment, which assisted in the higher sorption of heavy metals.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"61 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141530270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production and Applications of Cyanobacterial Phycocyanin: Trends and Prospects 蓝藻花青素的生产和应用：趋势与前景

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-19 DOI: 10.1007/s12088-024-01332-4

Diya Roy, Shaloo Verma, Sudipta Das, Hillol Chakdar, Sunil Pabbi

{"title":"Production and Applications of Cyanobacterial Phycocyanin: Trends and Prospects","authors":"Diya Roy, Shaloo Verma, Sudipta Das, Hillol Chakdar, Sunil Pabbi","doi":"10.1007/s12088-024-01332-4","DOIUrl":"https://doi.org/10.1007/s12088-024-01332-4","url":null,"abstract":"C-Phycocyanin (C-PC), is a natural blue pigment found mainly in cyanobacteria. Due to its extraordinary spectral properties and unique health benefits, this pigment has attracted significant attention in various industries. C-PC is widely studied and reported to have different pharmacological properties, notably antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and hepatoprotective activities. Commercial exploitation of cyanobacterial phycocyanin relies on mass cultivation of selected cyanobacteria using different strategies like phototrophic, heterotrophic, mixotrophic, two-stage, open, and closed systems. Nonetheless, the production is influenced by different environmental factors especially light, pH and temperature as well as the availability of high yielding strains. Some of the bottlenecks like breaking the genetic barrier of sub-optimal yield or response to environmental factors can be addressed by genetic and metabolic engineering using advanced molecular tools. The present review discusses the production and application of C-PC along with possible molecular interventions to improve C-PC production. We have also discussed how strain improvement and diversified application can harness the commercial potential of C-PC in future to a greater extent.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"12 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Larvicidal Efficacy of Green Synthesized Silver Nanoparticles on Aedes aegyptii and its Impact on Nontarget Daphnia magna 绿色合成银纳米粒子对埃及伊蚊的杀幼虫功效及其对非目标水蚤的影响

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-19 DOI: 10.1007/s12088-024-01327-1

Natasha Kudesia, A. Najitha Banu

{"title":"Larvicidal Efficacy of Green Synthesized Silver Nanoparticles on Aedes aegyptii and its Impact on Nontarget Daphnia magna","authors":"Natasha Kudesia, A. Najitha Banu","doi":"10.1007/s12088-024-01327-1","DOIUrl":"https://doi.org/10.1007/s12088-024-01327-1","url":null,"abstract":"The current study is based on the synthesis of silver nanoparticles using Aspergillus fumigatus and its larvicidal activity against Aedes aegyptii. The optical, morphological, structural, and elemental properties of synthesized silver nanoparticles were investigated by UV–Vis spectroscopy, Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Energy-dispersive X-ray analysis (EDX) and Zeta potential. The characterization was confirmed by the surface plasmon resonance band at 434 nm. The results validated the spherical shape and size (28–33 nm) of the nanoparticles. Biosynthesized silver nanoparticles (AgNPs) have been evaluated for their effectiveness in controlling Aedes aegyptii larvae. The larvicidal effect was evident in the experiment when Aedes larvae were exposed to five different log concentrations of Aspergillus fumigatus based-AgNPs. The mortality in the larvae had been observed at various exposure times. Exposure of third instar larvae of Aedes aegypti to biosynthesized silver nanoparticles resulted in lethal concentrations (LC50 and LC90) of 2.624 and 4.728 ppm, respectively. Moreover, the biotoxicity screening against non-target organism Daphnia magna revealed the nontoxic nature of biogenic nanosilver against non-target fauna. The findings indicate that Aspergillus fumigatus has the potential to facilitate the swift synthesis of silver nanoparticles, presenting a novel approach for vector control strategies, without causing any harm to other aquatic organisms occupying the same ecological niche.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141530142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic Changes in Phage Survivors of Multidrug-Resistant Klebsiella pneumoniae 耐多药肺炎克雷伯菌噬菌体存活者的表型变化

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-05 DOI: 10.1007/s12088-024-01217-6

Pallavi Bhat Ajakkala, Srajana Nayak, Biswajit Maiti, Anusha Rohit, Juliet Roshini Mohan Raj, Indrani Karunasagar

{"title":"Phenotypic Changes in Phage Survivors of Multidrug-Resistant Klebsiella pneumoniae","authors":"Pallavi Bhat Ajakkala, Srajana Nayak, Biswajit Maiti, Anusha Rohit, Juliet Roshini Mohan Raj, Indrani Karunasagar","doi":"10.1007/s12088-024-01217-6","DOIUrl":"https://doi.org/10.1007/s12088-024-01217-6","url":null,"abstract":"Multidrug-resistant Klebsiella pneumoniae (MDR-KP) infections have become a major global issue in the healthcare sector. Alternative viable tactics for combating bacterial infections, such as the use of bacteriophages, can be considered. One of the major challenges in phage therapy is the emergence of phage-resistant bacteria. This study isolated bacteriophages from water and soil samples against MDR-KP isolates. Susceptible bacterial hosts were exposed to phages at different concentrations and prolonged durations of time to obtain phage-resistant survivors. Phenotypic changes such as changes in growth rates, biofilm formation ability, antibiotic sensitivity patterns, and outer membrane proteins (OMPs) profiling of the survivors were studied. Our findings indicate that the phage ØKp11 and ØKp26 survivors had reduced growth rates and biofilm formation ability, altered antibiotic sensitivity patterns, and reduced OMPs expression compared with the parent MDR-KP002 isolate. These results suggest that the alternations in the bacterial envelope result in phenotypic phage resistance among MDR bacterial isolates.","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"15 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141256077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Role of Probiotics in Gut-Brain Axis Under Microgravity 益生菌对微重力条件下肠道-大脑轴的治疗作用

IF 3 4区生物学

Indian Journal of Microbiology Pub Date : 2024-06-04 DOI: 10.1007/s12088-024-01314-6

Moumita Sil, Dyuti Mitra, Nabanita Mukherjee, Maulesh Gadani, Abhijit Chatterjee, Payal Sharma, Arunava Goswami

{"title":"Therapeutic Role of Probiotics in Gut-Brain Axis Under Microgravity","authors":"Moumita Sil, Dyuti Mitra, Nabanita Mukherjee, Maulesh Gadani, Abhijit Chatterjee, Payal Sharma, Arunava Goswami","doi":"10.1007/s12088-024-01314-6","DOIUrl":"https://doi.org/10.1007/s12088-024-01314-6","url":null,"abstract":"Microgravity is a state of free fall which one experiences in space. Human-crewed missions are becoming more sophisticated in the ongoing times. The altered gravitational conditions exert several physiological changes in the astronauts. Among many, one of the significantly affected systems and least discussed so far is the neurological system. Earlier studies have shown that exposure to space condition leads to structural changes in the brain, including distorted neurons and apoptotic astrocytes. Recent studies show the velocity of the action potential is reduced. Hippocampal activity is disrupted leading to cognitive impairment. Neuro ocular change occurs in some astronauts. Probiotics like Bacillus coagulans and Lactobacillus sp. connect gut-brain axis. Several probiotics are effective in treating neurological structural disorders. To sum up, in orbital exploration, astronauts face challenges of cosmic radiation and microgravity, impacting neuronal morphology. Chronic low-dose X-ray exposure delays neurite outgrowth and induces apoptosis. Simulated microgravity intensifies these effects, causing a significant increase in late apoptotic neurons. Astrocytes exposed to microgravity undergo apoptosis, but surviving cells adapt. Microgravity induces cellular senescence in rat cells, mimicking aging. NASA Twin Study reveals cognitive declines post-microgravity. Probiotics show therapeutic potential in neurological disorders, influencing gene expression and apoptotic proteins. They alleviate neurodegeneration and delay senescence, emphasizing their role in neurological well-being. In this review we discuss baseline data in this area since few laboratories has started working on the effect of nanoparticles on probiotics under microgravity. This review would help us and others interested in this field worldwide to work cohesively in future.<h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"39 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141256073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0