Indian Journal of Pharmacy and Pharmacology最新文献_第8页

Right selection of oral anticoagulation for stroke prevention in atrial fibrillation 正确选择口服抗凝剂预防房颤卒中

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.029

A. Trailokya, D. Roy, P. Kerkar, Shahid Merchant, Rajeev Sethi, R. Karnik, S. Manchanda, Sadanand R Shetty, U. Jadhav, V. Vijan

{"title":"Right selection of oral anticoagulation for stroke prevention in atrial fibrillation","authors":"A. Trailokya, D. Roy, P. Kerkar, Shahid Merchant, Rajeev Sethi, R. Karnik, S. Manchanda, Sadanand R Shetty, U. Jadhav, V. Vijan","doi":"10.18231/j.ijpp.2022.029","DOIUrl":"https://doi.org/10.18231/j.ijpp.2022.029","url":null,"abstract":"Atrial fibrillation (AF) is considered as one of the most common cardiac arrhythmias worldwide and is always associated with a significantly increased risk of stroke and thromboembolism. VKAs (Warfarin & Acenocoumarol) are highly effective in reducing the risk of stroke in patients with AF, but bleeding issues & disutility sparked the development of direct oral anticoagulants (DOACs) or NOACs (Novel oral anticoagulants). These drugs, offer the convenience of once or twice daily dosing without the need for laboratory monitoring of coagulation activity (PT/ INR) or routine dose adjustment. Various clinical trials proved their non-inferiority to warfarin (VKA) in reducing the risk of stroke or systemic embolism, and each was associated with markedly lower rates of ICH than well-adjusted warfarin. Yet there are no direct head-to-head comparative trials for the efficacy & safety of NOACs. In this review we try to provide patient centric approach to assist Indian physicians in selecting right OAC therapy for SPAF with respect to best possible evidence and recommendations available worldwide.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85438170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inorganic nanoparticles: A review on method and material for fabrication 无机纳米颗粒:制备方法和材料综述

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.028

Shubhi Tiwari, G. Yadav, Sonam Sharma, Pranati Srivastava, Ajay Kumar

引用次数: 1

Protective effect of carwin capsules against cyclophosphamide induced chromosomal aberrations in mice 鹿角多糖胶囊对环磷酰胺诱导小鼠染色体畸变的保护作用

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.035

N. Thakur, N. Upmanyu, R. Saxena

{"title":"Protective effect of carwin capsules against cyclophosphamide induced chromosomal aberrations in mice","authors":"N. Thakur, N. Upmanyu, R. Saxena","doi":"10.18231/j.ijpp.2022.035","DOIUrl":"https://doi.org/10.18231/j.ijpp.2022.035","url":null,"abstract":"The concept of polyherbalism has been highlighted in , an Ayurvedic literature dating back to 1300 AD. Polyherbal formulations enhance the therapeutic action and reduce the concentrations of single herbs, thereby reducing adverse events. In the present study, the clastogenic effect of carwin capsuleshas been evaluated against cyclophosphamide (CP)-induced chromosomal aberrations in the bone marrow cells of the mice. Genotoxicity was carried out in mouse bone marrow cells. Animals were divided into four groups each containing four animals. Group I (control) was treated orally with vehicle (acacia suspension- 1ml/100gm), Group II was treated i.p. with cyclophosphamide (50 mg/kg, bw.), Group III was treated orally with carwin alone (1.5 mg/animal, bsa.), and Group IV was treated with cyclophosphamide + carwin. Animals were pretreated for 7 days with test drug (carwin). The evaluating parameter was to count total number of aberrated chromosomes and its various types. The results demonstrate that carwin was found to be significant (P<0.01) as compared to cyclophosphamide treated as the no. of total aberrated chromosomes in carwin treated was decreased effectively. And also carwin was able to significantly (P<0.01) protect the action caused by cyclophosphamide as well was also found to be effective antigenotoxic (P<0.01) as compared to cyclophosphamide, when total no. of aberrated cells and their types were scored. Therefore, the results suggest a genotoxic potential of carwin capsules.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88590207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacoeconomics of antidepressants in a tertiary care teaching hospital of rural India 印度农村三级护理教学医院抗抑郁药物经济学研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.033

T. Khan, Tabish S.M. Ahmed, Swapnil B. Kaikade

{"title":"Pharmacoeconomics of antidepressants in a tertiary care teaching hospital of rural India","authors":"T. Khan, Tabish S.M. Ahmed, Swapnil B. Kaikade","doi":"10.18231/j.ijpp.2022.033","DOIUrl":"https://doi.org/10.18231/j.ijpp.2022.033","url":null,"abstract":"Mental disorders constitute a wide spectrum ranging from sub-clinical states to very severe forms of disorders. Mental health problems can attain the disorder/disease/syndrome level, which are usually considered easy to recognize, define, diagnose and treat. To study the cost effectiveness of antidepressant drugs in a tertiary care teaching hospital of rural India and various factors associated with it. A cross sectional study was performed and the prescriptions were analyzed.The data from OPD was studied in a structured format.Drugs was categorized as per the pharmacological classification. The drugs were evaluated for their pharmacoeconomics. In an extensive study of 2months, 250 cases of psychiatric opd were evaluated.Depression (76%) was the most prevalent psychiatric ailment followed by anxiety (13%) and schizophrenia (11%). The prevalent age group was 21-40 years (38.4%). Females (71.54%) had the majority as compared to males (28.46%). Fluoxetine was the most prescribed antidepressant (45%). 76% of the patients were on monotherapy. Escitalopram-Clonazepam(45%) was the most frequently prescribed fixed dose combination. Average cost of therapy was calculated. Paroxetine(Rs 221) had maximum medication cost while Imipramine(Rs 21) had minimum medication cost.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83182349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable polymeric nanoparticles: An overview 可生物降解聚合物纳米颗粒:综述

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.025

S. Swain, D. Ghose

引用次数: 0

study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases 8种马里传统治疗炎性疾病的药用植物抗自由基活性、磷脂酶A和15-脂氧合酶抑制活性研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.031

B. Mahamadou N. H, Youl Estelle N.H, T. Karim, D. Seidina, Diakité Mamadou, Ouédraogo Moussa, Sanogo Rokia, Bah Sekou

引用次数: 3

Therapeutic potential and pharmacological properties of Indian herbs for the management of SARS-COV-2 coronavirus disease: A research based review 印度草药治疗SARS-COV-2冠状病毒病的治疗潜力和药理特性:基于研究的综述

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.026

S. Dutta, S. Mishra, Abinash Satapathy, T. Satapathy, Harsha Sahu

{"title":"Therapeutic potential and pharmacological properties of Indian herbs for the management of SARS-COV-2 coronavirus disease: A research based review","authors":"S. Dutta, S. Mishra, Abinash Satapathy, T. Satapathy, Harsha Sahu","doi":"10.18231/j.ijpp.2022.026","DOIUrl":"https://doi.org/10.18231/j.ijpp.2022.026","url":null,"abstract":"Corona virus (COVs) are RNA virus that comes from the family COVs are pathogenic to animals as well as human beings and can cause ailment related to respiratory system such as severe acute respiratory syndrome (SARS) and COVID-19. However treatment of COVID-19 is one of the major area of concern as there are no appropriate treatment options available, however few herbal products are being used to boost the immunity of patients and in turn prevent the occurrence of infection. Historically India has always been rich with plants and is known to use herbs and plants in traditional system of healing. India has distinct traditional system of medicine called AYUSH that represents Ayurveda, Yoga, Unani, Siddha and homeopathy. This traditional system of medicine can be used to fight against COVID-19 pandemic. Present study describes about different herbs and plants of Indian origin that can be used for effective management COVID-19 and in future that can act as potential candidate for development of improved drugs for therapy of COVID-19 infection.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81117177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of anti-microbial activity of imidazol [2, 1-B][1,3,4] thiadiazole by using molecular docking and ADMET studies 咪唑[2,1 - b][1,3,4]噻二唑抑菌活性的分子对接和ADMET研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-08-15 DOI: 10.18231/j.ijpp.2022.036

Shivani Gupta

引用次数: 0

A case report on cor pulmonale 肺心病1例

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-07-15 DOI: 10.18231/j.ijpp.2022.024

Shamna Haris, Shaiju S. Dharan

引用次数: 0

Prevalence and antibiotic susceptibility pattern of uropathogens causing urinary tract infection among pregnant women in Ujjain M.P. (India) 印度Ujjain M.P.孕妇尿路感染尿路病原体患病率及抗生素敏感性分析

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-07-15 DOI: 10.18231/j.ijpp.2022.017

Kaina Bhonsle, A. Vyas, H. Vyas, Abhiraj Ramchandani, K. Hemwani

{"title":"Prevalence and antibiotic susceptibility pattern of uropathogens causing urinary tract infection among pregnant women in Ujjain M.P. (India)","authors":"Kaina Bhonsle, A. Vyas, H. Vyas, Abhiraj Ramchandani, K. Hemwani","doi":"10.18231/j.ijpp.2022.017","DOIUrl":"https://doi.org/10.18231/j.ijpp.2022.017","url":null,"abstract":"Urinarytract infection is one of the most prevalent frequently found disorders in pregnant women caused by bacteria and if it is not diagnosed then untreated UTI can causes serious maternal and fetal complications. The purpose of this work was to study the prevalence of urinary tract infection among pregnant women of Ujjain and to identify uropatogens and their antibiotic susceptibility pattern in pregnant women of Ujjain. A total of 120 midstream urine samples of pregnant women were collected aseptically and cultured on different growth media. The isolated bacteria were identified by standard microbiological procedure and the antibiotic susceptibility pattern was recorded using Kirby-Bauer disc diffusion method. Out of 120 urine samples, 78 samples tested positive for UTI suggesting that (65%) of pregnant women suffered from UTI and most prevalent bacterial pathogen was (41.0%) followed by (23.0%), (11.5%), (14.1%) and (10.2%). Majority of the isolated uropathogens were showing high sensitivity towards Doripenem, Meropenem and Imipenem while very less sensitivity towards Ampicillin and Penicillin. The study shows high prevalence of UTI among pregnant women and occurrence of high resistance towards antibiotics. So routine screening of the pregnant women having UTI and proper selection of antibiotic for treatment is needed for reducing the risk of serious complications during pregnancy.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81149771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0