Indian Journal of Pharmacy and Pharmacology最新文献_第10页

Evaluation of potential antidiabetic activity of abelmoschus esculentus and evidence of possible pharmacokinetic interaction with metformin 猪沙鼠潜在的抗糖尿病活性评价及与二甲双胍可能的药代动力学相互作用的证据

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.047

R. Chakraverty, Debalina Sardar, P. Chakraborty

引用次数: 0

Validated high performance thin layer chromatographic analysis of leaves and flower extracts of 有效的高效薄层色谱分析方法

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.049

A. Chakraborty, H. Tripathi, Sarita Karole, Kavita R. Loksh

{"title":"Validated high performance thin layer chromatographic analysis of leaves and flower extracts of","authors":"A. Chakraborty, H. Tripathi, Sarita Karole, Kavita R. Loksh","doi":"10.18231/j.ijpp.2021.049","DOIUrl":"https://doi.org/10.18231/j.ijpp.2021.049","url":null,"abstract":"is a significant therapeutic plant has a place with family apocynaceae contains in excess of 70 distinct sorts of chemotherapeutic agents and alkaloids which help in treating different illnesses. For the most part, it is known as Vincarosea, Ammocallisrosea and Lochnerarosea. There are numerous or more than 400 alkaloids present in plant, which are used as flavor, agrochemicals, pharmaceuticals, fragrance, ingredients, food addictives, and pesticides. To develop a validated high performance thin layer chromatographic method for the analysis of leaves and flower extracts of Sample solutions were applied onto the plates with automatic TLC sampler Linomat V (Camag, Muttenz, Switzerland) and were controlled by WinCATS software. Plates were developed in 10 x 10cm twin trough glass chamber (Camag, Muttenz, Switzerland). A CAMAG TLC scanner was used for scanning the TLC plates. Pre-coated silica gel aluminium plates 60F254. For vincristine, simultaneous estimation of vincristine was performed by HPTLC on a silica gel plate using toluene-methanol-diethylamine (8.75: 0.75: 0.5, v/v/v) as the mobile phase. The method was validated as per the ICH guidelines. The Rf value was found to be 0.76 for flower and 0.80 for leaves at 250 nm which shows the presence of vincristin in . In this research paper, a validated HPTLC Method has been developed for the analysis of leaves and flower extracts","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83979704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical evaluation and investigation of anti-Fungal activity of turnip top extracts 萝卜顶提取物的植物化学评价及抗真菌活性研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.044

Aarti Sangray, A. Singh, A. Singh

{"title":"Phytochemical evaluation and investigation of anti-Fungal activity of turnip top extracts","authors":"Aarti Sangray, A. Singh, A. Singh","doi":"10.18231/j.ijpp.2021.044","DOIUrl":"https://doi.org/10.18231/j.ijpp.2021.044","url":null,"abstract":"To evaluate the activity of Ethanolic and Aqueous extracts of leaves of against three fungal strains i.e. MTCC3814, and Candida tropicalis MTCC9038 in-vitro.Phytochemical analysis of belonging to family brassicacaea was examined using Ethanolic and Aqueous extracts. Ethanolic and Aqueous extracts of leaves of were investigated individually for antifungal activity by Agar well diffusion method. Both the extracts were tested against selected fungal strains i.e. and to find the inhibitory activities of fungal growth at the dose level of 50 and 100 μg/ml.The phytochemical analysis of ethanolic and aqueous extracts confirmed the presence of phenolic compounds, glycosides, tannins, carbohydrates, proteins, amino acids, tannins, reducing suger, non-reducing suger and inorganic compounds such as calcium, magnesium, iron, carbonate & sulphates. Ethanolic extract of showed considerably high antifungal activities against selected microorganisms than aqueous extract.Although the active components were not isolated but antifungal active plant principles such as flavonoids, glycosides and tannins were observed in the extract. Ethanolic extract of possess effective antifungal properties for selected fungal strains i.e.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85337744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of mulmina mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in hospital quarantine (Dedicated Covid Health Centre) 莫米娜芒果辅助标准护理治疗对医院隔离治疗Covid -19阳性受试者的影响(专用Covid - Health Centre)

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.052

Ashwitha Shetty, M. Madhu, N. Rajesh, S. M. Ahmed

{"title":"Effect of mulmina mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in hospital quarantine (Dedicated Covid Health Centre)","authors":"Ashwitha Shetty, M. Madhu, N. Rajesh, S. M. Ahmed","doi":"10.18231/j.ijpp.2021.052","DOIUrl":"https://doi.org/10.18231/j.ijpp.2021.052","url":null,"abstract":"There are no approved drugs to treat COVID-19, and the vaccine is likely to be ready by early 2021. Many clinical studies are ongoing around the globe to find a cure or prevention of the disease. The objective of the proposed study is to determine the efficacy and safety profile of Mulmina Mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in Hospital Quarantine. Settings and Design: The enrolled subjects were randomized into either of the two treatment arms in the ratio of 1:1. The freshly diagnosed (24-48 hrs.) COVID-19 positive Male or Female is aged 20 to 65 years (both inclusive) hospitalized patients were approached and checked for their eligibility. They were recruited after signing the written informed consent form. The number of patients included in the study is 48. In efficacy, both the treatment arms and the reduction in clinical symptom scale value and ordinal scale value are seen on day 7. On the ordinal scale, 41.7% of subjects in Treatment arm A showed a reduction of 2 points on the day, and 16.7% of subjects show 2 points reduction in Treatment arm B. In Safety results, there was no clinically significant finding in safety parameters in Treatment arm B. Mulmina Mango showed encouraging results concerning RTPCR, CRP, Dopamine, IgG, CD4, and CD8 parameters. The properties of Mulmina Mango are highlighted below, along with the parameters for each property. Mulmina Mango, COVID-19, Treatment Arm A, Treatment Arm B, MoHFW (Ministry of Health and Family Welfare)","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91022277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective, observational study to see the effect of evogliptin on continuous glucose monitoring (CGM) in T2DM Indian patients: A real-world experience 回顾性观察研究，观察依格列汀对印度T2DM患者持续血糖监测(CGM)的影响:一个真实世界的经验

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.048

A. Trailokya, S. Erande, Amol Aiwale

{"title":"Retrospective, observational study to see the effect of evogliptin on continuous glucose monitoring (CGM) in T2DM Indian patients: A real-world experience","authors":"A. Trailokya, S. Erande, Amol Aiwale","doi":"10.18231/j.ijpp.2021.048","DOIUrl":"https://doi.org/10.18231/j.ijpp.2021.048","url":null,"abstract":"This study aimed to assess effectiveness of Evogliptin 5 mg through continues glucose monitoring (CGM) in patients with T2DM in retrospective observational real world settings. Overall 6 patients who received Evogliptin as routine clinical practice in management of T2DM were analyzed retrospectively from single center. Data collected from past medical records. FreeStyle Librepro 1.0.6 was used for CGM. CGM was done 15 days prior to adding Evogliptin and repeated immediately after that for next 15 days. Mean BG level, Percentage time in target range (80-140mg/dl), Percentage time above target and Percentage time below target were assessed prior and after adding Evogliptin in existing treatment regimen. Significant reduction in Mean blood glucose level seen after adding Evogliptin in existing treatment regimen from 215 mg/dl to 138 mg/dl (-77 mg/dl P=0.006). Significant improvement seen in Percentage time in target range (80-140mg/dl) from 17% to 44% (27% P value 0.007) and in Percentage time above target from 81% to 43% (- 38%, P valve 0.003). 13.5 % of the patients seen below target. Evogliptin was found to be effective when added to the patients who were uncontrolled on other oral anti-diabetic medications. It effectively showed improvement in continues glucose monitoring (CGM) parameters like Mean blood glucose, more number of patients were in Time in Target range i.e (80-140mg/dl) after adding Evogliptin to existing anti-diabetic medications & well tolerated. Small sample size and retrospective study","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75041682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research conducted on gestating women globally during trials 在试验期间对全球怀孕妇女进行的研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.054

S. Chaudhry, V. Sovani

引用次数: 0

Prevalence of DFU among diabetic patients and its management 糖尿病患者DFU的患病率及处理

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.046

Amit Kumar, S. Sai Prasanna, R. Charishma, R. Satya Divya, R. Sowjanya

{"title":"Prevalence of DFU among diabetic patients and its management","authors":"Amit Kumar, S. Sai Prasanna, R. Charishma, R. Satya Divya, R. Sowjanya","doi":"10.18231/j.ijpp.2021.046","DOIUrl":"https://doi.org/10.18231/j.ijpp.2021.046","url":null,"abstract":": To study the prevalence of DFU among diabetic patients and the management of DFU among diabetic patients.: Prospective observational study. : The study was conducted in inpatients with diabetes of all departments and inpatients with diabetic foot ulcer (DFU) of surgical department of age 20 to 80 of both genders with sample size 150 were included from September 2019 to march 2020. The prevalence of DFU among diabetic patients was 16%. Among them more diabetic cases were seen in age group of 50-59 and DFU in 40-49 and More diabetic cases are observed in male compared to female. DFU observed equally and the most common causative organism for DFU was staphylococcus aureus followed by proteus species, klebsiella and pseudomonas aeruginosa and more cases of DFU were noticed in diabetic patients with duration of 6-10 years. As the main cause of DFU is infection the primary treatment is anti microbial therapy and the most prescribed class of antibiotics is cephalosporins followed by nitroimidazoles, penicillins, oxazolidinones, lincosamides etc. surgical procedures like debridement, amputation and sometimes both were done in 9,14,1 patients respectively. : Our study revealed the information regarding the prevalence of DFU among diabetic patients is due to lack of knowledge and uncontrolled diabetes may develop poor circulation which leads to wound that may heal slowly which leads to DFU.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82928551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of prescribing pattern of phosphodiesterase-5 inhibitors and assessing effectiveness of sildenafil and tadalafil in patients with erectile dysfunction 磷酸二酯酶-5抑制剂处方模式评价及西地那非和他达拉非在勃起功能障碍患者中的疗效评估

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.050

Yatish Byndoor, Tamilisetti Vidya Sagar, Sanjay Kumar

{"title":"Evaluation of prescribing pattern of phosphodiesterase-5 inhibitors and assessing effectiveness of sildenafil and tadalafil in patients with erectile dysfunction","authors":"Yatish Byndoor, Tamilisetti Vidya Sagar, Sanjay Kumar","doi":"10.18231/j.ijpp.2021.050","DOIUrl":"https://doi.org/10.18231/j.ijpp.2021.050","url":null,"abstract":"Several factors may affect identification and treatment of erectile dysfunction by health care providers, this study evaluates prescribing pattern of PDE-5 inhibitors and assess effectiveness of Sildenafil and Tadalafil in patients with erectile dysfunction.This is a descriptive and observational study, observed participants without providing any interventions, after fulfilling inclusion and exclusion criteria, patients were enrolled into study and informed written consent was obtained from all patients, data was obtained from medical records, analysed descriptively. International Index of Erectile Function (IIEF) Questionnaire is used in assessment of erectile dysfunction and treatment outcomes.In our study, 80% of patients were prescribed with phosphodiesterase inhibitors and 20% received nutritional supplements. 80 percent of drugs were prescribed under generic name, subjects treated with Sildenafil/Tadalafil were found to be associated with higher mean scores for questions of International Index of Erectile Function (IIEF). Tadalafil scored high in terms of sexual desire domain.PDE5 inhibitors represent major first-line oral therapy option for men with erectile dysfunction, shift of market from brand to generic products allows more freedom of choice, although multiple reports suggest general equivalency of four major PDE5 inhibitors, tadalafil suggested to be preferable.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82331975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dengue virus: A review 登革病毒:综述

Indian Journal of Pharmacy and Pharmacology Pub Date : 2022-01-15 DOI: 10.18231/j.ijpp.2021.043

N. Singh, A. Singh, A. Singh

引用次数: 0

An online knowledge-attitude-practice survey in the community about diabetes mellitus in India 印度社区关于糖尿病的在线知识-态度-行为调查

Indian Journal of Pharmacy and Pharmacology Pub Date : 2021-10-27 DOI: 10.18231/j.ijpp.2021.045

R. Chakraverty, K. Samanta, Jyotirmoy Bandyopadhyay, Chandrima Sarkar

{"title":"An online knowledge-attitude-practice survey in the community about diabetes mellitus in India","authors":"R. Chakraverty, K. Samanta, Jyotirmoy Bandyopadhyay, Chandrima Sarkar","doi":"10.18231/j.ijpp.2021.045","DOIUrl":"https://doi.org/10.18231/j.ijpp.2021.045","url":null,"abstract":" To address the reasons for it is important to understand the knowledge, attitude and practices (KAP) of all pertinent stakeholders. This multicentrrising burden of Diabetes mellitus in India this survey is aimed at understanding the KAP quotients of the community regarding knowledge of laypersons regarding diabetes mellitus as this is lacking in Indian studies. A cross-sectional survey was conducted through online mode in India using a validated, field-tested questionnaire incorporating KAP domain questions regarding Diabetes mellitus (DM). Scores to questions were appropriately assigned. The mean (SD) age of the respondents was 35.2 (12.61) y and 62% had a graduate or higher level of education. The median (IQR) KAP scores were 10 (8-12), 5 (3-5) and 2 (2-3) out of a maximum of 18, 5 and 6, respectively. Higher educational and socioeconomic levels were associated with better attitude scores, but knowledge levels were comparable. Correlations between KAP scores were poor. This study reveals that laypeople have appropriate knowledge and attitude regarding diabetes mellitus to some degree but there are important lacunae and practices are often found wanting. These issues need to be addressed in sustained public sensitization and motivational campaigns to improve the future and treatment outcomes of Diabetes mellitus in India.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75971406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0