Indian Journal of Pharmacy and Pharmacology最新文献

4D printing and its potential applications in the healthcare sector 4D 打印及其在医疗保健领域的潜在应用

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.001

Suryakanta Swain, Debashsish Ghose

引用次数: 0

A study on appropriate use and stewardship of proton pump inhibitors 质子泵抑制剂的合理使用和管理研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.010

Naresh Mondal, Shilpi Maity, Alamki Phawa, Bireswar Roy, E. Satheesh Kumar, Narayana Swamy V.B

{"title":"A study on appropriate use and stewardship of proton pump inhibitors","authors":"Naresh Mondal, Shilpi Maity, Alamki Phawa, Bireswar Roy, E. Satheesh Kumar, Narayana Swamy V.B","doi":"10.18231/j.ijpp.2024.010","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.010","url":null,"abstract":"Objective: To analyze the prescribing pattern of use of PPI with respect to “FDA-Approved Indications and Doses for PPI Therapy.” Materials and Methods: After obtaining approval from the Institutional Ethics Committee, a cross-sectional study was carried out among 400 inpatients in a tertiary care hospital in Bangalore. The data were collected from the patient case profile and prescriptions and noted in a self-designed data collection form. The statistical analysis of the collected data was performed using SPSS software and Excel. Results: The study, conducted on 400 patients, revealed a male majority (60%) and a female representation of 40%. Proton Pump Inhibitors (PPIs), mainly Pantoprazole (74.70%), were frequently prescribed, notably in General Medicine (220 patients). PPI use was generally appropriate: indication (99%), dose (97%), frequency (92.8%), and duration (91.8%). However, irrational prescriptions were noted: indication (1%), dose (3%), frequency (7.3%), and duration (8.3%). 139 drug interactions were identified, categorized into Major (39.6%), Moderate (46%), and Minor (14.4%). For example, Ondansetron and tramadol exhibited a major interaction. Among PPI combinations, 93.75% could affect CYP2C19 metabolism, and 6.3% had additive/synergistic toxicity potential.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"41 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140973998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of luliconazole vs ketoconazole topical formulation in reversing damaged hair cuticle 氟环唑与酮康唑外用制剂在逆转受损头发角质层方面的效果对比

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.009

M. Khalse, Kamlesh Patel, Varsha Pawar

{"title":"Effectiveness of luliconazole vs ketoconazole topical formulation in reversing damaged hair cuticle","authors":"M. Khalse, Kamlesh Patel, Varsha Pawar","doi":"10.18231/j.ijpp.2024.009","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.009","url":null,"abstract":"Azole antifungal agents are effective agents for treating scalp ailments such as seborrheic dermatitis. Luliconazole (LZ) is a new azole with unique effects against clinically important dermatomycotic fungi. This study examines the impact of different topical formulation of Luliconazole vs Ketoconazole (KZ) on damaged hair cuticle repair after 5 and 10 washes, using SEM images and sensory Analysis.In this in-vitro study,twelve damaged hair tresses were divided into two groups, and treated with LZ and KZ formulations. Both groups underwent pretreatment with 20% Sodium Laureth sulfate (SLES) and damage induction using 9% HO and 20% ammonium solution, followed by respective LZ (Lupizol ZS, manufactured by Lupin Ltd, India) and KZ therapies. SEM imaging and expert sensory analysis were conducted at baseline, after 5, and 10 washes to evaluate surface characterization like cuticle upliftment, smoothness, and softness.After five washes, LZ-treated hair exhibited smooth, intact cuticles with no upliftment, improving to grade 1 cuticle damage. In contrast, KZ-treated hair continued to show substantial upliftment without damage grade improvement. After ten washes, LZ maintained grade 1 damage and 0 µm upliftment, while KZ-treated strands persisted in showing considerable cuticular distress. Sensory analysis supported these results, with LZ improving hair smoothness and softness by 2.42x and 2.72x respectively, after ten washes, significantly outperforming KZ. Visually, LZ-treated hair appeared smoother and healthier, indicating its greater effectiveness in enhancing hair integrity post-washing.The botanical conditioner-based formulation of LZ is more efficacious in enhancing hair integrity post-washing compared to the Ketoconazole formulation. Well-controlled human studies are required to further establish the clinical effects on human participants.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papillary thyroid cancer and its gene polymorphism; A molecular mechanistic perspective 甲状腺乳头状癌及其基因多态性；分子机理视角

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.002

Abid Ali Sheikh, M. Makhdoomi, Abid Hussain Rather, T. A. Lone, Nisar Ahmad Syed

{"title":"Papillary thyroid cancer and its gene polymorphism; A molecular mechanistic perspective","authors":"Abid Ali Sheikh, M. Makhdoomi, Abid Hussain Rather, T. A. Lone, Nisar Ahmad Syed","doi":"10.18231/j.ijpp.2024.002","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.002","url":null,"abstract":"Thyroid cancer stands as the predominant malignancy within the endocrine system, comprising about 1% of newly identified cancer instances. Papillary Thyroid Cancer (PTC) is the predominant form of thyroid cancer, representing 80% or more of thyroid malignancies. Thyroid carcinoma harbours assorted genetic alterations which are highly prevalent, several of these characteristics are unique to this form of cancer. The conventional oncogenic genetic modifications frequently observed in thyroid carcinoma encompass RAS mutations RET/PTC rearrangements and PAX8-peroxisome proliferator-activated receptor g (PPARg) fusion oncogene. The lately discovered activating mutation in BRAF (the gene for the B-type RAF kinase, BRAF) the most widespread genetic modification in thyroid cancer (30-83%). RKIP (RAF kinase inhibitory protein) had formerly been delineated as a phospholipid binding protein. Mammalian RKIP/PEBP differs from other identified proteins and its role is still being clarified. RKIP over-expression can inhibit MEK interaction with RAF-1 and B-RAF. It plays a role in thyroid cancer progression and lymph node metastasis. So, elucidating mutational profile and protein expression of above cell signalling molecules will be very useful in determining a proper therapeutic target for anti-cancer molecules. Given that tumors often possess numerous genetic and cell signalling abnormalities, thus inhibiting a single signalling pathway is often therapeutically inefficacious, more success could be foreseen with agents directed against multiple cellular pathways.By determining the genetic profile and protein expression of mentioned MAP Kinase pathway molecules new targets can be identified for chemotherapic drugs and novel strategies will be charted out to make modifications in the map kinase pathway with the aim to stop the occurrence and distant metastasis of thyroid cancer.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"55 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A small review on recent advances in transdermal drug delivery system 透皮给药系统最新进展综述

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.003

Prakash Raj K, Rajakarthikeyan U, Saranraj L, Sivakumar L, R. Yuvhraj, Buvaneshvaran K

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Cost-effective analysis of enalapril, amlodipine, and enalapril plus amlodipine combination in newly diagnosed patients of hypertension: A pharmacoeconomic comparison of the antihypertensive efficacy of drugs 对新诊断的高血压患者服用依那普利、氨氯地平和依那普利加氨氯地平复方制剂的成本效益分析：药物降压疗效的药物经济学比较

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.008

K. Katariya, Tushar Gosai, Akshay Hasmukhbhai Parmar

{"title":"Cost-effective analysis of enalapril, amlodipine, and enalapril plus amlodipine combination in newly diagnosed patients of hypertension: A pharmacoeconomic comparison of the antihypertensive efficacy of drugs","authors":"K. Katariya, Tushar Gosai, Akshay Hasmukhbhai Parmar","doi":"10.18231/j.ijpp.2024.008","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.008","url":null,"abstract":"Hypertension (HTN) is a chronic condition with severe complications, so early detection and effective management are essential to prevent cardiovascular events and reduce the associated economic burden. This study aims to compare the cost-effectiveness of enalapril, amlodipine, and their combination in terms of blood pressure reduction, considering overall efficacy and economic implications. A prospective, observational cost-effectiveness analysis was conducted in 150 newly diagnosed hypertensive patients who were prescribed either enalapril (5 mg), amlodipine (5 mg), or enalapril plus amlodipine (2.5 mg each). The primary outcome was the difference in systolic and diastolic blood pressure between baseline and follow-up, as well as the evaluation of overall efficacy and cost. Based on the data, statistical analysis was carried out using ANOVA and post hoc Tukey tests for drug efficacy, and cost-effectiveness was compared using MS Excel. After 30 days, all treatments significantly reduced systolic and diastolic blood pressure (p = 0.0001). The combination therapy with a lower dose showed superior efficacy in blood pressure reduction and was most cost-effective, requiring less expense for a 1 mmHg reduction in blood pressure compared to individual drugs with a higher dose. Quality of life assessment favored low-dose combination therapy, with fewer reported adverse effects. The combinationof amlodipine and enalapril at a lower dose demonstrated superior cost-effectiveness, efficacy in blood pressure reduction, and a favorable impact on patients' quality of life compared to individual drugs at a higher dose. This suggests that combination therapy may be a preferred option in the management of hypertension, emphasizing the importance of considering both clinical and economic factors in treatment decisions.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"55 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of monoclonal antibodies in preventing antimicrobial resistance (AMR) 单克隆抗体对预防抗菌药耐药性（AMR）的影响

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.005

R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath

{"title":"The impact of monoclonal antibodies in preventing antimicrobial resistance (AMR)","authors":"R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath","doi":"10.18231/j.ijpp.2024.005","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.005","url":null,"abstract":"Monoclonal antibodies (mAbs) have transformed modern medicine through precision targeting and therapeutic efficacy. This summary summarises the development, applications, and comparative characteristics of mAbs in the context of antiviral medicines and antibiotic treatment durations. Monoclonal antibodies are designed to target specific antigens with great affinity and specificity, making them important for diagnostics and treatments. Anti-virulence mAbs, a type of mAb, target pathogen virulence factors rather than pathogens themselves, providing a promising technique for combating infectious diseases while limiting resistance development. When comparing the duration of antibiotic medication versus mAb treatment, mAbs frequently provide a shorter and more tailored therapeutic regimen. This can lead to better patient outcomes, less resistance, and a lower risk of side effects associated with long-term antibiotic usage. Antigen selection, hybridoma creation, antibody synthesis, purification, and characterization are all steps in the mAb development process, with advances like recombinant DNA technology improving efficiency and scalability.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"117 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing prescribing practices in a rural hospital: A cross-sectional study using WHO prescribing indicators 评估一家农村医院的处方实践：使用世界卫生组织处方指标的横断面研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.007

Jijo P. Abraham, Reena R. Giri, Kavita M. Jaiswal

{"title":"Assessing prescribing practices in a rural hospital: A cross-sectional study using WHO prescribing indicators","authors":"Jijo P. Abraham, Reena R. Giri, Kavita M. Jaiswal","doi":"10.18231/j.ijpp.2024.007","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.007","url":null,"abstract":"This cross-sectional study aims to assess the prescribing practices of physicians at a rural hospital in Western India, focusing on adherence to WHO prescribing indicators. The main research question addressed the extent of alignment with optimal prescribing standards. 1: Evaluate prescribing patterns in a rural hospital using WHO indicators. 2: Assess alignment with WHO standards and identify areas for improvement. 3: Understand demographic influences on prescribing. 4: Provide insights for optimizing rural healthcare delivery.A prospective, descriptive, cross-sectional approach was employed in the outpatient department of the rural hospital. A total of 604 prescriptions were sampled over two months, and data were collected using a random sampling method. The study followed ethical standards, and prescriptions were analyzed for demographic characteristics, prescribing patterns, and adherence to WHO indicators. The average number of drugs per prescription was 3.5, indicating a tendency towards polypharmacy. While 86% of drugs were prescribed generically, the study revealed areas of suboptimal adherence to WHO prescribing indicators, including antibiotic prescriptions (29%) and injectable use (50%). The analysis also highlighted disparities in prescribing patterns based on gender and age. The study provides valuable insights into prescribing practices in a rural healthcare setting, emphasizing the need for interventions to streamline prescriptions and enhance adherence to global standards. The identified areas for improvement include addressing polypharmacy, promoting generic prescribing, and optimizing antibiotic and injectable use.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"53 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serendipity in psychotropic drugs: Unearthing the origins 精神药物的偶然性：发掘起源

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.004

Mehreen Imran, Semira

引用次数: 0

Investigation of effect of ellagic acid on premature ovarian insufficiency 鞣花酸对卵巢早衰的影响研究

Indian Journal of Pharmacy and Pharmacology Pub Date : 2024-05-15 DOI: 10.18231/j.ijpp.2024.006

V. V. Sarode, Sadhna P. Gautam

{"title":"Investigation of effect of ellagic acid on premature ovarian insufficiency","authors":"V. V. Sarode, Sadhna P. Gautam","doi":"10.18231/j.ijpp.2024.006","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.006","url":null,"abstract":"One common medical condition affecting the reproductive system in older women is premature ovarian failure (POF). POF can result from radiation therapy, chemotherapy, immune system problems, infection, inflammation, and genetic mutation.The current study examined the effect of Ellagic acid on Premature Ovarian Insufficiency.The study utilized, 8-12 months old 150 ± 20 gm, 42 female wistar rats. For the induction of Premature Ovarian Insufficiency, Tripterygium Glycoside (TG) was administered at a dosage of 50 mg/ml dissolved in water for injection once daily. Clomiphene Citrate, 1 mg/kg was administered orally once daily for 21 days. Ellagic acid was given orally once daily at concentration of 10 mg/kg, 20 mg/kg, 30 mg/kg. The statistic of the data was determined by using ANOVA test.The results showed that effect of Ellagic acid on premature ovarian insufficiency as evidenced by decreased levels of cholesterol, triglycerides, follicle stimulating hormone and Luteinizing hormone and increased levels of estrogen.According to the current study, female wistar rats with Tripterygium Glycoside induced Premature Ovarian Insufficiency can benefit from treatment with an Ellagic acid.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"54 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0