B. Mahamadou N. H, Youl Estelle N.H, T. Karim, D. Seidina, Diakité Mamadou, Ouédraogo Moussa, Sanogo Rokia, Bah Sekou
{"title":"8种马里传统治疗炎性疾病的药用植物抗自由基活性、磷脂酶A和15-脂氧合酶抑制活性研究","authors":"B. Mahamadou N. H, Youl Estelle N.H, T. Karim, D. Seidina, Diakité Mamadou, Ouédraogo Moussa, Sanogo Rokia, Bah Sekou","doi":"10.18231/j.ijpp.2022.031","DOIUrl":null,"url":null,"abstract":"Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 μg/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"288 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases\",\"authors\":\"B. Mahamadou N. H, Youl Estelle N.H, T. Karim, D. Seidina, Diakité Mamadou, Ouédraogo Moussa, Sanogo Rokia, Bah Sekou\",\"doi\":\"10.18231/j.ijpp.2022.031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 μg/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes\",\"PeriodicalId\":13313,\"journal\":{\"name\":\"Indian Journal of Pharmacy and Pharmacology\",\"volume\":\"288 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Pharmacy and Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18231/j.ijpp.2022.031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pharmacy and Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18231/j.ijpp.2022.031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases
Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 μg/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes
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