Immunity, Inflammation and Disease最新文献

{"title":"RETRACTION: lncRNA BZRAP1-AS1 Alleviates Rheumatoid Arthritis by Regulating miR-1286/COL5A2 Axis","authors":"","doi":"10.1002/iid3.70204","DOIUrl":"https://doi.org/10.1002/iid3.70204","url":null,"abstract":"<p><b>RETRACTION:</b> J. Zhu, S. Tu and Q. Qu, “lncRNA BZRAP1-AS1 Alleviates Rheumatoid Arthritis by Regulating miR-1286/COL5A2 Axis,” <i>Immunity, Inflammation and Disease</i> 10, no. 2 (2022): 163-174, https://doi.org/10.1002/iid3.558.</p><p>The above article, published online on 11 November 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Marc Veldhoen; and John Wiley &amp; Sons, Ltd. The retraction has been agreed upon due to inconsistencies and flaws identified in this article that affect the validity of the conclusions. The authors did not respond to address the concerns raised and did not provide their original data. The editors consider the results and conclusions reported in this article unreliable. The authors were informed of the retraction.</p>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: NEAT1 Enhances MPP + -Induced Pyroptosis in a Cell Model of Parkinson's Disease via Targeting miR-5047/YAF2 Signaling","authors":"","doi":"10.1002/iid3.70208","DOIUrl":"https://doi.org/10.1002/iid3.70208","url":null,"abstract":"<p><b>RETRACTION:</b> H. Shen, H. Song, S. Wang, D. Su and Q. Sun, “NEAT1 Enhances MPP + -Induced Pyroptosis in a Cell Model of Parkinson's Disease via Targeting miR-5047/YAF2 Signaling,” <i>Immunity, Inflammation and Disease</i> 11, no. 6 (2023): e817, https://doi.org/10.1002/iid3.817.</p><p>The above article, published online on 23 June 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Marc Veldhoen; and John Wiley &amp; Sons, Ltd. The retraction has been agreed upon due to the ASC western blot bands in Figure 1 C being found duplicated in a previously published article, representing a different scientific context. The authors were contacted for comment and supporting data but did not respond. The editors consider the results and conclusions of this article unreliable. The authors were informed of the retraction.</p>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of P2X7R in Retinal Diseases: A Review","authors":"Chunli Li,&nbsp;Binsheng Wang","doi":"10.1002/iid3.70203","DOIUrl":"https://doi.org/10.1002/iid3.70203","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>P2X purinoceptor 7 receptor (P2X7R) is an ATP-gated ion channel that, upon activation by ATP, triggers the release of inflammatory mediators and induces apoptosis in cells. This channel plays a crucial role in the onset and progression of various diseases. Recently, there has been a growing body of research focused on the function of P2X7R receptors in ophthalmic conditions, particularly concerning retinal diseases such as age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This article is to provide a comprehensive review of the advancements in the study of P2X7R and its association with retinal diseases, elucidating its role in these conditions and identifying potential avenues for future research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Electronic databases, including PubMed, Web of Science, and Wan fang Data were searched for relevant literature. The following keywords were used: “P2X7R”, Age-related macular degeneration”, “Diabetic retinopathy”, “Retinitis pigmentosa”. Both preclinical and clinical studies were included to provide a holistic understanding of P2X7R's role in retinal pathology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>P2X7R activation exacerbates retinal diseases by promoting inflammation and apoptosis. However, its role in disease progression and homeostasis complicates therapeutic targeting, highlighting the need for selective inhibitors and further research into its context-dependent functions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>P2X7R plays a critical role in the pathogenesis of retinal diseases. At the same time, preclinical studies suggest that P2X7R inhibition holds promise as a therapeutic strategy. Future research should focus on developing selective P2X7R inhibitors, elucidating the receptor's role in different disease stages, and identifying biomarkers to guide personalized treatment. Addressing these challenges will be essential for translating P2X7R-targeted therapies into clinical practice and improving outcomes for patients with retinal diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules","authors":"Meenal Sharma,&nbsp;Priyanka Wagh,&nbsp;Tanvi Shinde,&nbsp;Diptee Trimbake,&nbsp;Anuradha S. Tripathy","doi":"10.1002/iid3.70150","DOIUrl":"https://doi.org/10.1002/iid3.70150","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pattern recognition receptors (PRRs) are the receptors of the innate immune system that play a vital role in initiating innate immune response. PRRs recognize pathogen associated molecular patterns (PAMPs) and activate immune cells through a signaling cascade. Due to this remarkable ability to recognize pathogenic microbes and elucidation of an immune response in a well-organized manner, PRR agonizts are likely to have great potential as vaccine adjuvants. Recent advancements in vaccine development raised concerns regarding the reduced immunogenicity of various vaccines, questioning the vaccine efficacy. In such cases, the use of an adjuvant becomes crucial. Understanding the structure and downstream signaling of PRRs will provide the possibility of developing a novel therapeutic approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The rapidly evolving field of immunology and vaccinology, coupled with the increasing focus on PRRs in disease therapy, demands a comprehensive overview. In this review, we provide all-inclusive and contemporary gist on PRRs and the applications of their agonizts. We explored the potential of PRR agonizts as vaccine adjuvant. The current review integrates the basic understanding of PRRs and recent findings highlighting emerging trends of the same.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Our review highlights that combining multiple PRR agonizts could offer synergistic benefits. This approach might prove advantageous and could potentially enhance vaccine efficacy and reduce the need for excessive immunogens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A comprehensive understanding of PRR subset, agonizts of PRR and their application in vaccine adjuvant. This knowledge will be significant in formulating vaccine approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “miR-223 Improves Intestinal Inflammation Through Inhibiting the IL-6/STAT3 Signaling Pathway in Dextran Sodium Sulfate-Induced Experimental Colitis”","authors":"","doi":"10.1002/iid3.70209","DOIUrl":"https://doi.org/10.1002/iid3.70209","url":null,"abstract":"<p>J. Zhang, C. Wang, Z. Guo, B. Da, W. Zhu and Q. Li, “miR-223 Improves Intestinal Inflammation Through Inhibiting the IL-6/STAT3 Signaling Pathway in Dextran Sodium Sulfate-Induced Experimental Colitis,” <i>Immunity, Inflammation and Disease</i> 9, no. 1 (2021): 319-327, https://doi.org/10.1002/iid3.395.</p><p>The gel in Figure 4D was cut following the reviewer's suggestion during peer review. The uncut, annotated gels have been provided as a supplemental figure. The authors confirm that all the experimental results and corresponding conclusions mentioned in the paper remain unaffected. Supplemental Figure is shown as follows.</p><p>Supplemental Figure</p><p></p><p>The authors apologize for this error.</p>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Transcriptomic and Proteomic Data: IL-27B as a Key Protein in the Development of Septic Cardiomyopathy—A Retrospective Study","authors":"Yifeng Mao,&nbsp;Qingqing Chen,&nbsp;Yongpo Jiang,&nbsp;Xijiang Zhang,&nbsp;Qin Si,&nbsp;Panpan Xu,&nbsp;Zhongheng Zhang,&nbsp;Cheng Zheng,&nbsp;Ronghai Lin","doi":"10.1002/iid3.70207","DOIUrl":"https://doi.org/10.1002/iid3.70207","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Septic cardiomyopathy (SCM) is a potentially fatal complication of sepsis. In this study, transcriptomic and proteomic analyzes of serum samples from sepsis patients were conducted to uncover the underlying pathological mechanisms and identify potential therapeutic targets for SCM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective, dual-center study investigated the progression of sepsis to SCM in patients admitted to intensive care units. A total of 50 patients were enrolled and divided into two groups: sepsis with cardiomyopathy (25 cases) and sepsis without cardiomyopathy (25 cases). Co-expression network analysis was employed to elucidate the biological significance of differentially expressed proteins. By integrating proteomic and transcriptomic data, molecular networks were constructed to visualize interactions among key molecules, aiming to enhance data interpretation and support the study's findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Proteomic analysis identified 216 differentially expressed proteins (Fold change &gt; 1.5, <i>p</i>-value &lt; 0.05) between the two groups. Transcriptomic analysis revealed two proteins, including Interleukin-27 subunit beta (IL-27B) and carbonic anhydrase, co-downregulated in patients with septic cardiomyopathy. IL-27B was associated with the immune response, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated its involvement in the cytokine-cytokine receptor interaction signaling pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Comprehensive integrated transcriptomic and proteomic analyzes identified significant changes in protein expression associated with SCM, primarily associated with inflammation-related pathways and amino acid metabolism. These findings provide new insights into the pathological mechanisms of SCM and highlight potential therapeutic targets for its treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>The Clinical Research Ethics Committee of Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University approved this study, and written informed consent was given by all patients or their legal representatives. (NO.K20201110).</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of MHR, PLR Combined With NLRP1 for Severity and Long-Term Prognosis in Premature Coronary Artery Disease","authors":"Mengyun Zhu,&nbsp;Jianying Shen,&nbsp;Weijing Liu,&nbsp;Hui Sun,&nbsp;Yawei Xu","doi":"10.1002/iid3.70202","DOIUrl":"https://doi.org/10.1002/iid3.70202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the predictive value of platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) combined with nucleotide binding oligomeric domain like receptor protein 1 (NLRP1) for the severity of premature coronary heart disease (PCHD) and its 2-year long-term prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 132 patients with PCHD examined in our hospital from February 2020 to January 2022 were retrospectively selected as the research objects. All patients who met the criteria were divided into mild group, moderate group, and severe group according to the severity of PCHD. The patients were followed up for 2 years. Patients were then divided into good prognosis group (without adverse cardiovascular events, <i>n</i> = 96) and poor prognosis group (with adverse cardiovascular events, <i>n</i> = 36). The predictive value was evaluated by ROC curve and multivariate logistic regression analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the mild group, the levels of MHR, PLR, and NLRP1 in the moderate group and the severe group were significantly increased (<i>p</i> &lt; 0.05). The levels of MHR, PLR, and NLRP1 in the poor prognosis group were higher than the good prognosis group (<i>p</i> &lt; 0.05). The area under the curve (AUC) of MHR, PLR, and NLRP1 alone and in combination for predicting the 2-year long-term prognosis of patients was 0.787, 0.653, 0.869, and 0.926, respectively. Combined markers showed superior predictive accuracy (<i>p</i> &lt; 0.05). After adjusting for confounding factors such as treatment, comorbidities, weight, gender, and smoking, MHR, PLR, and NLRP1 were independent risk factors for severe progression and poor prognosis of PCHD (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>MHR, PLR, and NLRP1 were increased in patients with higher severity of PCHD and poor prognosis. The combined detection has certain clinical guiding value for PCHD. However, this study was a single-center retrospective study with a small sample size. Thus, the results need to be further verified.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Labs Help With Vaccination? In Vitro Tests in Diagnosis of Allergy to COVID-19 Vaccines–A Systematic Review","authors":"Jan Romantowski,&nbsp;Marika Gawinowska,&nbsp;Piotr Trzonkowski,&nbsp;Marek Niedoszytko","doi":"10.1002/iid3.70206","DOIUrl":"https://doi.org/10.1002/iid3.70206","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Since the outbreak of the coronavirus pandemic in 2019, vaccinations have proven to be a key strategy in disease prophylaxis. Although vaccines are safe from the perspective of the general population, hypersensitivity reactions have still been described, causing individuals to be reluctant in their vaccination decision. Since the description of first reports of COVID-19 vaccine allergy, many protocols of allergy work-up have been developed, including In Vitro and In Vivo tests. Although In Vivo tests were more accessible, many patients preferred In Vitro tests that would not involve contact with the allergen and be safe. This applied in particular to patients that had experienced a severe delayed hypersensitivity reaction in which In Vivo tests were highly limited and provocations were deemed high risk. Taking into account these circumstances, In Vitro tests might significantly enhance allergy work-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>National Center for Biotechnology Information (Pubmed) database was searched in May 2024 for articles on In Vitro diagnostic methods for COVID-19 vaccine allergy and hypersensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This article describes the In Vitro tests developed to date in the diagnosis of COVID-19 vaccine hypersensitivity: (1) analysis of specific IgE and IgG, (2) Basophil Activation Test, (3) Histamine Release Test, (4) IgM-dependent complement activation, (5) Lymphocyte Transformation Test, (6) Flow cytometry T-Cell markers, (7) Th1/Th2 cytokines concentration in cell culture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The article highlights the tests' advantages, flaws and possible clinical applications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta-Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay","authors":"Ganesh Bushi,&nbsp;Mahalaqua Nazli Khatib,&nbsp;Renuka Jyothi. S,&nbsp;Irwanjot Kaur,&nbsp;Abhishek Sharma,&nbsp;Suhaib Iqbal,&nbsp;M. Ravi Kumar,&nbsp;Ashish Singh Chauhan,&nbsp;Teena Vishwakarma,&nbsp;Praveen Malik,&nbsp;Quazi Syed Zahiruddin,&nbsp;Mahendra Pratap Singh,&nbsp;Muhammed Shabil,&nbsp;Rachana Mehta,&nbsp;Sanjit Sah,&nbsp;Hawra Albayat,&nbsp;Tarek Sulaiman,&nbsp;Ali Al bshabshe,&nbsp;Nawal A. Al Kaabi,&nbsp;Hayam A Alrasheed,&nbsp;Mubarak Alfaresi,&nbsp;Amal A. Sabour,&nbsp;Eman Alamri,&nbsp;Maha F. Al-Subaie,&nbsp;Ali A. Rabaan","doi":"10.1002/iid3.70205","DOIUrl":"https://doi.org/10.1002/iid3.70205","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Malaria is a life-threatening disease caused by Plasmodium parasites, transmitted through the bites of infected female Anopheles mosquitoes. It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant women. This review evaluates awareness, acceptance, hesitancy, and willingness to pay (WTP) for the RTS,S/AS01 malaria vaccine, along with the key factors influencing these outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted in Web of Science, PubMed, and Embase, covering publications up to 18 June 2024. Observational studies assessing awareness, acceptance, hesitancy, and WTP for the malaria vaccine in endemic regions were included. Two independent reviewers screened the studies. Data extraction was performed using Nested Knowledge software and analyzed with R v.4.4. Pooled prevalences were estimated using random-effects models, and heterogeneity was assessed with the I² statistic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighteen studies with 21,975 participants provided insights into malaria vaccine dynamics: 32% awareness (95% CI, 18%–50%), 83% acceptance (95% CI, 75%–89%), 14% hesitancy (95% CI, 7%–26%), and 58% WTP (95% CI, 34%–79%). Key determinants of acceptance included age, where younger adults (18–24 years) showed lower acceptance (OR = 0.64, 95% CI, 0.35–0.93). Employment, particularly farmers, had higher acceptance rates (OR = 3.20, 95% CI, 1.00–7.40). Lower socioeconomic status and larger family sizes were associated with decreased acceptance (OR = 0.18, 95% CI, 0.02–0.38).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review revealed an 83% acceptance rate for the malaria vaccine, with variability in awareness (32%), hesitancy (14%), and willingness to pay (58%). Age, employment, and socioeconomic status were significant determinants of acceptance. However, due to potential publication bias and high heterogeneity, these findings should be cautiously interpreted. The results highlight the necessity for targeted interventions to enhance vaccine acceptance. Further research is required to elucidate factors that influence vaccine acceptance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Progress in Mesenchymal Stem Cell Therapy: A Focus on Rheumatic Diseases","authors":"Helal F. Hetta,&nbsp;Alaa Elsaghir,&nbsp;Victor Coll Sijercic,&nbsp;Abdulrahman K. Ahmed,&nbsp;Sayed A. Gad,&nbsp;Mahlet S. Zeleke,&nbsp;Fawaz E. Alanazi,&nbsp;Yasmin N. Ramadan","doi":"10.1002/iid3.70189","DOIUrl":"https://doi.org/10.1002/iid3.70189","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rheumatic diseases are chronic immune-mediated disorders affecting multiple organ systems and significantly impairing patients' quality of life. Current treatments primarily provide symptomatic relief without offering a cure. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option due to their ability to differentiate into various cell types and their immunomodulatory, anti-inflammatory, and regenerative properties. This review aims to summarize the clinical progress of MSC therapy in rheumatic diseases, highlight key findings from preclinical and clinical studies, and discuss challenges and future directions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>A comprehensive review of preclinical and clinical studies on MSC therapy in rheumatic diseases, including systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, osteoporosis, Sjögren's syndrome, Crohn's disease, fibromyalgia, systemic sclerosis, dermatomyositis, and polymyositis, was conducted. Emerging strategies to enhance MSC efficacy and overcome current limitations were also analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and Discussion</h3>\u0000 \u0000 <p>Evidence from preclinical and clinical studies suggests that MSC therapy can reduce inflammation, modulate immune responses, and promote tissue repair in various rheumatic diseases. Clinical trials have demonstrated potential benefits, including symptom relief and disease progression delay. However, challenges such as variability in treatment response, optimal cell source and dosing, long-term safety concerns, and regulatory hurdles remain significant barriers to clinical translation. Standardized protocols and further research are required to optimize MSC application.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>MSC therapy holds promise for managing rheumatic diseases, offering potential disease-modifying effects beyond conventional treatments. However, large-scale, well-controlled clinical trials are essential to establish efficacy, safety, and long-term therapeutic potential. Addressing current limitations through optimized treatment protocols and regulatory frameworks will be key to its successful integration into clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}