Immunity, Inflammation and Disease最新文献

{"title":"Integration of Metabolomics and 16S Ribosomal RNA Sequencing to Elucidate the Pathogenesis of Ankylosing Spondylitis","authors":"Xin Wang,&nbsp;Haojie Xu,&nbsp;Yuyan Chao,&nbsp;Chao Sun,&nbsp;Tingting Wang,&nbsp;Xiaoyun Fan,&nbsp;Lin Tang,&nbsp;Shengqian Xu,&nbsp;Changhao Xie","doi":"10.1002/iid3.70183","DOIUrl":"https://doi.org/10.1002/iid3.70183","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Despite growing interest in the gut microbiota and blood metabolome in patients with ankylosing spondylitis (AS), its role remains poorly understood. Here, we investigate how microbial and metabolic alterations contribute to AS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fecal microbiome data from 40 AS patients were compared with those from 40 healthy controls (HCs) using 16S ribosomal RNA (rRNA) gene sequencing. The plasma metabolic profiles were analyzed and integrated with the microbiota data to identify biological characteristics specific to AS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>AS patients showed significant enrichment of specific genera, including <i>Megamonas, Elusimicrobium, Dysgonomonas, Ruminococcus_gauvreauii_group</i>, and <i>unclassified_Prevotellaceae</i>. Pathways with the most differentially expressed metabolites included bile secretion; neomycin, kanamycin, and gentamicin biosynthesis; and arachidonic acid metabolism. Positive correlations between <i>Megamonas</i> and <i>Elusimicrobium</i> and metabolites such as piribedil, <span>l</span>-cystathionine, and crocetin dialdehyde suggested microbial enrichment in AS patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A disrupted gut microbiota and altered metabolites are present in AS patients. Integrating microbiome and metabolomic data reveals significant disruptions in AS patients, improving our understanding of its pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Dysregulation in HIV and COVID-19 Co-infection: Therapeutic Implications","authors":"Maryam Nejabat,&nbsp;Mohammad Motamedifar,&nbsp;Saeid Amirizadeh Fard,&nbsp;Mohammadreza Heydari,&nbsp;Soudabeh Bemani","doi":"10.1002/iid3.70164","DOIUrl":"https://doi.org/10.1002/iid3.70164","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Co-infection with HIV and SARS-CoV-2 presents a complex clinical picture. Deciphering the immune response in this population, particularly the role of cytokines underlying immunopathogenesis could elucidates the development of targeted therapeutic interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective, two-stage study enrolled 75 individuals with HIV diagnosed with COVID-19 (case group) and 25 individuals from the general population infected with SARS-CoV-2 only (control group). COVID-19 diagnosis followed World Health Organization guidelines. Plasma cytokine levels were measured using a cytokine bead array.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The case group skewed slightly females (61.2% vs. 42.9% female in the control group) an average age of 3 years older (44.13 years vs. 40.86 years). Importantly, all the case group participants had mild complications, while a significant majority (88.1%) in the control group experienced severe complications. The control group displayed a substantially higher IgM titer 963 IU/mL compared to only 39.3 IU/mL in the case group. The control group had significantly higher levels of IL-6, IL-10, IFN-γ, TNF-α compared to the case group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests a potentially distinct immune response in HIV-positive patients when infected with SARS-CoV-2. Elucidating these differences could lead to the development of more effective treatment strategies for this vulnerable population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Complex Inflammatory and Nutritional Indices to Predict Prognostic Risk for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention","authors":"Ge Song,&nbsp;Xinchen Wang,&nbsp;Chen Wei,&nbsp;Yuewen Qi,&nbsp;Yan Liu,&nbsp;Ying Zhang,&nbsp;Lixian Sun","doi":"10.1002/iid3.70180","DOIUrl":"https://doi.org/10.1002/iid3.70180","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate the role of the systemic inflammatory response index (SIRI) and high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels in predicting the risk of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>Overall, 1377 patients with ACS who underwent PCI between January 2016 and December 2018 were consecutively enrolled. The patients were divided into MACEs (<i>n</i> = 60) and non-MACEs (<i>n</i> = 1317) groups. The study endpoints were MACEs, including cardiac-related mortality and rehospitalization for severe heart failure (HF), myocardial infarction (MI), and in-stent restenosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both groups showed significant differences in the patients with age &gt; 65 years, history of HF, acute MI, cardiogenic shock, left ventricular ejection fraction &lt; 40%, SIRI ≥ 2.848, SIRI/HDL-C ≥ 1.977, and SIRI × LDL-C ≥ 4.609. The Kaplan–Meier curve showed that the low SIRI group had higher cumulative survival than the high SIRI group. Additionally, the univariate and multivariate Cox proportional hazards model demonstrated that SIRI ≥ 2.848, SIRI/HDL-C ≥ 1.977, and SIRI × LDL-C ≥ 4.609 were independent risk factors for patients with ACS undergoing PCI. Restricted cubic spline models were generated to visualize the relationship between SIRI, SIRI/HDL-C, and SIRI × LDL-C and the prognostic risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SIRI ≥ 2.848, SIRI/HDL-C ≥ 1.977, and SIRI × LDL-C ≥ 4.609 were all independent prognostic risk factors in patients with ACS undergoing PCI, which may be useful markers for assessment for long prognosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of SARS-CoV-2 Antibody Before and After Both Vaccination and Natural Infection in China","authors":"Yang Guang,&nbsp;Liu Lina,&nbsp;Liu Hui","doi":"10.1002/iid3.70184","DOIUrl":"https://doi.org/10.1002/iid3.70184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to analyze the effects of temporal SARS-CoV-2 antibodies in China before and after both vaccination and natural infection, thereby providing an empirical basis for evaluating the effectiveness of various prevention methods, including vaccination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>IgG antibodies against SARS-CoV-2 were determined using chemiluminescence immunoassays, and antibody data was collected from published articles starting in early 2020 and from patients scheduled for surgery at the Hospital of Dalian Medical University between January 2022 and January 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A SARS-CoV-2 infection epidemic in Wuhan in January 2020 led to a 3.2% seropositivity rate of SARS-CoV-2 antibodies (total antibodies). While the seropositivity rate for SARS-CoV-2 antibodies in mainland China reached 37.2% following the implementation of China's zero-COVID policy and the immunization rate was above 90% in January 2022. By the end of 2022, the Chinese government eased strict control measures, resulting in a SARS-CoV-2 antibody (IgG) positivity rate of 86.7% in January 2023. In January 2024, the positivity rate for SARS-CoV-2 antibodies in post-pandemic was recorded at 94.0%. Antibody levels in the early part of 2023 were considerably higher than those measured in January 2022 (68.66 vs. 10.21, <i>p</i> &lt; 0.05); that in early 2024 were not substantially higher than those in January 2023 (49.29 vs. 68.66, <i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results of this study indicated that the immune barrier established by inactivated vaccines could be disrupted by the natural infection with SARS-CoV-2, resulting in a higher level of antibody production than vaccination. This effect can last for more than a year.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological and Burnout Effects of the COVID-19 Pandemic on Individuals","authors":"Bahar Ürün Ünal,&nbsp;Neslihan İyit,&nbsp;Yunus Akdoğan,&nbsp;Burcu Gök Erdoğan,&nbsp;Yüksel Duygu Altıparmak","doi":"10.1002/iid3.70181","DOIUrl":"10.1002/iid3.70181","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>COVID-19 infection has affected individuals mentally and socially in many areas. Restrictions, fear of infection, and anxiety about the future have created a great psychological burden on people. In this study, we aimed to investigate the significant negative effects of the COVID-19 pandemic on individuals' mental health and psychological functioning.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A 42-question questionnaire was applied to a total of 557 participants, including 350 people over the age of 18 who applied to the COVID-19 Vaccination Unit of Selçuk University Faculty of Medicine Hospital between December 2021 and May 2022 to be vaccinated and 207 people with a simultaneous online survey application. The psychological effects experienced by the participants due to the COVID-19 epidemic were questioned with psychological distress and burnout scales. Differences in the demographic characteristics of the participants were investigated according to the fear and anxiety sub-dimension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>According to the psychological distress scale, gender, COVID-19 vaccination status, educational status and place of residence were found to be significant. According to the burnout scale, gender, marital status, presence of chronic disease, COVID-19 posttest status, occupation and income status were found significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>The anxiety, fear, and stress levels reported by participants may not be consistent with an objective assessment by mental health professionals. The majority of participants were public sector employees and students, so the results regarding job loss anxiety cannot be generalized. No information was collected on participants' past medical psychiatric disorders within the scope of the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>It is obvious that stress and psychiatric disorders are more common in individuals with high perception of infectiousness and lethality of the agent, especially during epidemic periods. We think that this study will be useful for planning interventions to alleviate mental health problems of individuals in future epidemics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: lncRNA NEAT1/miR-495-3p Regulates Angiogenesis in Burn Sepsis Through the TGF-β1 and SMAD Signaling Pathways","authors":"","doi":"10.1002/iid3.70177","DOIUrl":"10.1002/iid3.70177","url":null,"abstract":"<p><b>RETRACTION</b>: Y. Meng, Z. Hao, H. Zhang, P. Bai, W. Guo, X. Tian and J. Xu, “lncRNA NEAT1/miR-495-3p Regulates Angiogenesis in Burn Sepsis Through the TGF-β1 and SMAD Signaling Pathways,” <i>Immunity, Inflammation and Disease</i> 11, no. 1 (2023): e758, https://doi.org/10.1002/iid3.758.</p><p>The above article, published online on January 16, 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement the journal Editor-in-Chief, Marc Veldhoen; and John Wiley &amp; Sons Ltd. The retraction has been agreed due scientific flaws and inconsistencies found in the methodology and results of this article. While the authors were able to provide some supporting data, this was not sufficient and the irregularities remain. The editors have lost confidence in the results and conclusions presented in this study. The authors disagree with the retraction.</p>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Concurrent Babesiosis and GCA/PMR","authors":"Xiaolin Wang,&nbsp;Haohua Huang,&nbsp;Lichang Chen,&nbsp;Simin Guo,&nbsp;Qi-Ming Gong","doi":"10.1002/iid3.70182","DOIUrl":"https://doi.org/10.1002/iid3.70182","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Babesiosis is a tick-transmitted illness caused by intraerythrocytic protozoa of the genus babesia. The severity of babesiosis ranges from asymptomatic infection to fatal disease. Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common interrelated inflammatory disorders that almost occur in people aged over 50 years. This report presents the first case of concurrent babesiosis and GCA/PMR in an old person.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 63-year-old man was admitted to the hospital with a 1-month history of fevers, accompanied by headache, muscle pain and fatigue. Laboratory tests revealed hemolytic anemia, with elevated C-reactive protein, serum IL-6 and erythrocyte sedimentation rate. FDG positron-emission tomography-computed tomography (PET-CT) scan exhibited increased uptake in aortic wall, multiple medium-to-large arteries and soft tissues. A blood smear revealed Babesia microti intracellular ring forms. Babesia microti infection was further confirmed by polymerase chain reaction (PCR) test. This patient was diagnosed as concurrent babesiosis and GCA/PMR. He was treated with glucocorticoid and antimicrobial therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Concurrent babesiosis and GCA/PMR is rare. Further studies are needed to understand the mechanism of interaction between babesiosis and human immune system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity","authors":"Karina Bingham,&nbsp;Yousef Al Zahrani,&nbsp;Iain Stewart,&nbsp;Michael A. Portelli,&nbsp;Andrew Fogarty,&nbsp;Tricia M. McKeever,&nbsp;Ananga Singapuri,&nbsp;Liam G. Heaney,&nbsp;Adel H. Mansur,&nbsp;Rekha Chaudhuri,&nbsp;Neil C. Thomson,&nbsp;John W. Holloway,&nbsp;Peter H. Howarth,&nbsp;Ratko Djukanovic,&nbsp;John D. Blakey,&nbsp;Anoop Chauhan,&nbsp;Christopher E. Brightling,&nbsp;Zara E. K. Pogson,&nbsp;Ian P. Hall,&nbsp;Luisa Martinez-Pomares,&nbsp;Dominick Shaw,&nbsp;Ian Sayers","doi":"10.1002/iid3.70116","DOIUrl":"https://doi.org/10.1002/iid3.70116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Asthma is a heterogeneous disease characterized by overlapping clinical and inflammatory features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to provide insight into the systemic inflammatory profile in asthma, greater understanding of asthma endotypes and the contribution of genetic risk factors to both.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>4205 patients with asthma aged 16–60 were recruited from UK centers; serum cytokines were quantified from 708, including cytokines associated with Type 1, 2 and 17 inflammation. 3037 patients were genotyped for 25 single nucleotide polymorphisms associated with moderate-severe asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Serum cytokines associated with Th2 inflammation showed high coordinated expression for example, IL-4/IL-5 (<i>R</i>² = 0.513). The upper quartile of the serum cytokine data identified 43.7% of patients had high levels for multiple Th2 cytokines. However, the groups defined by serum cytokine profile were not clinically different. Childhood-onset asthma was characterized by elevated total IgE, allergic rhinitis and dermatitis. Exacerbation prone patients had a higher BMI, smoking pack-years, asthma control questionnaire score and reduced lung function. Patients with blood eosinophils of &gt; 300 cells/µL had elevated total IgE and lower smoking pack-years. None of these groups had a differential serum cytokine profile. Asthma risk alleles for; rs61816764 (<i>FLG</i>) and rs9303277 (<i>IKFZ3</i>) were associated with childhood onset disease (<i>p</i> = 2.67 × 10⁻⁴ and 2.20 × 10⁻⁷; retrospectively). No genetic variant was associated with cytokine levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Systemic inflammation in asthma is complex. Patients had multiple overlapping inflammatory profiles suggesting several disease mechanisms. Genetic risk factors for moderate-severe asthma confirmed previous associations with childhood onset of asthma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte Subpopulations in the Healthy Human Lacrimal Gland and Their Variations With Age and Sex, Systematic Review 1960–2023","authors":"Claudia M. Trujillo-Vargas,&nbsp;Luisa María Rendón-Macías,&nbsp;Ronald Yamil Paredes Guerrero,&nbsp;Cinta S. de Paiva,&nbsp;Jaiberth Antonio Cardona-Arias","doi":"10.1002/iid3.70167","DOIUrl":"https://doi.org/10.1002/iid3.70167","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Immunosenescence has been associated with an imbalance in the lacrimal functional unit and histopathological changes in exocrine glands, especially in women.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To define the main lymphocyte subpopulations in the human lacrimal gland and their variations with age and sex, according to scientific articles published between 1960 and 2023.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A systematic review was performed on PubMed, ScienceDirect, and Google Scholar. The PRISMA 2020 guidelines were applied for the search and selection of studies.&lt;/p&gt;\u0000 \u0000 &lt;p&gt;The methodological quality was evaluated with the STROBE guidelines. A meta-analysis of three selected articles dichotomizing lymphocytic infiltrates according to age group was also performed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We selected 20 observational studies, including 774 healthy individuals (722 cadavers). The articles evaluated the lymphocyte infiltration with hematoxylin and eosin staining, immunohistochemistry and immunofluorescence. There was high variability in the criteria to define the apparently human lacrimal and to quantify the lymphocytic infiltration. There was an underrepresentation of individuals younger than 40 years (12.6%), and female sex (38.9%). Three articles reported an association of age and sex with lymphocytic infiltration in the healthy lacrimal gland, while two articles did not. Plasma cells were the most abundant lymphocyte subpopulation in the healthy lacrimal gland, including IgA-containing plasma cells. B cells were reported to be very scarce in the LG in two articles. In the meta-analysis of three selected articles, no statistical difference in lymphocytic infiltration was found between individuals younger and older than 60.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;There is the need of further observational studies, better defining the study design, with similar representation across sex and ages to ascertain what are the changes of lymphocytic composition in the lacrimal gland related to age and sex. Further studies are also needed to assess the dynamics of lymphocytic populations in a more detailed manner using cutting-edge methodologies such as single-cell sequencing or transcriptomics.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Trial Registration&lt;/h3&gt;\u0000 \u0000 ","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Characteristics and Outcomes of Lupus Nephritis Patients With Thrombocytopenia: A Single-Center Retrospective Study","authors":"Hui Diao,&nbsp;Yuting Fan,&nbsp;Di Kang,&nbsp;Zhiqing Chen,&nbsp;Yuewen Lu,&nbsp;Xiamin Huang,&nbsp;Xi Xia,&nbsp;Wei Chen","doi":"10.1002/iid3.70179","DOIUrl":"https://doi.org/10.1002/iid3.70179","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The objective of this study is to analyze and summarize the clinical characteristics and prognosis of lupus nephritis (LN) patients with thrombocytopenia and to improve the cognition of the disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>896 LN patients were enrolled in this study and their clinical and pathological data were collected and analyzed. The primary end point was mortality. The secondary end point was adverse renal outcomes, defined as doubling of the baseline serum creatinine or end-stage renal diseases. Cox regression model was used to analyze the risk factors of mortality or renal events in LN with and without thrombocytopenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 896 LN patients, 70 (7.8%) were diagnosed with thrombocytopenia. LN patients with thrombocytopenia had lower estimated glomerular filtration rate (eGFR) and higher systemic lupus erythematosus disease activity index (SLE-DAI), proportion of anemia, leukopenia, hypocomplementemia, and positive anti-cardiolipin antibodies, compared to those without thrombocytopenia. LN patients with thrombocytopenia had higher scores of activity index and more activity features (endocapillary hypercellularity, medullary loop necrosis) on kidney biopsy. There was no significant difference in patient survival and renal survival between LN patients with and without thrombocytopenia. Anemia was a risk factor for death in LN patients with thrombocytopenia and lower eGFR was a risk factor for adverse renal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LN patients with thrombocytopenia showed higher disease activity, more anti-cardiolipin antibody positivity and a higher activity index in kidney biopsy, but the prognosis was similar compared with those without thrombocytopenia. Anemia was a risk factor for death in LN patients with thrombocytopenia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}