Xiao-Min Wang, Pu Li, Lei Hu, Xiao Zhang, Jun Wang, Cheng-Xin Zhu, Kun Lv, Da-Wei Zhang
{"title":"低胸肌量：发热伴血小板减少综合征患者预后不良的新指标。","authors":"Xiao-Min Wang, Pu Li, Lei Hu, Xiao Zhang, Jun Wang, Cheng-Xin Zhu, Kun Lv, Da-Wei Zhang","doi":"10.1002/iid3.70271","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Severe fever with thrombocytopenia syndrome (SFTS) poses a serious threat to public health due to its high mortality. Low thoracic muscle mass predicts poor clinical outcomes in many diseases, but its significance in SFTS remains unclear.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This retrospective study involved 210 SFTS patients admitted to the First Affiliated Hospital of Anhui Medical University from 2020 to 2023. All subjects underwent chest computed tomography (CT) examination. Skeletal muscle index (SMI) was measured by CT images at the level of the twelfth thoracic vertebra (T12). The clinical data of patients from the survival and non-survival groups were compared, and the prognostic value of T12-SMI in SFTS patients was evaluated through least absolute shrinkage and selection operator regression and univariate and multivariate Cox regression.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Patients in the non-survival group had a lower SMI. Receiver operating characteristic analysis indicated that SMI may predict adverse outcomes in patients with SFTS. Multivariate Cox regression analysis demonstrated that SMI was independently connected to negative outcomes of SFTS. T12-SMI was correlated with albumin and creatinine.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Low SMI is associated with adverse outcomes in patients with SFTS. SMI may serve as a reliable prognostic marker for SFTS in clinical settings.</p>\n </section>\n </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70271","citationCount":"0","resultStr":"{\"title\":\"Low Thoracic Muscle Mass: A Novel Indicator of Poor Prognosis in Patients With Severe Fever With Thrombocytopenia Syndrome\",\"authors\":\"Xiao-Min Wang, Pu Li, Lei Hu, Xiao Zhang, Jun Wang, Cheng-Xin Zhu, Kun Lv, Da-Wei Zhang\",\"doi\":\"10.1002/iid3.70271\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Severe fever with thrombocytopenia syndrome (SFTS) poses a serious threat to public health due to its high mortality. Low thoracic muscle mass predicts poor clinical outcomes in many diseases, but its significance in SFTS remains unclear.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This retrospective study involved 210 SFTS patients admitted to the First Affiliated Hospital of Anhui Medical University from 2020 to 2023. All subjects underwent chest computed tomography (CT) examination. Skeletal muscle index (SMI) was measured by CT images at the level of the twelfth thoracic vertebra (T12). The clinical data of patients from the survival and non-survival groups were compared, and the prognostic value of T12-SMI in SFTS patients was evaluated through least absolute shrinkage and selection operator regression and univariate and multivariate Cox regression.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Patients in the non-survival group had a lower SMI. 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Low Thoracic Muscle Mass: A Novel Indicator of Poor Prognosis in Patients With Severe Fever With Thrombocytopenia Syndrome
Background
Severe fever with thrombocytopenia syndrome (SFTS) poses a serious threat to public health due to its high mortality. Low thoracic muscle mass predicts poor clinical outcomes in many diseases, but its significance in SFTS remains unclear.
Methods
This retrospective study involved 210 SFTS patients admitted to the First Affiliated Hospital of Anhui Medical University from 2020 to 2023. All subjects underwent chest computed tomography (CT) examination. Skeletal muscle index (SMI) was measured by CT images at the level of the twelfth thoracic vertebra (T12). The clinical data of patients from the survival and non-survival groups were compared, and the prognostic value of T12-SMI in SFTS patients was evaluated through least absolute shrinkage and selection operator regression and univariate and multivariate Cox regression.
Results
Patients in the non-survival group had a lower SMI. Receiver operating characteristic analysis indicated that SMI may predict adverse outcomes in patients with SFTS. Multivariate Cox regression analysis demonstrated that SMI was independently connected to negative outcomes of SFTS. T12-SMI was correlated with albumin and creatinine.
Conclusion
Low SMI is associated with adverse outcomes in patients with SFTS. SMI may serve as a reliable prognostic marker for SFTS in clinical settings.
期刊介绍：
Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including:
• cellular and molecular immunology
• clinical immunology
• allergy
• immunochemistry
• immunogenetics
• immune signalling
• immune development
• imaging
• mathematical modelling
• autoimmunity
• transplantation immunology
• cancer immunology
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