Indian Journal of Medical Microbiology最新文献

{"title":"Mapping cervical microbiome diversity and inflammatory milieu and its perturbation in asymptomatic bacterial vaginosis and Candida infections: Insights from a community clinic in Mumbai","authors":"Deepti Tandon ,&nbsp;Jyoti Suresh Batgire ,&nbsp;Zabiya Bharmal ,&nbsp;Kalyani Karandikar ,&nbsp;Anushree D. Patil ,&nbsp;Kiran Munne ,&nbsp;Clara Aranha ,&nbsp;Vikrant M. Bhor","doi":"10.1016/j.ijmmb.2026.101067","DOIUrl":"10.1016/j.ijmmb.2026.101067","url":null,"abstract":"<div><h3>Purpose</h3><div>The interplay between the local microbiome and inflammatory environment is crucial in modulating the immune response. This research addresses the paucity of studies in the Indian context by mapping the cervical microbiome and associated inflammatory milieu in 43 apparently healthy women and <strong>evaluating its perturbations with various asymptomatic vaginal infections.</strong></div></div><div><h3>Methods</h3><div>Cervical microbiome was mapped for forty three participants, aged 18-45, who were enrolled <strong>from a community clinic</strong> as a part of longitudinal contraceptive study from October 2021 to September 2023. Sociodemographic data, clinical history, and cervical and cervicovaginal lavage specimens were collected. Microbiome analysis involved nanopore sequencing of the <strong>entire</strong> 16S rRNA region amplicon, while cytokine assessment in cervicovaginal lavage specimens utilized multiplex immunoassays.</div></div><div><h3>Results</h3><div>Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Fusobacteria appeared as dominant phyla with 32.55% having asymptomatic bacterial vaginosis (BV),16.27% asymptomatic Candida, and 13.95% coinfections. The cervical microbiome was dominated by <em>Lactobacillus iners</em> (45.69%), followed by <em>Lactobacillus helveticus</em> (6.53%) and <em>Lactobacillus reuteri</em> (5.86%). Women with BV exhibited an increased abundance of Prevotella and Streptococcus, while Candida infections were associated with elevated Atopobium and Collinsella species. Pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-8) showed variable levels, <strong>with Lactobacillus</strong> positively correlating with the <strong>regulatory</strong> cytokine <strong>TNF-α</strong> in <strong>in Candida infections</strong>. <strong>In BV Lactobacillus species such as L. agilus, L.iners and <em>L. salivarius</em> showed positive correlation with TNF-α</strong>. Additionally, <em>Lactobacillus manihotivorans</em> <strong>was</strong> negatively associated with IL-1β, while <em>Lactobacillus brevis</em> and <em>Lactobacillus</em> <strong><em>zeae</em></strong> showed negative correlations with IL-8.</div></div><div><h3>Conclusion</h3><div>This study maps the cervical microbiome and cytokine profile of healthy Indian women and demonstrates that asymptomatic bacterial vaginosis and Candida infections induces variations, highlighting the complex host–microbe interactions that govern vaginal health.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101067"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plazomicin activity against carbapenem-resistant Escherichia coli: A brief report","authors":"Priti Kambli ,&nbsp;Shaoli Basu ,&nbsp;Susan Rodrigues ,&nbsp;Patricia J. Simner ,&nbsp;Matthew L. Robinson ,&nbsp;Jennifer Lu ,&nbsp;Camilla Rodrigues","doi":"10.1016/j.ijmmb.2026.101078","DOIUrl":"10.1016/j.ijmmb.2026.101078","url":null,"abstract":"<div><div>Carbapenem-resistant <em>Escherichia coli</em> (CR-<em>E. coli</em>) pose major therapeutic challenges. We evaluated the activity of plazomicin against 52 CR-<em>E.coli</em> isolates from a Mumbai tertiary hospital. Plazomicin demonstrated potent activity (Minimum Inhibitory Concentration [MIC] 0.19-2 mg/L) against isolates, including those harboring NDM or OXA-48-like carbapenemases, with or without aminoglycoside-modifying enzymes (AMEs). In contrast, isolates carrying 16S rRNA methyltransferases (RMTs) (e.g., <em>rmtB1</em>, <em>rmtC</em>, <em>rmtF1</em>) exhibited high-level resistance (MICs of ≥256 μg/mL). These findings not only highlight the advantage of plazomicin in AME-positive, RMT-negative strains, but also warn about the threat of emerging 16S RMT-mediated resistance that limit its clinical utility.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101078"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melioidosis in sickle cell hemoglobinopathies in eastern India: Cavitating pneumonia and immune susceptibility – a case series-based insight","authors":"Prasanta Raghab Mohapatra ,&nbsp;Aneri Parekh ,&nbsp;Bijayini Behera ,&nbsp;Siddarth Singh ,&nbsp;Supantha De","doi":"10.1016/j.ijmmb.2026.101075","DOIUrl":"10.1016/j.ijmmb.2026.101075","url":null,"abstract":"<div><div>Melioidosis, caused by <em>Burkholderia pseudomallei</em>, is an emerging infection in the tropics. Most of the melioidosis patients have underlying co-morbidities or occupational exposures. Hemoglobinopathies, such as thalassemia, are established risk factors for melioidosis; however, the association of SCD with melioidosis is infrequently reported. We report two culture-confirmed melioidosis cases from eastern India: a 58-year-old male with SCD on hydroxyurea and another 44-year-old with sickle cell trait, both presenting with cavitary lung lesions mimicking tuberculosis. SCD-related functional asplenia may heighten susceptibility. These cases emphasise the need for clinical vigilance in endemic areas and further research into SCD/SCT-associated immune vulnerabilities.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101075"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aims and Scope","authors":"","doi":"10.1016/S0255-0857(26)00048-4","DOIUrl":"10.1016/S0255-0857(26)00048-4","url":null,"abstract":"","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101090"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular profiling of virulence determinants and antimicrobial resistance in MRSA isolates from HIV-infected and non-HIV individuals","authors":"Marimuthu Ragavan Rameshkumar ,&nbsp;Ramachandran Vignesh ,&nbsp;Pachamuthu Balakrishnan ,&nbsp;Narasingam Arunagirinathan","doi":"10.1016/j.ijmmb.2026.101064","DOIUrl":"10.1016/j.ijmmb.2026.101064","url":null,"abstract":"<div><h3>Background</h3><div><em>Staphylococcus aureus</em> is an important pathogen exhibiting antibiotic resistance and multiple virulence factors. This study analyses the antimicrobial resistance and virulence genes of <em>Staphylococcus aureus</em> isolates from HIV and non-HIV patients from southern India.</div></div><div><h3>Methods</h3><div><em>S. aureus</em> strains from HIV (n = 125) and non-HIV (n = 100) patients were isolated using conventional bacterial culture techniques. Antimicrobial resistance and virulence genes were analysed using polymerase chain reaction (PCR).</div></div><div><h3>Results</h3><div>Methicillin resistance was detected in 88.8 % and 34 % of the <em>S. aureus</em> isolates from HIV and non-HIV patients, respectively, and all tested positive for the <em>mecA</em> gene. SCC<em>mec</em> type V was the most frequently detected SCC<em>mec</em> cassette in MRSA from both HIV (55.2%) and non-HIV patients (44.4 %). MRSA isolates from HIV patients were 98.2 % positive for the penicillin resistance gene <em>blaZ</em>, followed by the aminoglycoside resistance genes <em>aacA-aphD</em> (82 %), <em>aac(6′)/aph(2″)</em> (75.7 %) and <em>aph(3″)-IIIa</em> (51.4 %), the tetracycline resistance genes <em>tet(K)</em> (42.3 %) and <em>tet(M)</em> (13.5 %) and the erythromycin resistance genes <em>erm(C)</em> (55 %). Among the non-HIV-infected MRSA strains, 73.5 % were positive for <em>blaZ</em>, followed by <em>aac</em><em>(6’)/aph(2″)</em> (50 %)<em>, aacA-aphD</em> (47.1 %)<em>, aph(3”)-IIIa</em> (23.5 %)<em>,</em> and <em>erm(C)</em> (29.4 %)<em>.</em> The <em>seb</em> (7.2 %), <em>sea</em> (5.4 %), <em>seb</em> and <em>sed</em> (2.7 %), exfoliative toxin gene <em>eta</em> (3.6 %) and toxic shock syndrome toxin gene <em>tst</em> (8.1 %) were detected among MRSA from HIV patients, and the <em>sea</em> (5.9 %), <em>sec</em> (5.9 %), <em>eta</em> (5.9 %) and <em>tst</em> (8.8 %) were found among MRSA from non-HIV patients.</div></div><div><h3>Conclusions</h3><div>HIV patients are at a relatively greater risk of acquiring virulent and multidrug-resistant methicillin-resistant <em>S. aureus</em> infections than non-HIV patients.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101064"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon non-fermentative gram-negative superbugs - A surge in bacteraemia patients at an apex super speciality hospital","authors":"Munaza Aman,&nbsp;Insha Altaf,&nbsp;Bashir A. Fomda,&nbsp;Shagufta Roohi,&nbsp;Anjum Mir,&nbsp;Sehar Tariq,&nbsp;Uksim Qadri","doi":"10.1016/j.ijmmb.2026.101046","DOIUrl":"10.1016/j.ijmmb.2026.101046","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Gram negative bacteria are most common cause of bacteraemia, with one fourth being attributed to non-fermentive Gram negative bacteria (NFGNB). Contribution of NFGNB to antimicrobial resistance burden is also high. Commonly isolated NFGNB <em>Pseudomonas aeruginosa</em> and <em>Acinetobacter baumannii</em> have been well studied however there is paucity of data of uncommon species including, <em>Stenotrophomonas maltophilia, Burkholderia spp., Sphingomonas paucimobilis</em> in our region. This study was thus designed to explore implication of antimicrobial resistance and associated determinants for the surge of such organisms.</div></div><div><h3>Material and methods</h3><div>Antimicrobial susceptibility profile of NFGNB isolates, recovered from flag positive blood culture bottles on BacT/ALERT3D system, identified by VITEK 2 compact system, over a period of one year at the department of Microbiology and risk factors associated with upsurge of common and uncommon NFGNB were also compared.</div></div><div><h3>Results</h3><div>A total of 133 NFGNB isolates were recovered from bacteraemia patients. Among common NFGNB, <em>Acinetobacter baumannii</em> (34.6 %) was commonest followed by <em>Pseudomonas aeruginosa</em> (15 %). While among uncommon NFGNB <em>Acinetobacter non baumannii spp.</em> of <em>Acinetobacter baumannii complex</em> were most prevalent (15 %) followed by <em>Burkholderia cepacia complex</em> (10.5 %) and <em>Sphingomonas paucimobilis</em> (8.2 %). Eighty percent of isolates were MDR and association of uncommon NFGNB surge was observed to be associated with risk factors like hospital acquired infection, recent broad spectrum antimicrobial exposure, primary bacteraemia and catheter related infection <em>(p &lt; 0.05).</em></div></div><div><h3>Conclusion</h3><div>Bacteraemia due to MDR NFGNB is an alarming therapeutic management challenge as empirical treatment is not effective especially for uncommon NFGNB.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101046"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the myth of contamination: Early identification of MDR Corynebacterium striatum using MALDI-TOF in a neutropenic patient","authors":"Haripriya Bansal (Dr) ,&nbsp;Vivek Hada (Dr) ,&nbsp;Parmod Kumar (Dr) ,&nbsp;Anirban Kumir (Dr) ,&nbsp;Adarsh Patil (Dr) ,&nbsp;Vibhor Tak (Dr) ,&nbsp;Kumar Abhishek (Dr) ,&nbsp;Kuntal Kumar Sinha (Dr)","doi":"10.1016/j.ijmmb.2026.101077","DOIUrl":"10.1016/j.ijmmb.2026.101077","url":null,"abstract":"<div><div><em>Corynebacterium striatum</em> is a gram-positive curved bacilli included in “diphtheroids”. It is now being reported as a significant multidrug resistant nosocomial pathogen in immunocompromised patients. We describe a case of Catheter-related bloodstream infection caused by <em>Corynebacterium striatum</em> in an 86-year-old patient suffering from Acute Myeloid leukaemia. Rapid MALDI-TOF MS based identification of paired blood culture isolates confirmed true CRBSI. Prompt catheter removal and vancomycin therapy led to recovery. This case underscores the significance of MDR <em>Corynebacterium striatum</em> in oncology settings. It further emphasizes the need to identify and test for antimicrobial susceptibility of diphtheroids.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101077"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplex pneumonia panel for diagnosis of critically ill pneumonia patients in a tertiary care setting: A retrospective study","authors":"Sonya Joy ,&nbsp;Neethu Susan Philip ,&nbsp;Neetha Soma John","doi":"10.1016/j.ijmmb.2026.101066","DOIUrl":"10.1016/j.ijmmb.2026.101066","url":null,"abstract":"<div><h3>Purpose</h3><div>Acute respiratory infections (ARIs) are a major global health concern, causing over 4 million deaths annually, particularly in developing countries. Traditional diagnostic methods, such as microbial culture, are slow, leading to delayed treatment and increased antimicrobial resistance (AMR). This study evaluates the BIOFIRE Pneumonia Plus panel, a multiplex PCR-based assay, for detecting bacterial and viral pathogens and AMR genes in bronchoalveolar lavage (BAL) specimens.</div></div><div><h3>Methods</h3><div>A method-comparison study was conducted in a tertiary care setting using identified clinical data over one year. BAL specimens were analyzed using the BIOFIRE Pneumonia Plus panel and standard culture, and their results and turnaround times were compared.</div></div><div><h3>Results</h3><div>Among 303 specimens, the BIOFIRE Pneumonia Plus panel detected pathogens in 70.3 % of cases, significantly outperforming standard culture (14.85 %). The most frequently identified bacteria were <em>Pseudomonas aeruginosa</em> (20.08 %), <em>Klebsiella pneumoniae</em> (17.15 %), and <em>Haemophilus influenzae</em> (16.31 %). The most common viruses detected were human rhinovirus/enterovirus (18.81 %) and influenza A (9.24 %). AMR genes were found in 24.09 % of cases, with CTX-M and NDM being the most prevalent. The BIOFIRE panel provided results in 2 h 35 min, compared to 56 h 46 min for standard culture.</div></div><div><h3>Conclusion</h3><div>The BIOFIRE Pneumonia Plus panel enables rapid and accurate pathogen detection, improving clinical decision-making and supporting antimicrobial stewardship. Despite limitations such as the detection of colonizers or non-viable microorganisms, it is a valuable tool for enhancing ARI diagnostics and guiding targeted therapy.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101066"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“In vitro evaluation of sulbactam combination therapies for Acinetobacter baumannii”","authors":"Karthick Kumar Vaitheeswaran ,&nbsp;Seema Sood ,&nbsp;Manish Soneja ,&nbsp;Animesh Ray ,&nbsp;Shivam Pandey ,&nbsp;Arti Kapil ,&nbsp;Naveet Wig","doi":"10.1016/j.ijmmb.2026.101051","DOIUrl":"10.1016/j.ijmmb.2026.101051","url":null,"abstract":"<div><h3>Background and objectives</h3><div><em>Acinetobacter baumannii</em>, a leading cause of hospital-acquired infections in critically ill patients, is increasingly resistant to carbapenems, leading WHO to designate carbapenem-resistant <em>Acinetobacter baumannii</em> (CRAB) as a critical priority pathogen. While the 2024 IDSA guidelines recommend sulbactam-based regimens as the cornerstone of therapy, high-dose sulbactam is effective only against isolates with MICs up to 16–32 μg/mL. This study aimed to describe the sulbactam MIC distribution and to evaluate MIC reduction and synergy when combined with β-lactam antibiotics against CRAB.</div></div><div><h3>Methods</h3><div>CRAB isolates from respiratory samples of ventilator-associated pneumonia patients were tested using E-tests to determine MICs of individual antibiotics. Combinations of sulbactam with ceftriaxone, cefepime, and meropenem were assessed using the E-test cross method. Synergy was evaluated by the FIC index: synergy (≤0.5), additive (&gt;0.5–1), indifference (&gt;1–&lt;4), and antagonism (≥4).</div></div><div><h3>Results</h3><div>Thirty-five non-duplicate CRAB isolates were tested. All isolates were resistant to ceftriaxone, cefepime, and meropenem when tested individually, with MICs exceeding E-test detection limits. Hence, although sulbactam combinations significantly reduced MICs, the resulting values often remained above CLSI-defined susceptibility breakpoints.</div><div>Notably, sulbactam alone showed an MIC₅₀ of 12 μg/mL and an MIC₉₀ of 24 μg/mL. In combination, sulbactam MIC₅₀/MIC₉₀ values were reduced to 8/24 μg/mL with ceftriaxone, 6/16 μg/mL with cefepime, and 8/24 μg/mL with meropenem.</div><div>Sulbactam–cefepime showed the highest synergy (11.43 %) and additive effects (34.29 %), followed by sulbactam–ceftriaxone (2.86 % synergy; 31.43 % additive). Sulbactam–meropenem showed no synergy but 31.43 % additive effects. No antagonism was observed with any combination.</div></div><div><h3>Conclusion</h3><div>Combining sulbactam with β-lactams, particularly cefepime, significantly reduced sulbactam MICs. However, the β-lactam MICs themselves remained largely within not-susceptible ranges, highlighting that the observed benefit was confined primarily to sulbactam rather than the companion β-lactams. These findings supported further clinical studies of high-dose sulbactam–β-lactam combinations to optimize the pharmacodynamic efficacy of sulbactam against CRAB strains with elevated MICs.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101051"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaeoacremonium junior phaeohyphomycosis: A case report of the first human infection","authors":"G. Vithiya ,&nbsp;M. Srividhya ,&nbsp;T. Rajendran ,&nbsp;Supriya Sahu ,&nbsp;Diptanu Paul ,&nbsp;Madhucchanda Das ,&nbsp;Shivaprakash M. Rudramurthy ,&nbsp;Vinaykumar Hallur","doi":"10.1016/j.ijmmb.2026.101043","DOIUrl":"10.1016/j.ijmmb.2026.101043","url":null,"abstract":"<div><div><em>Phaeoacremonium junior</em> is a rare dematiaceous fungus found in woody plants, grapevine, and fruit trees. We report the first case of human infection with <em>Phaeoacremonium junior</em> who presented with a subcutaneous cyst after a thorn prick. Identification was done by sequencing the partial beta-tubulin and partial actin genes and their multigene phylogeny.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101043"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}