Indian Journal of Clinical Biochemistry最新文献

{"title":"Short-Chain Fatty Acids Ameliorates Lipid Profile, Oxidative Stress and Inflammation in Letrozole Induced Polycystic Ovary Syndrome Rat Model.","authors":"Ashwitha Acharya, Prasanna Kumar Shetty, Shipra Sonkusare, Roopashree Padmanabha Ganeshkodi, Suhasini Padarthi Chitrabanu, Ranjitha Acharya, Harshitha Somanatha, Deepthi Derappajjanamane, Suchetha Kumari Nalilu","doi":"10.1007/s12291-024-01273-1","DOIUrl":"10.1007/s12291-024-01273-1","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is one of the most common metabolic-reproductive disorders affecting reproductive-age women, causing an irregular menstrual cycle, hyperandrogenism, and polycystic ovarian morphology. Current therapies for PCOS focus on the management of symptoms. Short-chain fatty acids (SCFAs) play a significant role in PCOS by influencing the gut microbiota composition and metabolic pathways. The impact of short-chain fatty acids (SCFAs) on lipid profiles, inflammatory markers, and oxidative stress parameters in the PCOS model remains unclear. The present study aimed to elucidate the effect of SCFA on lipid profile, oxidative stress parameters, and inflammation in a high-fat diet-fed letrozole-induced PCOS model. 48 Female albino Wistar rats were randomised to 8 group (n = 6). The groups were treated with letrozole to induce PCOS and then treated with sodium acetate (SA), sodium propionate (SP), sodium butyrate (SB), and SCFA (3:1:1) mixture. This study observed a significant distortion in lipid profile, oxidative stress parameters and inflammatory markers. Our data showed, PCOS model showed elevated levels of triglycerides and very-low-density lipoprotein, which were significantly ameliorated when treated with SCFA (3:1:1), SA, SP, and SB. SP, SB, and SCFA (3:1:1) significantly lowered total cholesterol, while only SB and SCFA (3:1:1) significantly lowered low-density lipoprotein-cholesterol. Elevated high-density lipoprotein-cholesterol was observed in the SA, SB, and SCFA (3:1:1) treated group. The malondialdehyde level was lowered in the SCFA-treated groups, whereas the total antioxidant capacity, superoxide dismutase, and glutathione level was elevated. Our data showed a significant reduction in IL-6, IL-1β levels in the PCOS-induced group treated with SA, SP, SB, and SCFA (3:1:1). The findings of the present study suggest that short-chain fatty acids restructure dyslipidemia, oxidative stress and inflammation in a PCOS-induced model, highlighting their possible role as therapeutic dietary supplements in alleviating PCOS.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"588-597"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Paradigms in Understanding Neuron Fluctuations, Factors, Regulation, Pathophysiology of Epilepsy: Advancements in Diagnosis, Treatment and Management-An Update.","authors":"Pooja Sharma, Payal Gupta, Anita Rani Gill, Sunil Kumar, Pawan Kumar, Paavan Singhal, Mahiti Gupta, Raj Singh, Varruchi Sharma, Sharun Khan, Kuldeep Dhama, Ajay Sharma, Seema Ramniwas, Ravi Kant Sharma, Anil K Sharma","doi":"10.1007/s12291-024-01281-1","DOIUrl":"10.1007/s12291-024-01281-1","url":null,"abstract":"<p><p>Epilepsy has been attributed to be a most common universal brain neurological disorder afflicting more than 50 million people globally. Neural network is known to be hyperexcitable and hypersynchronous which ultimately result in seizures. Bibliographic databases for peer reviewed journals were searched for key words like epilepsy, seizures, neurological disorders, gut microbiota brain axis, antiepileptic phytomedicines and diagnostic tools. Current review brings forth the putative mechanism to understand the etiological and other vital factors during epileptic seizures and further advancements in the management of the epilepsy along with the role of gut microbiota and herbal medicines in the management of epilepsy. Modern strategies adopted for epilepsy diagnosis and therapeutic treatment methods would certainly pave a way for the neuroscientists to formulate a strategy for comprehensive assessment of epilepsy patients and finding a sustainable cure for the disease through basic and translational research.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"482-504"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Oxidative Stress Levels in Women with Different Phenotypes of Polycystic Ovary Syndrome and its Correlation with Lipid and Hormonal Profile.","authors":"Mandeep Kaur, Sukhjashanpreet Singh, Archana Beri, Anupam Kaur","doi":"10.1007/s12291-024-01265-1","DOIUrl":"10.1007/s12291-024-01265-1","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder and one of the leading causes of infertility in women. The hallmarks of PCOS include polycystic ovaries, hyperandrogenism, and anovulation. Oxidative stress (OS) is blamed to be an intriguing factor in developing metabolic syndromes. The present study recruited 141 PCOS cases, and 137 control women to determine serum OS levels and their correlation with lipid and hormonal profile. Student's t-test, chi-square, Pearson correlation, multiple comparison analysis, and receiver operating characteristic (ROC) curve were used to calculate the significance of the study. PCOS women had significantly increased levels of triglycerides, VLDL, total testosterone, LH, MDA, TOS, and OSI (<i>p</i> < 0.05). Levels of TAC were significantly lower in cases and showed a negative correlation with lipid profile, WHR, and total testosterone, while LH had a positive correlation. A positive correlation of MDA, TOS, and OSI levels was observed with BMI, WHR, hyperandrogenism, and lipid profile. Among all 4 phenotypes of PCOS, phenotype C had the lowest OS, followed by phenotype D and then phenotypes A and B. The ROC curve demonstrated that MDA had statistically significant diagnostic efficiency with the cut-off value of 2.9 umol/L (<i>p</i> < 0.05). The present study concluded that PCOS women with ovulatory dysfunction had more OS, indicating the role of OS in anovulation. Hyperandrogenism, obesity, and dyslipidemia were significantly correlated with increased OS and reduced antioxidant levels, revealing the relationship between clinical features of PCOS and OS.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"556-565"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of OncoMir Biomarkers: Comprehensive Analysis of Fatty Acid Pathway Genes in Colorectal Cancer Progression and Their Prognostic Implications.","authors":"Andisheh Oroujalian, Maryam Keshani, Farnoush Panahi, Mohadeseh Esmaeili, Zahra Koveitypour, Shahrzad Tabrizchi, Hamed Akbari, Mina Amiri, Maryam Esmaeili, Maryam Peymani, Farzad Seyed Forootan, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi","doi":"10.1007/s12291-024-01261-5","DOIUrl":"10.1007/s12291-024-01261-5","url":null,"abstract":"<p><p>MicroRNAs play a pivotal role in driving colorectal cancer (CRC) progression through their influence on gene expression. In this study, we conducted a comprehensive analysis of gene expression profiles in CRC cell lines, focusing on the genes involved in the fatty acid pathway and their associated microRNAs. Our analysis unveiled a consistent pattern of decreased expression for miR-16-5p, miR-195-5p, miR-27a-3p, and miR-497-5p across all CRC cell lines studied. Intriguingly, the targeted genes showed a contrasting trend, with increased expression levels. To reinforce our findings, we conducted a comparative analysis with The Cancer Genome Atlas database, which corroborated our results. Notably, we found a strong association between high expression levels of PPARD and VEGFA and a shorter Disease-Free Survival (DFS) in CRC patients. Conversely, elevated expression of PPARGC1A was linked to better overall survival outcomes. These findings underscore the significant impact of microRNAs on the regulation of gene expression in colorectal cancer and highlight potential biomarkers for assessing disease progression and patient outcomes.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-024-01261-5.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"519-532"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Quality Enhancement in Clinical Diagnostic Laboratories Through Lean and Six Sigma Methodologies: A Narrative Review.","authors":"Mohini Rathore, Amandeep Birdi, Snigdha Singh, Sojit Tomo, Mithu Banerjee, Dharmveer Yadav, Praveen Sharma","doi":"10.1007/s12291-025-01303-6","DOIUrl":"10.1007/s12291-025-01303-6","url":null,"abstract":"<p><p>Since long laboratories have been burdened heavily with the pressure of producing correct and timely reports. For the benefit of patients and doctors, it is imperative to emphasize the quality of results provided. Even with best practices adopted, one cannot ignore the possibility of errors that exist in the laboratory in the pre-examination, examination and post-examination phase. Error quantification can be done in variety of ways using quality indicators. Six sigma is one of these methods, classifying performance parameters as outstanding, excellent, good and poor in terms of defects per million opportunities in the pre- and post-examination phases and a sigma score with the help of bias%, CV% and total allowable error in the examination phase. The novelty of using lean Six sigma in laboratories is in its specific adaption to deal with the special difficulties and demands of laboratory settings along with more rapid and precise diagnostic results, thereby enhancing patient care and satisfaction. As optimistic as it sounds, there are obstacles associated with implementing lean six sigma also. Clinical laboratories frequently find it difficult to commit the capital and staff required for extensive six sigma projects. Thus precise measurements and benchmarks to assess the success of changes that have been put into place are some of the challenges that cannot be overlooked. Once accomplished, though, its advantage is undeniable. We have endeavored to evaluate lean six sigma at all three stages pre- examination, examination and post examination, discussing their challenges and providing guidance to others through a range of case studies.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"505-518"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"hsa-miR-885-5p As Post Transcription Regulator of Matrix metalloproteinase 9 in Tuberculous Meningitis.","authors":"Apoorva Aggarwal, Neeraj Singla, Monidipa Konar, Maninder Kaur, Kusum Sharma, Kajal Jain, Manish Modi, Sadhna Sharma","doi":"10.1007/s12291-024-01275-z","DOIUrl":"10.1007/s12291-024-01275-z","url":null,"abstract":"<p><p>Matrix metalloproteinase 9 (MMP9) has a potent role in neuroinflammation in tuberculous meningitis (TBM). Recent researches have highlighted the regulation of MMP9 levels by microRNAs, thereby altering their level and affecting critical functions, such as blood-brain barrier integrity. In this study, the activity of MMP9 was assessed by gelatin zymography, and the expression of hsa-miR-885-5p was evaluated by qRT-PCR in the cerebrospinal fluid (CSF) of TBM patients and healthy controls (HC). MMP9 expression was observed in the CSF of TBM patients only and none in HC. Additionally, hsa-miR-885-5p expression was significantly downregulated in TBM patients compared to healthy controls. These findings suggest that the dysregulation of hsa-miR-885-5p may lead to altered MMP9 levels in TBM patients, contributing to neuroinflammation. Therefore, targeting these microRNAs could serve as a new treatment modality to combat neuroinflammation in TBM patients.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"633-638"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional Scenario of Altered Glycosylation in HPV-Associated Cervical Cancer.","authors":"Ashi R Thobias, Kinjal A Patel, Kruti A Mehta, Bijal M Patel, Jayendra B Patel, Prabhudas S Patel","doi":"10.1007/s12291-024-01280-2","DOIUrl":"10.1007/s12291-024-01280-2","url":null,"abstract":"<p><p>Cervical cancer is one of the leading malignancies in women in India, with a high mortality rate and no available targeted therapy. This is due to a dearth of understanding of the underlying mechanisms regulating cervical carcinogenesis and the distinguished behavioral patterns of HPV-associated carcinomas. This study aims to understand the associations of HPV infection and cervical cancer with aberrant glycosylation, which is an enabling factor for other hallmarks of cancer. DNA and RNA were isolated from biopsy samples of 92 CC patients. HPV 16 and 18 infection was detected by endpoint type-specific PCR. The RNA samples were processed for expression analysis of the HPV 16-E6, HPV 16-E7 and HPV 16-E2 oncogenes. Analysis of the expression of glycosylated transcripts was performed via qPCR. HPV infection was correlated with the transcript levels of ST3GAL3, ST6GAL1, FUT5 and FUT8. In HPV 16- and 18-positive patients, the transcript levels of ST3GAL3, ST6GAL1 and FUT5 were increased, whereas FUT8 transcript levels were decreased. These data depict hyperglycosylation patterns associated with HPV infection. HPV-associated cancers show downregulation of core fucosylation and upregulation of ST3GAL3, ST6GAL1 and FUT5. The behavioral pattern of HPV-associated cancer could be due to its differential association with altered glycosylation.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-024-01280-2.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"598-605"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Exposure to Lead Increases Inflammation that Causes Cardiovascular Disease and Lowers Selenium levels.","authors":"Nagham J Kadam, Nadhum A N Awad, Saad Shaheen Hamadi Al-Taher","doi":"10.1007/s12291-024-01271-3","DOIUrl":"10.1007/s12291-024-01271-3","url":null,"abstract":"<p><p>Lead is a hazardous heavy metal. It has serious health effects due to its unique physical and chemical properties. Lead poisoning can induce inflammatory signaling pathways and oxidative stress. This course decreases resistance to diseases and infections. This study investigates the risks of occupational exposure to Lead in petroleum industry workers and its effect on the increase of high-sensitivity reactive protein (hs-CRP), which indicates an increased risk of heart disease. The study also investigated the antagonistic relationship between Lead and Selenium, as the latter is an important component of the antioxidant defense system. The study included two groups of males: the first group included ninety individuals working in oil well sites in Basrah, and the second group included ninety individuals who were not exposed. The results indicate high levels of toxic Lead, <i>P</i> ≥ 0.0001, and a significant increase in high-sensitivity C-reactive protein (hs-CRP), <i>P</i> ≥ 0.0001, in the worker's serum compared to the control group. In addition, there was a decrease in Selenium levels (<i>P</i> ≥ 0.001) in the worker's blood compared with the control group. High-sensitivity C-reactive protein (hs-CRP) was measured using a device (Finecare Plus, FS-112/FS-113/FS-205, Wondfo, China). Lead and Selenium levels were determined using an ICP-OES device (HORIBA Scientific, JY2000, France).</p><p><strong>Graphical abstract: </strong>Explaining the mechanism of lead toxicity.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-024-01271-3.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"626-632"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Test Providers to Diagnostic Stewards: Expanding the Role of Clinical Biochemists.","authors":"Prasenjit Mitra, Shruti Gupta, Praveen Sharma","doi":"10.1007/s12291-026-01437-1","DOIUrl":"10.1007/s12291-026-01437-1","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"479-481"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"hsa-miR-3529-5p through <i>F2RL3</i> Regulation as an Enhancer of Sensitivity to Cisplatin.","authors":"Nasibeh Sargazi Moghaddam, Baharak MohammadFakhim, Mohammad Sharifi, Atefeh Rajabian, Maryam Hariri, Mahmoud Khansari, Mohammad Saeed Soleimani Meigoli, Reza Morovatshoar, Sahar Hosseini, Niloufar Jafari Namini, Kamran Ghaedi, Nasrin Fattahi Doaltabadi","doi":"10.1007/s12291-024-01268-y","DOIUrl":"10.1007/s12291-024-01268-y","url":null,"abstract":"<p><p>The emergence of drug resistance in gastric cancer presents a critical challenge in oncological treatments, often leading to therapy failure and reduced patient survival. MicroRNAs (miRNAs) have been implicated in modulating drug resistance through various mechanisms, including altering the expression of genes involved in drug metabolism, DNA repair, and apoptosis. This study aimed to elucidate the role of miR-3529-5p in cisplatin resistance in gastric cancer by investigating its interaction with the gene F2RL3, which was identified as significantly overexpressed in cisplatin-resistant gastric cancer cells. Using RNA sequencing data and bioinformatics tools, differentially expressed genes (DEGs) were identified between cisplatin-resistant and sensitive cell lines, with F2RL3 emerging as a key gene overexpressed in resistant cells. The overexpression of miR-3529-5p using the pbud-egfb vector in AGS cells was conducted, followed by MTT assays to assess cell viability and resistance to cisplatin. qPCR was used to compare the expression of apoptosis-related genes between AGS/cis cells and AGS/miR-3529-5p/cis cells, while flow cytometry was employed to examine apoptosis levels. The results confirmed that increased miR-3529-5p expression leads to reduced F2RL3 levels, enhancing cell sensitivity to cisplatin. Cell viability assays showed a decrease in the IC50 of cisplatin in miR-3529-5p-overexpressing cells, indicating heightened drug sensitivity. Furthermore, gene expression analysis and apoptosis assays demonstrated that miR-3529-5p modulates apoptosis-related genes, promoting apoptosis in the presence of cisplatin. In conclusion, miR-3529-5p plays a significant role in reversing cisplatin resistance in gastric cancer by targeting F2RL3, suggesting its potential as a therapeutic target to enhance cisplatin efficacy in gastric cancer treatment.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"41 4","pages":"566-576"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}