Indian Journal of Clinical Biochemistry最新文献

Double Trouble: Unravelling the Health Hazards of Microplastics and Heavy Metals. 双重麻烦：解开微塑料和重金属对健康的危害。

IF 1.5

Indian Journal of Clinical Biochemistry Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI: 10.1007/s12291-024-01270-4

Prasenjit Mitra, Shruti Gupta, Praveen Sharma

引用次数: 0

Study of Glabranin as an Inhibitor Against Prostate Cancer: Molecular Docking, Molecular Dynamics Simulation, MM-PBSA Calculation and QSAR Prediction. Glabranin作为前列腺癌抑制剂的研究:分子对接、分子动力学模拟、MM-PBSA计算和QSAR预测

IF 1.5

Indian Journal of Clinical Biochemistry Pub Date : 2024-07-01 Epub Date: 2023-04-01 DOI: 10.1007/s12291-023-01134-3

Rene Barbie Browne, Nabajyoti Goswami, Probodh Borah, Jayanti Datta Roy

{"title":"Study of Glabranin as an Inhibitor Against Prostate Cancer: Molecular Docking, Molecular Dynamics Simulation, MM-PBSA Calculation and QSAR Prediction.","authors":"Rene Barbie Browne, Nabajyoti Goswami, Probodh Borah, Jayanti Datta Roy","doi":"10.1007/s12291-023-01134-3","DOIUrl":"10.1007/s12291-023-01134-3","url":null,"abstract":"Prostate cancer is the World's second most frequent malignancy, with the fifth-highest male mortality rate. In advanced prostate cancer patients, point mutations such as T877A and W741L are prevalent, imparting treatment resistance and hence promoting cancer development. The emergence of drug resistance in prostate cancer necessitates the development of suitable ligands to allow for stronger interactions with the receptors, which can inhibit cancer progression. The present study focuses on flavonoids produced by plants, which may act as inhibitors of point mutations like T877A and W741L in prostate cancer. This research was conducted using an in-silico method where the compound Glabranin and its derivatives were virtually screened to identify potential drugs for combating such point mutations. Thirty-five Molecular Dockings were performed to find the ligand-receptor complexes with the lowest binding energy. Moreover, employing a variety of tools, ligands were evaluated for drug-likeness and toxicity, indicating a promising drug candidate. Based on the results of Molecular Docking, Drug-likeness, and ADMET testing, eight structures were subjected to a 100 ns Molecular Dynamics simulation. A QSAR analysis was also performed based on the simulation findings. In this study, it was revealed that GlaMod2 phytocompound was effective against T877A and W741L mutations in prostate cancer. It was observed that the phytocompound was stable and had potential properties for the development of a novel drug to combat prostate cancer and drug resistance This phytocompound may therefore be effective in the development of prostate cancer inhibitors for patients with mutant androgen receptors.Graphical abstract: Supplementary information: The online version contains supplementary material available at 10.1007/s12291-023-01134-3.","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"262 1","pages":"331-343"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82971789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Perspectives on Selenium and Selenoproteins in Cardiomyopathy. 心肌病中硒和硒蛋白的新视角。

IF 1.5

Indian Journal of Clinical Biochemistry Pub Date : 2024-07-01 Epub Date: 2024-06-26 DOI: 10.1007/s12291-024-01246-4

Rajendra Prasad, Sonia Deswal, Munish Kumar

引用次数: 0

The Hepatocurative Effects of Zanthoxylum zanthoxyloides Alkaloids on Tetrachloromethane-Induced Hepatotoxicity on Albino Rats. Zanthoxylum zanthoxyloides 生物碱对四氯甲烷诱导的白化大鼠肝毒性的杀肝作用

IF 2.1

Indian Journal of Clinical Biochemistry Pub Date : 2024-04-01 Epub Date: 2022-11-12 DOI: 10.1007/s12291-022-01095-z

Thecla Okeahunwa Ayoka, Ngwu Nwachukwu, Aloysius Chinedu Ene, Chidi Uzoma Igwe, Charles Okeke Nnadi

{"title":"The Hepatocurative Effects of Zanthoxylum zanthoxyloides Alkaloids on Tetrachloromethane-Induced Hepatotoxicity on Albino Rats.","authors":"Thecla Okeahunwa Ayoka, Ngwu Nwachukwu, Aloysius Chinedu Ene, Chidi Uzoma Igwe, Charles Okeke Nnadi","doi":"10.1007/s12291-022-01095-z","DOIUrl":"https://doi.org/10.1007/s12291-022-01095-z","url":null,"abstract":"The study investigated the hepatocurative activity of the bulk alkaloids of Zanthoxylum zanthoxyloides in a tetrachloromethane (CCl4)-induced hepatotoxicity model in rats. The hepatocurative activity of the alkaloids at 200, 400 and 600 mg/kg doses was demonstrated by the assay of both enzymic and non-enzymic parameters. Sections of the liver were also subjected to histological examinations. Mapping techniques and data visualization approaches were adopted in finding relationships between the enzymic and non-enzymic parameters and the treatment groups. The bulk alkaloids caused dose-dependent effects on both the enzymic and non-enzymic parameters. The bulk alkaloids elicited a significant reduction (p < 0.05) in all liver and antioxidant enzymes activities compared with the untreated. The 600 mg/kg dose caused the restoration of the ALP, ALT and AST to 76.16, 10.72 and 11.83 iU/L respectively similar to the standard butylated hydroxytoluene. The 600 mg/kg dose also caused a slight increase in the activities of SOD, catalase and GPx to 11.45. 1.37 and 11.66 iU/L respectively when compared with the untreated rats. In the non-enzymic assays, the 600 mg/kg dose elicited a significant (p < 0.05) upregulation in the total bilirubin (1.18 mg/100 mL), total protein (3.75 g/dL), HDL (1.80 mMol/L) and vitamin C (2.41 mg/dL) and decrease in the CHOL (3.35 g/dL), TAG (1.85 mMol/L), LDL (0.67 mMol/L), BUN (39.55 mg/dL) and MDA (1.13 nMol/mL) when compared with the untreated rats. The restoration of the natural histo-architecture of the CCl4-damaged liver by the alkaloids further evidenced the hepatocurative activity of the bulk alkaloids.","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"39 2","pages":"188-196"},"PeriodicalIF":2.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic Evolution in Fabry Disease: Our Experience in Indian Cohort 法布里病的表型演变：我们在印度队列中的经验

IF 2.1

Indian Journal of Clinical Biochemistry Pub Date : 2024-01-10 DOI: 10.1007/s12291-023-01176-7

Usha Dave, Srilatha Kadali, Tajamul Hussain, Ananthaneni Radhika, Sagar Patel, Nirav Patel, S. Naushad

引用次数: 0

miR-335-5p Inhibits EMT and PI3K/AKT Pathways via MARCH8 miR-335-5p 通过 MARCH8 抑制 EMT 和 PI3K/AKT 通路

IF 2.1

Indian Journal of Clinical Biochemistry Pub Date : 2024-01-08 DOI: 10.1007/s12291-023-01175-8

Arjumand Bano, Geetika Suyal, A. Saraya, Rinu Sharma

引用次数: 0

Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy 抗癌 T 细胞的代谢重编程：以 AMPK 和 PPAR 为靶点优化癌症免疫疗法

IF 2.1

Indian Journal of Clinical Biochemistry Pub Date : 2024-01-08 DOI: 10.1007/s12291-023-01166-9

Abdul Jalil, Hassan Hadi Al-Kazzaz, Firas A. Hassan, Safaa Halool Mohammed, M. Merza, Tahani Aslandook, Ahmed Elewadi, Ali Fadhil, Ali Alsalamy

引用次数: 0

Role of Supply Chain Management in Clinical Laboratory 供应链管理在临床实验室中的作用

IF 2.1

Indian Journal of Clinical Biochemistry Pub Date : 2023-12-28 DOI: 10.1007/s12291-023-01178-5

Dr Prasenjit Mitra, Shruti Gupta, Praveen Sharma

引用次数: 0

Effects of Dietary Zinc Deficiency and Supplementation on Prepubertal Rat Testes: Sulfhydryl and Antioxidant Status 膳食缺锌和补锌对青春期前大鼠睾丸的影响：巯基和抗氧化状态

IF 2.1

Indian Journal of Clinical Biochemistry Pub Date : 2023-12-28 DOI: 10.1007/s12291-023-01167-8

D. Kumari, N. Nair, R. Bedwal

引用次数: 0

Effect of Junk Food on Hormonal and Metabolic Manifestations in Polycystic Ovarian Syndrome Phenotypes: A Case–Control Study of Kashmiri Population 垃圾食品对多囊卵巢综合征表型的荷尔蒙和代谢表现的影响：克什米尔人群的病例对照研究

IF 2.1

Indian Journal of Clinical Biochemistry Pub Date : 2023-12-24 DOI: 10.1007/s12291-023-01169-6

Khairatul Nisa, Najeebul Tarfeen, S. Mir, Zulaykha Khurshid, Mir Bilal Ahmad, Saba Wani, Humaira Bhat, B. Ganai

引用次数: 0