Indian Journal of Clinical Biochemistry最新文献

{"title":"Exploring the Associations of Maternal and Neonatal <i>eNOS</i> Gene Variant rs2070744 with Nitric Oxide Levels, Oxidative Stress and Adverse Outcomes in Preeclampsia: A Study in the Bangladeshi Population.","authors":"Sonia Tamanna, Taslimul Jannat, Shrabanti Devi, Zimam Mahmud, Mohammad Shakil Mahmood, Mir Fahim Faisal, Akramul Hasan, Md Zakir Hossain Howlader","doi":"10.1007/s12291-024-01264-2","DOIUrl":"https://doi.org/10.1007/s12291-024-01264-2","url":null,"abstract":"<p><p>Research has shown that endothelial dysfunction due to low nitric oxide (NO) bioavailability is one of the primary causes of preeclampsia (PE). Variations in the <i>eNOS</i> gene may be implicated in reducing NO levels. This study examined the relationship between <i>eNOS</i> gene variations and NO and malondialdehyde (MDA) levels in preeclamptic women and their neonates in Bangladesh. This study compared 100 healthy pregnant women (controls) with 82 preeclampsia-diagnosed women and their newborns. PCR-RFLP was used to detect eNOS gene variants, while spectrophotometric methods were used to measure NO and MDA levels in plasma. The maternal <i>eNOS</i> gene variant rs2070744 exhibited a significant relationship with PE risk, particularly under the dominant model and allele frequency scrutiny. Similarly, the neonatal <i>eNOS</i> gene variant rs2070744 exhibited a robust association with PE risk across various genetic models. The case‒control comparison of the genotypic distribution of NO and MDA in the studied subjects revealed that although PE mothers with TT genotypes had significantly lower NO levels than did the controls, the neonates of PE mothers with TT and CC genotypes showed a significant decrease in NO levels compared to their control groups. Moreover, the PE group and their neonates with the TT and CT genotypes had significantly greater MDA levels than did the control group. These findings illuminate the profound influence of <i>eNOS</i> gene variants on preeclampsia onset, suggesting a potential mechanism involving altered NO production via heightened oxidative stress among affected mothers and neonates. Consequently, screening for eNOS variants and estimating NO levels in pregnant women could offer early identification of those predisposed to PE, thus enabling timely interventions.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-024-01264-2.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 3","pages":"479-487"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Methylenetetrahydrofoate Reductase Gene C677T Polymorphism and Susceptibility to Polycystic Ovary Syndrome.","authors":"Vandana Rai, Pradeep Kumar","doi":"10.1007/s12291-024-01200-4","DOIUrl":"https://doi.org/10.1007/s12291-024-01200-4","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is the most common form of endocrinopathy of women. Several studies have investigated the association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with PCOS risk but the results are contradictory. So, the aim of the present study was to carry out a meta-analysis of a published case control studies to find out exact association between MTHFR gene C677T polymorphism and PCOS susceptibility. Pubmed, Springer link, Science Direct and Google Scholar databases were searched for case-control studies. Odds ratios (ORs) with 95% confidence intervals (CIs) was used as association measure and meta-analysis was performed using MIX and MetaAnalyst programs. Meta-analysis of 24 studies showed strong significant association between C677T polymorphism and PCOS risk (OR: T vs. C = 1.18, 95% CI 1.01-1.38, <i>p</i> = 0.03; OR: TT vs. CC = 1.37, 95% CI 1.0-1.89, <i>p</i> = 0.04; OR: TT + CT vs. CC = 1.31, 95% CI 1.07-1.62, <i>p</i> = 0.008; OR: CT vs. CC = 1.31, 95% CI 1.04-1.62, <i>p</i> = 0.02 and OR: TT vs. CT + CC = 1.10, 95% CI = 0.82-1.47, <i>p</i> = 0.04). In subgroup analysis, MTHFR C677T polymorphism is significantly associated with PCOS risk with Asian individuals but in Caucasian population MTHFR C677T polymorphism was not significantly associated with PCOS risk. In conclusion, C677T polymorphism is a risk factor for PCOS.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 3","pages":"382-391"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of D-Mannoheptulose and Doxorubicin as Potential Therapeutic Agents for Breast Cancer by Targeting Glycolysis and Inducing Apoptosis.","authors":"Ahmed Ghdhban Al-Ziaydi","doi":"10.1007/s12291-024-01266-0","DOIUrl":"https://doi.org/10.1007/s12291-024-01266-0","url":null,"abstract":"<p><p>Cell culture techniques are the vital basis for the majority of experimental cancer research. Targeting cancer cells metabolism is one of the key strategies for controlling the growth of cancer cells. D-Mannoheptulose (MH) (as Phytotherapy) a specific inhibitor, belonging to hexokinase category, to inhibit glycolysis pathway and Doxorubicin (DXR) (as Chemotherapy) has cytotoxic activity against cancer cells and anti-cancer effects by inducing apoptosis. Evaluating the effect of D-Mannoheptulose and Doxorubicin on the normal and breast cancer cell line by determining their anti-tumor activities. Cell culture of normal human mammary epithelial cells (HMECs) and MCF-7 cell line were achieved by using Minimum Essential Medium (MEM) and RPMI-1640 Medium. D-Mannoheptulose, and Doxorubicin stock and diluted solutions were prepared by using phosphate buffer saline (PBS), and dimethyl sulphoxide (DMSO) respectively. HMECs and MCF7 cell line were treated with MH, and DXR, cytotoxicity ratio was determined by methyl thiazolyl tetrazolium (MTT). The findings of study indicated a substantial increase in the cytotoxicity and antiproliferative effects of MH and DXR depending on the concentration gradient against breast cancer cell lines and IC50 values, while on the other hand, there was no significant cytotoxic effect on normal cells. Results of the study revealed that MH, DXR, can result in inhibiting the growth of breast cancer cell lines. This behaviour was mainly due to the increase in cytotoxicity through inhibiting the glycolysis pathway thereby resulting in apoptosis. This further lead to the decrease in HK activity and hence pyruvate as well as ATP amount. Overall, DXR and MH treatment display effective cytotoxic effects against the studied breast cancer cell lines.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 3","pages":"412-421"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms.","authors":"Yasser Fakri Mustafa, Ayman Faris Faisal, Marwa Mohammed Alshaher, Duha Adnan Hassan","doi":"10.1007/s12291-024-01297-7","DOIUrl":"https://doi.org/10.1007/s12291-024-01297-7","url":null,"abstract":"<p><p>Aging is an inevitable, multifaceted biological process characterized by the progressive decline of physiological functions, ultimately leading to increased susceptibility to chronic diseases and mortality. A combination of genetic, lifestyle, and environmental factors, including dietary habits, exposure to pollutants, and ultraviolet radiation, influence this natural phenomenon. The consequences of aging manifest as various health complications, such as cardiovascular diseases, Type 2 diabetes, neurodegenerative disorders, malignancies, and visible signs like dermal dryness and wrinkles. An imbalance between the body's antioxidant defenses and the production of reactive oxygen and nitrogen species leads to oxidative stress, which is a key part of the aging process. This imbalance induces cellular damage, apoptosis, and tissue dysfunction, accelerating age-related decline. Antioxidants, both endogenous and exogenous, play a pivotal role in mitigating oxidative stress by scavenging harmful free radicals. Micronutrients from food, such as certain vitamins, minerals, and phytochemicals, have gotten a lot of attention as exogenous antioxidants that may slow down or fix age-related problems. This review synthesizes findings from comprehensive literature searches on platforms such as PubMed, Scopus, Web of Science, and Google Scholar, encompassing studies published between 2018 and mid-2024. It looks into the biochemical roles and cell mechanisms that these micronutrients use to fight oxidative stress and support healthy aging. Micronutrients that are high in antioxidants, like vitamins A, C, and E; essential trace minerals, like zinc, copper, and selenium; and phytochemicals, like flavonoids, curcumin, and resveratrol, can help restore the body's oxidative balance. But, even though they seem to have good effects, there isn't enough solid scientific evidence to support the use of these micronutrients as anti-aging agents on their own. This review talks about how eating antioxidant-rich foods every day might be a safer and more long-lasting way to help people live longer and lessen the effects of age-related problems.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 3","pages":"322-338"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<b>Laboratory Medicine and Sustainability: A Call To Action</b>.","authors":"Prasenjit Mitra, Shruti Gupta, Praveen Sharma","doi":"10.1007/s12291-025-01328-x","DOIUrl":"https://doi.org/10.1007/s12291-025-01328-x","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 3","pages":"319-321"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Cisplatin Delivery via Liposomal Nanoparticles for Oral Cancer Treatment.","authors":"Parizad Ghanbarikondori, Razieh Bagheri Shahzadeh Aliakbari, Elham Saberian, Andrej Jenča, Adriána Petrášová, Janka Jenčová, Azim Akbarzadeh Khayavi","doi":"10.1007/s12291-024-01239-3","DOIUrl":"10.1007/s12291-024-01239-3","url":null,"abstract":"<p><p>Investigating the impact of liposomal Cisplatin on oral cancer cell line seeks to optimize drug delivery efficiency, decrease systemic toxicity, and amplify cytotoxicity specifically against malignant cells. Cisplatin was encapsulated within liposomal nanoparticles through thin-film hydration and extrusion methodologies. The physical and chemical characteristics of the nanoparticles, including zeta potential, size, drug load, and polydispersity index (PDI), were examined to evaluate their properties. The release of the drug was studied in a simulated body fluid environment in vitro. The stability of the nanoparticles was evaluated over a period of 45 days under normal bodily conditions. Ultimately, the liposomal formulations' efficacy was assessed in comparison to free drugs through cell viability assays conducted on the human tongue squamous cell carcinoma cell line CAL 27. The liposomal nanoparticles developed exhibited a favorable size range of 170 nm, a zeta potential of - 30 mV, and a low PDI of under 0.19, demonstrating uniform particle sizes. The encapsulation efficiencies were about % 90, and the drug loading capacities were sufficient. The in vitro release profiles displayed a sustained release pattern over 72 h. The liposomal formulations showed improved stability, with no notable changes in physicochemical properties throughout the study period. Cytotoxicity evaluations revealed that the liposomal Cisplatin formulation exhibited a remarkably higher cytotoxic effect on an oral cancer cell line relative to the unencapsulated drug. This research showcases the promise of liposomal formulations in optimizing the clinical efficacy of oral cancer treatments under superior drug delivery, diminished toxicity, and augmented cytotoxicity.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 2","pages":"211-217"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Healthcare in the Age of Artificial Intelligence: A New Era of Diagnostic Excellence in Laboratory Medicine.","authors":"Manoj Khokhar, Dharmveer Yadav, Praveen Sharma","doi":"10.1007/s12291-025-01315-2","DOIUrl":"10.1007/s12291-025-01315-2","url":null,"abstract":"","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 2","pages":"163-164"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Erythrocytes Methotrexate Polyglutamate Three Levels in Psoriatic Patients Treated with Methotrexate Monotherapy and Their Association with Disease Response.","authors":"Veera Krishna Goud, Alladi Charanraj Goud, Sivaranjini Ramassamy, M Jayanthi, R Medha, Laxmisha Chandrashekar","doi":"10.1007/s12291-024-01269-x","DOIUrl":"10.1007/s12291-024-01269-x","url":null,"abstract":"<p><p>Methotrexate is used to manage moderate to severe psoriasis and psoriatic arthritis. Methotrexate acts by inhibiting the enzymes involved in nucleotide synthesis. Methotrexate polyglutamates (MTXPGs) have a higher potency to inhibit Dihydrofolate reductase (DHFR), 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC), and thymidylate synthase (TS), compared to naïve methotrexate. Among all the MTXPGs, methotrexate polyglutamate three (MTXPG-3) is a more potent inhibitor of DHFR, ATIC, and TS enzymes. MTXPG-3 is anticipated to allow therapeutic drug monitoring in immune-mediated inflammatory diseases. We aim to study MTXPG-3 levels as a biomarker for both efficacy and adverse events among psoriatic patients treated with methotrexate monotherapy. We used the LC-MS/MS (Liquid Chromatography Mass Spectrophotometry) system for measuring erythrocyte MTXPG-3. We recruited 106 patients with psoriasis who were treated with methotrexate. Sixty-one of them had psoriatic arthritis (concomitant or in the past). The mean age was 45.08 ± 13.04 years. After twenty-four weeks of methotrexate treatment, 73(69%) were responders, and 33(31%) were non-responders. Thirty-nine (36%) experienced adverse effects, and 67(64%) did not experience any adverse effects. We observed a significant positive correlation between erythrocyte MTXPG-3 and methotrexate dose per week at weeks 12 and 16 but not at week 24. Erythrocyte MTXPG-3 did not correlate with response or adverse effects. It can be used as a marker of compliance.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-024-01269-x.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 1","pages":"89-96"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross Sectional Study of Vitamin D Levels in Western Rajasthan and Meta-Analysis for Estimation of Vitamin D Levels.","authors":"Surjit Singh, Divesh Jalan, Pankaj Bhardwaj, Praveen Sharma, Abhay Elhence","doi":"10.1007/s12291-022-01074-4","DOIUrl":"10.1007/s12291-022-01074-4","url":null,"abstract":"<p><p>Many studies showed Vitamin D deficiency is highly prevalent in healthy individuals. We planned to study the normal levels of Vitamin D in healthy individuals and make recommendation for defining deficiency of 25(OH)D in Indian population. <b>N</b>ormal healthy subjects 18 to 60 years of age were included. Estimation of serum calcium, serum phosphorus, iPTH and bone alkaline phosphatase levels with vitamin D (25(OH)D) levels were done to study the normal 25(OH)D levels and make recommendation for defining deficiency of 25(OH)D in Indian population. Meta-analysis was performed of studies which estimated the mean vitamin D levels in healthy individuals. There was significant positive correlation of serum 25(OH)D levels with calcium levels (r = 0.148; p-value = 0.003). The normal mean values of 25(OH)D levels in total population was 13.5 ± 7.83 ng/ml, iPTH was 59.8 ± 28.84 pg/ml, bone ALP was 14.6 ± 6.66 microg/ml. The normal upper bound of 25(OH)D in 97.5% of total population in our study is less than 33.19 ng/ml. The normal upper bound of iPTH and bone ALP in 97.5% of total population in our study was less than 123.97 pg/ml and 32.19 microg/ml, respectively. Pooled analysis of 33 studies revealed overall mean 25(OH)D levels in total population to be 13.95 ng/ml (95%CI - 12.37-15.54). The concept of initializing treatment based on serum Vitamin D levels using the RDA (20ng/ml) and EAR (16ng/ml) values as \"cutoff-points\" is not recommended as per Institute of Medicine Committee on Dietary Reference Intakes, Washington DC. Vitamin D levels less than 12.5ng/ml in a symptomatic individual should be the sole criteria for treatment rather than Vitamin D levels alone. <b>Trial Registration</b>: CTRI/2018/02/011820; CTRI/2018/02/011913.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"42 1","pages":"155-161"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80194074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulation of Hedgehog Interacting Protein (HHIP) in Gastric Cancer: Implications for Tumorigenesis.","authors":"Kulsum Akhtar, Gowhar Rashid, Tahseen Bilal Rather, Irfan Maqbool, Ishrat Parveiz, Gulzar Ahmad Bhat, Fazl Q Parray, Syed Besina Yasin, Syed Mudassar","doi":"10.1007/s12291-024-01293-x","DOIUrl":"10.1007/s12291-024-01293-x","url":null,"abstract":"<p><p>The increasing incidence of gastric cancer (GC) in the Kashmir Valley is concerning, but its root causes are largely unknown. Dysregulated activation of the Hedgehog signaling pathway has been linked to various cancers, and the Human Hedgehog Interacting Protein (HHIP), a tumor suppressor, is frequently dysregulated in malignancies. However, the expression of the HHIP gene in GC is inconsistent and poorly understood. This study aimed to examine HHIP gene expression in gastric cancer. We used methylation-specific PCR, Western Blot analysis, and quantitative reverse transcription PCR (qRT-PCR) to assess the hypermethylation and expression levels of HHIP gene promoters. The correlation between these results and clinical parameters (e.g. age, gender, histological type, class, stage, and lymph node metastasis) was studied with samples from 53 GC patients confirmed by histology. In 69.81% (37 out of 53) of the tumor tissue, HHIP hypermethylation was found. Of the 45 cases examined for mRNA expression, 53.33% (24 out of 45) showed a decrease in the HHIP mRNA level compared to the normal sample. In addition, 49.05% (26 out of 53) showed a decline in the expression of HHIP proteins. Almost all GC samples with reduced protein expression also showed a reduction in mRNA levels. These results suggest that the hypermethylation of the HHIP promoter leads to a decrease in the regulation of HHIP, which contributes to the activation of the hedgehog signal path and may play a critical role in the progress of GC. Our study highlights the significant link between HHIP hypermethylation and reduced gene expression at both mRNA and protein levels, suggesting that target HHIP gene methylation could be a promising treatment strategy for gastric cancer.</p>","PeriodicalId":13280,"journal":{"name":"Indian Journal of Clinical Biochemistry","volume":"40 1","pages":"46-58"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}