IEEE Transactions on NanoBioscience最新文献_第8页

A Molecular Communication Perspective on Synchronization of Coupled Microfluidic-Spectroscopy 微流控光谱耦合同步的分子通讯视角

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-04-02 DOI: 10.1109/TNB.2024.3384082

Xuewen Qian;Stefan Angerbauer;Malcolm Egan;Marco Di Renzo;Werner Haselmayr

{"title":"A Molecular Communication Perspective on Synchronization of Coupled Microfluidic-Spectroscopy","authors":"Xuewen Qian;Stefan Angerbauer;Malcolm Egan;Marco Di Renzo;Werner Haselmayr","doi":"10.1109/TNB.2024.3384082","DOIUrl":"10.1109/TNB.2024.3384082","url":null,"abstract":"A challenge for real-time monitoring of biochemical processes, such as cells, is detection of biologically relevant molecules. This is due to the fact that spectroscopy methods for detection may perturb the cellular environment. One approach to overcome this problem is coupled microfluidic-spectroscopy, where a microfluidic output channel is introduced in order to observe biologically relevant molecules. This approach allows for non-passive spectroscopy methods, such as mass spectrometry, to identify the structure of molecules released by the cell. Due to the non-negligible length of the microfluidic channel, when a sequence of stimuli are applied to a cell it is not straightforward to determine which spectroscopy samples correspond to a given stimulus. In this paper, we propose a solution to this problem by taking a molecular communication (MC) perspective on the coupled microfluidic-spectroscopy system. In particular, assignment of samples to a stimulus is viewed as a synchronization problem. We develop two new algorithms for synchronization in this context and carry out a detailed theoretical and numerical study of their performance. Our results show improvements over maximum-likelihood synchronization algorithms in terms of detection performance when there are uncertainties in the composition of the microfluidic channel.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"458-471"},"PeriodicalIF":3.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IEEE Transactions on NanoBioscience Publication Information 电气和电子工程师学会《纳米生物科学论文集》出版信息

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-28 DOI: 10.1109/TNB.2024.3378371

引用次数: 0

IEEE Transactions on NanoBioscience Information for Authors 电气和电子工程师学会《纳米生物科学学报》为作者提供的信息

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-28 DOI: 10.1109/TNB.2024.3378375

引用次数: 0

Production of Targeted Estrone Liposomes Using a Herringbone Micromixer 使用人字形微搅拌器生产靶向雌酮脂质体

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-26 DOI: 10.1109/TNB.2024.3382203

Mohamed Agam;Vinod Paul;Mohamed Abdelgawad;Ghaleb A. Husseini

{"title":"Production of Targeted Estrone Liposomes Using a Herringbone Micromixer","authors":"Mohamed Agam;Vinod Paul;Mohamed Abdelgawad;Ghaleb A. Husseini","doi":"10.1109/TNB.2024.3382203","DOIUrl":"10.1109/TNB.2024.3382203","url":null,"abstract":"Liposomes are spherical vesicles formed from bilayer lipid membranes that are extensively used in targeted drug delivery as nanocarriers to deliver therapeutic reagents to specific tissues and organs in the body. Recently, we have reported using estrone as an endogenous ligand on doxorubicin-encapsulating liposomes to target estrogen receptor (ER)-positive breast cancer cells. Estrone liposomes were synthesized using the thin-film hydration method, which is a long, arduous, and multistep process. Here, we report using a herringbone micromixer to synthesize estrone liposomes in a simple and rapid manner. A solvent stream containing the lipids was mixed with a stream of phosphate buffer saline (PBS) inside a microchannel integrated with herringbone-shaped ridges that enhanced the mixing of the two streams. The small scale involved enabled rapid solvent exchange and initiated the self-assembly of the lipids to form the required liposomes. The effect of different parameters on liposome size, such as the ratio between the flow rate of the solvent and the buffer solutions (FRR), total flow rate, lipid concentrations, and solvent type, were investigated. Using this commercially available chip, we obtained liposomes with a radius of 66.1 ± 11.2 nm (mean ± standard deviation) and a polydispersity of 22% in less than 15 minutes compared to a total of \u0000<inline-formula> <tex-math>$sim $ </tex-math></inline-formula>\u000011 hours using conventional techniques. Calcein was encapsulated inside the prepared liposomes as a model drug and was released by applying ultrasound at different powers. The size of the prepared liposomes was stable over a period of one month. Overall, using microfluidics to synthesize estrone liposomes simplified the procedure considerably and improved the reproducibility of the resulting liposomes.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"472-481"},"PeriodicalIF":3.7,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10479533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140293429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability Analysis for Large-Scale Multi-Agent Molecular Communication Systems 大规模多代理分子通信系统的稳定性分析。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-23 DOI: 10.1109/TNB.2024.3404592

Taishi Kotsuka;Yutaka Hori

{"title":"Stability Analysis for Large-Scale Multi-Agent Molecular Communication Systems","authors":"Taishi Kotsuka;Yutaka Hori","doi":"10.1109/TNB.2024.3404592","DOIUrl":"10.1109/TNB.2024.3404592","url":null,"abstract":"Molecular communication (MC) is recently featured as a novel communication tool to connect individual biological nanorobots. It is expected that a large number of nanorobots can form large multi-agent MC systems through MC to accomplish complex and large-scale tasks that cannot be achieved by a single nanorobot. However, most previous models for MC systems assume a unidirectional diffusion communication channel and cannot capture the feedback between each nanorobot, which is important for multi-agent MC systems. In this paper, we introduce a system theoretic model for large-scale multi-agent MC systems using transfer functions, and then propose a method to analyze the stability for multi-agent MC systems. The proposed method decomposes the multi-agent MC system into multiple single-input and single-output (SISO) systems, which facilitates the application of simple analysis technique for SISO systems to the large-scale multi-agent MC system. Finally, we demonstrate the proposed method by analyzing the stability of a specific large-scale multi-agent MC system and clarify a parameter region to synchronize the states of nanorobots, which is important to make cooperative behaviors at a population level.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"507-517"},"PeriodicalIF":3.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monodirectional Tissue P Systems With Proteins on Cells 细胞上带有蛋白质的单向组织 P 系统。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-23 DOI: 10.1109/TNB.2024.3404396

Bosheng Song;Chuanlong Hu;Xiangxiang Zeng

引用次数: 0

Design of DNA Storage Coding Scheme With LDPC Codes and Interleaving 利用 LDPC 编码和交错设计 DNA 存储编码方案。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-21 DOI: 10.1109/TNB.2024.3379976

Jae-Won Kim;Jaeho Jeong;Hee-Youl Kwak;Jong-Seon No

引用次数: 0

Electrochemical Synthesis of Molecularly Imprinted Polymers for L-Tyrosine Detection 用于检测 L-酪氨酸的分子印迹聚合物的电化学合成。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-20 DOI: 10.1109/TNB.2024.3379588

K. Ramya;K. S. Jaya Lakshmi;Khairunnisa Amreen;Sanket Goel

{"title":"Electrochemical Synthesis of Molecularly Imprinted Polymers for L-Tyrosine Detection","authors":"K. Ramya;K. S. Jaya Lakshmi;Khairunnisa Amreen;Sanket Goel","doi":"10.1109/TNB.2024.3379588","DOIUrl":"10.1109/TNB.2024.3379588","url":null,"abstract":"L-Tyrosine (L-Tyr), a critical amino acid whose aberrant levels impact melanin and dopamine levels in human body while also increasing insulin resistance thereby increasing the risk of type 2 diabetes. The objective of this study was to detect the amount of L-Tyr in human fluids by tailored electrochemical synthesis of well adhered, homogenous and thin molecularly imprinted polymers (MIPs) by the electro-polymerization of pyrrole on glassy carbon electrode modified functionalized multi-walled carbon nanotubes. The key benefits of this procedure over previous imprinting techniques were the elimination of expensive materials like Au and tedious multi-step synthesis, for L-Tyr detection using a handheld potentiostat. The developed particles were characterized using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscope, Chronoamperometry, and Cyclic Voltammetry. With strong reproducibility and stability, this optimized approach provides a rapid and effective method of preparing and sensing MIPs for the target analyte with a broad linear range of \u0000<inline-formula> <tex-math>$1~mu text{M}$ </tex-math></inline-formula>\u0000 to \u0000<inline-formula> <tex-math>$2000~mu text{M}$ </tex-math></inline-formula>\u0000. The Limit of Detection and Limit of Quantification were \u0000<inline-formula> <tex-math>$0.4~mu text{M}$ </tex-math></inline-formula>\u0000 and \u0000<inline-formula> <tex-math>$1.47~mu text{M}$ </tex-math></inline-formula>\u0000, respectively. The engineered sensor was validated for quantifying the concentrations of L-Tyr in human blood and serum samples, yielding satisfactory recovery and can be expanded in future to detect analytes simultaneous.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"410-417"},"PeriodicalIF":3.7,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Label Free Fluorescent Aptamer Sensor Based on the Combined Action of Graphene Oxide and SYBR Green I for the Detection of Aflatoxin B1 基于氧化石墨烯和 SYBR Green I 联合作用的无标记荧光拟合传感器，用于检测黄曲霉毒素 B1。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-20 DOI: 10.1109/TNB.2024.3403158

Mengyang Hu;Meng Cheng;Na Wang;Yidan Sang;Yafei Dong;Luhui Wang

{"title":"A Label Free Fluorescent Aptamer Sensor Based on the Combined Action of Graphene Oxide and SYBR Green I for the Detection of Aflatoxin B1","authors":"Mengyang Hu;Meng Cheng;Na Wang;Yidan Sang;Yafei Dong;Luhui Wang","doi":"10.1109/TNB.2024.3403158","DOIUrl":"10.1109/TNB.2024.3403158","url":null,"abstract":"Here, based on the characteristics of Graphene oxide(GO) and SYBR Green I(SGI) dye, an enzyme-free and label-free fluorescent biosensor with signal amplification through DNA strand reaction is proposed for the detection of Aflatoxin B1(AFB1) in food safety. Firstly, without the addition of AFB1, the substrate in the system includes a double stranded Apt-S with a long sticky end and two hairpins H1 and H2. Although the complementary pairing of bases may exhibit fluorescence due to the insertion of SGI dyes, the use of GO, which is highly capable of adsorbing single stranded parts and quenching fluorescence, cleverly reduces the background fluorescence. Adding the target AFB1 triggers DNA inter chain reactions, generating a large amount of long double stranded DNA H1-H2, thereby generating strong fluorescence signals under the action of SGI. More importantly, logical theory verification and computer simulation were conducted before biological experiments, providing a theoretical basis for the implementation of the biosensor. After analysis, the fluorescence biosensor exhibits a good linear relationship with AFB1 concentration in the range of 5-50nM, with a detection limit of 0.76nM. It also has good specificity, anti-interference ability, and practical application ability, and has broad application prospects in the field of food safety.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"24 1","pages":"37-45"},"PeriodicalIF":3.7,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance Analysis and ISI Mitigation With Imperfect Transmitter in Molecular Communication 分子通信中不完美发射机的性能分析和 ISI 缓解。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-14 DOI: 10.1109/TNB.2024.3375933

Dongliang Jing;Lin Lin;Andrew W. Eckford

引用次数: 0