IEEE Transactions on NanoBioscience最新文献_第9页

Plasmonic Optical Fiber Based Continuous in-Vivo Glucose Monitoring for ICU/CCU Setup 用于重症监护室/儿童重症监护室设置的基于等离子光纤的连续活体血糖监测。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-08-07 DOI: 10.1109/TNB.2023.3303345

Souvik Kundu;Shawana Tabassum;Ritwesh A. Kumar;E. Dale Abel;Ratnesh Kumar

{"title":"Plasmonic Optical Fiber Based Continuous in-Vivo Glucose Monitoring for ICU/CCU Setup","authors":"Souvik Kundu;Shawana Tabassum;Ritwesh A. Kumar;E. Dale Abel;Ratnesh Kumar","doi":"10.1109/TNB.2023.3303345","DOIUrl":"10.1109/TNB.2023.3303345","url":null,"abstract":"This paper reports a sensor architecture for continuous monitoring of biomarkers directly in the blood, especially for ICU/CCU patients requiring critical care and rapid biomarker measurement. The sensor is based on a simple optical fiber that can be inserted through a catheter into the bloodstream, wherein gold nanoparticles are attached at its far distal end as a plasmonic material for highly sensitive opto-chemical sensing of target biomolecules (glucose in our application) via the excitation of surface plasmon polaritons. For specificity, the nanoparticles are functionalized with a specific receptor enzyme that enables the localized surface plasmon resonance (LSPR)-based targeted bio-sensing. Further, a micro dialysis probe is introduced in the proposed architecture, which facilitates continuous monitoring for an extended period without fouling the sensor surface with cells and blood debris present in whole blood, leading to prolonged enhanced sensitivity and limit of detection, relative to existing state-of-the-art continuous monitoring devices that can conduct direct measurements in blood. To establish this proof-of-concept, we tested the sensor device to monitor glucose in-vivo involving an animal model, where continuous monitoring was done directly in the circulation of living rats. The sensor’s sensitivity to glucose was found to be 0.0354 a.u./mg.dl−1 with a detection limit of 50.89 mg/dl.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9953605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COTiR: Molecular Communication Model for Synthetic Exosome-Based Tissue Regeneration COTiR：基于合成外泌体的组织再生分子交流模型。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-08-07 DOI: 10.1109/TNB.2023.3302773

Saswati Pal;Sudip Misra;Ranjan K. Mallik

{"title":"COTiR: Molecular Communication Model for Synthetic Exosome-Based Tissue Regeneration","authors":"Saswati Pal;Sudip Misra;Ranjan K. Mallik","doi":"10.1109/TNB.2023.3302773","DOIUrl":"10.1109/TNB.2023.3302773","url":null,"abstract":"Mesenchymal stem cell (MSC)-derived exosomes are recognized as an unparalleled therapy for tissue damage rendered by COVID-19 infection and subsequent hyper-inflammatory immune response. However, the natural targeting mechanism of exosomes is challenging to detect the damaged tissue over long diffusion distances efficiently. The coordinated movement of exosomes is desired for successful identification of target sites. In this work, we propose a molecular communication model, CoTiR, with a bio-inspired directional migration strategy (DMS) for guided propagation of exosomes to target the damaged tissues. The model includes directional propagation, reception, and regeneration of tissue. The proposed model has the potential to be used in designing efficient communication systems in the nanodomain. We compare the proposed model to the basic random propagation model and show the efficacy of our model regarding the detection of multiple targets and the detection time required. Simulation results indicate that the proposed model requires a shorter period of time for a similar number of exosomes to detect the targets compared to the basic random propagation model. Furthermore, the results reveal a 99.96% decrease in the collagen concentration in the absence of inflammatory cytokine molecules compared to the collagen concentration in the presence of inflammatory cytokine molecules.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9972527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ratio Shift Keying Modulation for Time-Varying Molecular Communication Channels 时变分子通信信道的比移键控调制。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-07-25 DOI: 10.1109/TNB.2023.3298600

M. Okan Araz;Ahmet R. Emirdagi;M. Serkan Kopuzlu;Murat Kuscu

{"title":"Ratio Shift Keying Modulation for Time-Varying Molecular Communication Channels","authors":"M. Okan Araz;Ahmet R. Emirdagi;M. Serkan Kopuzlu;Murat Kuscu","doi":"10.1109/TNB.2023.3298600","DOIUrl":"10.1109/TNB.2023.3298600","url":null,"abstract":"Molecular Communications (MC) is a bio-inspired communication technique that uses molecules to encode and transfer information. Many efforts have been devoted to developing novel modulation techniques for MC based on various distinguishable characteristics of molecules, such as their concentrations or types. In this paper, we investigate a particular modulation scheme called Ratio Shift Keying (RSK), where the information is encoded in the concentration ratio of two different types of molecules. RSK modulation is hypothesized to enable accurate information transfer in dynamic MC scenarios where the time-varying channel characteristics affect both types of molecules equally. To validate this hypothesis, we first conduct an information-theoretical analysis of RSK modulation and derive the capacity of the end-to-end MC channel where the receiver estimates concentration ratio based on ligand-receptor binding statistics in an optimal or suboptimal manner. We then analyze the error performance of RSK modulation in a practical time-varying MC scenario, that is mobile MC, in which both the transmitter and the receiver undergo diffusion-based propagation. Our numerical and analytical results, obtained for varying levels of similarity between the ligand types used for ratio-encoding, and varying number of receptors, show that RSK can significantly outperform the most commonly considered MC modulation technique, concentration shift keying (CSK), in dynamic MC scenarios.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9924621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Level Residual Dual Attention Network for Major Cerebral Arteries Segmentation in MRA Toward Diagnosis of Cerebrovascular Disorders 多层残差双注意网络在脑血管疾病诊断中的脑主动脉MRA分割。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-07-24 DOI: 10.1109/TNB.2023.3298444

Subhash Chandra Pal;Dimitrios Toumpanakis;Johan Wikström;Chirag Kamal Ahuja;Robin Strand;Ashis Kumar Dhara

{"title":"Multi-Level Residual Dual Attention Network for Major Cerebral Arteries Segmentation in MRA Toward Diagnosis of Cerebrovascular Disorders","authors":"Subhash Chandra Pal;Dimitrios Toumpanakis;Johan Wikström;Chirag Kamal Ahuja;Robin Strand;Ashis Kumar Dhara","doi":"10.1109/TNB.2023.3298444","DOIUrl":"10.1109/TNB.2023.3298444","url":null,"abstract":"Segmentation of major brain vessels is very important for the diagnosis of cerebrovascular disorders and subsequent surgical planning. Vessel segmentation is an important preprocessing step for a wide range of algorithms for the automatic diagnosis or treatment of several vascular pathologies and as such, it is valuable to have a well-performing vascular segmentation pipeline. In this article, we propose an end-to-end multiscale residual dual attention deep neural network for resilient major brain vessel segmentation. In the proposed network, the encoder and decoder blocks of the U-Net are replaced with the multi-level atrous residual blocks to enhance the learning capability by increasing the receptive field to extract the various semantic coarse- and fine-grained features. Dual attention block is incorporated in the bottleneck to perform effective multiscale information fusion to obtain detailed structure of blood vessels. The methods were evaluated on the publicly available TubeTK data set. The proposed method outperforms the state-of-the-art techniques with dice of 0.79 on the whole-brain prediction. The statistical and visual assessments indicate that proposed network is robust to outliers and maintains higher consistency in vessel continuity than the traditional U-Net and its variations.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Plasmonic Sensor Based on Dual-Channel D-Shaped Photonic Crystal Fiber for Enhanced Sensitivity in Simultaneous Detection of Different Analytes 基于双通道 D 形光子晶体光纤的新型等离子传感器，用于提高同时检测不同分析物的灵敏度。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-07-11 DOI: 10.1109/TNB.2023.3294330

J. Divya;S. Selvendran;A. Sivanantha Raja;Vamsi Borra

{"title":"A Novel Plasmonic Sensor Based on Dual-Channel D-Shaped Photonic Crystal Fiber for Enhanced Sensitivity in Simultaneous Detection of Different Analytes","authors":"J. Divya;S. Selvendran;A. Sivanantha Raja;Vamsi Borra","doi":"10.1109/TNB.2023.3294330","DOIUrl":"10.1109/TNB.2023.3294330","url":null,"abstract":"A dual-channel D-shaped photonic crystal fiber (PCF) based plasmonic sensor is proposed in this paper for the simultaneous detection of two different analytes using the surface plasmon resonance (SPR) technique. The sensor employs a 50 nm-thick layer of chemically stable gold on both cleaved surfaces of the PCF to induce the SPR effect. This configuration offers superior sensitivity and rapid response, making it highly effective for sensing applications. Numerical investigations are conducted using the finite element method (FEM). After optimizing the structural parameters, the sensor exhibits a maximum wavelength sensitivity of 10000 nm/RIU and an amplitude sensitivity of −216 RIU\u0000<inline-formula> <tex-math>$^{-{1}}$ </tex-math></inline-formula>\u0000 between the two channels. Additionally, each channel of the sensor exhibits its unique maximal wavelength and amplitude sensitivities for different refractive index (RI) ranges. Both channels demonstrate a maximal wavelength sensitivity of 6000 nm/RIU. In the RI range of 1.31-1.41, Channel 1 (Ch1) and Channel 2 (Ch2) achieved their maximum amplitude sensitivities of −85.39RIU\u0000<inline-formula> <tex-math>$^{-{1}}$ </tex-math></inline-formula>\u0000 and -304.52 RIU\u0000<inline-formula> <tex-math>$^{-{1}}$ </tex-math></inline-formula>\u0000, respectively, with a resolution of \u0000<inline-formula> <tex-math>${5}times {10} ^{-{5}}$ </tex-math></inline-formula>\u0000. This sensor structure is noteworthy for its ability to measure both amplitude and wavelength sensitivity, providing enhanced performance characteristics suitable for various sensing purposes in chemical, biomedical, and industrial fields.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10178050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9773117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Synthesis of pH-Responsive Metal–Organic Frameworks for Delivery of Diclofenac Sodium 用于递送双氯芬酸钠的 pH 响应性金属有机框架的绿色合成。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-07-10 DOI: 10.1109/TNB.2023.3289787

Hafezeh Nabipour;Sohrab Rohani

{"title":"Green Synthesis of pH-Responsive Metal–Organic Frameworks for Delivery of Diclofenac Sodium","authors":"Hafezeh Nabipour;Sohrab Rohani","doi":"10.1109/TNB.2023.3289787","DOIUrl":"10.1109/TNB.2023.3289787","url":null,"abstract":"The current study developed a drug delivery system through the green chemistry-based synthesis of a biologically friendly metal-organic framework (bio-MOF) called Asp-Cu, which included copper ions and the environmentally friendly molecule L(+)-aspartic acid (Asp). For the first time, diclofenac sodium (DS) was loaded onto the synthesized bio-MOF simultaneously. The system’s efficiency was then improved by encapsulating it with sodium alginate (SA). FT-IR, SEM, BET, TGA, and XRD analyses confirmed that DS@Cu-ASP was successfully synthesized. DS@Asp-Cu was found to release the total load within 2 h when used with simulated stomach media. This challenge was overcome by coating DS@Cu-ASP with SA (SA@DS@Cu-ASP). SA@DS@Cu-ASP displayed limited drug release at pH 1.2, and a higher percentage of the drug was released at pH 6.8 and 7.4 due to the pH-responsive nature of SA. \u0000<inline-formula> <tex-math>$Itextit {n vitro}$ </tex-math></inline-formula>\u0000 cytotoxicity screening showed that SA@DS@Cu-ASP could be an appropriate biocompatible carrier with >90% cell viability. The on-command drug carrier was observed to be more applicable biocompatible with lower toxicity, as well as adequate loading properties and responsiveness, indicating its applicability as a feasible drug carrier with controlled release.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Game-Theoretic Analysis of Fusion Rules Over Molecular Reporting Channels 分子报告渠道融合规则的博弈论分析。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-07-06 DOI: 10.1109/TNB.2023.3290609

Sunil Kumar;Prabhat Kumar Sharma;Manav R. Bhatnagar

引用次数: 0

Molecular Beamforming for Actuation in Molecular Communication Networks 分子通信网络中的分子波束成形。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-07-04 DOI: 10.1109/TNB.2023.3292131

Joana Angjo;Ali E. Pusane;H. Birkan Yilmaz;Ertugrul Basar;Tuna Tugcu

{"title":"Molecular Beamforming for Actuation in Molecular Communication Networks","authors":"Joana Angjo;Ali E. Pusane;H. Birkan Yilmaz;Ertugrul Basar;Tuna Tugcu","doi":"10.1109/TNB.2023.3292131","DOIUrl":"10.1109/TNB.2023.3292131","url":null,"abstract":"The actuation accuracy of sensing tasks performed by molecular communication (MC) schemes is a very important metric. Reducing the effect of sensors fallibility can be achieved by improvements and advancements in the sensor and communication networks design. Inspired by the technique of beamforming used extensively in radio frequency communication systems, a novel molecular beamforming design is proposed in this paper. This design can find application in tasks related to actuation of nano machines in MC networks. The main idea behind the proposed scheme is that the utilization of more sensing nano machines in a network can increase the overall accuracy of that network. In other words, the probability of an actuation error reduces as the number of sensors that collectively take the actuation decision increases. In order to achieve this, several design procedures are proposed. Three different scenarios for the observation of the actuation error are investigated. For each case, the analytical background is provided and compared with the results obtained by computer simulations. The improvement in the actuation accuracy by means of molecular beamforming is verified for a uniform linear array as well as for a random topology.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic Point-of-Care Diagnostics for Multi-Disease Detection Using Optical Techniques: A Review 利用光学技术进行多种疾病检测的微流控医疗点诊断：综述。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-07-03 DOI: 10.1109/TNB.2023.3291544

Shaik Ahmadsaidulu;Oindrila Banik;Prasoon Kumar;Santosh Kumar;Earu Banoth

{"title":"Microfluidic Point-of-Care Diagnostics for Multi-Disease Detection Using Optical Techniques: A Review","authors":"Shaik Ahmadsaidulu;Oindrila Banik;Prasoon Kumar;Santosh Kumar;Earu Banoth","doi":"10.1109/TNB.2023.3291544","DOIUrl":"10.1109/TNB.2023.3291544","url":null,"abstract":"The lifestyle of modern society is a major contributing factor for the majority of patients suffering from more than one disease. To Screen and diagnose each of those diseases, there is a great need for portable, and economical diagnostic tools, which are highly stipulated to yield rapid and accurate results using a small volume of the samples such as blood, saliva, sweat, etc. Point-of-care Testing (POCT) is one of the approaches to harvest prompt diagnosis of numerous diseases. The Majority of Point-of-Care Devices (POCD) are developed to diagnose one disease within the specimen. On the other hand, multi-disease detection capabilities in the same point-of-care devices are considered to be an efficient candidate to execute the state-of-the-art platform for multi-disease detection. Most of the literature reviews in this field focus on Point-of-Care (POC) devices, their underlying principles of operation, and their potential applications. It is evident from a perusal of the scholarly works that no review articles have been written on multi-disease detection POC devices. A review study analyzing the current level and functionality of multi-disease detection POC devices would be of great use to future researchers and device manufacturers. This review paper is addressing the above gap by focusing on various optical techniques like fluorescence, Absorbance, and Surface Plasmon Resonance (SPR) for multi-disease detection by harnessing the microfluidic-based POC device.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IEEE Transactions on NanoBioscience Publication Information IEEE纳米生物科学学报

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2023-06-29 DOI: 10.1109/TNB.2023.3283631

引用次数: 0