IEEE Transactions on Biomedical Engineering最新文献_第5页

Optimization of Bipolar Microsecond Electric Pulses for DNA Vaccine Delivery.

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-03-04 DOI: 10.1109/TBME.2025.3547311

Robert H Williamson, Matthew R DeWitt, Driss Elhanafi, David A Zaharoff, Michael B Sano

{"title":"Optimization of Bipolar Microsecond Electric Pulses for DNA Vaccine Delivery.","authors":"Robert H Williamson, Matthew R DeWitt, Driss Elhanafi, David A Zaharoff, Michael B Sano","doi":"10.1109/TBME.2025.3547311","DOIUrl":"https://doi.org/10.1109/TBME.2025.3547311","url":null,"abstract":"Objective: Bipolar microsecond and submicrosecond pulsed electric fields have several advantages over longer duration monopolar pulses including significant reductions in muscle stimulation and perceived pain enabling their use in several novel clinical applications. In this study, treatment parameters were optimized to enhance DNA uptake in a 3D tissue model.Methods: 3D tissue models were subjected to microsecond pulsed electric field treatments with various waveforms, doses, and delivery rates. Small molecule uptake and viability were evaluated in search of optimal outcomes. Computational models were then used to derive reversible and lethal thresholds for each treatment group. DNA transfection was then evaluated for a subset of optimal parameters and compared to traditional electroporation protocols.Results: A 2-1-2 waveform with a 1ms dose delivered at a rate of 100μs/s resulted in the highest number of transfected cells yielding a 7730% increase over traditional monopolar pulse protocols.Conclusion: Bipolar microsecond pulses offer substantial promise for DNA delivery via reversible electroporation.Significance: Several gene-related therapeutics such as DNA vaccines are currently hindered by poor cellular uptake This crucial barrier to a new generation of such therapies can be overcome by improving DNA delivery as demonstrated in this work.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Advanced Self-similarity Measure: Average of Level-Pairwise Hurst Exponent Estimates (ALPHEE).

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-03-03 DOI: 10.1109/TBME.2025.3547253

Dixon Vimalajeewa, Raymond J Hinton, Fabrizio Ruggeri, Brani Vidakovic

{"title":"An Advanced Self-similarity Measure: Average of Level-Pairwise Hurst Exponent Estimates (ALPHEE).","authors":"Dixon Vimalajeewa, Raymond J Hinton, Fabrizio Ruggeri, Brani Vidakovic","doi":"10.1109/TBME.2025.3547253","DOIUrl":"https://doi.org/10.1109/TBME.2025.3547253","url":null,"abstract":"Many natural processes are characterized by complex patterns of self-similarity, where repetitive structures occur across different resolutions. The Hurst exponent is a key parameter used to quantify this self-similarity. While wavelet-based techniques are effective in estimating the Hurst exponent, their performance can be compromised by noise, outliers, and modeling assumptions. This study makes a dual contribution by introducing a novel method for estimating the Hurst exponent under standard modeling assumptions and applying this method to a significant study on gait data. The novel method leverages wavelet transforms (WT) to refine the traditional assessment of self-similarity, which typically depends on the regular decay of signal energies at various resolutions. Our method integrates the standard fractional Brownian motion (fBm) model with exact probability distributions of wavelet coefficients, combining estimates of the Hurst exponent from pairs of wavelet decomposition levels into a single estimate, named ALPHEE, that offers a more precise measure of self-similarity. The study investigates the use of self-similarity features in machine learning algorithms for identifying elderly adults who have had unintentional falls. By analyzing linear acceleration (LA) and angular velocity (AV) in 147 subjects (79 fallers, 68 non-fallers), the study finds higher regularity in LA and AV for fallers. The performance of classification models is compared with and without self-similarity features, suggesting these features enhance the detection of fallers versus non-fallers. The results show that integrating self-similarity features significantly improves performance, with the proposed method achieving 89.65% accuracy, compared to 82.75% using the standard method. This improvement surpasses existing studies based on the same dataset, suggesting that the proposed method more accurately captures self-similar properties, leading to better performance in gait data analysis.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Photoacoustic Eigen Waveform Analysis for Characterization of Cancellous Bone.

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-03-03 DOI: 10.1109/TBME.2025.3544876

Ting Feng, Caicai Huang, Chenyin Ni, Yejing Xie, Yihan Zhu, Chengcheng Liu, Qian Cheng, Dean Ta

{"title":"Robust Photoacoustic Eigen Waveform Analysis for Characterization of Cancellous Bone.","authors":"Ting Feng, Caicai Huang, Chenyin Ni, Yejing Xie, Yihan Zhu, Chengcheng Liu, Qian Cheng, Dean Ta","doi":"10.1109/TBME.2025.3544876","DOIUrl":"https://doi.org/10.1109/TBME.2025.3544876","url":null,"abstract":"Objective: Noninvasive photoacoustic (PA) imaging techniques afford abundant microstructure information for the diagnosis and therapeutic monitoring of diseases. However, their use for bone tissue imaging is challenging owing to the high scattering and attenuation properties of bone tissue. The PA signal waveforms inherently contain optical and ultrasonic properties related to bone health. This study entailed the development of a robust, compensation-free PA eigen waveform analysis (PEWA) method for characterizing high-scattering cancellous bone in transmission mode.Methods: Numerical simulations and experimental studies were conducted on cancellous bone models with various bone mineral densities (BMDs), optical, and ultrasonic properties. The resulting PA signals were analyzed using PEWA method, facilitating the quantification of parameters related to bone conditions, such as the exponential growth coefficient.Results: The simulation results indicate that bone specimens with lower BMDs have lower exponential growth coefficients. Furthermore, we found that the exponential growth coefficient has better robustness and stability than conventional amplitude-based parameter. The experimental findings from animal cancellous bone tissues ex vivo with different BMDs were in close agreement with the simulation results, thus demonstrating that the PEWA method can perform BMD assessments for cancellous bone.Significance: Considering that PA measurements are nonionizing and noninvasive and have sufficient penetration in both nonorganic (bone matrix) and organic tissues (bone marrow), the proposed compensation-free, PEWA bone evaluation method has the potential to facilitate early and rapid clinical assessment of osteoporosis. The proposed approach has considerable applicability in the domains of miniaturization equipment intelligent evaluation of bone health.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hearing loss caused by hair cell lesions. 毛细胞病变导致的听力损失。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-03-03 DOI: 10.1109/TBME.2025.3547059

Junyi Liang, Jiakun Wang, Wenjuan Yao

{"title":"Hearing loss caused by hair cell lesions.","authors":"Junyi Liang, Jiakun Wang, Wenjuan Yao","doi":"10.1109/TBME.2025.3547059","DOIUrl":"10.1109/TBME.2025.3547059","url":null,"abstract":"Objective: Hearing loss is a major public health problem faced all over the world and has now become one of the prevalent chronic diseases among the world's population. Most of the sensorineural hearing loss in the human ear is caused by structural damage and irreversible degeneration of the hair cells(HCs) in the cochlea. However, in current research, the microstructure of the organ of Corti (OC) within the cochlea is mostly ignored, which cannot explore the 3D overall structure of HCs.Methods: In this study, a multi-scale cochlear model containing a spiral OC is developed based on the experimental data of CT scan and light source imaging of the human ear, the clinically relevant lesions of the HCs in the OC are also explored.Results: HC loss affects the hearing by depleting traveling wave energy, whereas HC sclerosis increases the structural burden, and may result in a greater susceptibility to damage of the basilar membrane(BM) structure in different frequency ranges. Both loss and sclerosis may cause a rise in the stress on the remaining HCs, with the region of stress amplitude shifting towards the lesion area, thereby triggering secondary damage to the HC.Conclusion: The loss or sclerosis of HCs can cause varying degree of hearing loss.Significance: This article reveals the impact of HC lesions on the human ear's hearing perception process, providing corresponding theoretical guidance for the treatment of related lesions in clinic sensorineural hearing loss.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Model-Free Method to Quantify Memory Utilization in Neural Point Processes. 量化神经点过程内存利用率的无模型方法

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3546842

Gorana Mijatovic, Sebastiano Stramaglia, Luca Faes

{"title":"A Model-Free Method to Quantify Memory Utilization in Neural Point Processes.","authors":"Gorana Mijatovic, Sebastiano Stramaglia, Luca Faes","doi":"10.1109/TBME.2025.3546842","DOIUrl":"https://doi.org/10.1109/TBME.2025.3546842","url":null,"abstract":"Objective: Quantifying the predictive capacity of a neural system, intended as the capability to store information and actively utilize it for dynamic system evolution, is a key component of neural information processing. Information storage (IS), the main information-theoretic measure quantifying the active utilization of memory in a dynamic system, is only defined for discrete-time processes, and although recent theoretical work laid the foundations for its continuous-time analysis, a reliable computation method is still needed for broader application to neural data.Methods: This work introduces a method for the model-free estimation of the so-called memory utilization rate (MUR), the continuous-time counterpart of the IS, specifically designed to quantify the predictive capacity stored in neural point processes. Moreover, a surrogate data-based procedure is used to correct estimation bias and detect significant memory levels in the analyzed point process.Results: The method is first validated in simulations of Poisson processes, both memoryless and with memory, as well as in realistic models of coupled cortical dynamics and heartbeat dynamics. It is then applied to real spike trains reflecting central and autonomic nervous system activities: in spontaneously growing cortical neuron cultures, the MUR detected increasing levels of memory utilization across maturation stages, linked to the emergence of synchronized bursting; in heartbeat modulation analysis, the MUR reflected sympathetic activation and vagal withdrawal occurring with postural stress, but not with mental stress.Conclusion and significance: The proposed approach offers a novel, computationally reliable tool for the analysis of spike train data in computational neuroscience and physiology.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanosecond Pulsed Bipolar Cancellation of the Killing Effect on Glioblastoma.

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3536477

Zhijun Luo, Fei Guo, Sizhe Xiang, Shoulong Dong, Chenguo Yao, Huawen Liu

{"title":"Nanosecond Pulsed Bipolar Cancellation of the Killing Effect on Glioblastoma.","authors":"Zhijun Luo, Fei Guo, Sizhe Xiang, Shoulong Dong, Chenguo Yao, Huawen Liu","doi":"10.1109/TBME.2025.3536477","DOIUrl":"https://doi.org/10.1109/TBME.2025.3536477","url":null,"abstract":"Objective: Glioblastoma (GBM) is the deadliest type of cancer and current clinical treatments for malignant gliomas have many side effects. The article discusses the possibility that nanosecond pulsed electric fields (nsPEFs) can be focused on tumors for local killing. As well as the possibility of utilizing the CANCAN (canceled bipolar) effect to reduce neurostimulation and thus overcome side effects such as seizures and edema.Method: In this paper, we use cell ablation and viability experiments to investigated the BPC (Bipolar cancellation) effect of U87-MG cells under the action of nsPEFs of various pulse numbers and the electric field amplitude.Results: The results showed that maximum BPC efficiency (163.9%) was obtained with nsPEFs of 15 kV/cm and 15 pulses, and unipolar nsPEFs of 20 kV/cm and 15 pulses were able to achieve a killing effect of 90% with cell suspension, then this electric field is used as a reference for the ablation experiments.Conclusion: Cell ablation experiments found that the electric field threshold of 3D (3D-like tissue) cell ablation (5.805 ± 1.455 kV/cm) is lower than that of monolayer wall cells (8.95 ± 0.75 kV/cm), which can cause a larger ablation area under the same pulsed electric field conditions. In addition, the BPC effect was more significant for 3D cells, but the trends of ablation area and BPC efficiency were similar when modulating the number of pulses.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Spatial Auditory Brain-Computer Interface based on Low-Frequency Periodic Auditory Motion Stimulation Paradigm.

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3544646

Huanqing Zhang, Jun Xie, Chenguang Zhao, Zhiwei Jin, Fangzhao Du, Yujie Chen, Guanghua Xu, Qing Tao, Min Li

{"title":"A Novel Spatial Auditory Brain-Computer Interface based on Low-Frequency Periodic Auditory Motion Stimulation Paradigm.","authors":"Huanqing Zhang, Jun Xie, Chenguang Zhao, Zhiwei Jin, Fangzhao Du, Yujie Chen, Guanghua Xu, Qing Tao, Min Li","doi":"10.1109/TBME.2025.3544646","DOIUrl":"https://doi.org/10.1109/TBME.2025.3544646","url":null,"abstract":"This study aims to improve the performance of auditory brain-computer interfaces (BCIs) by developing two-target and three-target paradigms based on steady-state motion auditory evoked potential (SSMAEP) using low-frequency stimuli in a spatial audio environment. SSMAEP is elicited by auditory stimuli exhibited by periodic and discrete changes in auditory spatial position.Methods: We designed a periodic auditory motion stimulation paradigm to evoke SSMAEP. Two-target and three-target SSMAEP-BCIs were developed. For the two-target SSMAEP-BCI, two periodic auditory motion stimuli with different motion frequencies were located on the left (2 Hz) and right (1.6 Hz) sides of the head, respectively. For the three-target SSMAEP-BCI, three periodic auditory motion stimuli with different motion frequencies were located on the front (2 Hz), left (2.4 Hz) and right (1.6 Hz) sides of the head, respectively.Results: SSMAEP amplitudes were modulated by auditory selective attention. In the two-target BCI, the offline experiments showed a peak average information transfer rate (ITR) of 7.70 bits/min, while the online experiments had a mean accuracy of 82.83% and an ITR of 4.41 bits/min. The three-target BCI achieved a peak ITR of 12.04 bits/min offline, with an online mean accuracy of 80.45% and an ITR of 7.05 bits/min.Conclusion: The study confirms the feasibility and enhanced performance of spatial low-frequency SSMAEP-BCIs.Significance: This novel approach to SSMAEP-BCI offers a promising direction for enhancing auditory BCI performance, potentially improving user experience and application in complex environments.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amber Light-Assisted CBI Endoscopy for Superior Deep Vascular Visualization and Blood-Containing Tissue Depth Differentiation.

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3545853

Shipeng Zhang, Tianyu Xie, Gaowa Tuya, Guochen Ning, Longfei Ma, Zhe Zhao, Ye Fu, Hongen Liao

{"title":"Amber Light-Assisted CBI Endoscopy for Superior Deep Vascular Visualization and Blood-Containing Tissue Depth Differentiation.","authors":"Shipeng Zhang, Tianyu Xie, Gaowa Tuya, Guochen Ning, Longfei Ma, Zhe Zhao, Ye Fu, Hongen Liao","doi":"10.1109/TBME.2025.3545853","DOIUrl":"https://doi.org/10.1109/TBME.2025.3545853","url":null,"abstract":"Purpose: A novel compound band imaging (CBI) endoscopy system is introduced to enhance the visualization and depth differentiation of blood-containing tissues within mucosal structures. This system serves as a theranostics tool to supplement white light imaging (WLI), enabling more precise disease diagnosis and treatment.Methods: The system utilizes a combination of green and red narrow-band light, alongside amber wide-band light, synchronized with a rapid switching strategy and a color CMOS sensor. This design effectively avoids potential hardware cost increases associated with introducing additional narrow-band wavelengths and mitigates alignment challenges inherent in in vivo imaging using multiple narrow-band, time-separated techniques. Advanced image processing methods, including multi-scale HVS-guided contrast enhancement fusion and depth differentiation algorithms for blood-containing tissues, are employed to decouple images from the raw data and fuse spectral information.Results: The system underwent extensive testing to validate its imaging capabilities and methodology, yielding results that met expectations. Enhanced visibility and depth differentiation of vascular networks were demonstrated in both preclinical and clinical trials, with quantitative analyses confirming its superior performance compared to WLI.Conclusion: By integrating a sophisticated imaging setup with specialized processing algorithms, significant enhancements in imaging performance are achieved. Comprehensive evaluations confirm the system's feasibility, effectiveness, and potential for clinical translation. With further clinical validation, this system promises to advance endoscopic diagnostics and treatments by improving the clarity of critical vascular structures essential for clinical assessments.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A compact monocular dual-view 3D endoscope imaging system based on dichroic prism for minimally invasive surgery.

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-27 DOI: 10.1109/TBME.2025.3545764

Xueling Wei, Tianqi Huang, Guochen Ning, Jie Wang, Shipeng Zhang, Hanying Liang, Yuxuan Zhai, Longfei Ma, Hongen Liao

{"title":"A compact monocular dual-view 3D endoscope imaging system based on dichroic prism for minimally invasive surgery.","authors":"Xueling Wei, Tianqi Huang, Guochen Ning, Jie Wang, Shipeng Zhang, Hanying Liang, Yuxuan Zhai, Longfei Ma, Hongen Liao","doi":"10.1109/TBME.2025.3545764","DOIUrl":"10.1109/TBME.2025.3545764","url":null,"abstract":"Objective: During minimally invasive surgery (MIS), three-dimensional (3D) endoscopes provide valuable 3D perception of the patient's internal structures. However, due to the requirement of two cameras and a relatively large baseline distance, the imaging front-end of the conventional binocular 3D (CB3D) endoscope usually lacks compactness. We aim to develop a novel compact monocular dual-view 3D (MDV3D) endoscope imaging system.Methods: We develop a novel optical design for the MDV3D endoscope that exploits the dichroic prism's reflection capability to its internal light to realize MDV3D imaging, ensuring the 3D endoscope's imaging front-end with high compactness. Additionally, we propose a 3D reconstruction optimization method (MB-BEDE) to address the challenge of insufficient accuracy of 3D surface information posed by the typically micro baseline distance between the two virtual cameras in the MDV3D endoscope. Through seamless integration of our MDV3D endoscope and MB-BEDE method, we can obtain reliable real-time 3D information.Results: Evaluation experiments demonstrate our system's capability to provide accurate 3D surface information. Notably, compared to the CB3D endoscope imaging system occupying two channels in the robotic single-port laparo-endoscopic surgery (SPLS) platform, our system only requires one channel with a 5.60 mm diameter, presenting the advantage of creating more operating space for surgical instruments during robotic SPLS procedures.Conclusion and significance: The proposed system and method present a novel solution for developing compact and cost-effective 3D endoscope imaging systems in MIS, particularly in robotic SPLS.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave Imaging for Breast Cancer Detection: Performance Assessment of a Next-Generation Transmission System.

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-26 DOI: 10.1109/TBME.2024.3521410

Pedram Mojabi, Jeremie Bourqui, Zahra Lasemiimeni, Baldeep Grewal, Elise Fear

{"title":"Microwave Imaging for Breast Cancer Detection: Performance Assessment of a Next-Generation Transmission System.","authors":"Pedram Mojabi, Jeremie Bourqui, Zahra Lasemiimeni, Baldeep Grewal, Elise Fear","doi":"10.1109/TBME.2024.3521410","DOIUrl":"https://doi.org/10.1109/TBME.2024.3521410","url":null,"abstract":"Microwave imaging has been proposed for breast cancer detection and treatment monitoring. Prototype systems based on tomography and radar-based techniques have been tested on human subjects with promising results. Previously, we developed a system that estimated average permittivity in regions of the breast using signals transmitted through the tissues. Encouraging results with volunteers and patients motivated development of a system capable of creating more detailed images of the entire breast.Objective: In this paper, we aim to assess the performance of this next generation microwave imaging system and demonstrate scans of human subjects that relate to clinical information.Methods: With a novel imaging system, scans of homogeneous phantoms and phantoms with inclusions of various sizes are collected. The accuracy, detection and localization are assessed. A pilot study is carried out with a small group of volunteers with previous mammograms.Results: Images of flexible phantoms have average error of less than 10 % in the reconstructed average permittivity. Detection of inclusions of 1 cm diameter and greater is demonstrated. The feasibility of scanning human subjects is also demonstrated by providing microwave images of several healthy volunteers with previous mammograms.Significance: A novel high-resolution microwave transmission imaging system, in conjunction with a fast quantitative reconstruction algorithm capable of detecting 1 cm diameter inclusions, is designed for breast imaging applications. It can image various breast sizes without the need for matching fluid.Conclusion: Overall, the results indicate that this imaging system is well suited for further exploration of microwave imaging with human subjects.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0