IEEE Transactions on Biomedical Engineering最新文献_第10页

Hearing loss caused by hair cell lesions. 毛细胞病变导致的听力损失。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-03-03 DOI: 10.1109/TBME.2025.3547059

Junyi Liang, Jiakun Wang, Wenjuan Yao

{"title":"Hearing loss caused by hair cell lesions.","authors":"Junyi Liang, Jiakun Wang, Wenjuan Yao","doi":"10.1109/TBME.2025.3547059","DOIUrl":"10.1109/TBME.2025.3547059","url":null,"abstract":"Objective: Hearing loss is a major public health problem faced all over the world and has now become one of the prevalent chronic diseases among the world's population. Most of the sensorineural hearing loss in the human ear is caused by structural damage and irreversible degeneration of the hair cells(HCs) in the cochlea. However, in current research, the microstructure of the organ of Corti (OC) within the cochlea is mostly ignored, which cannot explore the 3D overall structure of HCs.Methods: In this study, a multi-scale cochlear model containing a spiral OC is developed based on the experimental data of CT scan and light source imaging of the human ear, the clinically relevant lesions of the HCs in the OC are also explored.Results: HC loss affects the hearing by depleting traveling wave energy, whereas HC sclerosis increases the structural burden, and may result in a greater susceptibility to damage of the basilar membrane(BM) structure in different frequency ranges. Both loss and sclerosis may cause a rise in the stress on the remaining HCs, with the region of stress amplitude shifting towards the lesion area, thereby triggering secondary damage to the HC.Conclusion: The loss or sclerosis of HCs can cause varying degree of hearing loss.Significance: This article reveals the impact of HC lesions on the human ear's hearing perception process, providing corresponding theoretical guidance for the treatment of related lesions in clinic sensorineural hearing loss.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Model-Free Method to Quantify Memory Utilization in Neural Point Processes. 量化神经点过程内存利用率的无模型方法

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3546842

Gorana Mijatovic, Sebastiano Stramaglia, Luca Faes

{"title":"A Model-Free Method to Quantify Memory Utilization in Neural Point Processes.","authors":"Gorana Mijatovic, Sebastiano Stramaglia, Luca Faes","doi":"10.1109/TBME.2025.3546842","DOIUrl":"https://doi.org/10.1109/TBME.2025.3546842","url":null,"abstract":"Objective: Quantifying the predictive capacity of a neural system, intended as the capability to store information and actively utilize it for dynamic system evolution, is a key component of neural information processing. Information storage (IS), the main information-theoretic measure quantifying the active utilization of memory in a dynamic system, is only defined for discrete-time processes, and although recent theoretical work laid the foundations for its continuous-time analysis, a reliable computation method is still needed for broader application to neural data.Methods: This work introduces a method for the model-free estimation of the so-called memory utilization rate (MUR), the continuous-time counterpart of the IS, specifically designed to quantify the predictive capacity stored in neural point processes. Moreover, a surrogate data-based procedure is used to correct estimation bias and detect significant memory levels in the analyzed point process.Results: The method is first validated in simulations of Poisson processes, both memoryless and with memory, as well as in realistic models of coupled cortical dynamics and heartbeat dynamics. It is then applied to real spike trains reflecting central and autonomic nervous system activities: in spontaneously growing cortical neuron cultures, the MUR detected increasing levels of memory utilization across maturation stages, linked to the emergence of synchronized bursting; in heartbeat modulation analysis, the MUR reflected sympathetic activation and vagal withdrawal occurring with postural stress, but not with mental stress.Conclusion and significance: The proposed approach offers a novel, computationally reliable tool for the analysis of spike train data in computational neuroscience and physiology.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanosecond Pulsed Bipolar Cancellation of the Killing Effect on Glioblastoma. 纳秒脉冲双极对消对胶质母细胞瘤的杀伤作用。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3536477

Zhijun Luo, Fei Guo, Sizhe Xiang, Shoulong Dong, Chenguo Yao, Huawen Liu

{"title":"Nanosecond Pulsed Bipolar Cancellation of the Killing Effect on Glioblastoma.","authors":"Zhijun Luo, Fei Guo, Sizhe Xiang, Shoulong Dong, Chenguo Yao, Huawen Liu","doi":"10.1109/TBME.2025.3536477","DOIUrl":"https://doi.org/10.1109/TBME.2025.3536477","url":null,"abstract":"Objective: Glioblastoma (GBM) is the deadliest type of cancer and current clinical treatments for malignant gliomas have many side effects. The article discusses the possibility that nanosecond pulsed electric fields (nsPEFs) can be focused on tumors for local killing. As well as the possibility of utilizing the CANCAN (canceled bipolar) effect to reduce neurostimulation and thus overcome side effects such as seizures and edema.Method: In this paper, we use cell ablation and viability experiments to investigated the BPC (Bipolar cancellation) effect of U87-MG cells under the action of nsPEFs of various pulse numbers and the electric field amplitude.Results: The results showed that maximum BPC efficiency (163.9%) was obtained with nsPEFs of 15 kV/cm and 15 pulses, and unipolar nsPEFs of 20 kV/cm and 15 pulses were able to achieve a killing effect of 90% with cell suspension, then this electric field is used as a reference for the ablation experiments.Conclusion: Cell ablation experiments found that the electric field threshold of 3D (3D-like tissue) cell ablation (5.805 ± 1.455 kV/cm) is lower than that of monolayer wall cells (8.95 ± 0.75 kV/cm), which can cause a larger ablation area under the same pulsed electric field conditions. In addition, the BPC effect was more significant for 3D cells, but the trends of ablation area and BPC efficiency were similar when modulating the number of pulses.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Spatial Auditory Brain-Computer Interface based on Low-Frequency Periodic Auditory Motion Stimulation Paradigm. 一种基于低频周期性听觉运动刺激范式的空间听觉脑机接口。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3544646

Huanqing Zhang, Jun Xie, Chenguang Zhao, Zhiwei Jin, Fangzhao Du, Yujie Chen, Guanghua Xu, Qing Tao, Min Li

{"title":"A Novel Spatial Auditory Brain-Computer Interface based on Low-Frequency Periodic Auditory Motion Stimulation Paradigm.","authors":"Huanqing Zhang, Jun Xie, Chenguang Zhao, Zhiwei Jin, Fangzhao Du, Yujie Chen, Guanghua Xu, Qing Tao, Min Li","doi":"10.1109/TBME.2025.3544646","DOIUrl":"https://doi.org/10.1109/TBME.2025.3544646","url":null,"abstract":"This study aims to improve the performance of auditory brain-computer interfaces (BCIs) by developing two-target and three-target paradigms based on steady-state motion auditory evoked potential (SSMAEP) using low-frequency stimuli in a spatial audio environment. SSMAEP is elicited by auditory stimuli exhibited by periodic and discrete changes in auditory spatial position.Methods: We designed a periodic auditory motion stimulation paradigm to evoke SSMAEP. Two-target and three-target SSMAEP-BCIs were developed. For the two-target SSMAEP-BCI, two periodic auditory motion stimuli with different motion frequencies were located on the left (2 Hz) and right (1.6 Hz) sides of the head, respectively. For the three-target SSMAEP-BCI, three periodic auditory motion stimuli with different motion frequencies were located on the front (2 Hz), left (2.4 Hz) and right (1.6 Hz) sides of the head, respectively.Results: SSMAEP amplitudes were modulated by auditory selective attention. In the two-target BCI, the offline experiments showed a peak average information transfer rate (ITR) of 7.70 bits/min, while the online experiments had a mean accuracy of 82.83% and an ITR of 4.41 bits/min. The three-target BCI achieved a peak ITR of 12.04 bits/min offline, with an online mean accuracy of 80.45% and an ITR of 7.05 bits/min.Conclusion: The study confirms the feasibility and enhanced performance of spatial low-frequency SSMAEP-BCIs.Significance: This novel approach to SSMAEP-BCI offers a promising direction for enhancing auditory BCI performance, potentially improving user experience and application in complex environments.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amber Light-Assisted CBI Endoscopy for Superior Deep Vascular Visualization and Blood-Containing Tissue Depth Differentiation. 琥珀光辅助CBI内窥镜用于优越的深部血管可视化和含血组织深度分化。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-28 DOI: 10.1109/TBME.2025.3545853

Shipeng Zhang, Tianyu Xie, Gaowa Tuya, Guochen Ning, Longfei Ma, Zhe Zhao, Ye Fu, Hongen Liao

{"title":"Amber Light-Assisted CBI Endoscopy for Superior Deep Vascular Visualization and Blood-Containing Tissue Depth Differentiation.","authors":"Shipeng Zhang, Tianyu Xie, Gaowa Tuya, Guochen Ning, Longfei Ma, Zhe Zhao, Ye Fu, Hongen Liao","doi":"10.1109/TBME.2025.3545853","DOIUrl":"https://doi.org/10.1109/TBME.2025.3545853","url":null,"abstract":"Purpose: A novel compound band imaging (CBI) endoscopy system is introduced to enhance the visualization and depth differentiation of blood-containing tissues within mucosal structures. This system serves as a theranostics tool to supplement white light imaging (WLI), enabling more precise disease diagnosis and treatment.Methods: The system utilizes a combination of green and red narrow-band light, alongside amber wide-band light, synchronized with a rapid switching strategy and a color CMOS sensor. This design effectively avoids potential hardware cost increases associated with introducing additional narrow-band wavelengths and mitigates alignment challenges inherent in in vivo imaging using multiple narrow-band, time-separated techniques. Advanced image processing methods, including multi-scale HVS-guided contrast enhancement fusion and depth differentiation algorithms for blood-containing tissues, are employed to decouple images from the raw data and fuse spectral information.Results: The system underwent extensive testing to validate its imaging capabilities and methodology, yielding results that met expectations. Enhanced visibility and depth differentiation of vascular networks were demonstrated in both preclinical and clinical trials, with quantitative analyses confirming its superior performance compared to WLI.Conclusion: By integrating a sophisticated imaging setup with specialized processing algorithms, significant enhancements in imaging performance are achieved. Comprehensive evaluations confirm the system's feasibility, effectiveness, and potential for clinical translation. With further clinical validation, this system promises to advance endoscopic diagnostics and treatments by improving the clarity of critical vascular structures essential for clinical assessments.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A compact monocular dual-view 3D endoscope imaging system based on dichroic prism for minimally invasive surgery. 基于二向色棱镜的小型单眼双视角三维内窥镜微创手术成像系统。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-27 DOI: 10.1109/TBME.2025.3545764

Xueling Wei, Tianqi Huang, Guochen Ning, Jie Wang, Shipeng Zhang, Hanying Liang, Yuxuan Zhai, Longfei Ma, Hongen Liao

{"title":"A compact monocular dual-view 3D endoscope imaging system based on dichroic prism for minimally invasive surgery.","authors":"Xueling Wei, Tianqi Huang, Guochen Ning, Jie Wang, Shipeng Zhang, Hanying Liang, Yuxuan Zhai, Longfei Ma, Hongen Liao","doi":"10.1109/TBME.2025.3545764","DOIUrl":"10.1109/TBME.2025.3545764","url":null,"abstract":"Objective: During minimally invasive surgery (MIS), three-dimensional (3D) endoscopes provide valuable 3D perception of the patient's internal structures. However, due to the requirement of two cameras and a relatively large baseline distance, the imaging front-end of the conventional binocular 3D (CB3D) endoscope usually lacks compactness. We aim to develop a novel compact monocular dual-view 3D (MDV3D) endoscope imaging system.Methods: We develop a novel optical design for the MDV3D endoscope that exploits the dichroic prism's reflection capability to its internal light to realize MDV3D imaging, ensuring the 3D endoscope's imaging front-end with high compactness. Additionally, we propose a 3D reconstruction optimization method (MB-BEDE) to address the challenge of insufficient accuracy of 3D surface information posed by the typically micro baseline distance between the two virtual cameras in the MDV3D endoscope. Through seamless integration of our MDV3D endoscope and MB-BEDE method, we can obtain reliable real-time 3D information.Results: Evaluation experiments demonstrate our system's capability to provide accurate 3D surface information. Notably, compared to the CB3D endoscope imaging system occupying two channels in the robotic single-port laparo-endoscopic surgery (SPLS) platform, our system only requires one channel with a 5.60 mm diameter, presenting the advantage of creating more operating space for surgical instruments during robotic SPLS procedures.Conclusion and significance: The proposed system and method present a novel solution for developing compact and cost-effective 3D endoscope imaging systems in MIS, particularly in robotic SPLS.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave Imaging for Breast Cancer Detection: Performance Assessment of a Next-Generation Transmission System. 微波成像用于乳腺癌检测：下一代传输系统的性能评估。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-26 DOI: 10.1109/TBME.2024.3521410

Pedram Mojabi, Jeremie Bourqui, Zahra Lasemiimeni, Baldeep Grewal, Elise Fear

{"title":"Microwave Imaging for Breast Cancer Detection: Performance Assessment of a Next-Generation Transmission System.","authors":"Pedram Mojabi, Jeremie Bourqui, Zahra Lasemiimeni, Baldeep Grewal, Elise Fear","doi":"10.1109/TBME.2024.3521410","DOIUrl":"https://doi.org/10.1109/TBME.2024.3521410","url":null,"abstract":"Microwave imaging has been proposed for breast cancer detection and treatment monitoring. Prototype systems based on tomography and radar-based techniques have been tested on human subjects with promising results. Previously, we developed a system that estimated average permittivity in regions of the breast using signals transmitted through the tissues. Encouraging results with volunteers and patients motivated development of a system capable of creating more detailed images of the entire breast.Objective: In this paper, we aim to assess the performance of this next generation microwave imaging system and demonstrate scans of human subjects that relate to clinical information.Methods: With a novel imaging system, scans of homogeneous phantoms and phantoms with inclusions of various sizes are collected. The accuracy, detection and localization are assessed. A pilot study is carried out with a small group of volunteers with previous mammograms.Results: Images of flexible phantoms have average error of less than 10 % in the reconstructed average permittivity. Detection of inclusions of 1 cm diameter and greater is demonstrated. The feasibility of scanning human subjects is also demonstrated by providing microwave images of several healthy volunteers with previous mammograms.Significance: A novel high-resolution microwave transmission imaging system, in conjunction with a fast quantitative reconstruction algorithm capable of detecting 1 cm diameter inclusions, is designed for breast imaging applications. It can image various breast sizes without the need for matching fluid.Conclusion: Overall, the results indicate that this imaging system is well suited for further exploration of microwave imaging with human subjects.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Passive Cavitation Imaging Using p^th Root Compression Delay, Sum, and Integrate Beamforming: In Vitro and in Vivo Studies. 利用pth根压缩延迟、Sum和集成波束形成增强被动空化成像：体外和体内研究。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-24 DOI: 10.1109/TBME.2025.3540101

Abhinav Kumar Singh, Pankaj Warbal, Katia Flores Basterrechea, Kenneth Bader, Himanshu Shekhar

{"title":"Enhancing Passive Cavitation Imaging Using pth Root Compression Delay, Sum, and Integrate Beamforming: In Vitro and in Vivo Studies.","authors":"Abhinav Kumar Singh, Pankaj Warbal, Katia Flores Basterrechea, Kenneth Bader, Himanshu Shekhar","doi":"10.1109/TBME.2025.3540101","DOIUrl":"10.1109/TBME.2025.3540101","url":null,"abstract":"Objective: Passive cavitation imaging (PCI) derived metrics can serve as surrogates for the outcome of bubble-mediated therapies. Passive cavitation imaging is limited by poor axial resolution and side lobe artifacts, particularly when algorithms such as delay, sum and integrate (DSI) beamforming are used. Methods to improve PCI performance remain an active research area given the need to balance imaging performance with computational complexity. The current study evaluated pth root compression delay, sum and integrate (prDSI) beamforming for PCI using in vitro and in vivo cavitation data collected with insonation parameters relevant to drug delivery, histotripsy ablation, and combined histotripsy and drug therapy.Methods: First, PCI was performed on a flow phantom perfused with ultrasound contrast agent (SonoVue) exposed to focused ultrasound. Next, the performance of prDSI was assessed on histotripsy bubble clouds generated in a red blood cell (RBC)-doped phantom. Finally, PCI was performed on data collected during histotripsy ablation of a thrombus in the femoral vein of a pig. Acoustic emissions generated by cavitation were recorded and processed with DSI, robust Capon, and prDSI beamforming. The imaging performance was evaluated using the axial width, signal-to-interference ratio, and binary statistical analysis-derived metrics.Results: The prDSI approach demonstrated comparable imaging performance to RCB, both in vitro and in vivo based on binary statistical metrics. Considerable improvement was observed in axial width and signal-to- interference ratio, while incurring only a moderately higher computational cost relative to standard DSI beamforming.Conclusions: The findings of this study demonstrate the potential of prDSI for monitoring of cavitation-mediated therapies.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling tissue electroporation: effects of electric field direction change between pulses and increased conductivity in post-IRE regions. 组织电穿孔建模：脉冲间电场方向变化和ire后区域电导率增加的影响。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-21 DOI: 10.1109/TBME.2025.3543237

Fei Guo, Xinghe Gou, Cong Zou

{"title":"Modeling tissue electroporation: effects of electric field direction change between pulses and increased conductivity in post-IRE regions.","authors":"Fei Guo, Xinghe Gou, Cong Zou","doi":"10.1109/TBME.2025.3543237","DOIUrl":"10.1109/TBME.2025.3543237","url":null,"abstract":"Objective: Irreversible electroporation (IRE) is a non-thermal tissue ablation technique that induces tissue ablation by applying high-voltage pulses through electrodes. In this paper, an improved numerical model for tissue IRE ablation, which includes the influence of electric field direction change between pulses and increased conductivity in post-IRE regions is developed for the first time. Our objective is to investigate the impact of these two factors on IRE ablation from a simulation perspective, providing guidance for preclinical treatment planning of tumors.Methods: We established a linear relationship between the angle of electric field direction change between previous pulse and latter pulse and the IRE threshold, and applied this relationship and increased conductivity in IRE regions during the previous pulse into modeling the tissue IRE ablation during the latter pulse sequentially.Results: Our study found that, compared to the traditional model, the improved model resulted in a reduction of 14.40 % in IRE area and 9.18 % in electroporation (EP) area over one cycle. The prediction accuracy of the improved simulation model was validated through potato slice experiments.Conclusion: Incorporating changes in electric field direction and increased conductivity in post-IRE regions into the numerical model significantly affects tissue parameters and ablation area.Significance: This improved modeling approach provides a more accurate prediction of ablation areas, which can enhance the precision of preclinical treatment planning for tumors.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Ultrasonic Backscatter Evaluation of Elastic and Mechanical Property in a Rabbit Tendinopathy Healing Model. 超声后向散射定量评价兔肌腱病愈合模型的弹性和力学性能。

IF 4.4 2区医学

IEEE Transactions on Biomedical Engineering Pub Date : 2025-02-20 DOI: 10.1109/TBME.2025.3544327

Qian Zheng, Min He, Mengyao Liu, Shuxin Sun, Chengcheng Liu, Ying Li, Lixin Jiang, Dean Ta

{"title":"Quantitative Ultrasonic Backscatter Evaluation of Elastic and Mechanical Property in a Rabbit Tendinopathy Healing Model.","authors":"Qian Zheng, Min He, Mengyao Liu, Shuxin Sun, Chengcheng Liu, Ying Li, Lixin Jiang, Dean Ta","doi":"10.1109/TBME.2025.3544327","DOIUrl":"10.1109/TBME.2025.3544327","url":null,"abstract":"Objective: This study investigates the feasibility of non-invasive ultrasound backscatter techniques for quantitative tendon characterization.Methods: Sixty-six New Zealand white rabbits were divided into three groups: normal control group (NC group), model control group (MC group), and low-intensity pulsed ultrasound (LIPUS) treatment group (LT group). Tendinopathy models were induced in MC and LT groups, with the LT group receiving LIPUS intervention and the MC group receiving sham ultrasound therapy. The NC group underwent no treatment. Ultrasound backscatter signals were acquired in vitro and in vivo using a 3.5 MHz unfocused transducer at 1, 4, 7, 14, and 28 days post-intervention. Signals of interest (SOI) from the Achilles tendon were extracted based on in vitro monolayer tissue and in vivo multilayer tissue models. The backscatter parameters including average integrated backscatter (AIB), spectral centroid shift (SCS), frequency slope of apparent backscatter (FSAB), and frequency intercept of apparent backscatter (FIAB) were calculated and analyzed to ultrasound elastic and mechanical properties.Results: The results revealed that backscatter parameters were strongly correlated with ultrasonic elastic properties and weakly correlated with mechanical properties, generally exhibiting negative correlations. Notably, AIB demonstrated stable characterization capability for both ultrasonic elastic and mechanical properties (in vitro: r = -0.71 for shear modulus; r = -0.43 for tensile modulus; in vivo: r = -0.70 for shear modulus; r = -0.50 for tensile modulus).Conclusion: This study validates the use of quantitative ultrasound backscatter as a viable technique for assessing tendon properties.Significance: ultrasound backscatter offers potential applications in tendon characterization.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0