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Editorial Board / Aims and Scope 编辑委员会/目标和范围

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2026-04-02 DOI: 10.1016/S1365-182X(26)00097-3

引用次数: 0

Identification of high functioning hepatocellular carcinoma transplant centers in the modern allocation system 高功能肝癌移植中心在现代分配体系中的识别。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2026-01-07 DOI: 10.1016/j.hpb.2025.12.037

Nina Eng , Elana Taute , Hien Dang , Sean P. Martin

{"title":"Identification of high functioning hepatocellular carcinoma transplant centers in the modern allocation system","authors":"Nina Eng , Elana Taute , Hien Dang , Sean P. Martin","doi":"10.1016/j.hpb.2025.12.037","DOIUrl":"10.1016/j.hpb.2025.12.037","url":null,"abstract":"<div><h3>Introduction</h3><div>Hepatocellular carcinoma (HCC) is a common indication for liver transplant. We set out to identify high performing HCC centers to understand their listing and donor acceptance patterns.</div></div><div><h3>Methods</h3><div>The Organ Procurement and Transplantation Network data was quired identifying patients with HCC. Centers were stratified into high functioning (HFC) and low functioning centers (LFC) based on the percentage of waitlisted patients who were transplanted and patients who died or were delisted (DDL).</div></div><div><h3>Results</h3><div>Multivariable analysis identified utilization of donor after circulatory death (DCD) (OR 2.25 p < 0.01) as the largest contributing factor in HFC. The current LFC transplant to DDL ratio is 1.3 whereas HFC have experiences a 1.8-fold increase from the implementation of acuity circle (AC) allocation with a transplant to DDL ratio of 9.5. Multivariable analysis suggests that this gain is related to adopting the use of DCD donor after the implantation of AC allocation (OR 4.22, p < 0.01).</div></div><div><h3>Conclusions</h3><div>High functioning HCC transplant center phenotype exists and appears to be most driven by the utilization of DCD donors. AC allocation has served to exacerbate disparities between HFC and LFC with the key adaptation made being the increased use of DCD donors.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 4","pages":"Pages 558-564"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smarter minutes, faster meetings: evaluating AI medical scribe utilisation in hepatobiliary multidisciplinary team meetings, a comparative performance study 更智能的会议记录，更快的会议：评估人工智能医疗记录仪在肝胆多学科团队会议中的使用情况，一项比较绩效研究。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2025-12-22 DOI: 10.1016/j.hpb.2025.12.032

Marwan Idrees, Sami Rahmeh, Kin Ng, Ruth Blanco Colino, James Mcallister, Shahid Farid

引用次数: 0

Simultaneous microwave ablation and liver resection in patients with colorectal liver metastases 微波消融联合肝切除在结直肠肝转移患者中的应用

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2025-12-19 DOI: 10.1016/j.hpb.2025.12.031

Hayeon Yu , Lukas Reider , Ulrika Asenbaum , Fredrik Waneck , Christoph Schwarz , Klaus Kaczirek , Stefan Stremitzer

{"title":"Simultaneous microwave ablation and liver resection in patients with colorectal liver metastases","authors":"Hayeon Yu , Lukas Reider , Ulrika Asenbaum , Fredrik Waneck , Christoph Schwarz , Klaus Kaczirek , Stefan Stremitzer","doi":"10.1016/j.hpb.2025.12.031","DOIUrl":"10.1016/j.hpb.2025.12.031","url":null,"abstract":"<div><h3>Background</h3><div>Intraoperative microwave ablation (MWA) can be used simultaneously with liver resection in patients with colorectal liver metastases (CLM) with curative intent. It is uncertain whether this treatment concept is limited by the number of intraoperative MWAs or the number of CLMs. This study was performed to investigate whether the number of CLMs and intraoperative MWAs is associated with overall survival (OS) and recurrence-free survival (RFS).</div></div><div><h3>Methods</h3><div>Patients with CLM who underwent both liver resection and intraoperative MWA between 1.1.2010 and 1.9.2020 were examined. The influence of the number of MWAs and CLMs on OS and RFS was assessed.</div></div><div><h3>Results</h3><div>Seventy-five patients were examined. The sex ratio (m:f) was 48:27. The median age was 61 years (range 34–86). The number of MWAs and CLMs was not associated with OS or RFS. Only adjuvant chemotherapy was associated with OS (HR 0.14 (0.04, 0.45), <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>The number of intraoperative MWAs and CLMs did not influence clinical outcomes. Liver resection and intraoperative MWA can be recommended to all patients regardless of the number of MWAs and CLMs, based on the findings of this study. Adjuvant chemotherapy emerges as a critical component of this multidisciplinary treatment strategy.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 4","pages":"Pages 541-546"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver resection extended to adjacent structures for advanced hepatoblastoma – a 25 year tertiary hepatobiliary and transplant center experience 晚期肝母细胞瘤的肝切除术扩展到邻近结构- 25年三级肝胆和移植中心的经验。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2025-12-23 DOI: 10.1016/j.hpb.2025.12.033

Víola B. Weeda , Khalid Sharif , Girish Gupte , Prabal Mishra , David Hobin , Pat McKiernan , James Bennett , Peter Bromley , Evelyn Ong , Thamara Perera , Bruce Morland , Darius F. Mirza

{"title":"Liver resection extended to adjacent structures for advanced hepatoblastoma – a 25 year tertiary hepatobiliary and transplant center experience","authors":"Víola B. Weeda , Khalid Sharif , Girish Gupte , Prabal Mishra , David Hobin , Pat McKiernan , James Bennett , Peter Bromley , Evelyn Ong , Thamara Perera , Bruce Morland , Darius F. Mirza","doi":"10.1016/j.hpb.2025.12.033","DOIUrl":"10.1016/j.hpb.2025.12.033","url":null,"abstract":"<div><h3>Background</h3><div>Refinement in perioperative chemotherapy coupled with surgical innovation improves prognosis in children with very high risk hepatoblastoma. Our aim was to evaluate and identify prognostic factors contributing to recurrence in hepatoblastoma resected along with adjacent structures.</div></div><div><h3>Methods</h3><div>An audit was conducted of patients surgically treated for hepatoblastoma at our center over 25 years.</div></div><div><h3>Results</h3><div>Thirty-six of 202 patients underwent resection of structures adjacent to the liver for suspected tumor spread. Over half (21/36) of patients underwent hepatectomy with resection of adjacent structures, and orthotopic liver or multi-visceral transplantation. Adjacent structures including lymph nodes, vascular structures, diaphragm, spleen, omentum, and stomach, showed viable tumor tissue in nineteen patients. Both overall survival and recurrence free survival were 75 % at a mean follow up of 113 months. Survival improved with a negative resection margin. Recurrence free survival decreased with tumor viability. Pathology subtypes showed distinct influence on survival.</div></div><div><h3>Conclusion</h3><div>This series shows favorable survival with aggressive surgical treatment. Adverse histology subtype, lung metastases, and resistance to chemotherapy are associated with higher risk of recurrence. Management at specialist centers with simultaneous hepatic resection and transplantation readily available, achieves optimum outcomes in this niche subgroup of children with advanced hepatoblastoma.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 4","pages":"Pages 547-557"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning model for recurrence-free survival in solitary resectable colorectal liver metastasis 孤立性可切除结直肠癌肝转移无复发生存的机器学习模型。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2025-12-15 DOI: 10.1016/j.hpb.2025.12.024

Mingshuai Wang , Jianli Duan , Hongwei Wang , Yuhong Li , Baocai Xing

{"title":"Machine learning model for recurrence-free survival in solitary resectable colorectal liver metastasis","authors":"Mingshuai Wang , Jianli Duan , Hongwei Wang , Yuhong Li , Baocai Xing","doi":"10.1016/j.hpb.2025.12.024","DOIUrl":"10.1016/j.hpb.2025.12.024","url":null,"abstract":"<div><h3>Background</h3><div>Solitary colorectal liver metastasis (SCRLM) exhibits substantial heterogeneity in recurrence patterns after hepatic resection, yet individualized prediction tools for recurrence-free survival (RFS) are lacking.</div></div><div><h3>Methods</h3><div>In this multicenter retrospective study, 698 SCRLM patients undergoing hepatic resection were analyzed (training cohort: n=574; validation cohort: n=124). RFS was the primary endpoint. Three predictive models—random survival forest (RSF), Gradient Boosting Machine (GBM), and eXtreme Gradient Boosting (XGBoost)—were developed and compared. Model performance was assessed via concordance index (C-index), time-dependent area under the ROC curve (AUROC), and calibration plots.</div></div><div><h3>Results</h3><div>The XGBoost model achieved the best performance, with AUROCs of 0.93 and 0.87 at 1 year, and 0.89 and 0.86 at 3 years, in the training and validation cohorts, respectively. Compared with the modified Clinical Score (m-CS), the model demonstrated significantly higher discrimination at 1, 2, and 3 years (all <em>P</em> < 0.001), and also identified a subgroup of patients more likely to benefit from postoperative chemotherapy. A user-friendly online tool was developed for clinical application: <span><span>https://scrlm.shinyapps.io/scrlmapp/</span><svg><path></path></svg></span>.</div></div><div><h3><em>Conclusion</em></h3><div>We developed and validated a machine learning–based model for SCRLM, enabling individualized recurrence risk prediction and guiding postoperative chemotherapy decisions. This approach may improve outcomes while reducing overtreatment.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 4","pages":"Pages 497-507"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perihilar cholangiocarcinoma: microscopic positive margin and its clinical relevance 肝门周围胆管癌：显微阳性切缘及其临床意义。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.hpb.2025.12.039

Giacomo Waller , Hideo Takahashi , Yuki Bekki , Rhea Raj , Salvatore Amodeo , Michael Buckstein , Maria Isabel Fiel , Marcelo E. Facciuto , Myron Schwartz , Ganesh Gunasekaran

{"title":"Perihilar cholangiocarcinoma: microscopic positive margin and its clinical relevance","authors":"Giacomo Waller , Hideo Takahashi , Yuki Bekki , Rhea Raj , Salvatore Amodeo , Michael Buckstein , Maria Isabel Fiel , Marcelo E. Facciuto , Myron Schwartz , Ganesh Gunasekaran","doi":"10.1016/j.hpb.2025.12.039","DOIUrl":"10.1016/j.hpb.2025.12.039","url":null,"abstract":"<div><h3>Introduction</h3><div>The prognostic impact of positive bile duct margins (R1) after resection of perihilar cholangiocarcinoma (PHC) remains unclear, and evidence on the role of adjuvant radiation (RT) is limited.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed 110 patients who underwent curative-intent resection for PHC from 1997 to 2018. Primary outcomes were overall survival (OS) and disease-free survival (DFS). Univariate and multivariate analyses were performed to identify risk factors of OS and DFS.</div></div><div><h3>Results</h3><div>R1 margins were present in 50 patients (45.5 %). Median OS and DFS for the cohort were 47.5 and 30.2 months. OS and DFS did not differ by margin status. On multivariable analysis, lymph node metastasis independently predicted worse OS (HR 3.81; p < 0.001) and DFS (HR 3.32; p = 0.001), while larger tumor size predicted recurrence (HR 3.12; p = 0.001). Adjuvant chemotherapy was associated with improved OS (HR 0.45; p = 0.049). Among R1 patients, adjuvant RT was associated with longer DFS (68.6 vs 17.8 months; p = 0.049) but not OS.</div></div><div><h3>Conclusions</h3><div>R1 resection was not associated with inferior survival in this cohort. Lymph node metastasis was the strongest prognostic factor. Adjuvant RT was associated with improved DFS in the R1 patients, supporting its use for local control and warranting prospective validation.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 4","pages":"Pages 574-581"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IHPBA news 2 IHPBA新闻2。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2026-04-02 DOI: 10.1016/S1365-182X(26)00103-6

引用次数: 0

Focal nodular hyperplasia in men: a systematic review 男性局灶性结节增生：系统综述。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2026-01-13 DOI: 10.1016/j.hpb.2025.12.040

Adele Gudynaite , Ieva Tveragaite , Povilas Ignatavicius

{"title":"Focal nodular hyperplasia in men: a systematic review","authors":"Adele Gudynaite , Ieva Tveragaite , Povilas Ignatavicius","doi":"10.1016/j.hpb.2025.12.040","DOIUrl":"10.1016/j.hpb.2025.12.040","url":null,"abstract":"<div><h3>Background</h3><div>Focal nodular hyperplasia (FNH) is a benign liver tumor commonly found in women, often linked to oral contraceptive use. Its occurrence in men is rare and frequently mimics malignant liver lesions, complicating diagnosis and management. This systematic review aims to evaluate the clinical presentation, diagnostic challenges, and treatment approaches of FNH in male patients.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to PRISMA guidelines and registered in the PROSPERO database (CRD420245397). PubMed, Web of Science, and ScienceDirect were searched up to July 30, 2024, for studies on FNH in male adults. Data extraction and quality assessment were performed independently by multiple reviewers using the Newcastle-Ottawa Scale.</div></div><div><h3>Results</h3><div>Out of 1771 records, 20 studies including 38 male patients were analyzed. FNH was incidentally discovered in 22 cases, with most patients asymptomatic or having nonspecific symptoms. Imaging often revealed central stellate scars. Surgical resection was performed in 25 patients, primarily due to diagnostic uncertainty. Observation was chosen in 11 cases.</div></div><div><h3>Conclusion</h3><div>FNH in men is uncommon and presents diagnostic difficulties due to its overlap with malignancies. The high rate of surgical treatment, even in asymptomatic patients, highlights the need for more accurate, non-invasive diagnostic tools.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 4","pages":"Pages 463-469"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correspondence: “Impact of post-hepatectomy liver failure on recurrence following major hepatectomy for colorectal cancer liver metastases” 对应：“肝切除术后肝衰竭对大肠癌肝转移术后复发的影响”。

IF 2.4 3区医学

Hpb Pub Date : 2026-04-01 Epub Date: 2025-12-13 DOI: 10.1016/j.hpb.2025.12.020

Ahmad Mahamid

引用次数: 0