Hpb最新文献

{"title":"Absolute risk of pancreatic cancer in people with acute pancreatitis - the Australian experience","authors":"Lucas Wigston, Eleonora D. Grande, Jacqueline Stephens, Mark E. Brooke-Smith, Minoti Apte, Daniel Croagh, Tony Pang, Chee Y. Ooi, Jeremy Wilson, Ross A. McKinnon, Richard C. Turner, Rachel E. Neale, Savio G. Barreto","doi":"10.1016/j.hpb.2026.05.011","DOIUrl":"10.1016/j.hpb.2026.05.011","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Pages 1281-1283"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intention to treat outcomes following management of locally advanced pancreatic ductal adenocarcinoma with curative intent: single centre cohort study","authors":"Moath Alarabiyat,&nbsp;Saad Rehman,&nbsp;Peter L. Labib,&nbsp;Sarah Powell-Brett,&nbsp;Lewis Hall,&nbsp;Dawn Edwards,&nbsp;Yuk T. Ma,&nbsp;Shivan Sivakumar,&nbsp;James Good,&nbsp;Soulat S. Raza,&nbsp;Bobby Dasari,&nbsp;Ravi Marudanayagam,&nbsp;David Bartlett,&nbsp;Keith J. Roberts,&nbsp;Robert Sutcliffe","doi":"10.1016/j.hpb.2026.06.008","DOIUrl":"10.1016/j.hpb.2026.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Advances in the management of locally advanced pancreatic ductal adenocarcinoma (LAPDAC) have resulted in only a modest improvement in outcomes. This study highlights treatment pathway and outcomes of the largest contemporary United Kingdom LAPDAC cohort to date.</div></div><div><h3>Methods</h3><div>LAPDAC patients between 01/2017–12/2022 were included. Patient and tumour characteristics, surgical and oncological outcomes were collected prospectively. Primary endpoint was overall survival (OS). Secondary endpoints were chemotherapy completion and resection rates, perioperative morbidity and mortality and disease-free survival (DFS).</div></div><div><h3>Results</h3><div>208 patients were included. 133 patients commenced neoadjuvant treatment (NAT) with 107 patients receiving at least 3 months and 65 completing 6 months. 44/133 (33%) patients were considered for surgery and 25 (19%) underwent resection. 80% of patients underwent venous and/or arterial resection. 52% of patients had R0 resection. 90-day mortality was 12%. Median OS was significantly longer for patients who had resection after NAT (12.6 months vs 30 months, P &lt; 0.001). Median DFS was 7.7 months with a 3-year rate of 14%. Completion of chemotherapy (6 months) was associated with prolonged OS.</div></div><div><h3>Conclusions</h3><div>Multimodality therapy that includes surgery can be accomplished in selected patients with LAPDAC and is associated with a median overall survival that approximates earlier stages of disease.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Pages 1250-1264"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total vascular exclusion in pediatric hepatectomy: reducing hemorrhage without added morbidity","authors":"Juri Fuchs,&nbsp;Lucas Rabaux-Eygasier,&nbsp;Geraldine Hery,&nbsp;Virginie Fouquet,&nbsp;Catherine Baujard,&nbsp;Florent Guerin,&nbsp;Sophie Branchereau","doi":"10.1016/j.hpb.2026.06.007","DOIUrl":"10.1016/j.hpb.2026.06.007","url":null,"abstract":"<div><h3>Background</h3><div>Major hepatectomy in children carries distinct risks and challenges, with intraoperative hemorrhage being a critical determinant of morbidity and survival. Total vascular exclusion (TVE) provides complete vascular control, but its use in adults is associated with high morbidity. Evidence for pediatric hepatectomy is lacking.</div></div><div><h3>Methods</h3><div>A single-center study of all children (&lt;18 years) undergoing major hepatectomy between 2013 and 2023 was performed. Patients were grouped by TVE use. Primary outcomes were major complications (Clavien–Madadi ≥ III) and posthepatectomy liver dysfunction. Secondary outcomes included CCI, blood loss, transfusion, renal function, hospital stay, and oncologic outcomes.</div></div><div><h3>Results</h3><div>A total of 125 patients were included (68% with hepatoblastoma). TVE was applied in 67 children (53.6%) with a median duration of 18 min. No episodes of hemodynamic instability occurred during TVE. Outcomes including major complications (6.0% TVE vs. 6.9% non-TVE, <em>p</em> = 1.000), as well as intraoperative blood loss and transfusion, did not differ significantly between the groups. No patient developed clinically relevant posthepatectomy liver failure or renal dysfunction.</div></div><div><h3>Conclusions</h3><div>This is the largest series of children undergoing hepatectomy using TVE. In contrast to adult liver surgery, where adverse physiological effects constrain its use, TVE can be safely performed in children, without increasing perioperative morbidity.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Pages 1241-1249"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apparent precision versus underlying heterogeneity in the systematic review of partial hepatectomy after liver transplantation.","authors":"Imen Ben Ismail","doi":"10.1016/j.hpb.2026.08.2001","DOIUrl":"https://doi.org/10.1016/j.hpb.2026.08.2001","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S1365-182X(26)00740-9","DOIUrl":"10.1016/S1365-182X(26)00740-9","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Page OFC"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148917333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IHPBA news 1","authors":"","doi":"10.1016/S1365-182X(26)00747-1","DOIUrl":"10.1016/S1365-182X(26)00747-1","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Page IBC"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148917482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning model offers promising individualized prediction for recurrence-free survival in solitary resectable colorectal liver metastasis: strengths, limitations, and future directions","authors":"Wangdong Xu,&nbsp;Xu Qiu,&nbsp;Jianliang Sun","doi":"10.1016/j.hpb.2026.05.009","DOIUrl":"10.1016/j.hpb.2026.05.009","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Page 1288"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes in gallbladder cancer: evidence from the UK nationwide CAPBIL study","authors":"Jane McClements,&nbsp;Wan Teng Lee,&nbsp;James Lucocq,&nbsp;Amanda Koh,&nbsp;Harivinthan Sellappan,&nbsp;Lauren Blackburn,&nbsp;Adam Brooks,&nbsp;Jake Clements,&nbsp;James Ng,&nbsp;Adam Frampton,&nbsp;Syeda Gulbahar,&nbsp;Brian Davidson,&nbsp;Michael Feretis,&nbsp;Bobby V.M. Dasari,&nbsp;Georgios Papadopoulos,&nbsp;Dimitrios Karavias,&nbsp;Alistair Rowcroft,&nbsp;Ewen M. Harrison,&nbsp;Victoria Morrison–Jones,&nbsp;Fenella Welsh,&nbsp;Dhanwant Gomez","doi":"10.1016/j.hpb.2026.06.009","DOIUrl":"10.1016/j.hpb.2026.06.009","url":null,"abstract":"<div><h3>Background</h3><div>To report management and survival outcomes of gallbladder cancer (GBC) in the United Kingdom and to identify prognostic factors associated with disease-free survival (DFS) and overall survival (OS).</div></div><div><h3>Methods</h3><div>Patients undergoing surgery for GBC between January 2014 and December 2022 across 24 UK centres were included. Demographic, treatment, histopathological, and survival data were analysed.</div></div><div><h3>Results</h3><div>516 patients underwent surgery for GBC, with a median follow-up of 25 months. Patients with T3–T4 tumours more frequently presented with jaundice, had non-incidental disease, and underwent major hepatectomy compared with those with T1–T2 tumours. Advanced stage, nodal metastasis, vascular invasion, and perineural invasion were more common in patients undergoing major hepatectomy, which was also associated with higher major morbidity and 30-day mortality. Propensity score–matched analysis demonstrated no significant benefit in DFS or OS among patients who received adjuvant therapy compared with those who did not. On multivariable analysis, T3–T4 stage, nodal disease, and perineural invasion predicted poorer DFS, while T3–T4 stage and nodal disease predicted worse OS.</div></div><div><h3>Discussion</h3><div>This nationwide study demonstrates the evolution of management practices for GBC in the UK. Adverse tumour biology remains the principal determinant of survival following surgery for GBC.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Pages 1265-1276"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical versus non-anatomical liver resection for hepatocellular carcinoma – an international multicenter propensity score-matched analysis of short- and long-term outcomes in an international multicenter cohort","authors":"Soufyan El Adel,&nbsp;Derar Jaradat,&nbsp;Tijs J. Hoogteijling,&nbsp;Ye-Xin Koh,&nbsp;Andrea Benedetti Cacciaguerra,&nbsp;Simone Conci,&nbsp;Davit Aghayan,&nbsp;Margarida Casellas,&nbsp;Paolo Magistri,&nbsp;Daniel Osei-Bordom,&nbsp;Nadia Rusolillo,&nbsp;Celine de Meyere,&nbsp;Gabriel Zozaya,&nbsp;Denis Fisenko,&nbsp;Francesco Ardito,&nbsp;Victor Lopez-Lopez,&nbsp;Jawad Ahmad,&nbsp;Steven White,&nbsp;Moritz Schmelzle,&nbsp;Tom Gallagher,&nbsp;Mohammad Abu Hilal","doi":"10.1016/j.hpb.2026.05.002","DOIUrl":"10.1016/j.hpb.2026.05.002","url":null,"abstract":"<div><h3>Background</h3><div>The optimal surgical technique for hepatocellular carcinoma (HCC) remains debated, particularly regarding the balance between perioperative morbidity and long-term oncological outcomes when comparing anatomical resection (AR) with non-anatomical resection (NAR).</div></div><div><h3>Methods</h3><div>This international, retrospective multicenter study included patients undergoing resection for solitary HCC ≤5 cm. Patients undergoing major hepatectomy (≥3 segments), two-stage hepatectomy, portal vein embolization, or non-curative procedures were excluded. After propensity score matching (PSM), perioperative outcomes, disease-free survival (DFS), and overall survival (OS) were analyzed, with subgroup analyses by surgical approach and tumour size.</div></div><div><h3>Results</h3><div>After propensity score matching, 442 patients were included in each group. NAR was associated with more favourable perioperative outcomes, including shorter operative time, lower blood loss, and lower rates of severe morbidity. DFS did not differ between groups. AR was associated with improved OS in the overall matched cohort (5-year OS: 77.2% vs. 67.2%; <em>p</em> = 0.041), in patients with larger tumours (≥3.6 cm; 81.3% vs. 61.3%; <em>p</em> = 0.022), and in those undergoing minimally invasive liver resection (74.5% vs. 63.2%; <em>p</em> = 0.001). No significant OS difference was observed in patients with smaller tumours (≤3.5 cm).</div></div><div><h3>Conclusion</h3><div>NAR was associated with better perioperative outcomes, whereas AR was associated with improved OS in selected analyses. As DFS did not differ between groups and subgroup findings were exploratory, these results should be interpreted cautiously. Overall, the findings support an individualized, tumour-tailored surgical approach.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Pages 1171-1181"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights in this issue","authors":"","doi":"10.1016/S1365-182X(26)00743-4","DOIUrl":"10.1016/S1365-182X(26)00743-4","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 9","pages":"Page iii"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148917336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}