Close correlation between patients' positive mood and postoperative complication burden in hepato-biliary-pancreatic cancer: a prospective comparative cohort trial.

IF 2.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Hpb Pub Date : 2025-07-26 DOI:10.1016/j.hpb.2025.07.015

Shunsuke Onoe, Yukihiro Yokoyama, Tsuyoshi Igami, Junpei Yamaguchi, Takashi Mizuno, Yoshikuni Inokawa, Hideki Takami, Masaki Sunagawa, Nobuyuki Watanabe, Shoji Kawakatsu, Tatsuya Tokura, Takahiro Imaizumi, Tomoki Ebata

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引用次数: 0

Abstract

Background: The impact of preoperative mood on complications remains poorly understood in hepato-biliary-pancreatic (HBP) surgery.

Methods: This prospective cohort study included patients who underwent resection for pancreatic ductal carcinoma and cholangiocarcinoma. Preoperative positive mood were measured by Vigor-Activity score according to Profile of Mood States, 2nd edition. The primary outcome was the whole burden of complications, represented by the comprehensive complication index (CCI). Patients were divided into low- and high-positive mood groups by the median Vigor-Activity score. The impact of mood state on CCI was assessed by restricted cubic spline regression.

Results: Between July 2021 and June 2022, 127 consecutive patients were enrolled. Preoperative findings and surgical procedures did not significantly differ between the low-positive (n = 64) and high-positive (n = 63) mood groups. The high-positive mood group had a significantly lower median CCI than the low-positive mood group (41.1 vs. 48.2, P = 0.026). The Vigor-Activity score had a nearly linear negative correlation with CCI and independently decreased CCI (P = 0.034).

Conclusion: Patients with preoperative high-positive mood had a lower CCI than those with low-positive mood after major HBP surgery. A patient's preoperative mood could affect the total burden of postoperative complications.

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一项前瞻性比较队列试验：肝胆胰癌患者积极情绪与术后并发症负担密切相关。

背景：术前情绪对肝胆胰（HBP）手术并发症的影响仍知之甚少。方法：这项前瞻性队列研究包括接受胰管癌和胆管癌切除术的患者。术前积极情绪根据《情绪状态量表》第2版采用活力-活动评分法测定。主要观察指标为并发症总负担，以综合并发症指数（CCI）表示。根据中位数活力-活动评分将患者分为低积极情绪组和高积极情绪组。用限制性三次样条回归评估情绪状态对CCI的影响。结果：在2021年7月至2022年6月期间，127名连续患者入组。低阳性情绪组（n = 64）和高阳性情绪组（n = 63）的术前检查结果和手术过程没有显著差异。高积极情绪组的CCI中位数明显低于低积极情绪组（41.1比48.2,P = 0.026）。活力-活动评分与CCI呈近线性负相关，且独立降低CCI （P = 0.034）。结论：术前高正性情绪患者CCI低于大HBP手术后低正性情绪患者。患者术前情绪会影响术后并发症的总负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hpb GASTROENTEROLOGY & HEPATOLOGY-SURGERY

CiteScore

5.60

自引率

3.40%

发文量

244

审稿时长

57 days

期刊介绍： HPB is an international forum for clinical, scientific and educational communication. Twelve issues a year bring the reader leading articles, expert reviews, original articles, images, editorials, and reader correspondence encompassing all aspects of benign and malignant hepatobiliary disease and its management. HPB features relevant aspects of clinical and translational research and practice. Specific areas of interest include HPB diseases encountered globally by clinical practitioners in this specialist field of gastrointestinal surgery. The journal addresses the challenges faced in the management of cancer involving the liver, biliary system and pancreas. While surgical oncology represents a large part of HPB practice, submission of manuscripts relating to liver and pancreas transplantation, the treatment of benign conditions such as acute and chronic pancreatitis, and those relating to hepatobiliary infection and inflammation are also welcomed. There will be a focus on developing a multidisciplinary approach to diagnosis and treatment with endoscopic and laparoscopic approaches, radiological interventions and surgical techniques being strongly represented. HPB welcomes submission of manuscripts in all these areas and in scientific focused research that has clear clinical relevance to HPB surgical practice. HPB aims to help its readers - surgeons, physicians, radiologists and basic scientists - to develop their knowledge and practice. HPB will be of interest to specialists involved in the management of hepatobiliary and pancreatic disease however will also inform those working in related fields. Abstracted and Indexed in: MEDLINE® EMBASE PubMed Science Citation Index Expanded Academic Search (EBSCO) HPB is owned by the International Hepato-Pancreato-Biliary Association (IHPBA) and is also the official Journal of the American Hepato-Pancreato-Biliary Association (AHPBA), the Asian-Pacific Hepato Pancreatic Biliary Association (A-PHPBA) and the European-African Hepato-Pancreatic Biliary Association (E-AHPBA).