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Oncological outcomes following left-sided pancreatic resection for grade 1 and grade 2 pancreatic neuroendocrine tumours: a population-cohort study comparing open with minimally-invasive surgery 1级和2级胰腺神经内分泌肿瘤左侧胰腺切除术后的肿瘤预后：一项比较开放手术和微创手术的人群队列研究

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-07-12 DOI: 10.1016/j.hpb.2026.07.003

Abdullah K. Malik, Yu-Hui H. Chang, Samuel J. Tingle, Steven A. White, Motaz Qadan, Zhi V. Fong, Sanjay Pandanaboyana

{"title":"Oncological outcomes following left-sided pancreatic resection for grade 1 and grade 2 pancreatic neuroendocrine tumours: a population-cohort study comparing open with minimally-invasive surgery","authors":"Abdullah K. Malik, Yu-Hui H. Chang, Samuel J. Tingle, Steven A. White, Motaz Qadan, Zhi V. Fong, Sanjay Pandanaboyana","doi":"10.1016/j.hpb.2026.07.003","DOIUrl":"10.1016/j.hpb.2026.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Minimally invasive left-sided pancreatectomy (MIS-LP) is increasingly adopted for resection of grade 1 and 2 pancreatic neuroendocrine tumours (PNETs), but its oncological equivalence to open left-sided pancreatectomy (O-LP) remains to be fully evaluated.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using SEER-Medicare data (2010–2019) including all patients who underwent left-sided pancreatectomy (LP) for PNETs. A multilevel Cox regression model was used to to provide adjusted hazard ratios (HR) for overall survival (OS) and cancer-specific survival (CSS) when comparing between MIS-LP and O-LP. A 6-month landmark survival analysis was performed to account for early postoperative deaths.</div></div><div><h3>Results</h3><div>A total of 772 patients were included, with 257 (33.3%) undergoing MIS-LP. Six-hundred-and-seventy-two patients had grade 1, and 100 patients had grade 2 PNETs. MIS-LP was associated with better OS (HR 0.48, 95% CI 0.26-0.86, P=0.014) and CSS (HR 0.35, 95% CI 0.14-0.88, P=0.026). In the 6-month landmark analysis, O-LP was associated with similar OS and CSS to MIS-LP.</div></div><div><h3>Conclusion</h3><div>MIS-LP is associated with improved early survival compared to O-LP in patients with low- to intermediate-grade PNETs.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 10","pages":"Pages 1371-1382"},"PeriodicalIF":3.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148602466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IHPBA news 1 IHPBA新闻

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-10-08 DOI: 10.1016/S1365-182X(26)02761-9

引用次数: 0

Cover 封面

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-10-08 DOI: 10.1016/S1365-182X(26)02754-1

引用次数: 0

From screen to scalpel: total telemedicine pathway shortens liver surgery clinic and OR wait times 从屏幕到手术刀：全远程医疗路径缩短肝脏手术门诊和手术室等待时间。

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-07-02 DOI: 10.1016/j.hpb.2026.06.020

Brittany Morocco, Robin Schmitz, Alexander S. Thomas, Molly Vincent, Andrew R. Watson, Samer Tohme, David A. Geller

引用次数: 0

Comment on: Incidence, timing, risk factors, and outcomes of unplanned reintubation after liver and pancreatic resection 评论：肝胰切除术后意外再插管的发生率、时机、危险因素和结果。

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-07-08 DOI: 10.1016/j.hpb.2026.07.001

Zelin Ye

引用次数: 0

Regrowth of disappearing liver lesions is rare and is not associated with diminished overall survival 消失的肝脏病变再生是罕见的，与总生存率降低无关。

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-07-03 DOI: 10.1016/j.hpb.2026.06.019

Bethel C. Ozed-Williams, Rick J. Jansen, Qianyun Luo, Christopher J. LaRocca, Jacob S. Ankeny, Schelomo Marmor, David G. Brauer, Eric H. Jensen

{"title":"Regrowth of disappearing liver lesions is rare and is not associated with diminished overall survival","authors":"Bethel C. Ozed-Williams, Rick J. Jansen, Qianyun Luo, Christopher J. LaRocca, Jacob S. Ankeny, Schelomo Marmor, David G. Brauer, Eric H. Jensen","doi":"10.1016/j.hpb.2026.06.019","DOIUrl":"10.1016/j.hpb.2026.06.019","url":null,"abstract":"<div><h3>Background</h3><div>Small colorectal liver metastases (CRLMs) commonly disappear following neoadjuvant chemotherapy. Some authors have suggested upfront surgery, fiducial placement or blind resection of these Disappearing Liver Lesions (DLLs). This retrospective review defines the natural history, recurrence patterns, and survival of patients with DLLs.</div></div><div><h3>Methods</h3><div>Patients who underwent liver directed surgery for small CRLMs (≤3 cm) were identified from a prospectively collected database. DLLs were defined as tumors not seen on pre-operative MRI or intra-operative ultrasound following neoadjuvant chemotherapy. Statistical analysis was conducted using Python 3.11(Python software foundation, 2023).</div></div><div><h3>Results</h3><div>The study included 72 patients with a median follow-up of 55 months. Overall survival was 73 months, and disease recurrence occurred in 46 patients (64%). After neoadjuvant chemotherapy, 29 patients (40%) had at least one DLL. Among patients with DLLs, distant hepatic or systemic recurrence occurred in 21 (72%). However, regrowth of DLL occurred in only 3 patients (10%). Two of these were treated with median survival of 97 months and the third had synchronous extrahepatic disease that precluded additional surgery.</div></div><div><h3>Discussion</h3><div>DLLs are common, but only rarely regrow (10%). Pre-emptive treatment or fiducial placement for small CRLMs is likely unnecessary and may lead to overtreatment.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 10","pages":"Pages 1354-1359"},"PeriodicalIF":3.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148601971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Major hepatic venous and caval injuries during hepatectomy following SIRT: a technical caution SIRT术后肝切除术中肝静脉和腔静脉损伤：技术警告。

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-06-04 DOI: 10.1016/j.hpb.2026.05.012

Laurence Webber, Bjoern-Ole Stueben, Mohammed Ballal, Mayank Bhandari, Lingjun Mou, Richard Bryant, David Cavallucci, Nicholas O'Rourke

引用次数: 0

Optimal lymph node examination and prognostic significance of positive lymph node ratio in distal cholangiocarcinoma: a multicenter cohort study of 852 patients 远端胆管癌最佳淋巴结检查及淋巴结阳性比例的预后意义：一项852例患者的多中心队列研究

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-07-01 DOI: 10.1016/j.hpb.2026.06.016

Hyewon Yun, Huisong Lee, Jin-Young Jang, Yoo-Seok Yoon, Ho Kyoung Hwang, Hyung-Il Seo, Hyung Jun Kwon, Hee Joon Kim, Yong Hoon Kim, Hongbeum Kim, In Seok Choi, Seung Eun Lee, Kwan Woo Kim, Chi-Young Jeong, Seog-Ki Min, Hyeon Kook Lee

{"title":"Optimal lymph node examination and prognostic significance of positive lymph node ratio in distal cholangiocarcinoma: a multicenter cohort study of 852 patients","authors":"Hyewon Yun, Huisong Lee, Jin-Young Jang, Yoo-Seok Yoon, Ho Kyoung Hwang, Hyung-Il Seo, Hyung Jun Kwon, Hee Joon Kim, Yong Hoon Kim, Hongbeum Kim, In Seok Choi, Seung Eun Lee, Kwan Woo Kim, Chi-Young Jeong, Seog-Ki Min, Hyeon Kook Lee","doi":"10.1016/j.hpb.2026.06.016","DOIUrl":"10.1016/j.hpb.2026.06.016","url":null,"abstract":"<div><h3>Background</h3><div>The optimal number of lymph nodes examined (LNE) during pancreaticoduodenectomy for distal bile duct cancer remains unclear. This study evaluated its impact on staging accuracy and the prognostic value of the positive lymph node ratio (PLR).</div></div><div><h3>Methods</h3><div>We analysed 852 patients who underwent PD for histologically confirmed distal cholangiocarcinoma detection rates across LNE groups were compared by chi-square test. Overall survival (OS) was assessed using Kaplan–Meier and multivariable Cox regression.</div></div><div><h3>Results</h3><div>Median LNE was 13 (IQR 7–19); 274 patients (32.2%) were node-positive (N1: 220, N2: 54). Node-positive detection increased with LNE (10.5% [LNE 1–3] to 47.0% [LNE ≥21]; p < 0.0001), with a threshold effect at LNE ≥12 (39.0% vs 23.2%; p < 0.001). Median OS was 73.8, 35.0, and 23.0 months for N0, N1, and N2, respectively (p < 0.001). Independent adverse prognostic factors were node-positive status, R1 margin, lymphovascular invasion, perineural invasion, poor differentiation, and age >60 years. PLR groups (<0.10, 0.10–0.25, ≥0.25) showed distinct median OS of 63.0, 32.0, and 22.0 months (p < 0.001).</div></div><div><h3>Conclusion</h3><div>Examination of at least 12 LNs is recommended for accurate nodal staging in distal cholangiocarcinoma. The AJCC 8th edition three-tier N classification provides meaningful prognostic discrimination.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 10","pages":"Pages 1334-1341"},"PeriodicalIF":3.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally invasive pancreatectomy with mesentericoportal venous resection: Results from a French national cohort 微创胰腺切除术联合肠系膜门静脉切除术：来自法国国家队列的结果。

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-06-19 DOI: 10.1016/j.hpb.2026.06.006

Elias Karam, Charles de Ponthaud, Alexandra Nassar, Clément Pastier, Antoine Castel, Alessandro Mazzotta, François-Régis Souche, Rami Rhaiem, Elsa Jolly, Jonathan Garnier, Régis Fara, Manon Viennet, Fabio Giannone, Johan Gagnière, Frédéric Borie, Mehdi Boubaddi, Lilian Schwarz, Clément Louis-Gaubert, François Pattou, Nicolas Meurisse, Marie André

{"title":"Minimally invasive pancreatectomy with mesentericoportal venous resection: Results from a French national cohort","authors":"Elias Karam, Charles de Ponthaud, Alexandra Nassar, Clément Pastier, Antoine Castel, Alessandro Mazzotta, François-Régis Souche, Rami Rhaiem, Elsa Jolly, Jonathan Garnier, Régis Fara, Manon Viennet, Fabio Giannone, Johan Gagnière, Frédéric Borie, Mehdi Boubaddi, Lilian Schwarz, Clément Louis-Gaubert, François Pattou, Nicolas Meurisse, Marie André","doi":"10.1016/j.hpb.2026.06.006","DOIUrl":"10.1016/j.hpb.2026.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Pancreatic resection (PR) may require portal/superior mesenteric vein resection (VR). Outcomes of minimally invasive PR (MIPR) with VR are poorly studied.</div></div><div><h3>Methods</h3><div>Multicentric retrospective cohort of MI pancreatoduodenectomy (MIPD) and left pancreatectomy (MILP) with or without VR between 2010 and 2021. Propensity score matching analysis stratified on age, sex, BMI, pancreas texture, tumor type, ASA score, conversion and surgical approach was performed.</div></div><div><h3>Results</h3><div>After matching, 234 MIPD were included, 78 (33.3%) with and 156 (66.7%) without VR. VR had greater blood loss (400 vs 300 mL; p = 0.033) and operative time (471 vs 430 min; p = 0.012). VR had 10.3% mortality compared to 4.5% (p = 0.097), similar severe morbidity (30.8% vs 37.8%: p = 0.313) and R0 resection rate (84.9% vs 90.8%: p = 0.252). After matching, 275 MILP, 25 (9%) with and 250 (91%) without VR were compared. VR had greater blood loss (350 vs 150mL; p = 0.019) and operative time (300 vs 240 min; p = 0.005). VR had 8% mortality versus 2% (p = 0.126), 19.2% severe morbidity versus 8% (p = 0.274) and lower R0 resection rate (58.3% vs 94.9%; p <0.001).</div></div><div><h3>Conclusion</h3><div>MIPR with VR has non-significant increased postoperative mortality, lower R0 resection rate and therefore cannot be considered as a standard of care.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 10","pages":"Pages 1318-1333"},"PeriodicalIF":3.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the interplay of operative volume at the hospital and surgeon level for pancreatic cancer 评估胰腺癌医院和外科手术量的相互作用。

IF 3.3 3区医学

Hpb Pub Date : 2026-10-01 Epub Date: 2026-07-21 DOI: 10.1016/j.hpb.2026.07.007

Dhruv J. Patel, Joseph H. Cotler, Bryan Palis, Anthony D. Yang, C.M. Schmidt, Ronald J. Weigel, Karl Y. Bilimoria, Ryan J. Ellis

{"title":"Assessing the interplay of operative volume at the hospital and surgeon level for pancreatic cancer","authors":"Dhruv J. Patel, Joseph H. Cotler, Bryan Palis, Anthony D. Yang, C.M. Schmidt, Ronald J. Weigel, Karl Y. Bilimoria, Ryan J. Ellis","doi":"10.1016/j.hpb.2026.07.007","DOIUrl":"10.1016/j.hpb.2026.07.007","url":null,"abstract":"<div><h3>Background</h3><div>The current retrospective study aimed to assess the interaction between surgeon-volume and hospital-volume on outcomes after pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC).</div></div><div><h3>Methods</h3><div>Patients with PDAC undergoing PD from 2008 to 2023 were identified using the National Cancer Database. Operative volumes of ≥20 cases/year defined high-volume hospitals (HVH) and ≥12 cases/year defined high-volume surgeons (HVS). Those below those thresholds were low-volume surgeons (LVS) and low-volume hospitals (LVH). Multivariable logistic regression was used to assess associations between surgeon/hospital volume and outcomes, relative to HVS/HVH.</div></div><div><h3>Results</h3><div>The inclusion cohort consisted of 50,519 patients treated by 3155 surgeons operating at 976 hospitals. 90-day mortality declined with increasing volume: LVS/LVH = 6.4%, HVS/LVH = 5.7%, LVS/HVH = 4.0%, HVS/HVH = 3.5% (p < 0.001). Patients undergoing surgery by HVS/LVH [Odds Ratio (OR): 1.58, 95% Confidence Interval (95%CI) (1.12, 2.24), p = 0.009] and LVS/LVH [OR: 1.59, 95%CI (1.24, 2.04), p < 0.001] had a higher adjusted likelihood of mortality. LVS/HVH was not associated with mortality compared with HVS/HVH. Both HVS/LVH [OR: 1.93, 95%CI (1.27, 2.92), p = 0.002] and LVS/LVH [OR: 1.60, 95% CI (1.15, 2.23), p = 0.006] had a higher likelihood of readmission.</div></div><div><h3>Conclusion</h3><div>Outcomes after PD for PDAC remain more greatly influenced by hospital-volume rather than surgeon-volume.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 10","pages":"Pages 1402-1412"},"PeriodicalIF":3.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0