Does a robotic approach decrease morbidity and mortality following pancreaticoduodenectomy for octogenarians? An American multi-center analysis.

IF 2.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Hpb Pub Date : 2025-07-30 DOI:10.1016/j.hpb.2025.07.016

Sarah B Hays, Kristine Kuchta, Andres A Abreu, Asmita Chopra, Emile Farah, Amudhan Kannan, Syed A Mehdi, Imad Radi, Kristen Ranson, Aram E Rojas, Adam Tcharni, Brian A Boone, Alessandro Paniccia, Patricio M Polanco, Carl R Schmidt, Mark S Talamonti, Herbert J Zeh, Amer H Zureikat, Melissa E Hogg

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引用次数: 0

Abstract

Background: Morbidity and mortality following pancreaticoduodenectomy (PD) have improved; however, the population is aging, and the use of robotic surgery is expanding. This study compares the selection of octogenarians who underwent PD, their outcomes, and whether robotic surgery provides an advantage.

Methods: This is a multi-institutional retrospective review from 2007 to 2023 of patients who underwent PD, including open and robotic approach. Pre-, intra-, and post-operative outcomes were analyzed; multivariable analysis (MVA) and propensity score matching (PSM) were performed.

Results: 2175 patients underwent PD for all causes; <80 years: n=1,952, >80 (octogenarians): n=223. Octogenarians had higher age unadjusted Charlson Comorbidity Index (2.8 vs 2.6, p<0.001), and more prior surgeries (67.9 % vs 56.1 %, p<0.001). On univariate analysis, octogenarians had higher average Clavien-Dindo grade (2.0 vs 1.7, p=0.002) and higher 90-day mortality (9.9 % vs 3.1 %, p<0.001). On MVA, age >80 was associated with increased risk of major morbidity (OR 1.50 [1.10-2.04], p=0.011) and 90-day mortality (OR 3.20 [1.85-5.54], p<0.001). Robotic PD (RPD) was associated with decreased risk of major morbidity (OR 0.69 [0.56-0.86], p<0.001). After PSM of octogenarians who underwent RPD, there was no statistically significant difference in mortality.

Conclusion: Pancreaticoduodenectomy has increased but acceptable morbidity in octogenarians. The increased risk may be mitigated by RPD.

查看原文本刊更多论文

机器人方法能降低八十多岁老人胰十二指肠切除术后的发病率和死亡率吗？美国的多中心分析。

背景：胰十二指肠切除术（PD）后的发病率和死亡率有所改善；然而，人口正在老龄化，机器人手术的使用正在扩大。本研究比较了接受PD治疗的80多岁老人的选择，他们的结果，以及机器人手术是否提供了优势。方法：这是一项2007年至2023年接受PD治疗的患者的多机构回顾性研究，包括开放和机器人入路。分析术前、术中、术后结果；进行多变量分析（MVA）和倾向评分匹配（PSM）。结果：2175例患者因各种原因接受PD治疗；80（80岁以上）：n=223。八旬老人的年龄未经调整的Charlson合并症指数更高(2.8 vs 2.6， p80与主要发病风险增加（OR 1.50 [1.10-2.04], p=0.011）和90天死亡率增加（OR 3.20[1.85-5.54]）相关。结论：胰十二指肠切除术增加了八旬老人的发病率，但可接受。RPD可以减轻增加的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hpb GASTROENTEROLOGY & HEPATOLOGY-SURGERY

CiteScore

5.60

自引率

3.40%

发文量

244

审稿时长

57 days

期刊介绍： HPB is an international forum for clinical, scientific and educational communication. Twelve issues a year bring the reader leading articles, expert reviews, original articles, images, editorials, and reader correspondence encompassing all aspects of benign and malignant hepatobiliary disease and its management. HPB features relevant aspects of clinical and translational research and practice. Specific areas of interest include HPB diseases encountered globally by clinical practitioners in this specialist field of gastrointestinal surgery. The journal addresses the challenges faced in the management of cancer involving the liver, biliary system and pancreas. While surgical oncology represents a large part of HPB practice, submission of manuscripts relating to liver and pancreas transplantation, the treatment of benign conditions such as acute and chronic pancreatitis, and those relating to hepatobiliary infection and inflammation are also welcomed. There will be a focus on developing a multidisciplinary approach to diagnosis and treatment with endoscopic and laparoscopic approaches, radiological interventions and surgical techniques being strongly represented. HPB welcomes submission of manuscripts in all these areas and in scientific focused research that has clear clinical relevance to HPB surgical practice. HPB aims to help its readers - surgeons, physicians, radiologists and basic scientists - to develop their knowledge and practice. HPB will be of interest to specialists involved in the management of hepatobiliary and pancreatic disease however will also inform those working in related fields. Abstracted and Indexed in: MEDLINE® EMBASE PubMed Science Citation Index Expanded Academic Search (EBSCO) HPB is owned by the International Hepato-Pancreato-Biliary Association (IHPBA) and is also the official Journal of the American Hepato-Pancreato-Biliary Association (AHPBA), the Asian-Pacific Hepato Pancreatic Biliary Association (A-PHPBA) and the European-African Hepato-Pancreatic Biliary Association (E-AHPBA).