Autism Research最新文献

{"title":"Visual mental imagery abilities in autism","authors":"Clara Bled, Quentin Guillon, Laurent Mottron, Isabelle Soulieres, Lucie Bouvet","doi":"10.1002/aur.3192","DOIUrl":"10.1002/aur.3192","url":null,"abstract":"<p>Sensory atypicalities such as over-reactivity to auditory input or unusual interest in perception-based information are a common feature of autism (Ben-Sasson et al., <span>2019</span>). However, these atypicalities as not limited to the “sensory” dimension as higher levels of perceptive functioning are also atypical in autism (Bertone et al., <span>2005</span>; Mottron, <span>2019</span>; Samson et al., <span>2011</span>). The Enhanced Perceptual Functioning (EPF) theory suggests a higher role, autonomy and performance of perceptive abilities in autism (Mottron et al., <span>2006</span>; Mottron & Gagnon, <span>2023</span>; Samson et al., <span>2011</span>). Perception in autism is argued to be more precise and less likely to be altered by prior knowledge. As visual mental imagery and perception activate the same neural networks and rely on the same content-dependent representations in visual areas (Kosslyn et al., <span>2006</span>), the enhanced visual abilities described in autism could induce enhanced visual mental imagery abilities. Thus, mental imagery might be a key interface between a particular cognitive functioning and the sensory particularities in autism. However, this cognitive mechanism has seldom been studied so far. The objective of this study was therefore to evaluate in depth mental imagery abilities in autism with the hypothesis of superior aptitudes in autism.</p><p>Mental imagery is defined as the evocation of a representation and its associated sensory information in the absence of a direct external stimulus (Pearson et al., <span>2015</span>). Mental imagery plays a central role in cognition as it allows one to remember past events, plan the future, represent oneself in space or even make decisions. These various uses of mental imagery are made possible by its four different stages: generation, maintenance, inspection and manipulation of mental images (Kosslyn et al., <span>2006</span>; Pearson et al., <span>2013</span>). A mental image is indeed “generated” as it is constructed “step by step” (Koenig et al., <span>1991</span>). Once generated, a mental image is subject to rapid decay with an average duration of only 250 ms (Kosslyn, <span>1994</span>). An active maintenance of the image in our attention window is then required. Subsequently, this image can then be inspected or manipulated in space. The “scanning” of mental images is one possible form of inspection activity (i.e., moving from one point to another in a mental image) (Finke & Pinker, <span>1983</span>). Mental images then can also be modified/transformed in space (Pearson et al., <span>2013</span>).</p><p>Visual mental imagery has anecdotally been indicated as an autistic strength (Grandin, <span>2009</span>). According to the self-reports of some autistic adults, autism entails a particular “way of thinking” described as “thinking in pictures”. Autistic individuals report using mental visual representation, and hence mental imagery, more frequent","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 10","pages":"2064-2078"},"PeriodicalIF":5.3,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal cortisol profiles in autistic adolescents and young adults: Associations with social difficulties and internalizing mental health symptoms","authors":"Laura Ilen,&nbsp;Farnaz Delavari,&nbsp;Clémence Feller,&nbsp;Olivia Zanoletti,&nbsp;Carmen Sandi,&nbsp;Maude Schneider","doi":"10.1002/aur.3184","DOIUrl":"10.1002/aur.3184","url":null,"abstract":"<p>Several autism-related characteristics, such as social difficulties, may contribute to high perceived stress and increased exposure to stressful life events in some autistic individuals. Repeated exposure to stress might lead to the dysfunction of the hypothalamic–pituitary-adrenocortical-axis and be a vulnerability factor for developing mental health difficulties. Previous studies show contradictory findings on salivary cortisol in autism. In the current study, we investigated diurnal cortisol profiles in autistic adolescents and young adults, as well as their associations with social difficulties, stress exposure, and mental health symptoms. Autistic (<i>n</i> = 48, <i>M</i>_age = 17.6) and nonautistic (<i>n</i> = 51, <i>M</i>_age = 18.4) participants collected salivary cortisol at home six times a day for 2 days. Social difficulties, exposure to stressful life events/bullying, and mental health symptoms were assessed with questionnaires and clinical interviews. Similar diurnal cortisol slopes (DCS) and cortisol awakening responses were observed between the groups, but autistic participants showed higher total cortisol output (AUC_G, area under the curve with respect to ground) during the day (<i>b</i> = 19.09, <i>p</i> = 0.009). In the autistic group, more severe social difficulties were associated with flatter DCS (<i>b</i> = 0.01, <i>p</i> = 0.007). Finally, cortisol alterations were associated with self-reported mental health symptoms, especially in autistic females in analyses uncorrected for multiple comparisons. In conclusion, our results do not indicate autism-related group-level alterations in most diurnal cortisol measures, but autistic youth showed higher total cortisol (AUC_G) compared with nonautistic peers. More detailed investigation of interindividual variability in cortisol profiles within autistic people might give us important insights into vulnerability to developing stress-related mental health difficulties.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 8","pages":"1601-1615"},"PeriodicalIF":5.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-childhood autism sibling recurrence in infants with a family history of autism","authors":"Tessel Bazelmans,&nbsp;Rowan Arthur,&nbsp;Greg Pasco,&nbsp;Elizabeth Shephard,&nbsp;Bosiljka Milosavljevic,&nbsp;Jannath Begum Ali,&nbsp;Andrew Pickles,&nbsp;Mark H. Johnson,&nbsp;Emily J. H. Jones,&nbsp;Tony Charman,&nbsp;The BASIS/STAARS Team","doi":"10.1002/aur.3182","DOIUrl":"10.1002/aur.3182","url":null,"abstract":"<p>Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 7","pages":"1501-1514"},"PeriodicalIF":5.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatosensory temporal sensitivity in adults on the autism spectrum: A high-density electrophysiological mapping study using the mismatch negativity (MMN) sensory memory paradigm","authors":"Emily L. Isenstein,&nbsp;Edward G. Freedman,&nbsp;Sophie Molholm,&nbsp;John J. Foxe","doi":"10.1002/aur.3186","DOIUrl":"10.1002/aur.3186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Atypical reactivity to somatosensory inputs is common in autism spectrum disorder and carries considerable impact on downstream social communication and quality of life. While behavioral and survey work have established differences in the perception of somatosensory information, little has been done to elucidate the underlying neurophysiological processes that drive these characteristics. Here, we implemented a duration-based somatosensory mismatch negativity (MMN) paradigm to examine the role of temporal sensitivity and sensory memory in the processing of vibrotactile information in autistic (<i>n</i> = 30) and neurotypical (<i>n</i> = 30) adults. To capture the variability in responses between groups across a range of duration discrepancies, we compared the electrophysiological responses to frequent standard vibrations (100 ms) and four infrequent deviant vibrations (115, 130, 145, and 160 ms). The same stimuli were used in a follow-up behavioral task to determine active detection of the infrequent vibrations. We found no differences between the two groups with regard to discrimination between standard and deviant vibrations, demonstrating comparable neurologic and behavioral temporal somatosensory perception. However, exploratory analyses yielded subtle differences in amplitude at the N1 and P220 time points. Together, these results indicate that the temporal mechanisms of somatosensory discrimination are conserved in adults on the autism spectrum, though more general somatosensory processing may be affected. We discuss these findings in the broader context of the MMN literature in autism, as well as the potential role of cortical maturity in somatosensory mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 9","pages":"1760-1777"},"PeriodicalIF":5.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in executive function in autism spectrum disorder: A systematic review and meta-analyses","authors":"Michael K. Yeung,&nbsp;Jieru Bai,&nbsp;Kwai-Lai Mak","doi":"10.1002/aur.3196","DOIUrl":"10.1002/aur.3196","url":null,"abstract":"<p>Individuals with an autism spectrum disorder (ASD) diagnosis show impairment in executive function (EF). However, findings are mixed regarding differences in the age effect on EF between autistic individuals and persons with typical development (TD). Questions remain regarding whether the age-related trajectories of EF in ASD are the same as or different from those in TD. To bridge this knowledge gap, we conducted a systematic review and meta-analyses of longitudinal studies that compared age-related changes in EF between ASD and TD groups (preregistration: osf.io/j5764). A literature search was conducted using PubMed, PsycINFO, and Web of Science on January 29, 2024. After screening by two independent reviewers, 14 longitudinal studies were included. Random-effects meta-analyses of studies involving a maximum total of 518 autistic and 3558 TD children and adolescents (mean baseline ages: 5.7–12.0 years) showed that ASD had significantly poorer EF than TD at both baseline and follow-up. However, there was no significant group difference in the age-related change in EF across domains, including working memory, inhibition, shifting, and planning. Robust Bayesian meta-analyses also provided substantial evidence in favor of the null hypothesis that ASD and TD groups showed similar changes over time for most EF processes. Limitations of the literature included the limited number of longitudinal studies and a narrow range of developmental stages and EF constructs analyzed across studies. Altogether, these findings suggest that autistic children and adolescents generally can improve in EF over time similarly to their neurotypical peers. This has important implications for parents and educators, encouraging appropriate EF training and intervention for autistic children and adolescents at an early stage.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 10","pages":"2045-2063"},"PeriodicalIF":5.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical and variable attention patterns reveal reduced contextual priors in children with autism spectrum disorder","authors":"Wenwen Hou,&nbsp;Rong Cheng,&nbsp;Zhong Zhao,&nbsp;Haotian Liao,&nbsp;Jing Li","doi":"10.1002/aur.3194","DOIUrl":"10.1002/aur.3194","url":null,"abstract":"<p>Accumulating evidence suggests that individuals with autism spectrum disorder (ASD) show impairments in using contextual priors to predict others' actions and make intention inference. Yet less is known about whether and how children with ASD acquire contextual priors during action observation and how contextual priors relate to their action prediction and intention inference. To form proper contextual priors, individuals need to observe the social scenes in a reliable manner and focus on socially relevant information. By employing a data-driven scan path method and areas of interest (AOI)-based analysis, the current study investigated how contextual priors would relate to action prediction and intention understanding in 4-to-9-year-old children with ASD (<i>N</i> = 56) and typically developing (TD) children (<i>N</i> = 50) during free viewing of dynamic social scenes with different intentions. Results showed that children with ASD exhibited higher intra-subject variability when scanning social scenes and reduced attention to socially relevant areas. Moreover, children with high-level action prediction and intention understanding showed lower intra-subject variability and increased attention to socially relevant areas. These findings suggest that altered fixation patterns might restrain children with ASD from acquiring proper contextual priors, which has cascading downstream effects on their action prediction and intention understanding.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 8","pages":"1572-1585"},"PeriodicalIF":5.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development","authors":"Fiona Journal,&nbsp;Martina Franchini,&nbsp;Michel Godel,&nbsp;Nada Kojovic,&nbsp;Kenza Latrèche,&nbsp;Stefania Solazzo,&nbsp;Maude Schneider,&nbsp;Marie Schaer","doi":"10.1002/aur.3188","DOIUrl":"10.1002/aur.3188","url":null,"abstract":"<p>Children with autism spectrum disorder (ASD) often face challenges in early social communication skills, prompting the need for a detailed exploration of specific behaviors and their impact on cognitive and adaptive functioning. This study aims to address this gap by examining the developmental trajectories of early social communication skills in preschoolers with ASD aged 18–60 months, comparing them to age-matched typically developing (TD) children. Utilizing the early social communication scales (ESCS), the research employs a longitudinal design to capture changes over time. We apply a principal component analysis (PCA) to ESCS variables to identify underlying components, and cluster analysis to identify subgroups based on preverbal communication profiles. The results reveal consistent differences in early social communication skills between ASD and TD children, with ASD children exhibiting reduced skills. PCA identifies two components, distinguishing objects-directed behaviors and social interaction-directed behaviors. Cluster analysis identifies three subgroups of autistic children, each displaying specific communication profiles associated with distinct cognitive and adaptive functioning trajectories. In conclusion, this study provides a nuanced understanding of early social communication development in ASD, emphasizing the importance of low-level behaviors. The identification of subgroups and their unique trajectories contributes to a more comprehensive understanding of ASD heterogeneity. These findings underscore the significance of early diagnosis, focusing on specific behaviors predicting cognitive and adaptive functioning outcomes. The study encourages further research to explore the sequential development of these skills, offering valuable insights for interventions and support strategies.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 10","pages":"2030-2044"},"PeriodicalIF":5.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program","authors":"Chaela Nutor,&nbsp;Aisha S. Dickerson,&nbsp;Tingju Hsu,&nbsp;Aseel Al-Jadiri,&nbsp;Carlos A. Camargo,&nbsp;Julie B. Schweitzer,&nbsp;Coral L. Shuster,&nbsp;Margaret R. Karagas,&nbsp;Juliette C. Madan,&nbsp;Bibiana Restrepo,&nbsp;Rebecca J. Schmidt,&nbsp;Claudia Lugo-Candelas,&nbsp;Jenae Neiderhiser,&nbsp;Sheela Sathyanarayana,&nbsp;Anne L. Dunlop,&nbsp;Patricia A. Brennan,&nbsp;program collaborators for Environmental influences on Child Health Outcomes","doi":"10.1002/aur.3185","DOIUrl":"10.1002/aur.3185","url":null,"abstract":"<p>This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1–18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 8","pages":"1651-1664"},"PeriodicalIF":5.3,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specificity of the short-story task for autism diagnosis when controlling for depression","authors":"Irina Jarvers,&nbsp;Johannes Pfisterer,&nbsp;Katrin Döhnel,&nbsp;Lore Blaas,&nbsp;Manuela Ullmann,&nbsp;Berthold Langguth,&nbsp;Rainer Rupprecht,&nbsp;Monika Sommer","doi":"10.1002/aur.3191","DOIUrl":"10.1002/aur.3191","url":null,"abstract":"<p>Securing an accurate autism-spectrum-condition diagnosis, particularly among women, remains challenging for autistic adults. Building upon previous research highlighting the short-story task (SST) as a promising tool for detecting fiction-based mentalizing difficulties in autistic adults, this study expands its scope. We investigated the SST's discriminative capacity across three distinct groups: autistic individuals (<i>n</i> = 32), nonautistic individuals without mental health problems (<i>n</i> = 32), and nonautistic individuals with clinical depression (<i>n</i> = 30). All three groups differed significantly from each other in their SST mentalizing score with the nonautistic group having the highest scores, the nonautistic but depressed group having medium scores and the autistic group showing the lowest scores. Receiver operator curve (ROC) analysis reaffirmed the SST's efficacy as a discriminator. Moreover, a linear regression analysis identified the SST mentalizing score, the SST comprehension score, and the number of books read per month as significant predictors of autism-spectrum-condition diagnosis. These findings bolster the SST's potential as a valuable adjunct in autism diagnostics, highlighting its discriminatory ability across diverse samples.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 9","pages":"1928-1933"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism","authors":"A. Than,&nbsp;G. Patterson,&nbsp;K. K. Cummings,&nbsp;J. Jung,&nbsp;M. E. Cakar,&nbsp;L. Abbas,&nbsp;S. Y. Bookheimer,&nbsp;M. Dapretto,&nbsp;S. A. Green","doi":"10.1002/aur.3179","DOIUrl":"10.1002/aur.3179","url":null,"abstract":"<p>Although aversive responses to sensory stimuli are common in autism spectrum disorder (ASD), it remains unknown whether the social relevance of aversive sensory inputs affects their processing. We used functional magnetic resonance imaging (fMRI) to investigate neural responses to mildly aversive nonsocial and social sensory stimuli as well as how sensory over-responsivity (SOR) severity relates to these responses. Participants included 21 ASD and 25 typically-developing (TD) youth, aged 8.6–18.0 years. Results showed that TD youth exhibited significant neural discrimination of socially relevant versus irrelevant aversive sensory stimuli, particularly in the amygdala and orbitofrontal cortex (OFC), regions that are crucial for sensory and social processing. In contrast, ASD youth showed reduced neural discrimination of social versus nonsocial stimuli in the amygdala and OFC, as well as overall greater neural responses to nonsocial compared with social stimuli. Moreover, higher SOR in ASD was associated with heightened responses in sensory-motor regions to socially-relevant stimuli. These findings further our understanding of the relationship between sensory and social processing in ASD, suggesting limited attention to the social relevance compared with aversiveness level of sensory input in ASD versus TD youth, particularly in ASD youth with higher SOR.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 7","pages":"1328-1343"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}