HIV Research & Clinical Practice最新文献

{"title":"A closer look: factors impacting HIV durable viral suppression among a cohort of clinic attendees in Trinidad & Tobago.","authors":"Elena Cyrus, Deidre A Okeke, Omari Lavia, Mary Jo Trepka, Allysha Maragh-Bass, Lunthita Duthely, Michael Sciauodone, Jeffrey Edwards","doi":"10.1080/25787489.2024.2443886","DOIUrl":"https://doi.org/10.1080/25787489.2024.2443886","url":null,"abstract":"<p><strong>Background: </strong>In Trinidad and Tobago, high HIV prevalence among key populations necessitates studying factors that impact durable viral suppression (DVS), crucial for effective HIV management and reducing transmission among at-risk networks. This study investigates these factors using clinical data from a major HIV care clinic in the Caribbean.</p><p><strong>Methods: </strong>A retrospective analysis of 533 adult people with HIV (people) at MRFTT from 2017 to 2021 assessed the proportion achieving DVS, defined as a sustained viral load <200 copies/ml over one year. Initial univariate analysis characterized individuals with DVS, followed by bivariate analysis to explore socio-demographic differences. Significant variables from bivariate analysis were examined in a regression model to identify DVS covariates.</p><p><strong>Results: </strong>The average age of the sample was 45 years (SD = 10.88), with 52.0% male and 72.1% of African descent. 31.5% achieved durable viral suppression (DVS). Those with DVS were predominantly women (54.1%), older (mean age 45, SD = 11.32), with more frequent clinic visits over five years (mean = 101, SD = 33.26). Regression analysis showed that women (OR = 1.43, 95% CI 0.99-2.07), individuals on long-term antiretroviral therapy (ART) (>5 years) (OR = 1.66, 95% CI 1.03-2.66), and those with extended clinic enrolment (>5 years) (OR = 1.82, 95% CI 1.08-3.06) had higher odds of achieving DVS.</p><p><strong>Conclusions: </strong>Only a third of the study sample achieved DVS, with men less likely to reach this goal. Lesser engagement in care correlated with lower DVS rates. Further research into social and structural barriers to clinic attendance, particularly among younger men, is recommended.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"26 1","pages":"2443886"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better outcomes of HIV-1 infection in women compared to men in an Ethiopian cohort.","authors":"S Bezalel-Rosenberg, K Mahlab-Guri, N Itai, L Kadar, S Nemet, I Asher, R Cohen, Z M Sthoeger, H Elinav, D Elbirt","doi":"10.1080/25787489.2025.2511376","DOIUrl":"https://doi.org/10.1080/25787489.2025.2511376","url":null,"abstract":"<p><p><b>Introduction:</b> Sex influences the presentation and progression of various diseases. Studies regarding the impact of sex on the course and outcome of HIV may be biased due to differences in socioeconomic status between women and men and uneven sex representation, among other factors, resulting in conflicting data. Thus, this study compared men and women of similar ethnicity and social class who were diagnosed with HIV in two Israeli HIV care centers to minimize the effect of non-biological elements in this study cohort.</p><p><p><b>Methods:</b> A retrospective HIV cohort of 334 women and 223 men diagnosed from 2000 to 2015. All patients were immigrants from Ethiopia who acquired HIV heterosexually and were of a similar socioeconomic status. Data regarding demographics, clinical status, virological (viral load [VL]) and immunological (CD4) status, and treatment modalities were collected for each patient.</p><p><p><b>Results:</b> At HIV diagnosis, male were older than female (43.2 ± 13.2 vs. 35.4 ± 11.95 years; <i>p</i> < 0.0001) with a higher VL (372,086 ± 757,366 vs. 237,442 ± 756,371 copies/mL; <i>p</i> = 0.0443) and lower CD4 cell counts (240.74 ± 178 vs. 302.54 ± 218.89 cells/µL; <i>p</i> = 0.0006). Mean follow-up (9.94 ± 4.11 years) was similar between sexes. Women demonstrated significantly higher CD4 cell counts (492.6 ± 267.2 vs. 382.4 ± 214.7 cells/µL; <i>p</i> = 0.0001), lower AIDS rates (13.47% vs. 21.97%; p = 0.0147), and reduced mortality (6.29% vs. 16.59%; <i>p</i> = 0.0002) then men. These differences persisted in subgroup analyses stratified by age and immunological status at diagnosis (measured by CD4 cell counts and VL). In a multivariate analysis male sex emerged as an independent risk factor for death, AIDS, and low CD4 cell counts.</p><p><p><b>Conclusions:</b> The clinical course and outcome of HIV infected women compared to men were more favorable, with lower rates of immunological impairment, AIDS, and mortality.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"26 1","pages":"2511376"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual adaptation of a nurse-driven strategy to improve blood pressure control among people with HIV.","authors":"Melissa Klein Cutshaw, Kelley A Jones, Nwora Lance Okeke, Corrilynn O Hileman, Barbara M Gripshover, Angela Aifah, Gerald S Bloomfield, Charles Muiruri, Valerie A Smith, Rajesh Vedanthan, Allison R Webel, Hayden B Bosworth, Christopher T Longenecker","doi":"10.1080/25787489.2025.2477396","DOIUrl":"10.1080/25787489.2025.2477396","url":null,"abstract":"<p><p>People with HIV are at increased risk of cardiovascular events; thus, care delivery strategies that increase access to comprehensive cardiovascular disease (CVD) risk management are a priority. We report the results of a multi-component telemedicine-based strategy to improve blood pressure control among people with HIV-Assess and Adapt to the Impact of COVID-19 on CVD Self-Management and Prevention Care in Adults Living with HIV (AAIM-High). The AAIM High strategy is a virtual adaptation of our previously published EXTRA-CVD strategy and consisted of hypertension education and six components: nurse-led care coordination (delivered by teleconference or telephone), home systolic blood pressure (SBP) monitoring, evidence-based treatment algorithms, electronic health records tools, technology coach, and communication preferences assessment. People with HIV (<i>n</i> = 74) with comorbid hypertension at three academic medical centers were enrolled in a single arm implementation study from January 2021 to December 2022. Over 12 months, the average patient-performed home SBP decreased by 7.7 mmHg (95% CI -11.5, -3.9). The percentage of patients at treatment goal, defined as average SBP <130 mmHg, increased from 46.0% to 72.5% at 12 months. By adapting to the growing use of telemedicine in healthcare delivery, our study effectively improved hypertension control in people with HIV through a virtual, nurse-led intervention.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"26 1","pages":"2477396"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating adherence in an active-controlled HIV pre-exposure prophylaxis trial (PrEPVacc) to inform the estimation of HIV incidence in a counterfactual placebo arm.","authors":"Sheila Kansiime, Christian Holm Hansen, Henry Bern, Julie Fox, David Dunn, Eugene Ruzagira, Richard Hayes, Sheena Mc Cormack","doi":"10.1080/25787489.2025.2513684","DOIUrl":"https://doi.org/10.1080/25787489.2025.2513684","url":null,"abstract":"<p><strong>Background: </strong>Inferring the counterfactual placebo HIV incidence using the estimated effectiveness of Emtricitabine/Tenofovir (TDF/FTC) in active-controlled pre-exposure prophylaxis (PrEP) trials has been suggested. However, it has not yet been widely applied. In this article, we evaluate adherence to TDF/FTC in the PrEPVacc trial (NCT04066881) and consider how such adherence data could be used to estimate the effectiveness of TDF/FTC and subsequently, HIV incidence in a counterfactual placebo arm in a predominantly female population.</p><p><strong>Methods: </strong>From December 2020 to March 2023 participants were recruited into the trial which included a comparison of Emtricitabine/Tenofovir Alafenamide (TAF/FTC) to TDF/FTC as PrEP over 26 weeks of follow-up, in Uganda, Tanzania, and South Africa. PrEP adherence was assessed in various ways.</p><p><strong>Results: </strong>Of 697 participants dispensed TDF/FTC, 87% were female, 54% were ≥ 25 years, and 59% were sex workers. In a random sample (41%) assessed at visit 6 (week 8), 76% had detectable TFV-DP levels, with 22% reaching levels consistent with ≥2 pills/week. Males, Verulam and Mbeya participants, those ≥ 25 years, not single, subsistence fisheries workers, and those who had any STI at baseline were more likely to have higher adherence. Of those assessed at visit 6, 29% were identified as white coat dosing. Estimated (crude) HIV incidence risk reduction ranged from 10% to 65%.</p><p><strong>Conclusions: </strong>TDF/FTC adherence in the PrEPVacc trial was low, with considerable levels of white coat dosing. Inferring the counterfactual placebo HIV incidence using the estimated effectiveness of TDF/FTC is a promising approach, however, the approach requires further elaboration and evaluation.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"26 1","pages":"2513684"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trans Equity Project: a multicomponent intervention to improve HIV prevention and care continua outcomes among men and women of transgender experience.","authors":"Allysha C Maragh-Bass, Elena Cyrus, Tatyana Woodard, Lekiah Lescott, Ashley French, Emily A Arnold, Mallory O Johnson, Omar Martinez","doi":"10.1080/25787489.2025.2515806","DOIUrl":"10.1080/25787489.2025.2515806","url":null,"abstract":"<p><strong>Purpose: </strong>Men and women of transgender experience encounter HIV-related health inequities based on race across the HIV care continua. We explored HIV prevention and care needs <i>via</i> focus groups, surveys, and Sexually Transmitted Infection (STI) testing experiences (<i>N</i> = 40); we supplemented this data via in-depth interviews with peer navigators.</p><p><strong>Methods: </strong>This study was conducted from 2020 to 2022. Analyses included coding and descriptive statistics. Nearly 63% identified as Black, and 20% identified as Latinx. Nearly 90% of participants reported ever having HIV tests; 10% of participants tested positive for other STIs.</p><p><strong>Results: </strong>Qualitative analyses yielded three core intervention components for men and women of transgender experience: (1) Comprehensive Trans Care; (2) Community, Mentorship, and Support; and (3) Life Skills and Professional Development. Study participants, community and scientific advisory board members agreed on the need for a peer-led, group-level intervention in English and Spanish.</p><p><strong>Conclusion: </strong>These needs and priorities are conducive to future interventions which build community agency, structural approaches, and health equity centered on men and women of transgender experience of color.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"26 1","pages":"2515806"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of provider preferences for HIV Care Coordination Program features: latent class analysis of a discrete choice experiment.","authors":"Chunki Fong, Madellena Conte, Rebecca Zimba, Jennifer Carmona, Gina Gambone, Abigail Baim-Lance, McKaylee Robertson, Mary Irvine, Denis Nash","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The PROMISE study assessed revisions designed to facilitate implementation of an HIV care coordination program (CCP) addressing gaps in care and treatment engagement among people living with HIV in New York City (NYC). Through latent class analysis (LCA) of a discrete choice experiment (DCE), we explored heterogeneity of provider preferences regarding CCP features. From January-March 2020, 152 NYC CCP providers completed a DCE with 3-4 levels on each of 4 program attributes: 1) Help with Adherence to Antiretroviral Therapy (ART), 2) Help with Primary Care Appointments, 3) Help with Issues Other than Primary Care, and 4) Where Program Visits Happen. We used LCA to assess patterns of preference, and choice simulation to estimate providers' endorsement of hypothetical CCPs. LCA identified three subgroups. The two larger subgroups (<i>n</i> = 133) endorsed more intensive individual program features, including directly observed therapy, home visits, and appointment reminders with accompaniment of clients to their appointments. The smallest subgroup (<i>n</i> = 19) endorsed medication reminders only, appointment reminders without accompaniment, and meeting at the program location rather than clients' homes. Choice simulation analysis affirmed the highest degree of endorsement (62%) for hypothetical programs combining the intensive features described above. Results indicated providers' preference for intensive program features and also reinforced the need for flexible service delivery options. Provider perspectives on service delivery approaches can inform program adjustments for successful long-term implementation, which in turn can improve patient outcomes.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"25 1","pages":"2300923"},"PeriodicalIF":1.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Impact TB co-infections on immune tolerance among people living with HIV: a systematic review.","authors":"","doi":"10.1080/25787489.2024.2416301","DOIUrl":"https://doi.org/10.1080/25787489.2024.2416301","url":null,"abstract":"","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"25 1","pages":"2416301"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of human immunodeficiency virus drug resistance and factors associated with high viral load among adolescents on antiretroviral therapy in Dar Es Salaam, Tanzania.","authors":"Irene Maseke, Agricola Joachim, Doreen Kamori, Ahmed Abade, Nyambura Moremi, Mtebe Majigo","doi":"10.1080/25787489.2024.2400827","DOIUrl":"10.1080/25787489.2024.2400827","url":null,"abstract":"<p><strong>Background: </strong>Resistance to antiretrovirals against human immunodeficiency virus (HIV) poses a threat to zero transmission of HIV by 2030. Few studies have been conducted on HIV drug resistance (HIVDR) mutations targeting adolescents. We determined the prevalence, pattern of HIVDR mutations, and factors associated with unsuppressed HIV viral load among adolescents on antiretroviral therapy (ART).</p><p><strong>Methods: </strong>From March to June 2020, we conducted a cross-sectional study at the Infectious Disease Clinic in Dar es Salaam, Tanzania. HIV-1 viral load was tested using m2000rt Real-Time HIV-1 assay. A sample with a viral load equal or more than 1,000 copies/ml was tested for HIVDR mutations. We determined the factors associated with unsuppressed viral load using logistic regression. A <i>p</i>-value less than 0.05 was considered significant.</p><p><strong>Results: </strong>We enrolled 131 participants with a median age (interquartile range) of 15 (13-18) years. Of all, 24(18.3%) had a viral load above 1000 copies/ml. HIVDR mutations were found in 19/24(68.4%). Mutation to protease inhibitors, nucleotide reverse transcriptase inhibitors, and non-nucleoside reverse transcriptase inhibitors were 1(5.2%), 9(47.4%), and 11(57.9%), respectively. Non-antiretroviral therapy and orphanages were independently associated with unsuppressed viral load.</p><p><strong>Conclusion: </strong>The prevalence of HIVDR and unsuppressed HIV viral load among adolescents are relatively high. The use of non-antiretroviral therapy and orphanage influenced the persistence of high viral load. Strategies for surveillance of HIVDR early warning signs should be devised among adolescents.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"25 1","pages":"2400827"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General and healthcare-related HIV stigma among cisgender Brazilian women: the role of socioeconomic vulnerability.","authors":"Angelo Brandelli Costa, Murilo Martins da Silva, Lara Wiehe Chaves, Milena Gelain, Isadora Graeff Bins-Ely, Felipe Alckmin-Carvalho, Guilherme Welter Wendt","doi":"10.1080/25787489.2024.2361179","DOIUrl":"10.1080/25787489.2024.2361179","url":null,"abstract":"<p><strong>Background: </strong>HIV-related stigma is associated with worse health outcomes and lower adherence to antiretroviral therapy. There is limited data on the stigma faced by Latin American cisgender women, although they are among the populations most affected by HIV. This study aims to provide insight into the Stigma Index Brazil, with the objective of estimating the prevalence of HIV-related stigma among cisgender women in Brazil and to investigate the role of low socioeconomic status in stigma experience.</p><p><strong>Methods: </strong>This is a cross-sectional community-based study. A total of 30 people with HIV were trained to recruit participants from their peer networks; 1,768 people with HIV from all regions of Brazil participated in the study, of which 566 participants were cisgender women. We used the Stigma Index, an instrument that assesses global trends in HIV-related stigma from the perspective of people with HIV.</p><p><strong>Results: </strong>Approximately 70% of participants reported some form of HIV-related stigma. The most prevalent forms were discriminatory comments or gossiping (51.26%) and verbal harassment (30.99%). More than 20% experienced any health care related HIV-stigma in the last 12 months, the most frequent being the avoidance of physical contact (10.02%). Women in social vulnerability faced more stigma compared to the group without social vulnerability, both in general contexts (75.79% vs 64.32%; χ2 = 8.67, <i>p</i> < 0.05) and in healthcare contexts (24.12% vs 16.02%; χ2 = 4.06, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>We found a high prevalence of stigma associated with HIV faced by Brazilian women from all regions of the country, both in everyday life and in healthcare contexts. Evidence-based interventions to reduce stigma in the general population, and specific mental health care aimed at women with HIV in Brazil, especially among those with greater socioeconomic vulnerability, are urgent.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"25 1","pages":"2361179"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating knowledge, practice, and attitude of Syrian population on sexually transmitted infections and human immunodeficiency virus.","authors":"Sarya Swed, Hidar Alibrahim, Khaled Albakri, Mohammed Amir Rais, Safwan Al-Rassas, Wael Hafez, Bisher Sawaf, Mohammad Badr Almoshantaf, Mohamed Elsayed, Ebraheem Albazee, Huzaifa Ahmad Cheema, Wehba Hraiz, Fatima Taieb, Venus Hussain Ameen, Amine Rakab, Talha Bin Emran, Elrashed AbdElrahim, Hamid Osman, Refat Khan Pathan, Mayeen Uddin Khandaker","doi":"10.1080/25787489.2024.2356409","DOIUrl":"10.1080/25787489.2024.2356409","url":null,"abstract":"<p><strong>Background: </strong>Human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) can cause severe and fatal complications; knowledge about these diseases is essential for promoting safe sex practices and modifying behaviours that are harmful to one's health. This study investigates Syrian people's understanding, attitudes, and behaviors towards HIV/AIDS and STIs, aiming to identify factors promoting safe sex practices and modifying harmful behaviors.</p><p><strong>Methods: </strong>This online cross-sectional study was conducted in Syria between 3 September and 23 November 2022, involving all 18+ individuals. The questionnaire was adapted from a previous study containing 74 questions from five sections: socio-demographic information, knowledge and practice regarding STIs, knowledge and practice regarding HIV/AIDS, attitude towards HIV/AIDS, and attitude regarding STIs and analyzed using descriptive and multivariate logistic regression.</p><p><strong>Results: </strong>The study involved 1073 participants mostly aged between 18-30, with 55.3% females. Over half had good awareness of STIs and HIV/AIDS, with 55% and 63% respectively. Specifically, the overall knowledge level of STI type, signs/symptoms, risks of transmission, preventive methods, and complications for untreated STIs were (45.7%), (52.9%), (58.1%), (66.1%), and (59.6%), respectively. Medical field respondents had higher knowledge of HIV (P-value < 0.05, OR = 2).</p><p><strong>Conclusion: </strong>Our results show that Syrian people have a knowledge level of STIs and HIV was moderate. However, the attitude toward STIs was negative, as less than half of the participants had a good attitude. It is essential to solve these knowledge gaps, especially in low-income countries such as Syria.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"25 1","pages":"2356409"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}