HIV Research & Clinical Practice最新文献

{"title":"QuantiFERON-TB gold plus in people living with HIV: independence from CD4+ T-cell counts in a low TB-burden setting.","authors":"Erika Asperges, Roberto Gulminetti, Laura Maiocchi, Stefano Novati, Layla Pagnucco, Paolo Sacchi, Valentina Zuccaro, Angelo Tavano, Francesco Siviero, Pietro Guidicini, Enrica Bono, Giuseppe Albi, Patrizia Cambieri, Bianca V Mariani, Raffaele Bruno","doi":"10.1080/25787489.2026.2624947","DOIUrl":"https://doi.org/10.1080/25787489.2026.2624947","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis screening is recommended for people living with HIV. The QuantiFERON-TB test measures the cell-mediated response against <i>M. Tuberculosis</i>. The Gold-In-Tube measures the response of CD4+ T-cells, often leading to indeterminate results. The new Gold-Plus (QFT-GP) also measures CD8+ T-cells response, thus reducing uncertainties. However, studies on people living with HIV, that would benefit from a test independent from CD4+ T-cells, are scarce.</p><p><strong>Objective: </strong>This study addresses this gap by evaluating the performance of QFT-GP specifically in a large cohort of people living with HIV in a low TB-endemic setting.</p><p><strong>Methods: </strong>We retrospectively evaluated the frequency of indeterminate QFT-GP tests in a cohort of people living with HIV with at least one test. We collected demographic data, CD4+ and CD8+ T-cell count at nadir and at the time of testing, and history of prior TB infection or treatment. We correlated the QFT-GP results to the CD4+ T-cell count.</p><p><strong>Results: </strong>Six hundred and ninety five patients were included (males/females 72.5/27.5%), median age was 51 ± 14 years. Only 1,2% of tests were indeterminate, and there was no association with the CD4+ or CD8+ T-cell count at the moment of the test or at the nadir.</p><p><strong>Conclusions: </strong>QFT-GP has few indeterminate results, even in patients with a low CD4+ T-cell count.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2624947"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of viral suppression before, during, and after pregnancy among women on antiretroviral therapy in Uganda: six-year real-world experience.","authors":"Collins Ankunda, Jude Emunyu, Sharon Namasambi, Brendah Kyomuhangi, Conrad Sserunjogi, Iving Mumbere, Jane Nakawesi","doi":"10.1080/25787489.2026.2637206","DOIUrl":"10.1080/25787489.2026.2637206","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the effectiveness of antiretroviral therapy (ART) and associated factors on viral suppression before, during, and after pregnancy (maternal timeline).</p><p><strong>Methods: </strong>We conducted a cohort study, retrospectively reviewing records of 1291 pregnant and breastfeeding women on ART. Descriptive statistics summarised the demographics and clinical characteristics. Chi-square, Fisher's exact, and generalised estimating equations were used to assess variations in viral suppression across the maternal timeline.</p><p><strong>Results: </strong>ART regimens comprised 62.5% dolutegravir (DTG)-, 28.8% efavirenz (EFV)-, 4.5% nevirapine (NVP)-, and 4.2% protease inhibitor (PI)-based therapy. Viral suppression rates before, during, and after pregnancy were DTG- (95.0%, 94.6%, 95.7%), EFV- (94.9%, 94.2%, 93.6%), NVP- (93.1%, 94.7%, 93.5%), and PI-based (79.6%, 88.0%, 85.7%). ART regimens varied in effectiveness, with statistical significance observed before (<i>p</i> < 0.001) and after (<i>p </i>= 0.018), but not during pregnancy (<i>p</i> = 0.678). PI-based regimens showed higher risk of non-suppression in the non-adjusted model (IRR = 3.20, 95% CI: 1.63-6.30, p = 0.001). In the adjusted model, poor adherence (aIRR = 7.80, 95% CI: 2.54-23.90, <i>p</i> < 0.001), fair adherence (aIRR = 5.03, 95% CI: 1.11-22.86, <i>p</i> =  0.036), second-line ART (aIRR = 3.14, 95% CI: 1.75-5.62, <i>p</i> < 0.001), and third-line ART (aIRR = 8.48, 95% CI: 1.82-39.43, <i>p</i> = 0.006) remained significant.</p><p><strong>Conclusion: </strong>ART effectiveness showed variation before and after, but not during pregnancy. EFV- and NVP-based regimens achieved suppression rates comparable to DTG across maternal timelines, with the exception of PI-based regimens. Adherence and ART drugs influence outcomes more than regimen choice alone, with good adherence essential for optimal maternal outcomes.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2637206"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypocoagulability among people living with HIV at Hoima Regional Referral Hospital, Western Uganda: a cross-sectional study.","authors":"Abdisalam Ahmed Sandeyl, Mohamed Jayte, Farah Dubad Abdi, Hassan Omar Ali, Abdisamad Guled Hersi, Zakarie Abdullahi Hussein, Venance Emmanuel Mswelo, Abdalla Ahmed Deifa, Abishir Mohamud Hirsi, Jacinto Amandua","doi":"10.1080/25787489.2026.2649042","DOIUrl":"https://doi.org/10.1080/25787489.2026.2649042","url":null,"abstract":"<p><strong>Background: </strong>Coagulation abnormalities are an under-recognized complication among people living with HIV. Despite widespread antiretroviral therapy (ART), hematologic dysfunction, including coagulation and platelet abnormalities, continues to contribute to morbidity in sub-Saharan Africa.</p><p><strong>Objective: </strong>This study aimed to determine the prevalence, associated factors, and clinical features of hypocoagulability among people with HIV at Hoima Regional Referral Hospital (HRRH).</p><p><strong>Methods: </strong>We conducted a cross-sectional study at HRRH, Western Uganda, from May to July 2025. Sociodemographic, clinical, and behavioral data were collected via questionnaires and chart review. Laboratory evaluation included platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), and international normalized ratio (INR). Hypocoagulability was defined as ≥ 1 abnormal parameter: PT > 13.5 s, aPTT > 35 s, INR > 1.2, or platelet count <150,000/µL. Multivariable logistic regression identified independent factors associated with hypocoagulability.</p><p><strong>Results: </strong>The study enrolled 389 HIV-positive adults. Hypocoagulability was detected in 121 participants (31.1%). The most frequent abnormalities were prolonged PT (14.1%), elevated INR (11.8%), prolonged aPTT (11.1%), and thrombocytopenia (9.3%). Independent factors associated with hypocoagulability included older age (aOR: 2.012, 95% CI = 1.165-4.813), alcohol use (aOR: 2.177, 95% CI = 1.250-3.792), ART-naïve status (aOR: 3.159, 95% CI 1.057-9.364), and unsuppressed viral load (aOR: 2.235, 95% CI = 1.297-3.851). Clinically, affected participants more commonly reported easy bruising (33.1%), frequent nose bleeds (29.8%), and heavy menstrual bleeding among women (39.2%) compared to participants without hypocoagulability.</p><p><strong>Conclusion: </strong>These findings highlight the importance of early detection, promotion of ART adherence, targeted screening of high-risk groups, and integrated management strategies to reduce bleeding-related morbidity in HIV care.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2649042"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring HIV self-testing and implementation determinants among migrants: perspectives from West, East, Central, and Southern African migrants and key informants in the Netherlands.","authors":"Oladipupo Shobowale, Kai J Jonas, Sarah E Stutterheim","doi":"10.1080/25787489.2026.2629083","DOIUrl":"https://doi.org/10.1080/25787489.2026.2629083","url":null,"abstract":"<p><strong>Background: </strong>HIV self-testing (HIVST) has the potential to increase testing uptake among populations underserved by facility/clinic-based services, including African migrants in Europe. However, research on HIVST among African migrants in Europe and other high-income countries remains limited.</p><p><strong>Objective: </strong>To explore perspectives on HIVST, identify barriers and facilitators to uptake, and provide recommendations to inform effective implementation among African migrants in the Netherlands.</p><p><strong>Methods: </strong>Between February 2021 and May 2023, semi-structured interviews were conducted with 26 African migrants and 13 key informants, including healthcare providers (general practitioners, HIV specialists, testing service providers), policy and research professionals, and migrant community representatives. Data were analyzed using an inductive thematic approach. The Consolidated Framework for Implementation Research (CFIR) was applied post hoc to contextualize study findings within a broader implementation context.</p><p><strong>Results: </strong>Participants' perspectives on HIVST centered on three themes: enhanced autonomy in decision-making and testing processes; navigating autonomy and support for self-testing and care linkage; and HIVST within the Dutch context and prevention landscape. Factors potentially influencing successful uptake and implementation were identified across multiple CFIR domains, including perceived relative advantage over facility/clinic-based testing, evidence on reliability, and procedural complexity (Innovation Characteristics); low self-efficacy, self-testing and linkage to care support needs (Individual Characteristics); HIV stigma, limited awareness and low visibility of HIVST (Outer Setting); and perceived incompatibility with existing healthcare systems (Inner Setting).</p><p><strong>Conclusions: </strong>Although HIVST can address key testing barriers among African migrants, targeted implementation strategies are needed to guarantee equitable access, proper use, and optimal outcomes. These include enhanced dissemination of HIVST information, normalization of HIV testing and self-testing, provision of person-centered support, and establishing clear pathways for timely care linkage when required.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2629083"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability and preferences regarding long-acting injectable antiretroviral therapy among people with HIV in Pakistan.","authors":"Muhammad Wasay Shahid, Masood-Ur- Rehman, Faizur Rehman, Mehran Riaz, Malik Muhammad Umair, Nasim Akhtar, Musarat Jabeen, Ali Ahmed","doi":"10.1080/25787489.2026.2635223","DOIUrl":"https://doi.org/10.1080/25787489.2026.2635223","url":null,"abstract":"<p><strong>Background: </strong>Long-acting injectable antiretroviral therapy (LAI-ART) is an emerging alternative to daily oral ART, offering the potential to improve adherence, reduce dosing frequency, and alleviate treatment fatigue among people with HIV. There is limited evidence on its real-world acceptability, feasibility, and implementation challenges in low- and middle-income countries, such as Pakistan, where structural barriers and health system limitations may influence uptake.</p><p><strong>Objective: </strong>This study explores the perspectives on the feasibility and acceptability of LAI-ART among people currently receiving oral ART in Pakistan.</p><p><strong>Methods: </strong>A qualitative study was conducted from November 2024 to January 2025, involving in-depth interviews from people in the ART center in Islamabad and community-based organizations, and one focus group discussion (FGD) with participants who are actively engaged in community-based peer advocacy across Pakistan. The data were analyzed using conventional thematic analysis with inductive coding.</p><p><strong>Results: </strong>We conducted interviews with 37 participants, with one-to-one discussions with 31 people with HIV and 6 participants in FGD. Participants perceived LAI-ART as beneficial due to the elimination of pill burden, improved adherence, fewer side effects, lesser logistical demands, and greater privacy. However, injection-related adverse events, longer clinic waiting times, and limited availability were key barriers to its implementation. Those unwilling to adopt LAI-ART cited trust in oral ART, the convenience of multi-month refills, concerns of reduced adherence, work-related constraints.</p><p><strong>Conclusion: </strong>LAI-ART is acceptable to people with HIV in Pakistan, offering adherence and privacy benefits. However, successful implementation depends on addressing concerns around safety, supply, and access through responsive, stigma-free, and people-centered care models.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2635223"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful initiation of fully parenteral antiretroviral therapy in a treatment-naïve person with HIV-1 infection and intestinal failure.","authors":"Krystof Sram, Hanus Rozsypal, Stanislav Sevela, Jakub Lhotan, David Jilich","doi":"10.1080/25787489.2026.2657707","DOIUrl":"https://doi.org/10.1080/25787489.2026.2657707","url":null,"abstract":"<p><strong>Introduction: </strong>In patients with severe surgical and gastrointestinal complications, standard oral combination antiretroviral therapy (ARV) may be temporarily impossible. Long-acting cabotegravir/rilpivirine (CAB/RPV LA) is approved for virologically suppressed individuals pretreated with oral therapy, but data on its use in treatment-naïve, critically ill patients with absent enteral absorption are extremely limited.</p><p><strong>Clinical presentation: </strong>We report a 26-year-old male admitted with fulminant hypertriglyceridaemic necrotizing pancreatitis complicated by abdominal compartment syndrome, multiple laparotomies, open abdomen with enteric fistulae, short bowel syndrome type I, chronic intestinal failure requiring parenteral nutrition, portal vein thrombosis, and prolonged intensive care. HIV-1 infection was diagnosed early (HIV RNA 5,000 copies/mL; CD4+ 780 cells/µL). Within three months, HIV RNA rose to 320,000 copies/mL and CD4+ declined to 570 cells/µL. Given absent gastrointestinal passage, standard ARV was initially deferred, but rapid virological rebound necessitated urgent treatment. An off-label fully parenteral regimen was initiated: intravenous zidovudine (AZT) with intramuscular CAB/RPV LA. Therapy was well tolerated alongside surgery, parenteral nutrition, antimicrobials, and anticoagulation. HIV RNA decreased to <20 copies/mL within 65 days and remained suppressed, with CD4+ recovery. Intravenous AZT was discontinued after 35 days, and CAB/RPV LA continued as maintenance during recovery and home parenteral nutrition.</p><p><strong>Discussion: </strong>Fully parenteral ARV, including CAB/RPV LA, may provide a safe and effective bridge to durable viral suppression in patients with absolute contraindications to oral therapy, warranting further evaluation.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2657707"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why addressing HIV stigma should be our number one priority in the HIV response.","authors":"Sarah E Stutterheim","doi":"10.1080/25787489.2026.2638007","DOIUrl":"10.1080/25787489.2026.2638007","url":null,"abstract":"<p><p>If we are to achieve the UNAIDS 95-95-95 goals, and eventually eradicate HIV, we need to prioritise stigma reduction, and we need to be smart about how we do it. This position paper gives an overview of the ways in which HIV stigma impacts the cascade of care outcomes, provides guidance for effective stigma reductions interventions, and delineates priorities for understanding and addressing stigma in the HIV response. It makes clear that various forms of stigma deleteriously impact prevention and testing, linkage to care, initiation and adherence to antiretroviral treatment, and viral suppression, and it describes stigma reduction methods for public stigma, self-stigma, and structural stigma. It furthermore argues that stigma interventions should be systematically developed, theory- and evidence-based, tailored to context, and co-designed and co-implemented with recipient populations. Lastly, this paper argues for a better measurement of stigma, not by seeking consensus on construct definitions and corresponding measures but rather through the transparent reporting of definitions and their operationalisations.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2638007"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing healthcare satisfaction and prevalence of diabetes and hypertension among older adults living with HIV in Eastern Uganda: a cross-sectional study.","authors":"Kenedy Kiyimba, Ronald Kibuuka, Jonathan Babuya, Nichola Kabahinda, Richard Maseruka, Tonny Lukwago Wotoyitidde, Samuel Baker Obakiro, Dan Kibuule","doi":"10.1080/25787489.2026.2637352","DOIUrl":"10.1080/25787489.2026.2637352","url":null,"abstract":"<p><strong>Background: </strong>The use of antiretroviral therapy (ART) in the management of HIV/AIDS has greatly increased the life expectancy of people living with HIV. However, longer life spans have been accompanied by a growing burden of non-communicable diseases (NCDs). This study assessed healthcare satisfaction and the prevalence of diabetes and hypertension among older adults living with HIV (50 years and above) at Mbale Regional Referral Hospital in Eastern Uganda.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at Mbale Regional Referral Hospital (MRRH) involving 400 HIV-positive patients aged more than 50 years on ART. The sociodemographic information, ART history, and comorbidities were obtained. Bivariate and multivariable logistic regression analyses were performed to identify predictors of comorbidities.</p><p><strong>Results: </strong>The prevalence of DM and HTN were 28.3% and 27.1%, respectively. Participants aged ≥64 years had significantly higher odds of HTN (AOR: 2.25; 95% CI: 1.27-3.19; <i>p</i> = 0.029). Changing ART regimens three or more times was associated with HTN (AOR: 2.55; 95% CI: 1.08-4.73; <i>p</i> = 0.015). Living 6-10 km from a health facility increased the odds of DM (AOR: 5.46; 95% CI: 1.12-26.54; <i>p</i> = 0.044). Overall, 91% of the participants reported satisfaction with the healthcare received.</p><p><strong>Conclusion: </strong>DM and HTN are highly prevalent among older adults living with HIV in Eastern Uganda and are associated with advanced age, ART regimen changes, and healthcare access challenges. The integration of NCD screening and management into HIV care are key for improving long-term outcomes in this population.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2637352"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating viral load information flow and provider decision-making for adolescent clients at HIV clinics in Kenya.","authors":"Deepa Oja, Christine Kundu, Alvin Onyango, Cyrus Mugo, Irene Njuguna, Hellen Morra, Dalton Wamalwa, Jillian Pintye, Grace John-Stewart, Molly R Altman, Pamela Kohler","doi":"10.1080/25787489.2026.2650034","DOIUrl":"https://doi.org/10.1080/25787489.2026.2650034","url":null,"abstract":"<p><strong>Background: </strong>Achieving viral suppression goals for adolescents with HIV requires multifaceted strategies, including efficient and effective health systems to routinely monitor HIV viral load (VL) and support adolescents when adherence falters.</p><p><strong>Objective: </strong>This study aimed to identify where gaps in information flow occur in return of HIV VL results to clinics and adolescents and to explore how providers determine 'good adherence' prior to confirmation of virological failure.</p><p><strong>Methods: </strong>Four focus group discussions and ten in-depth interviews were conducted with purposively selected healthcare workers (<i>n</i> = 39) from various phases of VL information flow. We used thematic analysis to identify themes.</p><p><strong>Results: </strong>Themes consisted of individual- and family-level challenges, facility-level barriers, supply chain constraints affecting laboratory-related delays, client-specific factors impacting dissemination of VL results, reluctance to repeat VL until adherence challenges are resolved.</p><p><strong>Conclusion: </strong>The identified themes highlighted that individual, social, and health systems factors were perceived as contributing to success or delay in the ability to obtain timely VL results and repeat confirmatory VL testing.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2650034"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma in UK health care: a key barrier to reaching zero HIV transmission by 2030.","authors":"Tom Weeks, Edwin van Teijlingen, Pramod Regmi","doi":"10.1080/25787489.2026.2653328","DOIUrl":"https://doi.org/10.1080/25787489.2026.2653328","url":null,"abstract":"<p><strong>Background: </strong>With zero HIV transmission by 2030 firmly on the agenda of the UK Government, the UK Health Security Agency (UKHSA), the National Health Service (NHS), and the voluntary sector in the United Kingdom (UK), therefore, the objective of this review is to explore whether this ambitious goal is possible.</p><p><strong>Methods: </strong>EBSCO, PubMed, and CHINAL databases were searched using relevant keywords around stigma/stigmatisation in the NHS/UK health care settings. In addition, hand-searching and reference mining were conducted. Data were extracted, synthesised, and presented through a narrative analysis.</p><p><strong>Results: </strong>Initial searching yielded 68 papers, and six papers were eligible for this review. Thematic methods were used to analyse and synthesise the included studies. The results indicated that people living with HIV continue to express concerns about stigma and discrimination when accessing health care. These issues remain significant barriers to accessing health care services.</p><p><strong>Conclusion: </strong>HIV-related stigma continues to undermine zero HIV transmission ambitions. Until this issue is effectively addressed, achieving the goal of zero HIV transmission by 2030 may remain challenging.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"27 1","pages":"2653328"},"PeriodicalIF":1.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}