HIV Research & Clinical Practice最新文献

{"title":"Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV","authors":"Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson","doi":"10.1080/25787489.2022.2150815","DOIUrl":"https://doi.org/10.1080/25787489.2022.2150815","url":null,"abstract":"<p><b>Background:</b> Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up.</p><p><b>Methods:</b> In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI. Groups were matched for sex, age, baseline BMI and follow-up duration. Significant WG was defined as an increase of ≥5% from 1st visit weight over follow-up. PAFs and 95% CIs were estimated to quantify the proportion of the outcome that could be avoided if the risk factors were not present.</p><p><b>Results:</b> 118 PLWH switched to INSTI and 163 remained on current ART. Of 281 PLWH (74.3% males), mean follow-up was 4.2 years, age 50.3 years, median time since HIV diagnosis 17.8 years, CD4 cell count 630 cells/µL at baseline. PAF for weight gain was the greatest for high BMI (45%, 95% CI: 27–59, <i>p</i> &lt; 0.001), followed by high CD4/CD8 ratio (41%, 21–57, <i>p</i> &lt; 0.001) and lower physical activity (32%, 95% CI 5–52, <i>p</i> = 0.03). PAF was not significant for daily caloric intake (−1%, −9-13, <i>p</i> = 0.45), smoking cessation during follow-up (5%, 0–12, <i>p</i> = 0.10), INSTI switch (11%, −19-36; <i>p</i> = 0.34).</p><p><b>Conclusions:</b> WG in PLWH on ART is mostly influenced by pre-existing weight and low physical activity, rather than switch to INSTI.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"126 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138530417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of opportunistic infections and its predictors among HIV/AIDS patients on antiretroviral therapy in Gondar University Comprehensive and Specialized Hospital, Ethiopia.","authors":"Mequanente Dagnaw,&nbsp;Haileab Fekadu,&nbsp;Adhanom Gebre Egziabher,&nbsp;Tesfaye Yesfue,&nbsp;Meera Indracanti,&nbsp;Alemu Tebeje","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Introduction:</b> Opportunistic infections (OIs) are the leading cause of morbidity and mortality among adults living with HIV. Current and accurate information about the occurrence of opportunistic infections in HIV-infected adults is critical for developing more effective treatments and interventions. However, few studies have been conducted in Ethiopia on the prevalence of common opportunistic infections in HIV-infected adults. Thus, the purpose of this study was to determine the prevalence and predictors of opportunistic infections among HIV-infected adults receiving antiretroviral therapy (ART) at the comprehensive specialized hospital affiliated with the University of Gondar.<b>Methods:</b> Between January 11, 2015, and January 10, 2021, a retrospective cohort study was conducted at the University of Gondar comprehensive specialized hospital. A total of 715 HIV-infected adults on ART were included in the study. Data were extracted from the charts of HIV-infected adults using a data extraction form adapted from the ART entry and follow-up forms. Epi-dataTM Version 4.5 was used to enter data, and StataTM Version 16 was used to analyze the data. The time interval between opportunistic infections was estimated using the Kaplan Meier survival curve. To identify risk predictors of opportunistic infections, bivariate and multivariate semi-parametric and parametric regression models were fitted.<b>Result:</b> This study included the records of 715 HIV-infected adults-initiated ART between January 11, 2015, to January 10, 2021. During the follow-up period, the overall incidence of opportunistic infections was 4.1 (95 percent CI 3.74 to 4.44) per 10,000 person-year observation, with a median of 57 months (IQR = 40-69 months). Pneumocystis' pneumonia at 90(16.51%) was the most encountered OI at follow-up. Adults are presenting with baseline CD4 < 200 cells/µl counts (AHR = 1.41, 95% CI 1.18 to 1.69), bedridden baseline functional status (AHR = 1.35, 95% CI 1.01 to 1.82), WHO clinical stage II (AHR = 5.87, 95% CI 3.97 to 8.69) and WHO clinical stage III (AHR = 5.85, 95% CI 3.55 to 9.65) were notably associated with the incidence of opportunistic infections development.<b>Conclusions:</b> Opportunistic infections are uncommon among HIV-infected adults in this study. In terms of predictors, such as a low CD4 count and an advanced WHO stage (II or III), bedridden functional status was found to be significantly associated with OIs.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"24 1","pages":"2187013"},"PeriodicalIF":1.6,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9204059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early infant diagnosis of HIV infection at the John F. Kennedy Medical Center, Monrovia, Liberia.","authors":"Umar I U,&nbsp;M A Adeiza,&nbsp;R C Ideh,&nbsp;O Ogbuagu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Background:</b> Vertical transmission accounts for majority of new HIV infections among children worldwide. Ninety percent of HIV-positive children reside in Sub- Saharan Africa with their infection predominantly acquired via vertical transmission. In 2004, the vertical transmission rate of HIV in Africa was estimated at 25 - 40% but, remarkably, the rate has significantly decreased to less than 5% in most African countries following implementation and expansion of prevention of MTCT (PMTCT) programs.<b>Objective:</b> To determine the rate of and factors associated with vertical transmission of HIV among attendees of early infant diagnosis (EID) program of an academic and community-based tertiary facility in Liberia.<b>Design:</b> A retrospective cross-sectional analysis.<b>Methods:</b> A retrospective review of medical records of babies seen at Pediatric Unit of Infectious Disease Clinic of John F Kennedy Medical Center (JFKMC) in Monrovia, Liberia between January 1, 2016 and December 31, 2020. All subjects were children born to HIV-positive mothers and who had HIV DNA PCR testing performed between the ages of 6 weeks and 6 months. Children who suffered early neonatal death and those who did not undergo PCR testing were excluded. Demographics of mother to child pairs as well as factors known to influence vertical transmission of HIV such as partial (15.8%) or full (84.2%) participation in prevention of MTCT (PMTCT) programs, mode of delivery, breastfeeding and utilization of post-exposure prophylaxis were collected and assessed. Binomial logistic regression analyses were used to assess factors associated with vertical transmission.<b>Results:</b> During the study timeframe, 284 children had a HIV DNA PCR test with a male:female ratio - 1.3:1. Sixteen tested positive (conducted at a mean of 155 days post birth) giving a vertical transmission rate of 5.6%. For 239 mothers (84.2%) who had full PMTCT, 1.3% of their children tested positive, while for 45 mothers (15.8%) who had partial PMTCT, 28.8% of their children being positive. Two hundred and seventy six children (97%) had exclusive breastfeeding, 13 of whom tested positive while 2 children who were mixed fed tested positive. Children who had Nevirapine vs no prophylaxis (OR = 1.89[95% CI 1.16 - 2.96]), were delivered via caesarian section vs vaginal delivery (OR= 2.26[95% CI 1.92 - 4.12].) and full versus partial participation in PMTCT programs (OR = 4.02[95% CI 2.06 - 4.13] were more likely to have negative HIV test.<b>Conclusion:</b> Vertical transmission rate was found to be high in Liberia and may be driven by suboptimal PMTCT program participation including post-exposure prophylaxis for infants. Therefore, strategies to scale up and improve uptake of PMTCT services are needed to mitigate the burden of HIV among children.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"23 1","pages":"136-140"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10499525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation markers in virologically suppressed HIV-Infected patients after switching to dolutegravir plus lamivudine vs continuing triple therapy: 48-week results in real-life setting","authors":"F. Lombardi, S. Belmonti, D. Moschese, M. Fabbiani, A. Borghetti, A. Ciccullo, E. Visconti, S. Di Giambenedetto","doi":"10.1080/25787489.2022.2080625","DOIUrl":"https://doi.org/10.1080/25787489.2022.2080625","url":null,"abstract":"Objectives: To evaluate the impact of a treatment switch to dolutegravir plus lamivudine on the soluble inflammatory biomarkers of HIV-infected patients treated in a real-life setting. Materials and methods: This was a longitudinal study that enrolled virologically-suppressed patients on stable 3-drug ART who switched at baseline to dolutegravir + lamivudine (2DR-group), based on the clinician’s decision, or maintained triple therapy (3DR-group). Subjects in the 3DR-group were matched with those in the 2DR-group for age, gender and type of anchor drug. Plasma levels of interleukin-6 (IL-6), I-FABP, D-dimer and C-reactive protein (CRP) were quantified by a microfluidic ultrasensitive ELISA assay at baseline and at 48 weeks. Results: Overall 208 subjects were enrolled: 101 in the 2DR-group and 107 in the 3DR-group. At baseline, biomarker levels were comparable between groups. The differences in mean log10 change from baseline to 48 weeks between groups (2DR versus 3DR) were: IL-6 (pg/L) −0.051(95% CI −0.115/0.009) versus 0.004 (95% CI −0.046/0.054) (p = 0.159); I-FABP (pg/mL), −0.088 (95% CI −0.14/-0.041) versus 0.033 (95%CI −0.007/0.072) (p < 0.001); D-dimer (pg/mL), −0.011(95% CI-0.055/0.033) versus −0.021 (95% CI −0.071/0.030) (p = 0.780) and CRP (pg/mL), −0.028 (95%CI −0.118/0.063) versus 0.118 (95% CI 0.024/0.211) (p = 0.028). Conclusions: At 1 year, switching to a dolutegravir plus lamivudine dual regimen in this setting showed a favorable trend for two biomarkers analyzed, i.e., I-FABP and CRP, as compared to continuing a triple therapy. These results add important new data in support of the safety of this approach in terms of its effect on the inflammatory milieu.","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"117 1","pages":"28 - 36"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79481468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"We are looking at the future right now\": community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment interruptions in the United States.","authors":"Karine Dubé, John Kanazawa, Christopher Roebuck, Steven Johnson, William B Carter, Lynda Dee, Beth Peterson, Kenneth M Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Sukyung Kim, Daniel Rosenbloom, Brad R Evans, Melanie Anderson, Daria J Hazuda, Lisa Shipley, Kevin Bateman, Bonnie J Howell, Karam Mounzer, Pablo Tebas, Luis J Montaner","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>People with HIV (PWH) and community members have advocated for the development of a home-based viral load test device that could make analytical treatment interruptions (ATIs) less burdensome.</p><p><strong>Objective: </strong>We assessed community acceptability of a novel home-based viral load test device.</p><p><strong>Methods: </strong>In 2021, we conducted 15 interviews and 3 virtual focus groups with PWH involved in HIV cure research. We used conventional thematic analysis to analyze the data.</p><p><strong>Results: </strong>PWH viewed the home-based viral load test device as a critical adjunct in ongoing HIV cure trials with ATIs. The ability to test for viral load at home on demand would alleviate anxiety around being off ART. Participants drew parallels with glucometers used for diabetes. A preference was expressed for the home-based test to clearly indicate whether one was detectable or undetectable for HIV to mitigate risk of HIV transmission to partners. Perceived advantages of the device included convenience, sense of control, and no puncturing of veins. Perceived concerns were possible physical marks, user errors and navigating the logistics of mailing samples to a laboratory and receiving test results. Participants expressed mixed effects on stigma, such as helping normalize HIV, but increased potential for inadvertent disclosure of HIV status or ATI participation. Increasing pluri-potency of the device beyond viral load testing (e.g., CD4+ count test) would increase its utility. Participants suggested pairing the device with telemedicine and mobile health technologies.</p><p><strong>Conclusions: </strong>If proven effective, the home-based viral load test device will become a critical adjunct in HIV cure research and HIV care.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"23 1","pages":"120-135"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10606345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of supervised aerobic exercise on clinical physiological and mental parameters of people living with HIV: a systematic review and meta-analyses of randomized controlled trials.","authors":"Panagiota Kalatzi,&nbsp;Petros C Dinas,&nbsp;Costas Chryssanthopoulos,&nbsp;Eleftherios Karatzanos,&nbsp;Serafim Nanas,&nbsp;Anastassios Philippou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Background:</b> The benefits derived from supervised aerobic exercise in people living with human immunofeficiency virus- HIV (PLWH) have not yet been clearly identified.<b>Objective:</b> To evaluate the impact of supervised aerobic exercise on immunological, cardiorespiratory, pulmonary, hemodynamic and mental parameters of PLWH.<b>Methods:</b> A systematic review was carried out in accordance to PRISMA guidelines. PubMed, Physiotherapy Evidence Database (PEDro) and Cochrane Central Register of Controlled Trials (CENTRAL) were screened up to August 2021, for the identification of English written randomized trials, with participants aged 18 years and older, at any stage of the disease, with or without co-morbidities. The risk of bias assessment was conducted according to the Cochrane Collaboration's tool for assessing risk of bias. Meta- analyses were conducted using continuous, inverse variance, random-effects model.<b>Results:</b> Ten studies were suitable for meta-analysis based on inclusion criteria. Supervised aerobic exercise appeared to have beneficial effects on depressive symptoms [mean difference (MD)= -4.18 (confidence interval (CI)= (-6.55)-(-1.81), Z = 3.46, <i>p</i> = 0.0005, I²=0%, n = 2], forced expiratory volume in 1 sec [MD = 0.70, CI = 0.39-1.00, Z = 4.41, <i>p</i> < 0.0001, I²=0%, n = 2], and on the maximum oxygen uptake [MD = 1.38, CI = -0.02-2.78, Z = 1.94, <i>p</i> = 0.05, I²=94%, n = 4] of PLWH. No exercise effect was found for CD4 T-cell count (<i>p</i> = 0.16, n = 5), systolic blood pressure (<i>p</i> = 0.91, n = 2) and diastolic blood pressure (<i>p</i> = 0.72, n = 2).<b>Conclusions:</b> Supervised continuous aerobic exercise may improve lung function, depressive symptomatology and aerobic capacity of PLWH, however, the small number of available studies and the high heterogeneity concerning VO2max demonstrate the need for more research in this area.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"23 1","pages":"107-119"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10499057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV.","authors":"Giovanni Guaraldi,&nbsp;Jovana Milic,&nbsp;Elena Bacchi,&nbsp;Federica Carli,&nbsp;Marianna Menozzi,&nbsp;Iacopo Franconi,&nbsp;Alessandro Raimondi,&nbsp;Giacomo Ciusa,&nbsp;Valentina Masi,&nbsp;Michela Belli,&nbsp;Stefano Guaraldi,&nbsp;Emanuele Aprile,&nbsp;Maria Mancini,&nbsp;Cristina Mussini,&nbsp;Jordan E Lake,&nbsp;Kristine M Erlandson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Background:</b> Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up.</p><p><p><b>Methods:</b> In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI. Groups were matched for sex, age, baseline BMI and follow-up duration. Significant WG was defined as an increase of ≥5% from 1st visit weight over follow-up. PAFs and 95% CIs were estimated to quantify the proportion of the outcome that could be avoided if the risk factors were not present.</p><p><p><b>Results:</b> 118 PLWH switched to INSTI and 163 remained on current ART. Of 281 PLWH (74.3% males), mean follow-up was 4.2 years, age 50.3 years, median time since HIV diagnosis 17.8 years, CD4 cell count 630 cells/µL at baseline. PAF for weight gain was the greatest for high BMI (45%, 95% CI: 27-59, <i>p</i> < 0.001), followed by high CD4/CD8 ratio (41%, 21-57, <i>p</i> < 0.001) and lower physical activity (32%, 95% CI 5-52, <i>p</i> = 0.03). PAF was not significant for daily caloric intake (-1%, -9-13, <i>p</i> = 0.45), smoking cessation during follow-up (5%, 0-12, <i>p</i> = 0.10), INSTI switch (11%, -19-36; <i>p</i> = 0.34).</p><p><p><b>Conclusions:</b> WG in PLWH on ART is mostly influenced by pre-existing weight and low physical activity, rather than switch to INSTI.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"24 1","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9187151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early switching of tenofovir disoproxil fumarate (TDF) in HIV-infected patients with TDF-induced nephrotoxicity: a prospective study","authors":"S. Patamatamkul, N. Songumpai, Paruspak Payoong, P. Katavetin, O. Putcharoen","doi":"10.1080/25787489.2022.2113967","DOIUrl":"https://doi.org/10.1080/25787489.2022.2113967","url":null,"abstract":"Background: Tenofovir disoproxil fumarate (TDF) can induce proximal renal tubulopathy (PRT) and necessitate changes in treatment regimen. This prospective study aimed to compare tubular function recovery following early switching versus late switching of TDF in human immunodeficiency virus (HIV)-infected patients with TDF-induced PRT. Methods: For this prospective study, conducted during 2017–2019, we enrolled HIV-1-infected, virologically suppressed adults undergoing TDF-containing combination antiretroviral therapy. Patients were separated into a late-switching group (LSG) and an early-switching group (ESG). The LSG included patients having an estimated glomerular filtration rate (eGFR) decrease ≥25% from the pretreatment level or Fanconi syndrome. The ESG included patients having ≥2 of the following indicators of PRT: fractional excretion of phosphate (FEUP) ≥10%, low tubular maximum reabsorption of phosphate (TmP)/GFR, or uricosuria; fractional uric acid excretion ≥10%; urine protein–creatinine index (UPCI) ≥500 mg/g creatinine, normoglycemic glycosuria, or decrease in eGFR of 15%–24%. Recovery of proximal tubular function at 6 and 12 months after TDF discontinuation was assessed. Complete recovery was defined as normalization of all abnormal tubular markers. Results: Thirty-three HIV-infected patients were enrolled (70% male). Except for tubular function markers, baseline characteristics were not significantly different between the two groups. The proportion of patients having complete recovery was significantly higher in the ESG (p = 0.007, log-rank test). FEUP improved significantly in the ESG after TDF discontinuation; improvements of eGFR and UPCI were greater in the LSG. An eGFR change of 10% from baseline was the only independent predictor of failure to achieve complete recovery after switching. After median follow-up of 2.25 years post-trial, sustained recovery of eGFR within 5% of pre-TDF eGFR was achieved only in the ESG. Conclusions: Early-switching of TDF in HIV patients with PRT may allow complete recovery of proximal renal tubular function.","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"17 1","pages":"99 - 106"},"PeriodicalIF":1.6,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75134593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher religiosity and spirituality are associated with ethnic group membership among middle-aged and older adults living with HIV","authors":"Jeremy D Delgadillo, Laura M. Campbell, M. Marquine, Anne Heaton, A. Rooney, A. Umlauf, D. Jeste, D. Moore, R. Moore","doi":"10.1080/25787489.2022.2113962","DOIUrl":"https://doi.org/10.1080/25787489.2022.2113962","url":null,"abstract":"Background: HIV is a chronic illness that impacts the lives of more than 1 million people in the United States. As persons living with HIV (PWH) are living longer, it is important to understand the influence that religiosity/spirituality has among middle-aged and older PWH. Objective: Compare the degree of religiosity/spirituality among middle-aged and older PWH and HIV-negative individuals, and to identify demographic, clinical, and psychosocial factors associated with religiosity/spirituality among PWH. Method: Baseline data on 122 PWH and 92 HIV-negative individuals (ages 36-65 years; 61.1% Non-Hispanic White) from a longitudinal study were analyzed for the current study. Recruitment occurred through HIV treatment clinics and community organizations in San Diego. Participants completed questionnaires on religiosity, spirituality, and psychosocial functioning. Independent samples t-tests, Pearson correlations, and multiple linear regression analyses were conducted to test the study objective. Results: No significant differences in religiosity/spirituality were found between PWH and HIV-negative individuals. Demographic and psychosocial variables were unrelated to religiously/spirituality among HIV-negative individuals. Among PWH, multiple linear regression models indicated higher daily spirituality was significantly associated with racial/ethnic minority membership (Hispanic/Latino, African American/Black, or Other), fewer years of estimated duration of HIV, greater social support, and higher grit. Greater engagement in private religious practices was significantly associated with racial/ethnic minority membership and higher social support. Conclusions: For PWH, being a racial/ethnic minority and having higher social support was associated with greater engagement in religious/spiritual practices. Future longitudinal studies should examine whether religion/spirituality impacts well-being across the lifespan among racial/ethnic minority groups of PWH.","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"3 5 1","pages":"91 - 98"},"PeriodicalIF":1.6,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83473174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher religiosity and spirituality are associated with ethnic group membership among middle-aged and older adults living with HIV.","authors":"Jeremy D Delgadillo,&nbsp;Laura M Campbell,&nbsp;Maria J Marquine,&nbsp;Anne Heaton,&nbsp;Alexandra S Rooney,&nbsp;Anya Umlauf,&nbsp;Dilip V Jeste,&nbsp;David J Moore,&nbsp;Raeanne C Moore","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Background:</b> HIV is a chronic illness that impacts the lives of more than 1 million people in the United States. As persons living with HIV (PWH) are living longer, it is important to understand the influence that religiosity/spirituality has among middle-aged and older PWH.</p><p><p><b>Objective:</b> Compare the degree of religiosity/spirituality among middle-aged and older PWH and HIV-negative individuals, and to identify demographic, clinical, and psychosocial factors associated with religiosity/spirituality among PWH.</p><p><p><b>Method:</b> Baseline data on 122 PWH and 92 HIV-negative individuals (ages 36-65 years; 61.1% Non-Hispanic White) from a longitudinal study were analyzed for the current study. Recruitment occurred through HIV treatment clinics and community organizations in San Diego. Participants completed questionnaires on religiosity, spirituality, and psychosocial functioning. Independent samples <i>t</i>-tests, Pearson correlations, and multiple linear regression analyses were conducted to test the study objective.</p><p><p><b>Results:</b> No significant differences in religiosity/spirituality were found between PWH and HIV-negative individuals. Demographic and psychosocial variables were unrelated to religiously/spirituality among HIV-negative individuals. Among PWH, multiple linear regression models indicated higher daily spirituality was significantly associated with racial/ethnic minority membership (Hispanic/Latino, African American/Black, or Other), fewer years of estimated duration of HIV, greater social support, and higher grit. Greater engagement in private religious practices was significantly associated with racial/ethnic minority membership and higher social support.</p><p><p><b>Conclusions:</b> For PWH, being a racial/ethnic minority and having higher social support was associated with greater engagement in religious/spiritual practices. Future longitudinal studies should examine whether religion/spirituality impacts well-being across the lifespan among racial/ethnic minority groups of PWH.</p>","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"23 1","pages":"91-98"},"PeriodicalIF":1.6,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243211/pdf/nihms-1853480.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9999834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}