Asian Journal of Organic Chemistry最新文献_第2页

Construction of 1,4‐Oxazepinones via a Cascade Aza‐Michael/SN2 Annulation of Trifluoromethyl Pyrazole‐Derived Oxadienes with a‐Bromohydroxamates 通过三氟甲基吡唑衍生恶二烯与 a-溴羟肟酸酯的级联 Aza-Michael/SN2 嵌合反应制备 1,4-氧氮杂卓酮类化合物

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Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400244

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Recent Advances in Synthesis of Enantioenriched 2‐Substituted Piperidine Derivatives 对映体 2-取代哌啶衍生物合成的最新进展

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Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400257

{"title":"Recent Advances in Synthesis of Enantioenriched 2‐Substituted Piperidine Derivatives","authors":"","doi":"10.1002/ajoc.202400257","DOIUrl":"10.1002/ajoc.202400257","url":null,"abstract":"<div><div>Enantioenriched 2‐substituted piperidines are very important unit for drug discovery. Ready access to a wide range of such compounds, decorated with functional handles at 2‐position with stereo‐defined centre significantly enhance the quality and diversity of chemical libraries for screening of drug discovery. The ability to control the stereochemistry of piperidine at the 2‐position remains an area of interest in organic synthesis to allow the development of novel, structurally diverse 3D molecules. Among the various ways to obtain enantioenriched 2‐substituted piperidines, asymmetric hydrogenation is widely studied. Asymmetric synthesis, Kinetic resolution, and chiral pool synthesis methodologies are also important ways to obtain the enantioenriched 2‐substituted piperidines. This review article summarized the main four ways to achieve particularly the enantioenriched substituted piperidines only at 2‐position considering the chemical routes, excluding the biocatalytic approach. 1. Introduction 2.1 Asymmetric Hydrogenation of 2‐substituted Pyridines 2.2 Asymmetric Synthesis 2.3. Kinetic resolution of racemic 2‐substituted Piperidine derivatives 2.4. Chiral pool synthesis 3. Conclusions & outlook</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"13 10","pages":"Article e202400257"},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent Advances on Synthesis of 2H‐Chromenes, and Chromenes Fused Hetrocyclic Compounds 2H-Chromenes 和 Chromenes Fused Hetrocyclic 化合物合成的最新进展

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Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400259

Rohit Kumar Maurya , Ashutosh Dey , Vikash Kumara , Mahender Khatravath

{"title":"Recent Advances on Synthesis of 2H‐Chromenes, and Chromenes Fused Hetrocyclic Compounds","authors":"Rohit Kumar Maurya , Ashutosh Dey , Vikash Kumara , Mahender Khatravath","doi":"10.1002/ajoc.202400259","DOIUrl":"10.1002/ajoc.202400259","url":null,"abstract":"<div><div>Chromenes and <em>2H</em>‐Chromenes are vital components of natural products, pharmaceuticals, and agrochemicals that have captured the attention of researchers worldwide. These heterocyclic compounds represent an essential class of structural scaffolds, and the quest for their synthesis in a mild and straightforward way has gained significant momentum. Chromenes are oxygen‐containing heterocycles that have been widely studied due to their potential medicinal properties. In the last two decades, researchers have made remarkable progress towards the synthesis of chromene based heterocyclic compounds using O‐propargylated benzaldehydes as a substrate. These substrates are highly versatile and contain functional groups that make them ideal for a wide range of reactions. This review article provides an in‐depth analysis of the latest advances in alkynes’ functionalization, emphasizing the substrate scope, limitations, regioselectivity control, and applications of these reactions. The review also covers a range of critical methods and strategies, including multicomponent reactions, used for the general synthesis of numerous types of chromene derivatives.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"13 10","pages":"Article e202400259"},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141609397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Unravelling the Optoelectronic and Biological Properties of Phenanthroimidazo [1,2‐c] Quinazoline‐Based Donor‐Acceptor Materials 揭示基于菲咯咪唑[1,2-c]喹唑啉的供体-受体材料的光电和生物特性

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400285

Prabhu Ganesan , Revathi Ranganathan , Rajadurai Vijay Solomon , Peer Muhamed Noorani , Paramaguru Ganesan , Nooruddin Thajuddin , Anbazhagan Venkattappan , Renganathan Rajalingam , Peng Gao

{"title":"Unravelling the Optoelectronic and Biological Properties of Phenanthroimidazo [1,2‐c] Quinazoline‐Based Donor‐Acceptor Materials","authors":"Prabhu Ganesan , Revathi Ranganathan , Rajadurai Vijay Solomon , Peer Muhamed Noorani , Paramaguru Ganesan , Nooruddin Thajuddin , Anbazhagan Venkattappan , Renganathan Rajalingam , Peng Gao","doi":"10.1002/ajoc.202400285","DOIUrl":"10.1002/ajoc.202400285","url":null,"abstract":"<div><div>Imidazo[1,2‐c]quinazoline, a class of fused imidazole and quinazoline acceptor units, is widely established as biologically and broadly spectral active materials, while their optoelectronic properties were seldom investigated in the literature. In this context, this research work introduced two donors of varying strength, such as triphenylamine (TP) and phenothiazine (PZ) units, into the phenanthroimidazo [1,2‐c] quinazoline acceptor unit to form donor‐acceptor type luminescence materials such as TPQZ and PZQZ, respectively and were characterized by NMR and mass spectroscopy. Both these materials exhibited intramolecular charge transfer (ICT) type absorption (∼380–450 nm) and emission (∼540–600 nm) characteristics, which attributed to the electronic transition occurring from the HOMO of the TP/PZ donor to the LUMO+1 and LUMO+2 of the imidazo [1,2‐c] quinazoline acceptor unit, as predicted using DFT calculations. Increasing the electron donor strength was not only limited to fine‐tuning the π→π* based localized (∼400–450 nm) to ICT (∼450–650 nm) emission characteristics in both the solution and solid‐state conditions but also found to improve the zone of inhibition to 16 mm against <em>Staphylococcus aureus</em>/<em>Bacillus subtilis</em> bacterial species. The scope of realizing the luminescence nature of this acceptor unit is further expanded towards tagging biological samples such as E. coli. Overall, this work opens up a new paradigm in developing luminescent materials utilizing imidazo[1,2‐c]quinazoline acceptor unit for optoelectronic and biological applications.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"13 10","pages":"Article e202400285"},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pd(0)/TPPMS‐Catalyzed Tsuji–Trost Type Cross‐Coupling of Allylic Alcohols with Organoboron Compounds in Water Pd(0)/TPPMS 催化的水中烯丙基醇与有机硼化合物的辻-特罗斯特型交叉偶联反应

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Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400132

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Intramolecular [2+2] Cycloadditions of α‐Heteroatom Substituted γ,δ‐Unsaturated Ketenes α-杂原子取代的γ、δ-不饱和酮的分子内 [2+2] 环加成反应

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Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400302

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Collective Synthesis of Furanocoumarin Natural Products Through a Radical‐mediated Construction of Furanocoumarin Skeletons 通过自由基介导的呋喃香豆素骨架构建集体合成呋喃香豆素天然产物

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Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400277

Yuko Kotaka , Masaya Nakajima , Tetsuhiro Nemoto

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Synthesis and Properties of Fused Polycyclic Donor–Acceptor Compounds Containing Carbazole and Diazapyrene Skeletons 含咔唑和重氮apyrene 骨架的融合多环受体-捐体化合物的合成及其性质

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Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400289

Suzuho Kurimoto , Yoshimitsu Tachi , Masatoshi Kozaki

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pH Sensitive Dual Cross‐Linked Anionic and Amphoteric Interpenetrating Network Hydrogels for Adsorptive Removal of Anionic and Cationic Dyes 用于吸附去除阴离子和阳离子染料的 pH 值敏感型双交联阴离子和两性互穿网络水凝胶

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400238

{"title":"pH Sensitive Dual Cross‐Linked Anionic and Amphoteric Interpenetrating Network Hydrogels for Adsorptive Removal of Anionic and Cationic Dyes","authors":"","doi":"10.1002/ajoc.202400238","DOIUrl":"10.1002/ajoc.202400238","url":null,"abstract":"<div><div>The contamination of water by organic dye compounds are worldwide environmental problem due to their highly toxic nature. To address this environmental issue, a simple technique with highly efficient dye removal was developed to prepare pH‐ sensitive dual‐crosslinked anionic and amphoteric interpenetrating network (IPN) hydrogels based on Na‐carboxymethyl cellulose (Na‐CMC) using jute stick‐based cellulose. Crosslinked Na‐CMC and crosslinked κ‐carrageenan (KC) were interlaced by H‐bonding in anionic IPN hydrogel (An‐gel), but crosslinked Na‐CMC and crosslinked Chitosan (CS) were interlaced by electrostatic interaction in amphoteric IPN hydrogel (Am‐gel). In various operating conditions (pH, temperature, etc.) An‐gel displayed a higher number of swelling ratios of about 2560% at pH 7.2 and Am‐gel of about 1874% at pH 5.5. Based on the point of zero charge, An‐gel achieved the maximum removal efficiency of 81.62 % for methylene blue (MB) at pH 7.2, whereas Am‐gel achieved 85.38% removal efficiency for eosin yellow (EY) at pH 5.5. The adsorption kinetics of IPN hydrogels followed a pseudo‐second order model and best fitted by Langmuir isotherm model. The removal efficiency of MB and EY decreased slightly with increasing temperature. The values of ΔH°, ΔG°, and ΔS° indicated an exothermic, spontaneous, and disordered adsorption process.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"13 10","pages":"Article e202400238"},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141520292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lewis Acid‐Catalyzed Tandem Annulation of Propargylic Alcohols with 2‐Allylphenols and Their Anti‐tumor Activities 路易斯酸催化的丙炔醇与 2-烯丙基苯酚的串联嵌段反应及其抗肿瘤活性

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI: 10.1002/ajoc.202400265

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