Asian Journal of Organic Chemistry最新文献

I2/K2S2O8‐Catalyzed Cascade Synthesis of Insecticidal 2‐Imino‐1,3‐Thiazoles: A Sustainable Approach to Bioactive Heterocycles I2/ k2s2o8催化级联合成杀虫2-亚胺-1,3-噻唑：生物活性杂环的可持续途径

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.202500567

Bin‐Heng Nie , Hao‐Ran Yan , Chu‐Xin Rong , Bo Yang , Ri‐Yuan Tang

引用次数: 0

Unlocking Tellurium‐Centered Radicals: From Intermediates in Total Organic Syntheses to Stable Organotellurides and Catalysts 解锁以碲为中心的自由基：从全有机合成的中间体到稳定的有机碲化物和催化剂

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.202500492

Sebastián Barata‐Vallejo , María del Rosario Torviso , Al Postigo

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Transition Metal Catalyst Free Expedient Catechol Oxidation to Quinone via Photocatalysis 不含过渡金属催化剂的邻苯二酚光催化氧化制醌

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.70140

Dr. Souvik Barman

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A Serendipitous Non‐Metal‐Mediated Sp3 C─H Functionalization of 2‐Methyl Indolyl Scaffold for the Synthesis of 2‐Alkenyl Indoles* 非金属介导的Sp3 C─H功能化2-甲基吲哚基支架合成2-烯基吲哚*

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.202500575

Diksha Bansal , Gokulprasanth Nataraj , Mrinal Kanti Das , Saikat Chaudhuri

{"title":"A Serendipitous Non‐Metal‐Mediated Sp3 C─H Functionalization of 2‐Methyl Indolyl Scaffold for the Synthesis of 2‐Alkenyl Indoles*","authors":"Diksha Bansal , Gokulprasanth Nataraj , Mrinal Kanti Das , Saikat Chaudhuri","doi":"10.1002/ajoc.202500575","DOIUrl":"10.1002/ajoc.202500575","url":null,"abstract":"<div><div>Challenging conventional methodologies, we pioneer a groundbreaking approach by C─H functionalization of sp<sup>3</sup> carbon, which leads to the effective synthesis of 2‐alkenyl indole scaffold, bioactive olefin. Our study introduces an innovative approach by utilizing previously unexplored starting materials, expanding the possibilities of C─H functionalization. In contrast to previous studies that rely on metal‐based catalysts, our strategy harnesses a cost‐effective and environmentally friendly method. This functionalization was effectively promoted by NH<sub>4</sub>Cl and MgSO<sub>4</sub>, ensuring high efficiency, exceptional selectivity, and excellent yields under mild conditions. A series of spectroscopic techniques, including NMR (¹H, ¹<sup>3</sup>C, 19F, and DEPT‐135), IR, and mass spectrometry, were used for the detailed characterization of the synthesized 2‐alkenyl indoles. This method not only demonstrates broad functional group compatibility but also establishes a sustainable alternative to traditional metal‐catalyzed processes. By redefining the scope of this reaction, our work paves the way for future advancements in organic synthesis and biomedical applications.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 10","pages":"Article e00575"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recyclable Glucose‐Derived Carbon–Silica Supported Ni(0) Nanocatalyst for Suzuki–Miyaura Cross‐Couplings 用于Suzuki-Miyaura交叉偶联的可回收葡萄糖衍生碳-二氧化硅负载Ni(0)纳米催化剂

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.202500585

Dinesh Babu Arumugam , Dr. K. Santhakumar

{"title":"Recyclable Glucose‐Derived Carbon–Silica Supported Ni(0) Nanocatalyst for Suzuki–Miyaura Cross‐Couplings","authors":"Dinesh Babu Arumugam , Dr. K. Santhakumar","doi":"10.1002/ajoc.202500585","DOIUrl":"10.1002/ajoc.202500585","url":null,"abstract":"<div><div>In this study, we report a renewable, glucose‐derived nickel(0) nanoparticles for the Suzuki–Miyaura cross‐coupling (SMC) reaction. A key feature of the catalyst is that, glucose plays the dual role which functions both as a reductant and as a carbon source for the support, enabling the formation of Ni(0) under additive‐free conditions. Further, to gain the insight of physiochemical properties, the Ni(0)NPs is characterized by PXRD, SEM, EDX, TEM, BET, XPS, ICP‐MS, and elemental mapping. The catalyst comprises metallic Ni nanoparticles (∼13 nm), uniformly dispersed on a composite support of amorphous carbon and silica. Moreover, XPS demonstrates retention of the Ni(0) oxidation state and ICP‐MS reveals no Ni‐leaching even after six catalytic cycles, indicating the system having excellent stability and indeed heterogeneity. The system performs consistently by maintaining the yields across six consecutive cycles, with favorable turnover number (TON) and turnover frequency (TOF). A CHEM21 metrics assessment is also provided to support the evaluation of reaction efficiency and operational safety.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 10","pages":"Article e00585"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Hetero and Homo Nazarov‐Like Cyclizations 杂基和Homo Nazarov-Like环化的最新进展

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.70136

Dr. Nagam Satish

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Visible‐Light‐Mediated Regioselective Trichloromethyl Hydroxylation of Alkenes: A Metal‐Free Strategy for β‐Trichloromethyl Alcohols 可见光介导的区域选择性三氯甲基烯烃羟基化：β-三氯甲基醇的无金属策略

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.202500511

Xian Jiang , Duoduo Xiao , Renhua Su , Yanfu Jiang , Jiantao Zhang , Weibing Liu , Peng Zhou

引用次数: 0

Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core 新型含硒化嘧啶核二氢吡啶-亚胺盐的合成

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.70141

Dr. Reinier Lemos , Dr. Mauro De Nisco , Dr. Yoana Pérez‐Badell , Dr. Gabriella Pinto , Dr. Marco Morelli , Prof. Margarita Suárez , Dr. Silvana Pedatella

{"title":"Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core","authors":"Dr. Reinier Lemos , Dr. Mauro De Nisco , Dr. Yoana Pérez‐Badell , Dr. Gabriella Pinto , Dr. Marco Morelli , Prof. Margarita Suárez , Dr. Silvana Pedatella","doi":"10.1002/ajoc.70141","DOIUrl":"10.1002/ajoc.70141","url":null,"abstract":"<div><div>Functionalizing organic molecules with selenium‐containing fragments is a strategy to increase the biological properties of natural products and biomolecules. Therefore, in the present study, this strategy was followed to develop a new series in which the 1,3‐selenazine ring is condensed with a 1,4‐dihydropyridine, a nitrogen‐containing six‐membered heterocycle, as both entities are known to have proven biological activity. The 2‐iminium chloride salts of 5,8‐dihydro‐2<em>H</em>‐pyrido[3,2‐<em>e</em>][1,3]selenazine derivatives were easily synthesized in one step from the corresponding <em>o</em>‐chloroformyl‐1,4‐dihydropyridine and selenourea in good yields. Also, a comparative study of selenourea towards thiourea and urea was carried out to assess the contribution of chalcogen to the reaction pathway. All derivatives have been fully characterized by a whole set of instrumental techniques to determine their chemical structure. Further, theoretical calculations at the DFT level have predicted the optimized minimum energy structure for the hybrid compounds. Molecular docking was used to predict the potential application of the new compounds as inhibitors of the main protease of SARS‐CoV‐2, paving the way to study the possible application of these compounds in medicinal chemistry.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 10","pages":"Article e70141"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data‐Driven Chemometric Modeling for Predicting the Performance of Sulfonated MXene Thin‐Film Nanocomposite Membranes in Desalination 基于数据驱动的化学计量模型预测磺化MXene薄膜纳米复合膜在海水淡化中的性能

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.202500465

Lukka Thuyavan Yogarathinam , Sani I. Abba , Jamilu Usman , Abdulhayat M. Jibrin , Isam H. Aljundi , Nadeem Baig

{"title":"Data‐Driven Chemometric Modeling for Predicting the Performance of Sulfonated MXene Thin‐Film Nanocomposite Membranes in Desalination","authors":"Lukka Thuyavan Yogarathinam , Sani I. Abba , Jamilu Usman , Abdulhayat M. Jibrin , Isam H. Aljundi , Nadeem Baig","doi":"10.1002/ajoc.202500465","DOIUrl":"10.1002/ajoc.202500465","url":null,"abstract":"<div><div>Machine learning (ML) has emerged as a valuable tool in advancing thin‐film nanocomposite (TFN) membranes for sustainable water treatment. In this study, a novel data‐driven chemometric framework integrated with ML was developed to predict the performance of sulfonated MXene‐incorporated TFN polyamide membranes for desalination applications. Six ML algorithms namely kernel support vector machine (k‐SVM), decision tree (DT), long short‐term memory (LSTM), recurrent neural network (RNN), random forest (RF), and a hybrid k‐SVM model optimized using particle swarm optimization (k‐SVM‐PSO) were systematically evaluated. Feature engineering of sulfonated MXene concentration, membrane characteristics such as contact angle, surface roughness, surface charge, and physiochemical properties of electrolytes showed prominent control in electrolyte flux and rejection. The metaheuristic‐driven k‐SVM‐PSO model showed outstanding predicted accuracy for electrolyte flux with R<sup>2</sup> = 0.983, based on physicochemical properties parameters of TFN membrane and sulfonated MXene and electrolytes. Predictive ML algorithms also strongly agreed with the experimental dataset in determining non‐linear flux dynamics related to organic foulants fouling patterns. Furthermore, the spectral intensity of chlorinated TFN membranes was successfully predicted, with DT and RF models achieving the highest performance (R<sup>2</sup> = 0.999 and minimal error metrics). This chemometric approach enables advanced prediction of membrane performance for desalination.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 10","pages":"Article e00465"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Electrochemically Catalyzed Direct Hydroxylation/Carbonylat‐ion of Benzyl C─H Bonds Using Water as Oxygen Source 以水为氧源的电化学催化苄基C ~ H键直接羟基化/羰基化

IF 2.7 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI: 10.1002/ajoc.202500455

Hui Luo , Yan Wang , Yu He , Zhongjie Wang , Dianjun Li , Jinhui Yang

引用次数: 0