Seyed Parsa Hashemian, Seyed Mohammad Arabi Zanjani, Younes Latifi, Mahdi Behraveshfar, Mohammad Bagher Teimouri
{"title":"Front Cover: Planar, Twisted, and Curved π-Extended Pyrrolo[3,2-b]Pyrroles: Recent Advances in Synthesis, Properties, and Applications (Asian J. Org. Chem. 8/2025)","authors":"Seyed Parsa Hashemian, Seyed Mohammad Arabi Zanjani, Younes Latifi, Mahdi Behraveshfar, Mohammad Bagher Teimouri","doi":"10.1002/ajoc.70146","DOIUrl":"10.1002/ajoc.70146","url":null,"abstract":"<p>This cover blends the core concept of review e202500565 by Mohammad Bagher Teimouri and co-workers with elements of Iranian culture. The unique 3D architecture of pyrrolo[3,2-<i>b</i>]pyrroles is reflected in the curved forms of the clouds and the warped flying carpet. Their main feature, photophysical properties, is symbolized by the emission of light from the pyrrolopyrrole-embedded 3D molecules, illuminating the carpet. Persian carpets are widely recognized as a primary cultural symbol of Iranian handicrafts, and the stylized clouds, inspired by the Persian miniature art, together highlight the scientific theme through a culturally rich and imaginative lens. The overall atmosphere of the image can somewhat evoke “Tales from the One Thousand and One Nights” (a collection of Middle Eastern folktales). Image credit: Azadeh Badiee Dezfuly and Seyed Parsa Hashemian.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aces.onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.70146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cover Feature: Ligand-Induced Selectivity in the Reaction of Conjugated Enyne with Enolic Ester: A DFT-Based Mechanistic Study (Asian J. Org. Chem. 8/2025)","authors":"Shivangi Gupta, Puneet Gupta","doi":"10.1002/ajoc.70145","DOIUrl":"10.1002/ajoc.70145","url":null,"abstract":"<p>The cover image illustrates a reaction where two reactants react in the presence of the palladium catalyst via divergent pathways depending on the ligand environment. The presence of different ligands (L1 and L2) directs the catalytic cycle through distinct mechanistic routes, ultimately yielding two different products. This highlights the pivotal role of ligand identity in dictating reaction selectivity and product outcome. More details can be found in article number e202400819 by Shivangi Gupta and Puneet Gupta. \u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aces.onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nickel-Catalyzed Hydrogenation and Dehydrogenation Processes: A Useful Tool in Organic Synthesis","authors":"Rahul Paul, Sk Shamim Ahamed, Tapas Ghosh","doi":"10.1002/ajoc.202500069","DOIUrl":"10.1002/ajoc.202500069","url":null,"abstract":"<p>Catalytic hydrogenation and dehydrogenation are fundamental transformations in organic synthesis, traditionally dominated by noble metals. In recent decades, nickel has emerged as a sustainable and cost-effective alternative due to its rich redox chemistry, broad applicability, and catalytic efficiency. This review comprehensively summarizes the progress in nickel-catalyzed hydrogenation and dehydrogenation reactions over the past three decades, emphasizing the evolution of catalyst design and mechanistic understanding as well. This review is structured into three major categories based on catalyst type: homogeneous, heterogeneous, and nanoparticle-supported catalyst. Each section is further divided into direct hydrogenation, transfer hydrogenation, and dehydrogenation reactions, covering a wide range of substrates including alkynes, alkenes, carbonyl compounds, nitroarenes, amines, and alcohols. Structure–activity relationships, mechanistic pathways, and chemoselectivity trends are critically analyzed to provide insights into the role of nickel in these transformations. Challenges and future directions in developing next-generation nickel catalysts for green and selective transformations are also outlined.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qihao Jin, Yi-Jie Wang, Prof. Xinxin Wu, Prof. Jian-Ping Zou
{"title":"Phosphorylated Hydrazones and Diazophosphonate Synthesis Through Base-Promoted Radical Reactions","authors":"Qihao Jin, Yi-Jie Wang, Prof. Xinxin Wu, Prof. Jian-Ping Zou","doi":"10.1002/ajoc.202500427","DOIUrl":"10.1002/ajoc.202500427","url":null,"abstract":"<p>Herein, we report a regioselective phosphonylation of aldehyde-derived hydrazones via P-centered radical addition, expanding C─P bond formation to include dialkyl phosphites. Optimization studies established manganese acetate as an efficient oxidant and silver nitrate as the optimal catalyst, enabling mild and efficient radical phosphonylation. Notably, 4-methylbenzenesulfonylhydrazones underwent an unexpected transformation, affording diazo phosphonates instead of phosphonylated products. This study offers a practical and versatile method for C─P bond formation and provides new insights into radical-mediated hydrazone functionalization, with potential applications in pharmaceuticals and materials science.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prakash K. Mandal, Md Tanjul Hoque, Dr. Anindya S. Manna, Dr. Ramlal Baidya, Dr. Rajesh Nandi, Dr. Subhasis Pal, Dr. Nilay Karchaudhuri, Dr. Dilip K. Maiti
{"title":"Non-Noble Metal Catalysis in Focus: Unlocking Latest Emergent Frontiers in Amide Annulation Through C─H/C─X Activation","authors":"Prakash K. Mandal, Md Tanjul Hoque, Dr. Anindya S. Manna, Dr. Ramlal Baidya, Dr. Rajesh Nandi, Dr. Subhasis Pal, Dr. Nilay Karchaudhuri, Dr. Dilip K. Maiti","doi":"10.1002/ajoc.202500478","DOIUrl":"10.1002/ajoc.202500478","url":null,"abstract":"<p>The non-noble metal-catalyzed annulation of amide molecules through the proximal C─H/C─X (X = halogens, O, S, N, C etc.) has emerged as a transformative approach in contemporary synthetic chemistry, enabling the efficient construction of diverse heterocyclic frameworks. This sustainable strategies address the limitations of noble metal catalysis, offering cost-effective and environmentally benign alternatives through utilizing earth-abundant metals such as Mn, Fe, Co, Ni, and Cu in those methods by harnessing their catalytic potential for activating inert bonds in diverse amides leveraging the inherent directing ability. By incorporating various electrophilic or nucleophilic coupling partners wisely, nonmetal catalysis has provided access toward pharmaceutically active heterocyclic ingredients, mainly spiro-/fused-N-heterocycles like isoquinolones, indolones, indoles, isoquinolines etc. through one-pot atom-economical activation-annulation cascade routes. Additionally, mechanistic studies have discussed in detail to understand the insights of non-noble metal catalyzed amide cyclization toward pharmaceutically active N-heterocyclic scaffolds properly through the individual steps engaged, namely, metal coordination, inert bond activation, bond cleavage, insertion or migratory insertion and eventually cyclization pathway via reductive elimination, which enables this review more valuable and useful to the readers of the aforementioned field and beyond.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irina A. Borisova, Denis D. Borisov, Natalia G. Kolotyrkina, Bo Zhou, Long-Wu Ye, Roman A. Novikov, Yury V. Tomilov
{"title":"GaCl3-Promoted Reactions of Donor-Acceptor Cyclopropanes with Conjugated Diacetylenes","authors":"Irina A. Borisova, Denis D. Borisov, Natalia G. Kolotyrkina, Bo Zhou, Long-Wu Ye, Roman A. Novikov, Yury V. Tomilov","doi":"10.1002/ajoc.202500392","DOIUrl":"10.1002/ajoc.202500392","url":null,"abstract":"<p>The reaction of 1,2-zwitterionic complexes of 2-arylcyclopropane-1,1-dicarboxylates (ACDC), generated using gallium trichloride, with conjugated substituted diacetylenes was studied. The series of the substituted 1,1′-binaphthalenes were obtained in yields up to 57%. The reaction occurs via a cascade addition/annulation/elimination pathway involving both triple bonds of conjugated diacetylenes. The regioselectivity of this process was studied, and it was shown that binaphthalenes formed exclusively as 1,1′-regioisomers.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Construction of C5-Tetrasubstituted Pyrazolines and Isoxazolines: An Update","authors":"Ram Singh Jat, Ruzin Khan, M. Bhanuchandra","doi":"10.1002/ajoc.202500497","DOIUrl":"10.1002/ajoc.202500497","url":null,"abstract":"<p>Heterocyclic pyrazolines and isoxazolines serve as valuable precursors in various pharmaceutically, biologically active organic molecules and natural products. In recent years, considerable research interest has been directed toward the synthesis of pyrazolines and isoxazolines. In this review, we are presenting the recent advances (2020-present) in the synthesis of pyrazolines and isoxazolines containing a C5-tetrasubstituted carbon center as a key structural motif in contemporary organic synthesis. Further, we also describe the synthetic applications, reaction pathways, reactive species, substrate scope, and limitations involved in these processes. Reaction mechanisms and future challenges are also discussed wherever appropriate. Pyrazolines and isoxazolines can be produced using a variety of methods, including 1,3-dipolar cycloaddition reactions, metal-free and metal-catalyzed conditions. More importantly, intramolecular cyclization of hydrazones and oximes is among the predominant strategies for the construction of C─C and C−heteroatom bond forming reactions in such heterocycle synthesis.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atsuya Kawazoe, Masaki Shiraishi, Prof. Dr. Iwao Hachiya
{"title":"Synthesis of 1-Naphthylamines Utilizing [4 + 2] Cycloaddition Between 3-Amino-2-pyrones and Benzynes","authors":"Atsuya Kawazoe, Masaki Shiraishi, Prof. Dr. Iwao Hachiya","doi":"10.1002/ajoc.202500533","DOIUrl":"10.1002/ajoc.202500533","url":null,"abstract":"<p>Synthesis of 1-naphthylamines is developed using [4 + 2] cycloaddition between 3-amino-2-pyrone, which is prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl ketones, and benzyne generated from o-silylaryl triflates. This synthetic strategy was successfully applied to the syntheses of iodonaphthalene, naphthylimide, and benzo[a]carbazole derivatives.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aces.onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.202500533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of 3,3-disubstituted Tetrahydroisoquinolines (THIQs) via Base-mediated [4 + 2] Annulation","authors":"Jiaxu Feng, Yingying Wu, Lulu Xu, Xiangdi Wang","doi":"10.1002/ajoc.202500563","DOIUrl":"10.1002/ajoc.202500563","url":null,"abstract":"<p>In this research we represented a simple and elegant method for 3,3-disubstituted THIQs via base-mediated [4 + 2] annulation of α-amino acid ester derivatives and 1,2-bis(bromomethyl)benzene under mild conditions. This protocol features good substrate tolerance, mild conditions and moderate to excellent yields. The synthetic potential of this protocol was highlighted by scale-up experiments and further structural elaboration.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front Cover: Durable Metal-Organic Frameworks by Covalent Hybridization with Polyurethane and Polyallophanate (Asian J. Org. Chem. 7/2025)","authors":"Shizuka Anan, Kazuki Sada, Kenta Kokado","doi":"10.1002/ajoc.202580701","DOIUrl":"10.1002/ajoc.202580701","url":null,"abstract":"<p>The single crystal of a metal-organic framework (MOF) or polyurethane network is easily broken into fragments by putting a small weight, shown by a cat or a dog, on it due to its fragility. In contrast, integration of the MOF single crystal with polyurethanes through covalent bonds significantly enhances its durability. The integrated crystal deforms, but it maintains a substantial crystal structure without being destroyed, even under the great weight of an elephant. More details can be found in article number e202400642 by Shizuka Anan, Kazuki Sada, and Kenta Kokado.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.202580701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}