Asian Journal of Organic Chemistry最新文献

Synthetic Strategies of Heterocycle-Linked Sulfonamide Hybrids as Emerging Anticancer Agents: An Update 杂环连接的磺胺类化合物作为新型抗癌药物的合成策略研究进展

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-31 DOI: 10.1002/ajoc.70534

Sk Shamim Ahamed, Uma Sankar Mandal, Rahul Paul, Nilanjan Saha, Tapas Ghosh

{"title":"Synthetic Strategies of Heterocycle-Linked Sulfonamide Hybrids as Emerging Anticancer Agents: An Update","authors":"Sk Shamim Ahamed, Uma Sankar Mandal, Rahul Paul, Nilanjan Saha, Tapas Ghosh","doi":"10.1002/ajoc.70534","DOIUrl":"https://doi.org/10.1002/ajoc.70534","url":null,"abstract":"<div>\u0000 \u0000 Sulfonamide-containing heterocycles constitute a versatile and synthetically accessible class of scaffolds in contemporary anticancer drug discovery. In recent years, substantial progress has been made in developing efficient synthetic methodologies that enable the construction and late-stage diversification of sulfonamide-based hybrid architectures. This review provides a comprehensive overview of advances reported over the past five years in the synthesis of heterocycle-integrated sulfonamide derivatives. Particular emphasis is placed on strategic bond-forming approaches, modular scaffold assembly, and late-stage sulfonylation protocols that facilitate structural diversification and rapid library generation. The discussion is organized according to the nature of the heterocyclic core, encompassing oxygen-containing systems (e.g., coumarins, flavones, naphthoquinones, and oxadiazoles), nitrogen-rich frameworks (including benzimidazoles, quinazolines, quinolines, triazines, and imidazole-pyridine hybrids), nitrogen–sulfur fused scaffolds (such as benzothiazoles, thiadiazoles, and thienopyrimidines) and chalcone-based sulfonamide hybrids, which represent an important class of molecularly hybridized anticancer scaffolds. Key synthetic strategies-ranging from classical annulation methods and nucleophilic aromatic substitution to carbodiimide-mediated coupling, Curtius rearrangement, click chemistry, and late-stage N-sulfonylation are critically analyzed with respect to efficiency, scope, and synthetic practicality. Collectively, these advances highlight the growing strategic importance of sulfonamide-linked heterocyclic hybrids as promising platforms for anticancer drug development.\u0000 </div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"15 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cascade Annulation Enabled Access to Functionalized Polyaza Tetracycles With Fused Imidazo Scaffolds for Fluorescence “Turn-Off” Sensing of Benzaldehyde Derivatives 级联环化使融合咪唑支架获得功能化聚氮四环，用于苯甲醛衍生物的荧光“关闭”感应

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-31 DOI: 10.1002/ajoc.70530

Swarnali Ghosh, Saiful Islam, Anindita Sarkar, Tiyasa Ray, Kamalika Sen, Akhikesh Mahato, Anup Pramanik, Asish R Das

{"title":"Cascade Annulation Enabled Access to Functionalized Polyaza Tetracycles With Fused Imidazo Scaffolds for Fluorescence “Turn-Off” Sensing of Benzaldehyde Derivatives","authors":"Swarnali Ghosh, Saiful Islam, Anindita Sarkar, Tiyasa Ray, Kamalika Sen, Akhikesh Mahato, Anup Pramanik, Asish R Das","doi":"10.1002/ajoc.70530","DOIUrl":"https://doi.org/10.1002/ajoc.70530","url":null,"abstract":"<div>\u0000 \u0000 Regioselective Ru(II)-catalyzed C(sp2)─H activation with concomitant (4+2) cascade annulation materializes the benzimidazo- and imidazopyridine-fused quinazolinyl ketones and quinazoline derivatives employing acyl azides and α-azido ketones as the representative coupling surrogates. The insight of this protocol is established through control experiments and DFT analyses. Again, versatility is underscored by devising chemoselective imine bond reduction and directed nitro group functionalization ortho to the carbonyl moiety. In addition, bioactive ibuprofen-appended benzimidazo-quinazolinyl methanone analogue (3q) and aspirin-appended tetracyclic benzimidazo-quinazoline analogue (5l) have also been turned up, underscoring its potential significance as a novel pharmacologically relevant framework. Interestingly, a benzimidazo-quinazoline derivative (5c) showcased a pronounced fluorescence “turn-off” response toward benzaldehyde and its substituted variant, with LODs of 2.03, 1.24, and 1.19 µM, respectively, exhibiting high sensitivity and selectivity.\u0000 </div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"15 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoselective Synthesis of Quinazoline and Quinazolinone Derivatives via NH4I-Mediated Oxidative Annulation Under Metal- and Additive-Free Conditions 在无金属和添加剂的条件下，nh4i介导的氧化环化化学选择性合成喹唑啉及其衍生物

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-17 DOI: 10.1002/ajoc.70527

Yongzhen Li, Yajing Liu, Jiajin Luo, Zhiwei Xi, Shuo-Wen Wang, Ji-Kai Wen, Shi Tang

引用次数: 0

Synthesis of Tetrasubstituted 2-Pyrrolines via Zn(II)-Catalyzed [3+2] Annulation of NH2-Enaminones and N-Tosylaziridines Zn（II）催化[3+2]环化nh2 -胺酮和n - tosylaziridine合成四取代2-吡咯啉

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-17 DOI: 10.1002/ajoc.70520

Qingna Yang, Yan Xie, Liang Xie, Xinying Li, Ziyan Wu, Yucai Jiang, Huiyan Lou, Lulu Chen, Changyuan Zhang

引用次数: 0

Electrocatalytic Synthesis of Dithiosulfonates From Tetrasulfides and Sodium Arylsulfinates 四硫化物和芳基亚磺酸钠电催化合成二硫代磺酸盐

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-17 DOI: 10.1002/ajoc.70521

Xiaoxiao Li, Yingming Song, Yue Yu, Wei Wang

{"title":"Electrocatalytic Synthesis of Dithiosulfonates From Tetrasulfides and Sodium Arylsulfinates","authors":"Xiaoxiao Li, Yingming Song, Yue Yu, Wei Wang","doi":"10.1002/ajoc.70521","DOIUrl":"https://doi.org/10.1002/ajoc.70521","url":null,"abstract":"<div>\u0000 \u0000 Sustainable unsymmetrical disulfide synthesis is of significant interest due to the crucial role of disulfide bonds in protein stabilization, peptide drug design, and medicinal chemistry, as exemplified by Disulfiram and ADT-OH. Additionally, sulfone-containing compounds such as Eletriptan and Dapsone exhibit important pharmaceutical activities. Combining these two motifs, dithiosulfonates (compounds containing a S–S–S(O)2 linkage) represent a class of compounds with high research potential. Traditional methods for unsymmetrical disulfide synthesis suffer from malodorous thiols, overoxidation, toxicity, and reliance on precious metals. Although pre-activation strategies using RSSTs reagents have enabled efficient cross-coupling, the preparation of RSSTs themselves remains challenging, with conventional routes suffering from low atom economy and toxicity, while photocatalytic approaches require expensive iridium catalysts. Herein, we report a mild, transition-metal-free electrochemical approach for the synthesis of dithiosulfonates from tetrasulfides and sodium arylsulfinates. This method avoids malodorous thiols, toxic reagents, and precious metal catalysts, providing a greener and more sustainable route to structurally diverse dithiosulfonates.\u0000 </div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"15 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-Induced Radical 1,2-Aminosulfonylation of Alkene to Synthesize β-Amino Sulfonamides 光诱导烯烃自由基1,2-氨基磺酰化合成β-氨基磺酰胺

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-17 DOI: 10.1002/ajoc.70518

Shuai-Xiao Lu, Yan-Bing Wei, Wen-Chao Yang, Yong Zhang

引用次数: 0

Synthesis of 3-Chalcogenyl-benzo[b]Chalcogenophenes via Chalcogenation/Cyclization of Alkynes Promoted by Selectfluor 选择性氟促进炔的硫代/环化合成3-硫代基苯并[b]硫代酚

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-15 DOI: 10.1002/ajoc.70516

Jean C. Kazmierczak, Kelvin V. Hübner, Eduarda R. Fritz, Paola S. Hellwig, Claudio C. Silveira, Ricardo F. Schumacher

引用次数: 0

Steroids With Insecticidal Activity Against the Larvae of Diaphorina citri Kuwayama From Tinospora sagittata 具有杀虫活性的甾体激素对矢状Tinospora Kuwayama柑橘蚜蝇幼虫的作用

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-14 DOI: 10.1002/ajoc.70517

Fei Liu, Li-Ming Zhan, Yang Han, Kai-Cheng Yang, Jia-Qi Song, Ting Liu, Li-Jun Zhang, Hai-Bing Liao

{"title":"Steroids With Insecticidal Activity Against the Larvae of Diaphorina citri Kuwayama From Tinospora sagittata","authors":"Fei Liu, Li-Ming Zhan, Yang Han, Kai-Cheng Yang, Jia-Qi Song, Ting Liu, Li-Jun Zhang, Hai-Bing Liao","doi":"10.1002/ajoc.70517","DOIUrl":"https://doi.org/10.1002/ajoc.70517","url":null,"abstract":"<div>\u0000 \u0000 Twelve steroids (1−12) including one undescribed and a new natural product were isolated from the roots of Tinospora sagittata. The chemical structures of those compounds were elucidated by spectroscopic methods, electronic circular dichroism (ECD) or single-crystal x-ray diffraction analysis. Notably, compounds 2 and 3 are a pair of C-5 epimers. Except for compounds 3 and 4, the remaining compounds were isolated from Tinospora sagittata (T. sagittata) for the first time. Biologically, at a concentration of 1 and 10 mg/L, two compounds showed insecticide activity. Especially, at a concentration of 10 mg/L, compounds 6 and 12 showed the potent activities, with corrected mortality rates of 68.42% and 71.07%, comparable to that of the positive control spirotetramat (71.07%). Research on the potential insecticidal mechanism of compound 12 revealed that six target proteins were predicted via network pharmacology and molecular docking analyses, with EGFR subsequently identified as the most probable target through western blot verification.\u0000 </div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"15 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-Phenacylpyridinium Salts-Involved Formal Cyclization Reactions to Access Spiro[cyclopropane-1,3'-indolines] n -苯酰基吡啶盐参与的形式环化反应获得螺旋[环丙烷-1,3'-吲哚]

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-09 DOI: 10.1002/ajoc.70512

Jinyan Liang, Yanjing Zheng, Kejing Shi, Donghui Guo, Shoujie Shen

引用次数: 0

N-Heterocycle Promoted the Synthesis of Tertiary Amides n -杂环促进叔酰胺的合成

IF 2.3 4区化学

Asian Journal of Organic Chemistry Pub Date : 2026-08-09 DOI: 10.1002/ajoc.70515

Xinyu Zhang, Rui Sun, Haoran Liang, Yuzhen Zhang, Dongni Lin, Xiao Yang

引用次数: 0