Asian Journal of Organic Chemistry最新文献_第10页

Gold(I)‐catalyzed Synthesis of Axially Chiral Indolo[2,3‐c]carbazole Exhibiting Advanced Electrochromic Response 金(I)催化合成具有高级电致变色反应的轴向手性吲哚[2,3-c]咔唑

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-03-01 DOI: 10.1002/ajoc.202400695

Prof. Dr. Takanori Suzuki , Dr. Wataru Nojo , Yuiki Kawada , Soichiro Sugiyama , Takaya Ikeuchi , Prof. Dr. Yusuke Ishigaki , Prof. Dr. Hiroaki Ohno

引用次数: 0

Blue‐LED Self‐Assembly‐Assisted Synthesis of New Photostable Organoboron Esters for Live‐Cell Imaging 蓝光led自组装辅助合成用于活细胞成像的新型光稳定有机硼酯

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-03-01 DOI: 10.1002/ajoc.202400613

Mónica G. Flores‐Amaro , María C. García‐López , David A. Velázquez Hernández , Horacio Reyes‐Pérez , Valeria Villarreal‐García , Rosa Martha Jiménez‐Barrera , Rodrigo Chan‐Navarro , Vianey González‐Villasana , Diana Reséndez‐Pérez.

{"title":"Blue‐LED Self‐Assembly‐Assisted Synthesis of New Photostable Organoboron Esters for Live‐Cell Imaging","authors":"Mónica G. Flores‐Amaro , María C. García‐López , David A. Velázquez Hernández , Horacio Reyes‐Pérez , Valeria Villarreal‐García , Rosa Martha Jiménez‐Barrera , Rodrigo Chan‐Navarro , Vianey González‐Villasana , Diana Reséndez‐Pérez.","doi":"10.1002/ajoc.202400613","DOIUrl":"10.1002/ajoc.202400613","url":null,"abstract":"<div><div>In this work, we report a blue‐LED self‐assembly‐assisted synthesis of novel emissive organoboron esters, achieved in just 30 minutes with quantitative yields. The molecular structure in solution (characterized by 1H and 11B NMR, and mass spectrometry) was further confirmed via X‐ray molecular diffraction analysis for compound 3, where the boron ion adopts a distorted tetrahedral geometry. The photophysical properties of these molecules were analyzed in solution, revealing that 1, featuring tert‐butyl groups and boron heterocycles with a nitro‐substituent, exhibits superior photostability compared to its derivatives. Photobleaching values showed an inverse correlation with the oxidation potentials of compounds 1–3, except for 4, used as a reference. Mass spectrometry further revealed greater energetic stability of the molecular ion of 1. Notably, compound 3 demonstrated good solubility, high photostability, and adequate biocompatibility, making it a promising fluorescent dye for biomedical applications. Cytotoxicity assays in HEK‐293 cells across different concentrations confirmed its non‐toxic nature. Theoretical calculations further supported the high chemical stability of all compounds, attributing it to a synergistic interaction between electronic and steric effects, which protect the fluorophores by substitution of Schiff bases and formation of boron heterocycles. Additionally, 3 exhibited strong, non‐hazardous blue fluorescence when tested on HEK‐293 and MDA‐MB‐231 cells.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 3","pages":"Article e202400613"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Feature: Microcrystalline Cellulose and Cellulose Nanocrystals: Ecofriendly and Sustainable Support Materials in Heterogeneous Nanocatalysis for Green Organic Transformations (Asian J. Org. Chem. 2/2025) 微晶纤维素和纳米纤维素：绿色有机转化中生态友好和可持续的支持材料[j]。化学2/2025)

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-14 DOI: 10.1002/ajoc.202580202

Vinay S. Sharma, Saloni Mishra, Anuj S. Sharma, Neha Sharma, Rajender S. Varma, Pranav S. Shrivastav, Achalkumar Ammathnadu Sudhakar

{"title":"Cover Feature: Microcrystalline Cellulose and Cellulose Nanocrystals: Ecofriendly and Sustainable Support Materials in Heterogeneous Nanocatalysis for Green Organic Transformations (Asian J. Org. Chem. 2/2025)","authors":"Vinay S. Sharma, Saloni Mishra, Anuj S. Sharma, Neha Sharma, Rajender S. Varma, Pranav S. Shrivastav, Achalkumar Ammathnadu Sudhakar","doi":"10.1002/ajoc.202580202","DOIUrl":"https://doi.org/10.1002/ajoc.202580202","url":null,"abstract":"The cover design illustrates the applicability of microcrystalline cellulose and cellulose nanocrystals in organic transformations. In the illustration, an organic chemist is excited to explore the wide potential of these commercially viable materials in various sustainable organic reactions within the green forest of cellulose. Microcrystalline cellulose and cellulose nanocrystals offer high catalytic efficiency and selectivity in organic reactions, promoting greener and more sustainable processes. The biocompatibility and renewable nature of these materials attract the attention of organic chemists, especially when compared to traditional catalysts. More details can be found inarticle number e202400586 by Pranav S. Shrivastav, Achalkumar Ammathnadu Sudhakar, and co-workers.<figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>\u0000 ","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.202580202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Biosynthesis of Depsides, Depsidones, and Diphenyl Ethers from Fungi and Lichens (Asian J. Org. Chem. 2/2025) 封面：真菌和地衣中depides， Depsidones和Diphenyl醚的生物合成（亚洲杂志）。化学2/2025)

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-14 DOI: 10.1002/ajoc.202580201

Qiaolin Ji, Dr. Yudai Matsuda

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Design and Synthesis of Novel Spiro [Chromane‐2,4′‐Piperidin]‐4‐One Derivatives: Anti‐Proliferative Investigation and Molecular Docking Studies 新型螺旋[铬-2,4 ' -胡椒苷]-4- 1衍生物的设计与合成：抗增殖研究及分子对接研究

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-01 DOI: 10.1002/ajoc.202400604

Srinuvasu Nakka , Suryansh Sengar , Kosana Sai Chaitanya , Swati , Ala Chandu , Murugesan Sankaranarayanan , Vivek Sharma , Nagaraju Devunuri , Kondapalli Venkata Gowri Chandra Sekhar

{"title":"Design and Synthesis of Novel Spiro [Chromane‐2,4′‐Piperidin]‐4‐One Derivatives: Anti‐Proliferative Investigation and Molecular Docking Studies","authors":"Srinuvasu Nakka , Suryansh Sengar , Kosana Sai Chaitanya , Swati , Ala Chandu , Murugesan Sankaranarayanan , Vivek Sharma , Nagaraju Devunuri , Kondapalli Venkata Gowri Chandra Sekhar","doi":"10.1002/ajoc.202400604","DOIUrl":"10.1002/ajoc.202400604","url":null,"abstract":"<div><div>Chemists around the globe are extensively working for remedial solutions to cancer, one of the greatest health hazards. We have synthesized twenty‐three novel spiro [chromane‐2,4′‐piperidin]‐ 4 ‐one derivatives (KBS and KMS series of analogues) as part of our ongoing research to combat this deadly disease, and confirmed their structures using 1H NMR, 13C NMR, HRMS, and FT‐IR. Furthermore, we employed single‐crystal XRD to identify the compound structures of KBS4 and KMS10. We have tested the compounds on the cell line such as MCF‐7; U87‐MG; SCC‐25; and HEK‐293T, via WST‐1 assay. Eight compounds showed IC50 values ranging 3.9–10 μM; against the cell line MCF‐7. The best compounds of all were KMS9 (IC50=3.83 μM), KMS5 (IC50=4.14 μM), and KBS8 (IC50=8.24 μM), which promoted apoptosis in MCF‐7 cells. KMS5 and KMS9 compounds showed G1 cell cycle arrest, while compound KBS8 showed G2 cell cycle arrest. Insilco ADME studies were carried out. Molecular docking and dynamics experiments showed how KMS5, KMS9, and KBS8 bind to the active region of the EGFR family – a group of receptor tyrosine kinase (RTK) proteins (PDB ID: 7JXP, 2.16 Å). Further structural modifications of the KMS5, KMS9, and KBS8 may improve their activity against breast cancer.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 2","pages":"Article e202400604"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of Depsides, Depsidones, and Diphenyl Ethers from Fungi and Lichens 从真菌和地衣中合成depides， Depsidones和Diphenyl醚

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-01 DOI: 10.1002/ajoc.202400451

Qiaolin Ji , Dr. Yudai Matsuda

引用次数: 0

Facile Synthesis of 1,4,2‐Dioxazines Using Aromatic Chlorooximes and 2‐Chloroethanol/2‐Chlorophenols 芳香族氯肟和2-氯乙醇/2-氯酚的简易合成1,4,2-二恶嗪

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-01 DOI: 10.1002/ajoc.202400475

Lavina Gladis Serrao , Dr. Mahagundappa Rachappa Maddani

引用次数: 0

Ultrasmall Fe3O4 Nanoparticles on ZrO2 as Catalysts for CO2 Hydrogenation to Lower Olefins ZrO2上的超小Fe3O4纳米颗粒作为CO2加氢制低烯烃催化剂

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-01 DOI: 10.1002/ajoc.202400379

Huda S. Alghamdi , Mohammed A. Sanhoob , Afnan M. Ajeebi , Md. Abdul Aziz , M. Nasiruzzaman Shaikh , Lee Hwei Voon

{"title":"Ultrasmall Fe3O4 Nanoparticles on ZrO2 as Catalysts for CO2 Hydrogenation to Lower Olefins","authors":"Huda S. Alghamdi , Mohammed A. Sanhoob , Afnan M. Ajeebi , Md. Abdul Aziz , M. Nasiruzzaman Shaikh , Lee Hwei Voon","doi":"10.1002/ajoc.202400379","DOIUrl":"10.1002/ajoc.202400379","url":null,"abstract":"<div><div>Organic synthesis presents significant opportunities for converting the abundant and hazardous carbon dioxide (CO2) in the atmosphere into a more sustainable carbon source. To reduce the carbon footprint, we explored the direct hydrogenation of CO2 to lower (C2‐4=) olefins using various catalysts composed of ZrO2‐supported alkali‐metal‐promoted superparamagnetic iron oxide nanoparticles (SPIONs; Fe3O4). These catalysts are notable for their straightforward preparation; we employed a cost‐effective dry‐mixing method to create a range of alkali metal‐doped SPIONs supported on ZrO2. Results showed that the strong interactions between Fe3O4 and the ZrO2 support enhanced CO2 hydrogenation performance compared to other forms.. Under optimal conditions – using a gas hourly space velocity (GHSV) of 4500 mL/h/gcat. and a feed ratio of H2:CO2=3 : 1 – this catalyst achieved over 22 % CO2 conversion and high selectivity for light (C2–4=) olefins at 30 bar and 375 °C, with 30 wt% Fe3O4 loading on ZrO2 and 2 wt% K promoter. We also investigated several variables, including alkali metal concentration, iron content, reaction conditions, and catalyst stability over 96 hours.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 2","pages":"Article e202400379"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent Dependent Selectivity in the Synthesis of 1,2‐Disubstituted and 2‐Substituted Benzimidazoles by Dehydrogenative Coupling Reactions with Ruthenium‐Polyoxoniobate Catalysts 钌-聚氧膦酸盐催化剂脱氢偶联反应合成1,2-二取代和2-取代苯并咪唑的溶剂依赖性选择性

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-01 DOI: 10.1002/ajoc.202400575

Rajasekharan Jayakumari Deepak , Aswathi Ravindran N. E. , Ramasamy Karvembu

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Zinc‐Catalysed (3+2) Cycloaddition of Enaminone with Tosylhydrazide to Synthesise 1H‐Pyrazole via C−N and S−N Bond Cleavage 锌催化（3+2）胺酮与甲酰基肼环加成通过C - N和S - N键裂解合成1h -吡唑

IF 2.8 4区化学

Asian Journal of Organic Chemistry Pub Date : 2025-02-01 DOI: 10.1002/ajoc.202400549

Sanjukta Roy , Rana Chatterjee , Rambabu Dandela

引用次数: 0