Sachin M. Thorat, Dr. Anindita Bhowmick, Dr. Sunderraman Sambasivan, Prof. Dr. Ramakrishna G. Bhat
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引用次数: 0
Abstract
A metal-free, visible light mediated protocol has been developed to synthesize 2-amino-1,3,4-thiadiazoles (ATZ) from commercially available aldehydes and thiosemicarbazides. This one-pot strategy has been achieved by the condensation of aldehydes with substituted thiosemicarbazides in presence of 2,4,6-tri(p-tolyl)pyrylium tetrafluoroborate (TPP-TFB) as a photoredox catalyst. Different aldehydes/hetero aldehydes, as well as thiosemicarbazides reacted smoothly under the reaction conditions to afford the 2-amino-1,3,4-thiadiazoles in good to excellent yields. The practicality of the developed protocol has been successfully demonstrated by the facile one-pot synthesis of commercial herbicide Tebuthiuron on a gram scale. A series of control experiments, cyclic voltammetry, and fluorescence studies have been carried out to support the proposed reaction pathway.
期刊介绍:
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.