由5-氨基- 1h -吡唑-4-碳酰胺合成6-（氯甲基）吡唑[3,4-d]嘧啶

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-01 DOI:10.1002/ajoc.202500556

Kancharla Niteesh, Cheng-Yen Chung, Chun-Han Cha, Wei-Zheng Zeng, Naoto Uramaru, Ichiro Arai, Pei-Jane Huang, Prof. Fung Fuh Wong

引用次数: 0

摘要

建立了以5-氨基- 1h -吡唑-4-乙醛为原料，经酰胺化和序杂环化两步合成6-（卤代甲基）吡唑[3,4-d]嘧啶的简易级联法。该合成方法以5-氨基- 1h -吡唑-4-乙醛为原料，在2-卤代乙酰氯、三甲胺、氢氧化铵等市售安全剂的存在下，制备了1,3-二取代6-（卤代甲基）吡唑[3,4-d]嘧啶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Facile Cascade Synthesis of 6-(Chloromethyl)pyrazolo[3,4-d]pyrimidines from 5-Amino-1H-pyrazole-4-carbaldehydes

查看原文本刊更多论文

Facile Cascade Synthesis of 6-(Chloromethyl)pyrazolo[3,4-d]pyrimidines from 5-Amino-1H-pyrazole-4-carbaldehydes

A facile cascade method was developed for synthesis of 6-(halomethyl)pyrazolo[3,4-d]pyrimidines from 5-amino-1H-pyrazole-4-carbaldehydes via amidation and sequential heterocyclization in two steps. This synthetic method allowed to prepare 1,3-disubstituted 6-(halomethyl)pyrazolo[3,4-d]pyrimidines by using series of 5-amino-1H-pyrazole-4-carbaldehydes as the starting materials in presence of the commercially available safety agents, including 2-haloacetyl chloride, trimethylamine, and ammonium hydroxide.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.