Pd‐Catalyzed Highly Regioselective N‐Acylation of Indoles with Difluorocarbene as a Carbonyl Source

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI:10.1002/ajoc.202500542

Lu Wang , Cheng‐Xian Hu , Xue Yang , Yu‐Lu Du , Jian‐Hua Zhang , Ying Fu , Zheng‐Yin Du

引用次数: 0

Abstract

A novel method has been developed for the exclusively N‐regioselective synthesis of N‐benzoylindoles, utilizing readily available aryl halides, indoles, and sodium difluorochloroacetate. The in situ‐generated carbonyl group produced through difluorocarbene transfer serves as a bridging moiety that facilitates the simultaneous formation of one C─C bond, one C─N bond, and one C═O bond in this transformation.

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以二氟乙烯为羰基源的pd催化吲哚的高区域选择性n -酰化反应

利用现成的芳基卤化物、吲哚和二氟氯乙酸钠，开发了一种专门用于n -区域选择性合成n -苯甲酰啉的新方法。通过二氟苯转移产生的原位生成的羰基作为桥接基团，在这种转化中促进同时形成一个C─C键、一个C─N键和一个C = O键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.