Hypertension最新文献_第5页

Association Between Migraine and Hypertension in 2 Million Adolescents. 200万青少年偏头痛与高血压的关系

IF 8.3 1区医学

Hypertension Pub Date : 2025-09-04 DOI: 10.1161/hypertensionaha.125.24861

Inbal Akavian,Itay Nitzan,Gilad Twig,Estela Derazne,Arnon Afek,Bar Cohen,Ronit Calderon-Margalit

{"title":"Association Between Migraine and Hypertension in 2 Million Adolescents.","authors":"Inbal Akavian,Itay Nitzan,Gilad Twig,Estela Derazne,Arnon Afek,Bar Cohen,Ronit Calderon-Margalit","doi":"10.1161/hypertensionaha.125.24861","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.24861","url":null,"abstract":"BACKGROUNDAn association between migraine and hypertension has long been suggested. However, previous studies yielded conflicting results, and only a few were conducted in adolescents. We aimed to investigate the association between migraine and hypertension in a large population-based study of adolescents.METHODSWe conducted a cross-sectional study of 2 155 077 adolescents (mean age 17.2±0.5 years) who underwent preenlistment screening for mandatory military service between 1990 and 2019. All recruits underwent hypertension screening, and those with suspected hypertension underwent a comprehensive evaluation to confirm the diagnosis. Migraine diagnoses were determined based on examinations by board-certified neurologists. Logistic regression models were used to estimate the odds ratios (OR) for hypertension among individuals with migraine, adjusting for potential confounders.RESULTSAmong 61 314 adolescents diagnosed with migraine, 444 (0.7%) were diagnosed with hypertension, compared with 4570 (0.2%) among nonmigraineurs, yielding a multivariable adjusted OR of 3.01 (95% CI, 2.72-3.33). The association was stronger for severe migraine (OR, 4.41 [95% CI, 3.87-5.03]). Associations were stronger for a diagnosis of severe hypertension (adjusted OR, 3.34 [95% CI, 2.92-3.82]) than with mild hypertension (adjusted OR, 2.67 [95% CI, 2.30-3.10]).CONCLUSIONSOur study demonstrates a significant association between migraine and hypertension, which is more pronounced in cases of high-severity migraine. These findings suggest that adolescents with migraine may benefit from targeted hypertension screening to facilitate early detection and management.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"61 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

G-CSF Mediates Increased Renal Neutrophils and Kidney Damage in a Psoriasis Mouse Model. 银屑病小鼠模型中G-CSF介导肾中性粒细胞增加和肾损伤。

IF 8.3 1区医学

Hypertension Pub Date : 2025-09-04 DOI: 10.1161/hypertensionaha.125.25111

Ziche Chen,Garrett Tessmer,Bianca A Nguyen,Jason Meyer,Mohammad Saleem,Taseer Ahmad,Rachael Bogle,Lam C Tsoi,Tzushan Sharon Yang,Johann E Gudjonsson,Annet Kirabo,Nicole L Ward,Matthew R Alexander

{"title":"G-CSF Mediates Increased Renal Neutrophils and Kidney Damage in a Psoriasis Mouse Model.","authors":"Ziche Chen,Garrett Tessmer,Bianca A Nguyen,Jason Meyer,Mohammad Saleem,Taseer Ahmad,Rachael Bogle,Lam C Tsoi,Tzushan Sharon Yang,Johann E Gudjonsson,Annet Kirabo,Nicole L Ward,Matthew R Alexander","doi":"10.1161/hypertensionaha.125.25111","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.25111","url":null,"abstract":"BACKGROUNDPsoriasis is an autoimmune skin disease associated with increased incidence and severity of chronic kidney disease and hypertension. The mechanisms linking psoriasis skin inflammation with these comorbidities remain unclear.METHODSWe used flow cytometry, radiotelemetric blood pressure measurements, and histological and ELISA-based assessments of renal damage in mice with experimental psoriasis induced by keratinocyte-specific overexpression of Tie2 (KC-Tie2) and their littermate controls.RESULTSCompared with littermate controls, KC-Tie2 mice with chronic skin inflammation developed albuminuria, histological evidence of glomerulosclerosis, and elevated blood pressure. KC-Tie2 mice had a selective and marked increase in circulating and renal neutrophils, along with increased neutrophil extracellular trap formation in the kidneys by flow cytometry. KC-Tie2 mice also exhibited increased bone marrow granulopoiesis along with increases in cutaneous and systemic G-CSF (granulocyte colony-stimulating factor), the primary mediator of granulopoiesis. Finally, neutralization of G-CSF decreased renal neutrophils and kidney damage in KC-Tie2 mice.CONCLUSIONSOur findings demonstrate G-CSF-dependent increases in renal neutrophil accumulation and renal damage in a mouse model of psoriasis. Results suggest a novel link between chronic psoriasiform skin inflammation and renal damage via G-CSF-mediated granulopoiesis, providing new insight into interorgan communication in psoriasis and a potential new therapeutic target for the treatment of psoriasis-related renal dysfunction.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"13 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies. 血管紧张素转换酶抑制剂与血管紧张素受体阻滞剂的疗效比较：多数据库靶点试验模拟研究。

IF 8.3 1区医学

Hypertension Pub Date : 2025-09-04 DOI: 10.1161/hypertensionaha.125.25549

Chao Xie,Ruixuan Chen,Shiyu Zhou,Yaduan Lin,Jiao Liu,Licong Su,Mingzhen Pang,Zhixin Guo,Fan Luo,Linjiang Chen,Yaozhong Kong,Sheng Nie

{"title":"Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies.","authors":"Chao Xie,Ruixuan Chen,Shiyu Zhou,Yaduan Lin,Jiao Liu,Licong Su,Mingzhen Pang,Zhixin Guo,Fan Luo,Linjiang Chen,Yaozhong Kong,Sheng Nie","doi":"10.1161/hypertensionaha.125.25549","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.25549","url":null,"abstract":"BACKGROUNDACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin receptor blockers) are equally recommended as first-line treatment for cardiovascular and renal protection in clinical practice. Evidence on the comparative effectiveness of both drugs on long-term death is inconclusive.METHODSThis multidatabase cohort study used a target trial emulation framework based on the UK Biobank database and the China Renal Data System. Participants who were newly prescribed ACE inhibitors or ARBs were included. Primary and secondary outcomes were 5-year all-cause mortality and major adverse cardiovascular events, respectively. Propensity score matching was performed to balance the baseline characteristics.RESULTSA total of 72 534 and 255 806 patients were identified from the UK Biobank database and the China Renal Data System database. After propensity score matching, cumulative incidence of 5-year all-cause mortality among patients with ACE inhibitor and ARB initiation was 3.45% (3.17%-3.74%) and 3.04% (2.76%-3.31%), with estimated risk differences and hazard ratios of 0.42% (95% CI, 0.02%-0.81%) and 1.13 (95% CI, 1.07-1.19) in the UK Biobank database. Consistent results were obtained in the China Renal Data System database (risk difference, 1.48% [95% CI, 1.10%-1.86%] and hazard ratio, 1.12 [95% CI, 1.09-1.14]). In addition, patients with ACE inhibitor initiation were associated with higher risk of major adverse cardiovascular events than those with ARB initiation in both the China Renal Data System database and UK Biobank database.CONCLUSIONSThis study suggests ACE inhibitor initiation was associated with higher risks of all-cause mortality and major adverse cardiovascular events compared with ARB initiation. These findings highlight the importance of carefully weighing the selection of angiotensin-aldosterone system inhibitors.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"15 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Body Mass Index a Predictor of Preeclampsia? 体重指数是子痫前期的预测指标吗？

IF 8.2 1区医学

Hypertension Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1161/HYPERTENSIONAHA.125.25392

Fannie Lajeunesse-Trempe, Marie-Eve Piché, Emmanuel Bujold

引用次数: 0

Correction: Vascular Endothelial Growth Factor Blockade Promotes the Transition From Compensatory Cardiac Hypertrophy to Failure in Response to Pressure Overload. 更正：血管内皮生长因子阻断促进代偿性心脏肥厚向压力过载反应衰竭的转变。

IF 8.2 1区医学

Hypertension Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1161/HYP.0000000000000251

Yasuhiro Izumiya, Ichiro Shiojima, Kaori Sato, Douglas B Sawyer, Wilson S Colucci, Kenneth Walsh

引用次数: 0

Correction: Rat Strain Effects of AT1 Receptor Activation on D1 Dopamine Receptors in Immortalized Renal Proximal Tubule Cells. 校正：大鼠品系永生化肾近端小管细胞AT1受体激活对D1多巴胺受体的影响。

IF 8.2 1区医学

Hypertension Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1161/HYP.0000000000000253

Chunyu Zeng, Zheng Wang, Ulrich Hopfer, Laureano D Asico, Gilbert M Eisner, Robin A Felder, Pedro A Jose

引用次数: 0

Pulse Pressure Impairs Cognition via White Matter Disruption. 脉压通过白质破坏损害认知。

IF 8.2 1区医学

Hypertension Pub Date : 2025-09-01 Epub Date: 2025-07-10 DOI: 10.1161/HYPERTENSIONAHA.124.24543

Deborah L O King, Richard N Henson, Marta Correia, James B Rowe, Cam-Can Consortium, Kamen A Tsvetanov

{"title":"Pulse Pressure Impairs Cognition via White Matter Disruption.","authors":"Deborah L O King, Richard N Henson, Marta Correia, James B Rowe, Cam-Can Consortium, Kamen A Tsvetanov","doi":"10.1161/HYPERTENSIONAHA.124.24543","DOIUrl":"10.1161/HYPERTENSIONAHA.124.24543","url":null,"abstract":"Background: In older adults, elevated pulse pressure predicts cognitive decline, independent of overall blood pressure. It is proposed to compromise cerebrovascular integrity, potentially leading to brain damage, though the underlying mechanisms remain unclear. We hypothesized that pulse pressure affects cognition by disrupting white matter microstructure, and that it does so independently of other cardiovascular risk factors.Methods: Latent indices of pulse pressure, overall blood pressure, and heart rate variability were estimated in a cross-sectional, population-based cohort (n=708, aged 18-88 years). An indicator of white matter microstructure was derived from diffusion-weighted imaging, termed the peak width of skeletonized mean diffusivity (PSMD). Cognitive function was assessed using measures of processing speed.Results: In robust regression, pulse pressure was significantly associated with PSMD, with PSMD also being associated with processing speed. Thus, higher pulse pressure was associated with greater white matter disruption, which in turn was associated with slower processing. This motivated testing whether PSMD mediates the effects of pulse pressure on processing speed using structural equation models. PSMD mediated this effect, accounting for 72% of the effect after adjusting for age, and remained significant after adjusting for other cardiovascular factors. We then expanded the model to show that vascular-related changes in processing speed also drive changes in higher cognitive functions.Conclusions: High pulse pressure disrupts the microstructural integrity of white matter in the brain, leading to slower processing speed. We propose that better management of pulse pressure could help to preserve white matter integrity and reduce cognitive decline in later life.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"1480-1491"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetically Predicted Expression of Autophagy-Related Genes and Thoracic Aortic Aging: A Mendelian Randomization Study. 基因预测自噬相关基因表达与胸主动脉衰老：孟德尔随机研究。

IF 8.2 1区医学

Hypertension Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1161/HYPERTENSIONAHA.125.25181

Karim Kohansal Vajargah, Marie-Joe Dib, Cameron Beeche, Hamed Tavolinejad, Stephen Burgess, Julio A Chirinos

引用次数: 0

Improving Blood Pressure Control in Preeclampsia by Adjusting Nifedipine Dosing. 调整硝苯地平剂量改善子痫前期血压控制。

IF 8.2 1区医学

Hypertension Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1161/HYPERTENSIONAHA.125.25267

Line Malha, Phyllis August

引用次数: 0

Drinking Water Sodium, Blood Pressure, and Kidney Health. 饮用水、钠、血压和肾脏健康。

IF 8.2 1区医学

Hypertension Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1161/HYPERTENSIONAHA.125.25435

Ewout J Hoorn

引用次数: 0