Hypertension最新文献_第10页

Chronic ACTH Infusion Alters the Diurnal Rhythm of Sodium Excretion, Inducing Nondipping Blood Pressure and Salt-Sensitivity in Male Mice. 慢性ACTH输注改变雄性小鼠钠排泄的昼夜节律，诱导非浸入性血压和盐敏感性。

IF 8.3 1区医学

Hypertension Pub Date : 2025-08-06 DOI: 10.1161/hypertensionaha.124.24473

Hannah M Costello,Céline Grenier,Jessica R Ivy,Alicja Czopek,Natalie K Jones,Georgios Krilis,Kevin Stewart,Josselin Nespoux,Megan C Holmes,Dawn E W Livingstone,Neeraj Dhaun,Matthew A Bailey

{"title":"Chronic ACTH Infusion Alters the Diurnal Rhythm of Sodium Excretion, Inducing Nondipping Blood Pressure and Salt-Sensitivity in Male Mice.","authors":"Hannah M Costello,Céline Grenier,Jessica R Ivy,Alicja Czopek,Natalie K Jones,Georgios Krilis,Kevin Stewart,Josselin Nespoux,Megan C Holmes,Dawn E W Livingstone,Neeraj Dhaun,Matthew A Bailey","doi":"10.1161/hypertensionaha.124.24473","DOIUrl":"https://doi.org/10.1161/hypertensionaha.124.24473","url":null,"abstract":"BACKGROUNDCushing syndrome causes hypertension and increased cardiovascular risk. The hypertensive mechanisms are not clearly defined. We hypothesized that glucocorticoid excess would induce salt-sensitivity, reflecting an impaired pressure-natriuresis response and abnormal salt handling by the kidney.METHODSWe modeled Cushing syndrome in male C57BL/6J mice with prolonged adrenocorticotropic hormone (ACTH) infusion and measured blood pressure on a control diet and following high-salt intake. In a separate group, we assessed renal function and salt excretion, the in vivo pressure-natriuresis response, and ex vivo artery function.RESULTSACTH infusion increased blood pressure, induced nondipping and caused a transition to salt-sensitivity. ACTH infusion reduced the urine sodium/potassium ratio and abolished the diurnal rhythm of sodium excretion. In isolated renal artery, the response to nitric oxide was diminished, and at the mRNA level, we found evidence of arterial remodeling and enhanced TGF-β (transforming growth factor beta) signaling. Autoregulation of renal blood flow was impaired, as was the pressure-natriuresis response.CONCLUSIONSACTH infusion impairs sodium excretion and causes a transition to nondipping and salt-sensitive blood pressure. Renal hemodynamic and tubular abnormalities impair the pressure-natriuresis response. Our findings provide a landscape of the complex physiological response to ACTH excess that may contribute to poor cardiovascular health in Cushing syndrome.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"16 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Restricted Feeding Attenuates Salt-Sensitive Hypertension and Renal Damage. 限时喂养减轻盐敏感性高血压和肾损害。

IF 8.3 1区医学

Hypertension Pub Date : 2025-08-06 DOI: 10.1161/hypertensionaha.125.24857

Lauren Yunker,Kristie Usa,Adaysha C Williams,John J Reho,Justin L Grobe,Michelle L Gumz,Alison J Kriegel

{"title":"Time-Restricted Feeding Attenuates Salt-Sensitive Hypertension and Renal Damage.","authors":"Lauren Yunker,Kristie Usa,Adaysha C Williams,John J Reho,Justin L Grobe,Michelle L Gumz,Alison J Kriegel","doi":"10.1161/hypertensionaha.125.24857","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.24857","url":null,"abstract":"BACKGROUNDTime-restricted feeding (TRF), a type of intermittent fasting, has been shown to improve blood pressure; however, there is limited data on its effects in salt-sensitive (SS) hypertension. We hypothesized that TRF intervention would attenuate the progression of hypertension and renal damage in Dahl SS rats on a high-salt diet.METHODSChronic 24-hour femoral mean arterial pressure (MAP) was recorded during 1 week of ad libitum low-salt or high-salt feeding, followed by 1 week of ad libitum feeding or TRF (16 hours fasting: 8 hours ad libitum) of the same diet. Cosinor analysis was performed on MAP traces. Comprehensive metabolic phenotyping was performed during the second week of the study. Sodium excretion and creatinine clearance were assessed in 4-hour windows over the final study day.RESULTSRats on high salt developed higher blood pressure during week 1. Implementation of TRF during week 2 blunted further increases in MAP. Reduced MAP during the active phase was responsible for the lower 24-hour MAP in TRF rats. In rats on TRF, the respiratory exchange ratio was reduced during fasting without altering daily sodium intake or body weight. On the final study day, high-salt TRF rats exhibited time-dependent differences in sodium excretion and creatinine clearance.CONCLUSIONSThe TRF regimen attenuated SS hypertension and renal damage in male SS rats on a high-salt diet without altering sodium intake or body weight. If these findings translate clinically, TRF may provide an alternative to a salt-restricted diet for management of SS hypertension.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"17 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Point-of-Care Placental Growth Factor for Predicting Adverse Outcomes in Sierra Leone. 点护理胎盘生长因子预测塞拉利昂不良后果。

IF 8.3 1区医学

Hypertension Pub Date : 2025-08-05 DOI: 10.1161/hypertensionaha.125.24526

Katy Kuhrt,Rossetta Cole,Moses M'Bayoh,Chileshe Mabula-Bwalya,Alice Hurrell,Alexandra Ridout,Cristina Fernandez-Turienzo,Paul T Seed,Lucy C Chappell,Kate Bramham,Andrew H Shennan

{"title":"Point-of-Care Placental Growth Factor for Predicting Adverse Outcomes in Sierra Leone.","authors":"Katy Kuhrt,Rossetta Cole,Moses M'Bayoh,Chileshe Mabula-Bwalya,Alice Hurrell,Alexandra Ridout,Cristina Fernandez-Turienzo,Paul T Seed,Lucy C Chappell,Kate Bramham,Andrew H Shennan","doi":"10.1161/hypertensionaha.125.24526","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.24526","url":null,"abstract":"BACKGROUNDPlGF (placental growth factor) concentrations are lower in preeclampsia, a major cause of maternal death; testing improves diagnosis and outcomes. We evaluated 2 novel, whole blood, point-of-care PlGF tests (RONIA and Lepzi Quanti) in a low-resource setting for predicting adverse outcomes.METHODSA prospective observational cohort study in women with hypertension, 24 to 36+6 weeks of gestation, Sierra Leone. Eligible women underwent concealed RONIA and Lepzi Quanti PLGF testing. Optimal rule-out and rule-in thresholds were determined for predicting maternal (death and eclampsia) and perinatal (stillbirth, termination previability, and neonatal death) composite outcomes. Sensitivity, specificity, negative predictive values, and positive predictive values were assessed.RESULTSAnalysis included women with RONIA (n=488) and Lepzi Quanti (n=140) PlGF tests. Optimal thresholds were >60 or >90 pg/mL (rule-out) and <20 or <12 pg/mL (rule-in) for RONIA and Lepzi Quanti, respectively. For tests <34 weeks, RONIA <60 pg/mL had high sensitivity and negative predictive value for ruling out maternal (94.9% and 94.6%) and perinatal (100%) composite outcomes. RONIA <20 pg/mL indicated higher risk (positive predictive values, 16.3% and 40.9% respectively). Lepzi Quanti <90 pg/mL had 100% sensitivity and negative predictive value for ruling out maternal and perinatal composites. Conversely, with Lepzi Quanti <12 pg/mL, nearly one-fourth and half of pregnancies experienced the maternal and perinatal composites (positive predictive values, 22.0% and 48.0%). Performance declined slightly at later gestations.CONCLUSIONSPoint-of-care PlGF testing shows accurate rule-out performance for serious outcomes, with potential for risk stratification in low-resource settings. For both tests, a minority of cases fell into an intermediate category, which would warrant increased surveillance to determine progress.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"15 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is It Time to Abandon the Kidney-Centered View on the Origin of Primary Hypertension? 原发性高血压的起源是时候放弃以肾为中心的观点了吗？

IF 8.3 1区医学

Hypertension Pub Date : 2025-08-05 DOI: 10.1161/hypertensionaha.125.24002

Liffert Vogt,Vitória Cunha,Anna F Dominiczak,Guido Grassi,Marek Rajzer,Agostino Virdis,Thomas Weber

{"title":"Is It Time to Abandon the Kidney-Centered View on the Origin of Primary Hypertension?","authors":"Liffert Vogt,Vitória Cunha,Anna F Dominiczak,Guido Grassi,Marek Rajzer,Agostino Virdis,Thomas Weber","doi":"10.1161/hypertensionaha.125.24002","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.24002","url":null,"abstract":"Traditionally, the kidney has been thought to play a key role in the development of hypertension. Disturbed sodium regulatory pathways can lead to primary hypertension, with abnormalities in the pressure-natriuresis mechanism contributing to its onset. An adverse intrauterine environment and postnatal stressors can affect nephron number, further linking renal development to hypertension risk. The development of hypertension may, however, also be influenced by alternative factors beyond the kidney. Monogenic diseases and polygenic risk scores are associated with hypertension development. Epigenetic mechanisms can influence the phenotype of the vascular endothelium in response to environmental stimuli, potentially leading to changes in blood pressure. Regulation of vascular tone, microvascular rarefaction, and interactions with the immune system are other nonrenal factors contributing to hypertension. The exposome, including air pollution and noise, has its impact already before conception via maternal and paternal influences, as well as later in life. In addition, lifestyle factors such as sodium and alcohol intake and tobacco use have been linked to hypertension through mechanisms such as increased sympathetic activity and vasoconstriction, highlighting the importance of behavioral factors in hypertension development. Age-related stiffening becomes important in later life, influences blood pressure phenotype, and may even precede hypertension development. Considering these multiple contributors, relevant for pathophysiology, prevention, and management of hypertension, the question arises whether the kidney-centered view on hypertension is sufficient or whether a more integrative, multifactorial perspective is needed. Full understanding of renal and nonrenal factors and their interactions driving hypertension is crucial to curb the global burden of this disease.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"29 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cosyntropin-Stimulated Aldosterone Reserve of the Nondominant Adrenal Predicts Surgical Outcomes in Primary Aldosteronism. 共syntropin刺激的非显性肾上腺醛固酮储备预测原发性醛固酮增多症的手术结果。

IF 8.3 1区医学

Hypertension Pub Date : 2025-08-04 DOI: 10.1161/hypertensionaha.125.24999

Peeradon Vibhatavata,James J Shields,Juilee Rege,Aaron Udager,William E Rainey,Adina F Turcu

{"title":"Cosyntropin-Stimulated Aldosterone Reserve of the Nondominant Adrenal Predicts Surgical Outcomes in Primary Aldosteronism.","authors":"Peeradon Vibhatavata,James J Shields,Juilee Rege,Aaron Udager,William E Rainey,Adina F Turcu","doi":"10.1161/hypertensionaha.125.24999","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.24999","url":null,"abstract":"BACKGROUNDAdrenal vein sampling (AVS) is commonly used to direct therapy of primary aldosteronism (PA). We hypothesized that cosyntropin stimulation during AVS exposes the reserve of aldosterone-producing cells in the nondominant adrenal gland and might predict postoperative outcomes.METHODSPatients with PA who underwent successful AVS before and after cosyntropin stimulation between January 2015 and December 2024 in a tertiary-referral center were included. The nondominant adrenal aldosterone reserve was assessed with (1) contralateral aldosterone reserve ratio (=aldosterone postcosyntropin-to-baseline ratio in the nondominant adrenal vein) and (2) lateralization index (LI) ratio (=LIpost-cosyntropin/LIbaseline). Lateralization was based on LI ≥4.RESULTSFour hundred thirty-four patients (57% men; mean age, 53±12 years) were included. AVS lateralized only at baseline in 52 (12%) patients, only after cosyntropin in 46 (11%), and in both protocols in 166 (38%); 170 (39%) patients had bilateral PA. PA severity decreased from cases lateralized in both protocols, to postcosyntropin only, baseline only, and consistently bilateral; conversely, the contralateral aldosterone reserve increased across these groups. The contralateral aldosterone reserve was higher in patients without PA cure and bilateral PA (median [interquartile range], 11.2 [5.0-23.5] and 17.9 [9.1-32.0], respectively, versus 4.9 [2.5-9.4] in those cured; P<0.01) and in Black individuals, those aged ≥45 years, and with CACNA1D mutations. Contralateral aldosterone reserve and postcosyntropin lateralization and contralateral suppression were predictive of residual PA, while baseline parameters were not.CONCLUSIONSCosyntropin stimulation during AVS unveils the aldosterone reserve in the nondominant adrenal gland, exposing the risk of residual disease after adrenalectomy.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"26 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage-Derived LCN2 Promotes Methamphetamine-Induced Pulmonary Hypertension. 巨噬细胞来源的LCN2促进甲基苯丙胺诱导的肺动脉高压。

IF 6.9 1区医学

Hypertension Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1161/HYPERTENSIONAHA.124.24548

Jie Zhou, Zhenzhen Xu, Dao-Bo Peng, Xiaoting Li, Sheng Chang, Ke Duan, Yating Jiang, Cihang Gu, Xiaojia Peng, Wei-Bing Xie

{"title":"Macrophage-Derived LCN2 Promotes Methamphetamine-Induced Pulmonary Hypertension.","authors":"Jie Zhou, Zhenzhen Xu, Dao-Bo Peng, Xiaoting Li, Sheng Chang, Ke Duan, Yating Jiang, Cihang Gu, Xiaojia Peng, Wei-Bing Xie","doi":"10.1161/HYPERTENSIONAHA.124.24548","DOIUrl":"10.1161/HYPERTENSIONAHA.124.24548","url":null,"abstract":"Background: Methamphetamine (METH), a novel amphetamine-type psychostimulant, is recognized as a risk factor for pulmonary hypertension (PH). Macrophage activation is a key event in pulmonary vascular remodeling and PH progression, but the specific mechanisms of METH-induced PH (METH-PH) remain unclear.Methods: A METH-PH mouse model was constructed using wild-type and Lipocalin 2 (LCN2) knockout (LCN2-/-) mice. The involvement and underlying mechanism of LCN2 in METH-PH formation were explored using a METH-PH mouse model and a coculture system of macrophages and pulmonary artery smooth muscle cells.Results: In this study, LCN2 was identified as a key regulator of perivascular inflammation and pulmonary vascular remodeling in PH. In the METH-PH mouse model, LCN2 expression was elevated in macrophages within lung tissues. Compared with wild-type mice, LCN2-/- mice were protected from METH-PH, exhibiting reduced pulmonary vascular remodeling and right ventricular pressure. Mechanistically, LCN2 regulates IL-1β (interleukin-1β) production and secretion through NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation. In pulmonary artery smooth muscle cells, macrophage-derived LCN2 upregulates the expression of SLC7A11 (solute carrier family 7 member 11) and GPX4 (glutathione peroxidase 4), thereby reducing reactive oxygen species production and preventing ferroptosis.Conclusions: Our data revealed a novel mechanism linking LCN2 to macrophages, inflammatory responses, vascular remodeling, and intercellular interactions, indicating that LCN2 could serve as a therapeutic target for METH-induced PH.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"1355-1367"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Aspirin Affect Extracellular Vesicles Involved in the Pathogenesis of Preeclampsia? A Systematic Review and Meta-Analysis. 阿司匹林是否影响细胞外囊泡参与子痫前期发病？系统回顾和荟萃分析。

IF 6.9 1区医学

Hypertension Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI: 10.1161/HYPERTENSIONAHA.125.24826

Angel Nilesh D'Crus, Soumyalekshmi Nair, Jessica Jellins, Fabricio Da Silva Costa, Jon Hyett, Carlos Salomon

{"title":"Does Aspirin Affect Extracellular Vesicles Involved in the Pathogenesis of Preeclampsia? A Systematic Review and Meta-Analysis.","authors":"Angel Nilesh D'Crus, Soumyalekshmi Nair, Jessica Jellins, Fabricio Da Silva Costa, Jon Hyett, Carlos Salomon","doi":"10.1161/HYPERTENSIONAHA.125.24826","DOIUrl":"10.1161/HYPERTENSIONAHA.125.24826","url":null,"abstract":"Background: Preeclampsia is a challenging pregnancy disorder to treat, and current preventive measures are not always effective. Aspirin is prescribed as a preventive agent for pregnant women who are at high risk of developing preeclampsia although there is no definitive conclusion for its mechanism of action or efficacy. Extracellular vesicles (EVs) provide a picture of the physiological state of the cells from which they originate and have been implicated in both normal and pathological pregnancies. This study reviewed the potential effects of aspirin on EVs when prescribed for prevention of preeclampsia.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used to identify published studies from the CENTRAL, The Cochrane Library (Cochrane Central Register of Controlled Trials), MEDLINE (Medical Literature Analysis and Retrieval System online) on PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, and Embase (Excerpta Medica Database) from inception to March 2024.Results: Sixty-three studies met the inclusion criteria and were grouped as studies on aspirin-mediated prevention of preeclampsia (n=31), studies on EVs in the pathogenesis of preeclampsia (n=28), and studies on the effects of aspirin on EVs in preeclampsia (n=4). Meta-analysis of randomized control trials showed that the odds of preeclampsia occurrence is 36% less likely in the aspirin treatment group (odds ratio, 0.64 [95% CI, 0.47-0.87]; P<0.01). EVs are involved in the pathogenesis of preeclampsia, and aspirin effectively reduced the negative effects of EVs in both in vitro and in vivo studies.Conclusions: Aspirin has an inhibitory effect on EVs in preeclampsia. However, further studies are needed to understand and confirm the mechanisms involved.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"1277-1291"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP. 心衰大鼠PVN中nNOS的降解：CHIP的作用

IF 6.9 1区医学

Hypertension Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1161/HYPERTENSIONAHA.125.24896

Tapan A Patel, Kenichi Katsurada, Hong Zheng, Kaushik P Patel

{"title":"Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP.","authors":"Tapan A Patel, Kenichi Katsurada, Hong Zheng, Kaushik P Patel","doi":"10.1161/HYPERTENSIONAHA.125.24896","DOIUrl":"10.1161/HYPERTENSIONAHA.125.24896","url":null,"abstract":"Background: One salient feature of congestive heart failure (CHF) is the exaggerated sympathetic drive. Reduced nNOS (neuronal nitric oxide synthase) within the paraventricular nucleus (PVN) is primarily responsible for the enhanced sympathetic tone in CHF. Here, we examined the role of CHIP (C-terminus of heat shock cognate protein 70-interacting protein) as a key regulator of nNOS in the PVN.Methods: CHF in rats was induced by left coronary artery ligation. Alterations in the expression of nNOS, CHIP, HSP70 (heat shock protein 70), and HSP90 (heat shock protein 90) in the PVN of CHF rats were evaluated by Western blot and immunofluorescence techniques. Neuronal NG108-15 cells were used to analyze the effect of CHIP overexpression (using the pCMV3-CHIP-GFP spark plasmid) on nNOS expression in vitro. CHIP overexpression was achieved by viral injections in the PVN of normal rats.Results: CHIP (50%) and HSP70 (33%) were significantly upregulated in the PVN of rats with CHF. Overexpression of CHIP in neuronal NG108-15 cells showed an ≈74% increase in CHIP with a concomitant decrease in nNOS expression (≈49%). Overexpression of CHIP significantly increased ubiquitination of nNOS (46%) in NG108-15 cells. Overexpression of CHIP in the PVN of normal control rats significantly reduced NO-mediated inhibition of renal sympathetic nerve activity, blood pressure, and heart rate.Conclusions: Overall, these studies identify overexpression of CHIP, which triggers ubiquitination and proteasomal degradation of nNOS in the PVN results in reduced inhibitory sympathetic tone in CHF.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"1292-1302"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Blood Pressure Reflexes in Women With Endometriosis. 子宫内膜异位症患者血压反射的改变。

IF 8.3 1区医学

Hypertension Pub Date : 2025-08-01 DOI: 10.1161/hypertensionaha.125.25089

Auni C Williams,Lacy M Alexander

{"title":"Altered Blood Pressure Reflexes in Women With Endometriosis.","authors":"Auni C Williams,Lacy M Alexander","doi":"10.1161/hypertensionaha.125.25089","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.25089","url":null,"abstract":"BACKGROUNDEndometriosis is a risk factor for cardiovascular disease. COX (Cyclooxygenase) is upregulated in endometriotic lesions, potentially exaggerating pressor reflexes, a major risk factor for adverse cardiovascular events. The purpose of this study was to determine whether women with endometriosis demonstrate exaggerated pressor responses. We hypothesized that women with endometriosis would show exaggerated BP compared with healthy women during handgrip exercise and cold pressor testing (CPT).METHODSIn a single-blind, randomized, crossover design, women with (Endo ; n=11) and without (HC; n=9) endometriosis underwent a CPT and handgrip with postexercise ischemia following aspirin (a nonselective COX inhibitor; 650 mg) or placebo. Blood pressure was continuously monitored during baseline (5 minutes) and hand submersion (3 minutes; 4-8 °C) during CPT, and during baseline (5 minutes), 30% maximal voluntary contraction handgrip (2 minutes), and postexercise ischemia (3 minutes) for handgrip with postexercise ischemia.RESULTSWomen with endometriosis demonstrated attenuated pressor responses to CPT (∆MAP Endo 21±16 versus HC 34±20 mm Hg; P<0.01) and handgrip with postexercise ischemia (handgrip/postexercise ischemia: ΔMAP Endo=12±13/13±10 mm Hg, HC=24±14/20±8 mm Hg; P<0.01). There was no effect of aspirin on blood pressure response to either CPT or handgrip with postexercise ischemia.CONCLUSIONSCompared with age-matched HC, women with endometriosis demonstrate lower increases in blood pressure in response to cold exposure and exercise. Aspirin, a COX inhibitor, had no impact on these responses. Collectively, these results suggest that women with endometriosis demonstrate altered central integration and attenuated sympathetic outflow and end-organ responsiveness.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"135 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium Aspirin Preeclampsia Early Prevention and Response (CASPER) Trial in Blantyre, Malawi: A Double-Blinded Cluster Randomized Trial. 钙阿司匹林先兆子痫早期预防和反应（CASPER）试验在马拉维布兰太尔：双盲集群随机试验。

IF 6.9 1区医学

Hypertension Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1161/HYPERTENSIONAHA.125.24675

Memory M Ngwira, Angela Makris, Renuka Shanmugalingam, John L Mbotwa, Josiah Mayani, Luis A Gadama, Annemarie Hennessy

{"title":"Calcium Aspirin Preeclampsia Early Prevention and Response (CASPER) Trial in Blantyre, Malawi: A Double-Blinded Cluster Randomized Trial.","authors":"Memory M Ngwira, Angela Makris, Renuka Shanmugalingam, John L Mbotwa, Josiah Mayani, Luis A Gadama, Annemarie Hennessy","doi":"10.1161/HYPERTENSIONAHA.125.24675","DOIUrl":"10.1161/HYPERTENSIONAHA.125.24675","url":null,"abstract":"Background: Preeclampsia remains one of the major causes of maternal and neonatal mortality and morbidity, and yet it is uncertain whether aspirin combined with calcium would reduce the burden of preeclampsia in Malawian women, as elsewhere. This study assessed the efficacy of early low-dose aspirin in preventing in women given calcium to prevent preeclampsia/eclampsia in Blantyre, Malawi.Methods: This was a pragmatic, double-blind, cluster randomized controlled trial conducted in 4 urban health centers and Queen Elizabeth Central Hospital in Blantyre. A total of 306 women at high risk of preeclampsia were assigned to low-dose aspirin (150 mg/day) or placebo from 12 to 16 weeks until 34 weeks of gestation in clusters. All women were given calcium 1 g/day. The intention-to-treat analysis and adherence analysis were conducted with the primary end point of preeclampsia.Results: A total of 39 women were lost to follow-up, and 1 withdrew consent. Data for 266 women were available for analysis. Overall, preeclampsia occurred in 15.8% (42/266) and eclampsia in 2.3% (6/266) of all women. There was no statistically significant difference in the rate of preeclampsia between the low-dose aspirin group 19.3% (26/135) and placebo group (12.2% 16/131; adjusted odds ratio, 1.16 [95% CI, 0.41-3.41]; P=0.781). No statistically significant difference was observed in the secondary maternal and neonatal outcomes. The overall adherence was 69%.Conclusions: In high-risk women treated with calcium, additional low-dose aspirin resulted in no difference in the rate of preeclampsia, cesarean section rates, or important neonatal outcomes in Malawi.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"1316-1325"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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