Hypertension最新文献

{"title":"Early Pregnancy Blood Pressure Trajectories and Hypertension Years After Pregnancy.","authors":"James M Roberts, Stacey E Alexeeff, Baiyang Sun, Mara Greenberg, Alexis King, Mai N Nguyen-Huynh, Alan S Go, Erica P Gunderson","doi":"10.1161/HYPERTENSIONAHA.125.24649","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24649","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease risk. Blood pressure (BP) trajectories ≤20 weeks' gestation predict HDP outcomes. We hypothesized that early-pregnancy BP patterns stratify risk of developing hypertension years after pregnancy.</p><p><strong>Methods: </strong>This prospective cohort of 174 774 women without prior hypertension, kidney, liver, or heart disease, or history of preeclampsia entered prenatal care ≤14 weeks and delivered a stillborn or live singleton birth at Kaiser Permanente Northern California hospitals (2009-2019). Electronic health records provided data, including HDP for each birth, longitudinal outpatient clinical BP measurements, International Classification of Diseases codes, and medication use to identify new-onset hypertension from 2 months through 14 years post-delivery (2009-2023). Latent class trajectory modeling identified 6 BP trajectory (BPT) groups capturing both BP levels and slopes from 0 to 20 weeks' gestation. Multivariable Cox regression models estimated the hazard ratio (95% CIs) of new-onset hypertension after pregnancy associated with early-pregnancy BP trajectories, with effect modification by HDP.</p><p><strong>Results: </strong>BP trajectories were associated with an increasing gradient of hypertension risk after pregnancy within each HDP group. Adjusted hazard ratios were higher among preeclampsia and gestational hypertension groups than for no HDP. From lowest to highest BPT groups, hazard ratios ranged from 2.91 to 27.31 for preeclampsia, 4.20 to 27.81 for gestational hypertension, and 2.92 to 10.96 for no HDP compared with lowest BP trajectories of the no HDP group (all reference 1.0).</p><p><strong>Conclusions: </strong>Early-pregnancy BP trajectories are strongly associated with new-onset hypertension years after pregnancy. Combined with HDP, they may stratify risk for targeted surveillance and early interventions and improve the prediction of cardiovascular disease risk in women.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total and Free Placental Growth Factor Levels During Preeclampsia and Fetal Growth Restriction.","authors":"A Jungelson, A Ridoux, M Barthe, D Redel, H Abbas, B Haddad, S A Karumanchi, Edouard Lecarpentier","doi":"10.1161/HYPERTENSIONAHA.125.24736","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24736","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to evaluate total circulating PlGF (placental growth factor) and free PlGF concentrations to provide insights into the mechanisms of decreased PlGF noted in preeclampsia and fetal growth restriction.</p><p><strong>Methods: </strong>We conducted a retrospective single-center study in pregnant women receiving care for suspected preeclampsia and/or fetal growth. Serum angiogenic proteins (sFLT1 [soluble fms-like tyrosine kinase] and free PlGF) were measured on an automated platform as part of standard-of-care. Total PlGF concentrations in the serum were directly measured using a validated biochemical procedure that dissociated circulating sFLT1 and PlGF complexes. Small for gestational age (SGA) was defined by birthweight ≤10th percentile.</p><p><strong>Results: </strong>Of the 407 women studied, 155 women did not develop preeclampsia or SGA (control group), 111 women developed SGA without preeclampsia (SGA group), 71 women developed preeclampsia without SGA (preeclampsia group), and 70 developed preeclampsia and SGA (preeclampsia+SGA group). Despite reductions in free PlGF levels (229 [158-321] pg/mL), total PlGF levels were not reduced in the preeclampsia group (1020 [738-1444] pg/mL) compared with the control group (1077 [763-1595] pg/mL). In contrast, the total PlGF levels were significantly reduced in the SGA group (744 [462-1161] pg/mL; <i>P</i><0.0001) and the preeclampsia +SGA group (616 [349-917] pg/mL; <i>P</i><0.0001) compared with the control group (1077 [763-1595] pg/mL).</p><p><strong>Conclusions: </strong>Placental dysfunction associated with preeclampsia, characterized by reduced free PlGF levels but unchanged total PlGF, is driven by excessive placental production of sFLT1. Placental dysfunction associated with SGA, marked by reductions in both free and total PlGF, is mediated by decreased placental PlGF production.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preeclamptic Placental CD19+ B Cells Are Causal to Hypertension During Pregnancy.","authors":"Owen Herrock, Nathan Campbell, Evangeline Deer, Lorena M Amaral, Darby Whitney, Rachael Morris, Kedra Wallace, Ty Turner, E Hawthorne Cleveland, Sheila Belk, George W Booz, Denise C Cornelius, Babbette LaMarca","doi":"10.1161/HYPERTENSIONAHA.124.24552","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.124.24552","url":null,"abstract":"<p><strong>Background: </strong>Patients with preeclampsia exhibit hypertension and chronic inflammation characterized by CD (cluster determinant) 4+T cells, B cells secreting AT1-AA (agonistic autoantibody against the angiotensin II type 1 receptor), inflammatory cytokines, and complement activation. Importantly, a history of COVID-19 during pregnancy is associated with an increased incidence of a preeclampsia-like phenotype and is partly mediated by CD4+T cells. We recently showed pregnant patients with a history of COVID-19 with or without preeclampsia produce AT1-AA, indicating the importance of B lymphocytes in the progression of preeclampsia and possibly of COVID-19. Therefore, we hypothesize that B cells from patients with preeclampsia with or without COVID-19 history induce the preeclampsia phenotype through AT1-AA.</p><p><strong>Methods: </strong>Placental B cells were isolated from normal pregnant, patients with preeclampsia, normotensive COVID-19 history, or preeclampsia COVID-19 history at delivery. Then, 3×10⁵ B cells were transferred intraperitoneally into pregnant athymic rats at gestational day 12. On gestational day 18, carotid catheters were inserted. On gestational day 19, mean arterial pressure was measured, and tissues were collected.</p><p><strong>Results: </strong>Preeclampsia B-cell recipients had significantly increased mean arterial pressure, AT1-AA, inflammatory cytokines, and complement activation compared with normal pregnant B-cell recipients. Recipients of B cells with COVID-19 history had markers of inflammation and hypertension but not to the level of significance as recipients of preeclampsia B cells. Inhibition of AT1-AA attenuated the hypertension that occurred in response to preeclampsia or preeclampsia B cells with COVID-19 history.</p><p><strong>Conclusions: </strong>This study demonstrates the important role of B cells in contributing to hypertension and chronic inflammation during preeclampsia with or without COVID-19 history through secretion of AT1-AA.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in Postpartum Care After a Hypertensive Disorder of Pregnancy in the United States.","authors":"Megan M McLaughlin, Neda Ghaffari, Catherine Lee, Malamo E Countouris, Phoebe Ashley, Amanda Schnell-Herringer, Divya P Mallampati, Juan M Gonzalez, Alexis L Beatty","doi":"10.1161/HYPERTENSIONAHA.124.24569","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.124.24569","url":null,"abstract":"<p><strong>Background: </strong>The postpartum period is a critical time for blood pressure monitoring and cardiovascular risk factor modification in individuals with hypertensive disorders of pregnancy (HDP), who are at increased risk for cardiovascular disease.</p><p><strong>Methods: </strong>We analyzed data from the Pregnancy Risk Assessment Monitoring System, a nationally representative US population-based survey of postpartum women with live births from 2016 to 2022. Among individuals with HDP, we evaluated the association between race, ethnicity, and other socioeconomic factors and (1) postpartum visit attendance and (2) postpartum counseling/screening.</p><p><strong>Results: </strong>Among 42 858 participants with HDP (weighted n=2 011 284), 90% reported attending a postpartum visit. Adjusting for other factors, Hispanic individuals (odds ratio, 0.75 [95% CI, 0.60-0.94]), non-Hispanic Black individuals (odds ratio, 0.75 [95% CI, 0.62-0.91]), and individuals of other or multiple races (odds ratio, 0.57 [95% CI, 0.44-0.74]) were less likely to attend a postpartum visit, compared with non-Hispanic White individuals. Individuals with lower income, lower educational attainment, and those with Medicaid or no insurance were significantly less likely to report attending a postpartum visit. Among those who reported attending a postpartum visit, only 56.3% reported receiving postpartum counseling on healthy lifestyle, 60.9% reported receiving screening for cigarette smoking, and 23.7% reported receiving testing for diabetes.</p><p><strong>Conclusions: </strong>Most individuals with HDP reported attending a postpartum visit, but there were significant disparities in postpartum visit attendance by race/ethnicity, health insurance, and socioeconomic status. In addition, many participants reported not receiving postpartum counseling or screening for cardiovascular risk factors. This represents a missed opportunity to equitably improve the long-term cardiovascular health of individuals with HDP.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Ciliary Neurotrophic Factor in Angiotensin II-Induced Hypertension.","authors":"Sebastian A Potthoff, Ivo Quack, Yuri Mori, Guang Yang, Denada Arifaj, Ehsan Amin, Jaroslawna Meister, Sven G Meuth, Marta Kantauskaite, Doron Argov, Ioana Alesutan, Jakob Voelkl, Joon-Keun Park, Lars C Rump, Marc Rio, Gervaise Loirand, Ralf A Linker, Johannes Stegbauer","doi":"10.1161/HYPERTENSIONAHA.124.22845","DOIUrl":"10.1161/HYPERTENSIONAHA.124.22845","url":null,"abstract":"<p><strong>Background: </strong>Ciliary neurotrophic factor (CNTF), mainly known for its neuroprotective properties, belongs to the IL-6 (interleukin-6) cytokine family. In contrast to IL-6, the effects of CNTF on the vasculature have not been explored. Here, we examined the role of CNTF in AngII (angiotensin II)-induced hypertension.</p><p><strong>Methods: </strong>Hypertension was chronically induced with AngII (1000 ng/kg per minute, osmotic mini-pumps, 14 days) in CNTF-knockout and wild-type mice (with or without nephrectomy and 1% NaCl drinking water). Blood pressure was measured by tail-cuff and radiotelemetry. Effects of CNTF on vascular function and the JAK2/STAT3 pathway were measured in vivo, in the isolated perfused kidney, and in mouse and human vascular smooth muscle cells.</p><p><strong>Results: </strong>At baseline, systolic blood pressure was similar between both groups. During AngII infusion, blood pressure increase was significantly attenuated and hypertensive heart and kidney damage was significantly attenuated in CNTF-knockout compared with wild-type mice. Accordingly, renal pressor response to AngII but not KCl or phenylephrine was significantly decreased in CNTF-knockout compared with wild-type mice. Acute CNTF (5 µmol/L) administration nearly restored the AngII-dependent renal pressor response. Chronic CNTF treatment in CNTF-knockout mice increased blood pressure response to AngII to levels observed in wild-type mice. CNTF augments AngII-induced activation of the JAK2/STAT3 pathway in vitro in vascular smooth muscle cells. The significance of this interaction was shown, as the increase in renal pressor response by CNTF was abolished by JAK2/STAT3 inhibitors.</p><p><strong>Conclusions: </strong>Our results demonstrate a major impact of CNTF on blood pressure regulation by modulating AngII-induced pressor response via a JAK2/STAT3-dependent mechanism and indicate that CNTF is an important regulatory cytokine in hypertension.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"652-664"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women's Health Initiative.","authors":"Bernhard Haring, Aaron K Aragaki, Daichi Shimbo, Stephen R Rapp, Charles B Eaton, Michael J LaMonte, Jean Wactawski-Wende, Matthew A Allison, Aladdin H Shadyab, Jacques E Rossouw, Eric A Whitsel, Nora Franceschini, Charles Kooperberg, Pinkal Desai, Michael S Simon, Michael Böhm, Pradeep Natarajan, Sylvia Wassertheil-Smoller, JoAnn E Manson","doi":"10.1161/HYPERTENSIONAHA.124.24482","DOIUrl":"10.1161/HYPERTENSIONAHA.124.24482","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"82 4","pages":"e70-e72"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypotensive Episodes on 24-Hour Ambulatory Blood Pressure and Cognitive Function: Insights From the SPRINT Study.","authors":"Wenxin Zhang, Susan Redline, Anand Viswanathan, Simon B Ascher, Darshana Hari, Stephen P Juraschek, Christophe Tzourio, Paul E Drawz, Lewis A Lipsitz, Murray A Mittleman, Yuan Ma","doi":"10.1161/HYPERTENSIONAHA.124.24222","DOIUrl":"10.1161/HYPERTENSIONAHA.124.24222","url":null,"abstract":"<p><strong>Background: </strong>Hypotensive episodes detected by 24-hour ambulatory blood pressure (BP) monitoring capture daily cumulative hypotensive stress and could be clinically relevant to cognitive impairment, but this relationship remains unclear.</p><p><strong>Methods: </strong>We included participants from the Systolic Blood Pressure Intervention Trial (receiving intensive or standard BP treatment) who had 24-hour ambulatory BP monitoring measured near the 27-month visit and subsequent biannual cognitive assessments. We evaluated the associations of hypotensive episodes (defined as systolic BP drops of ≥20 mm Hg between 2 consecutive measurements that reached <100 mm Hg) and hypotensive duration (cumulative time of systolic BP <100 mm Hg) with subsequent cognitive function using adjusted linear mixed models. We further assessed 24-hour average BP and variability.</p><p><strong>Results: </strong>Among 842 participants with treated hypertension (mean age, 71±9 years; 29% women), the presence (versus absence) of recurrent hypotensive episodes (11%) was associated with lower digit symbol coding scores (difference in <i>Z</i> scores, -0.249 [95% CI, -0.380 to -0.119]) and their faster declines (difference in <i>Z</i> score changes, -0.128 [95% CI, -0.231 to -0.026]). A consistent dose-response association was also observed for longer hypotensive duration with worse Montreal Cognitive Assessment and digit symbol coding scores. The association with digit symbol coding scores remained significant after further adjusting for 24-hour average BP and variability and was not observed for hypotension defined by clinic, orthostatic, or 24-hour average BP. Intensive BP treatment increased 24-hour hypotensive episodes and modified its association with the decline in digit symbol coding score.</p><p><strong>Conclusion: </strong>Twenty-four-hour hypotensive episodes were associated with worse cognitive function, especially in processing speed, and could be a novel marker for optimal BP control and dementia prevention.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"627-637"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Hypertensionology and the Mosaic Theory of Hypertension.","authors":"Sanjay Rajagopalan, Robert D Brook, Thomas Münzel","doi":"10.1161/HYPERTENSIONAHA.124.18733","DOIUrl":"10.1161/HYPERTENSIONAHA.124.18733","url":null,"abstract":"<p><p>Hypertension is a multifactorial condition influenced by the intricate interplay of biological and genetic determinants. The growing field of Environmental Hypertensionology endorses the outsized role of environmental factors in the pathogenesis and exacerbation of hypertension. It provides a clinical approach to address these factors at the individual and societal levels. Environmental stressors contributing to blood pressure levels can be viewed within the mosaic model of hypertension, which offers a comprehensive framework for understanding blood pressure regulation through its connection with multiple other nodes causally related to the pathogenesis of hypertension. This review synthesizes growing evidence supporting the impact of several factors in the physical environment and adverse stressors embedded in key provisioning systems, including air, noise, and chemical pollution, along with aspects of the built environment, green spaces, food systems, on the global burden of hypertension. Although many factors may not be directly in the causal cascade of hypertension, the web of connections between many behooves an understanding of the important nodes for intervention. Public health strategies emphasizing the redesign of environments present an unprecedented opportunity to enhance global hypertension control rates. Future research should thus focus on integrating environmental risk assessment and interventions into clinical practice, optimizing urban planning, and public policy to achieve meaningful reductions in the global burden of hypertension. By understanding hypertension as a mosaic of interconnected causes, healthcare professionals are better equipped to individualize treatment, combining lifestyle interventions and multiple drug classes to target environmental and genetic factors driving high blood pressure.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"561-572"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficiency of Endothelial <i>Piezo2</i> Impairs Pulmonary Vascular Angiogenesis and Predisposes Pulmonary Hypertension.","authors":"Feng Wei, Ziying Lin, Wenju Lu, Haiyun Luo, Huazhuo Feng, Shiyun Liu, Chenting Zhang, Yulin Zheng, Jiyuan Chen, Shaocong Mo, Chen Wang, Zizhou Zhang, Wei Feng, Junqi Zhu, Qifeng Yang, Min Du, Weiguo Kong, Aofeng Liu, Jiaxuan Lai, Xiang Li, Xuefen Wu, Ning Lai, Yuqin Chen, Kai Yang, Jian Wang","doi":"10.1161/HYPERTENSIONAHA.124.22948","DOIUrl":"10.1161/HYPERTENSIONAHA.124.22948","url":null,"abstract":"<p><strong>Background: </strong>Mechanosensitive Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) channel plays a key role in pulmonary hypertension (PH). However, the role of Piezo2 in PH remains unclear.</p><p><strong>Methods: </strong>Endothelial cell (EC)-specific Piezo2 knockout (<i>Piezo2</i>^flox/flox, Tek-Cre⁺; <i>Piezo2</i>^<i>EC-/-</i>) rats and primarily cultured pulmonary microvascular ECs were used to determine the role of Piezo2 in PH.</p><p><strong>Results: </strong>Data analysis of publicly accessible single-cell RNA-sequencing data sets uncovered significant downregulation of Piezo2 in lung ECs from patients with idiopathic pulmonary arterial hypertension, which was verified in the lungs/ECs from PH rat models induced by hypoxia or monocrotaline. Comparing to wild-type rats, <i>Piezo2</i>^<i>EC</i>^<i>-/-</i> rats exhibited exacerbated PH in both hypoxia-induced PH and monocrotaline-induced PH, characterized by the worsened hemodynamical and histological changes. <i>Piezo2</i>^<i>EC</i>^<i>-/-</i> rats showed dramatic loss of pulmonary microvessels, in association with the decreased intracellular free calcium concentration ([Ca²⁺]_i) and downregulation of VEGFR2 (vascular endothelial growth factor receptor 2) and phosphorylated SRF (serum response factor) in pulmonary microvascular ECs. Knockout of Piezo2 or treatment with a calcium chelator, EDTA, impaired the ability of tube formation and migration in pulmonary microvascular ECs, which was restored by supplementation of extra calcium. A safflower oil diet rich in linoleic acid, which can enhance the stability and function of Piezo2, effectively alleviated PH development in a hypoxia-induced PH rat model.</p><p><strong>Conclusions: </strong>This study demonstrates that EC-specific knockout of Piezo2 exacerbates PH pathogenesis, at least partially, through the suppression of [Ca²⁺]_i/phosphorylated SRF/VEGFR2 signaling axis in pulmonary vascular ECs. Targeted activation of Piezo2 could be a novel effective strategy for the treatment of PH.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"583-597"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Use of an Old Drug: Minoxidil for Resistant Hypertension.","authors":"Michael Bursztyn, Iddo Z Ben-Dov","doi":"10.1161/HYPERTENSIONAHA.124.23976","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.124.23976","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"82 4","pages":"543-548"},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}