Hypertension最新文献

{"title":"CD38⁺ T-Cell Count Is an Immunologic Phenotype Associated With Blood Pressure.","authors":"Chuan Lin, Yajuan Xiao, Xin Zhou, Suhan Zhou, Reema Abdullah, Jianghua Chen, Fei Han, Pingping Ren, Liang Xiao","doi":"10.1161/HYPERTENSIONAHA.126.27403","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27403","url":null,"abstract":"<p><strong>Background: </strong>T lymphocytes play a crucial role in the development of hypertension and associated end-organ damage. CD38 is a well-established surface marker for T-cell activation. However, clinical evidence linking CD38⁺ T cells, or other specific T-cell subsets, with blood pressure (BP) changes remains limited. We therefore sought to determine whether CD38⁺ T-cell abundance correlates with BP and whether anti-CD38 therapy influences BP in humans and mice.</p><p><strong>Methods: </strong>We performed correlation analyses between peripheral immune cell counts and BP in 197 normotensive and 53 hypertensive subjects. The impact of CD38-targeted therapy on BP was evaluated in multiple myeloma patients (control, n=50; daratumumab, n=27). In addition, we used a murine model of angiotensin II-induced hypertension to characterize T-cell frequency and phenotype in the circulation and kidney by flow cytometry.</p><p><strong>Results: </strong>Circulating CD38⁺ T-cell abundance was inversely correlated with BP in both normotensive and hypertensive subjects. This finding was recapitulated in hypertensive mice, which also showed concomitant accumulation of CD38⁺ T cells in the kidney. In patients, daratumumab-induced depletion of CD38⁺ cells reduced systolic BP by ≈10 mm Hg for 4 to 6 weeks. This BP-lowering effect was similarly observed in hypertensive mice given an antimurine CD38 antibody.</p><p><strong>Conclusions: </strong>Our data identify circulating CD38⁺ T cells as a novel immunologic biomarker that inversely correlates with BP, potentially reflecting T-cell transmigration during BP elevation.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e27403"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Elasticity in Chinese Youth: References and the Role of Muscle.","authors":"Hongbo Dong, Yan Li, Minjun Li, Xiangjun Xie, Pei Xiao, Yanyan Li, Lina Lan, Jingfan Xiong, Jie Mi","doi":"10.1161/HYPERTENSIONAHA.126.27207","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27207","url":null,"abstract":"<p><strong>Background: </strong>Arterial elasticity, noninvasively assessed by carotid-femoral pulse wave velocity (cfPWV), is an important determinant of cardiovascular health, yet reference values are lacking for Chinese youth. Moreover, the interplay between adiposity, skeletal muscle mass, and blood pressure regarding cfPWV remains unclear.</p><p><strong>Methods: </strong>We analyzed 2077 Chinese children and adolescents aged 6 to 14 years from a cross-sectional survey. Among them, 1382 nonobese, normotensive, and metabolically healthy participants were selected as the reference population to derive sex-, age-, and height-specific cfPWV centiles, from which cfPWV <i>Z</i> scores were calculated in the overall population to examine potential correlates.</p><p><strong>Results: </strong>In the reference population, cfPWV increased with age and height in both sexes, with a steeper rise after the age of 10 years. In the overall population, higher fat mass index and systolic blood pressure were independently associated with higher cfPWV <i>Z</i> scores, whereas higher appendicular skeletal muscle mass index was associated with lower cfPWV <i>Z</i> scores in both boys (β=-0.123, <i>P</i>=0.018) and girls (β=-0.135, <i>P</i>=0.027). Although excess adiposity was associated with impaired arterial elasticity (odds ratio, 1.99 [95% CI, 1.06-3.74]) in boys with low-to-medium muscle mass, this association was attenuated among those with high muscle mass (odds ratio, 1.32 [95% CI, 0.65-2.65]). These patterns were not clearly observed in girls.</p><p><strong>Conclusions: </strong>This study establishes the first growth-specific cfPWV reference standards for Chinese youth. The favorable association of muscle mass with arterial elasticity suggests that muscle-building strategies could be considered alongside weight management in early pediatric cardiovascular prevention.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e27207"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cautionary Data on Antihypertensives in Aortic Diseases.","authors":"Guan Fan, Alan Daugherty, Hong S Lu","doi":"10.1161/HYPERTENSIONAHA.126.27758","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27758","url":null,"abstract":"","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"83 10","pages":"e27758"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemogenetic Ca²⁺ Channel Mitigates Aortic Dissection and Antihypertensive Risk.","authors":"Xuan Wang, Xiao-Tian Li, Hao-Nan Chen, Hong-Li Zou, Jin Kuang, Yan-Ni Hu, Jin-Fu Peng, Chang-Ping Hu, Qing Wang, Mi Wang, Zheng Zhang","doi":"10.1161/HYPERTENSIONAHA.126.27008","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27008","url":null,"abstract":"<p><strong>Background: </strong>Thoracic aortic dissection (TAD) is a highly lethal disease without effective drug therapy. Guidelines recommend control of risk factors, particularly of causal hypertension. Antihypertensive drugs are diverse in mechanisms of action, but no randomized controlled trials have been undertaken to evaluate their efficacy and safety, and guide rational drug selection for this disease.</p><p><strong>Methods: </strong>Antihypertensive drugs were evaluated in a 3-aminopropionitrile-induced mouse model of TAD. Pharmacovigilance analysis using the Food and Drug Administration Adverse Events Reporting System and Medical Information Mart for Intensive Care databases, along with a systematic meta-analysis of 32 studies, was performed to assess drug-associated risks in aortic diseases. Signaling pathways related to smooth muscle cell contractility, adhesion, and cytoskeleton stabilization were examined in human and mouse tissues. A chemogenetic mouse strain with smooth muscle cell-specific expression of the pharmacologically selective actuator module 4-serotonin type 3 receptor channel was generated to modulate Ca²⁺ signaling.</p><p><strong>Results: </strong>Here, we assessed 8 classes of antihypertensives in a mouse TAD disease model but unexpectedly observed that hydrochlorothiazide and minoxidil exacerbated the disease. Pharmacovigilance analysis linked diuretic use to an increased TAD-associated risk in patients. TAD pathogenesis and the harmful drug effects are attributable to blunted Ca²⁺-dependent smooth muscle cell contractility and adhesion. To this therapeutic end, we leveraged a chemogenetic Ca²⁺-permeable cation channel (pharmacologically selective actuator module 4-serotonin type 3 receptor) exclusively activated by the clinical drug varenicline. The humanized chemogenetic device boosted smooth muscle cell Ca²⁺ signaling, potentiated the Ca²⁺-dependent cellular processes, and protected against TAD and the aggravated phenotype induced by hydrochlorothiazide/minoxidil.</p><p><strong>Conclusions: </strong>This study calls for pharmacovigilance of certain antihypertensives in TAD, and suggests that pharmacologically selective actuator module 4-serotonin type 3 receptor, as a viable means of tuning Ca²⁺ signaling, holds translational potential for TAD therapy.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e27008"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omaveloxolone Driven NRF2 Activation as a Novel Therapeutic Strategy for Pulmonary Hypertension.","authors":"Chuangjia Huang, June Bai, Ang Luo, Lei Yang, Xingting Wang, Linlin Dang, Changlei Bao, Jinsheng Zhu, Zixuan Chen, Bitao Wu, Jintao Long, Jieyi Feng, Zinan Luo, Yingying Xiao, Hanliang Sun, Shuxin Liang, Li Zhang, Jing Hua, Demin Gou, Ankit A Desai, Li Li, Caojin Zhang, Aiai Chu, Haiyang Tang","doi":"10.1161/HYPERTENSIONAHA.126.26711","DOIUrl":"10.1161/HYPERTENSIONAHA.126.26711","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary arterial hypertension is a progressive and life-threatening disorder characterized by elevated pulmonary arterial pressure, right ventricular hypertrophy, and eventual right heart failure. Omaveloxolone, an orally bioavailable synthetic triterpenoid recently approved for Friedreich's ataxia, improves mitochondrial bioenergetics and restores redox homeostasis. We investigated whether pharmacological activation of NRF2 (nuclear factor erythroid 2-related factor 2) by Omaveloxolone confers therapeutic benefit in pulmonary hypertension (PH).</p><p><strong>Methods: </strong>The effects of Omaveloxolone were evaluated in chronic hypoxia-induced PH in mice, monocrotaline-induced PH in rats, and sugen/hypoxia-induced PH in rats, together with studies in human pulmonary artery endothelial and smooth muscle cells.</p><p><strong>Results: </strong>NRF2 expression and nuclear localization were reduced in PH lungs and hypoxia-exposed cells, whereas Omaveloxolone restored NRF2 activity and increased downstream antioxidant enzymes. In endothelial cells, Omaveloxolone reduced oxidative stress, suppressed inflammatory signaling, and inhibited endothelial-to-mesenchymal transition. In smooth muscle cells, it attenuated oxidative stress and normalized abnormal proliferation, migration, and apoptosis. Omaveloxolone reduced HIF (hypoxia-inducible factor)-2α accumulation in endothelial cells and inhibited HIF-1α stabilization in smooth muscle cells. NRF2 knockdown attenuated these effects, supporting pathway dependency. Omaveloxolone attenuated PH, reduced right ventricular hypertrophy and vascular remodeling, and improved right ventricular function across hypoxia, monocrotaline, and sugen/hypoxia models under both preventive and therapeutic regimens.</p><p><strong>Conclusions: </strong>These findings demonstrate that Omaveloxolone exerts disease-modifying effects in PH by activating NRF2-dependent cytoprotective pathways, reducing oxidative stress, and suppressing inflammation, supporting its translational potential as a therapeutic strategy.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e26711"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TSP-1 Endothelial Signaling Impairs Brain Angiogenesis in Preeclampsia.","authors":"Esthefanny Escudero-Guevara, Felipe Troncoso, Hermes Sandoval, Cristian Vargas, Marcelo Alarcón, Hiten D Mistry, Lesia O Kurlak, Manu Vatish, Rodrigo Moore-Carrasco, Jesenia Acurio, Carlos Escudero","doi":"10.1161/HYPERTENSIONAHA.126.27749","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27749","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia adversely affects fetal brain angiogenesis, with potential acute and long-term consequences. However, the mechanisms underlying these cerebrovascular alterations remain unclear. We investigated whether TSP-1 (thrombospondin-1), an antiangiogenic glycoprotein, mediates communication between fetoplacental and fetal brain endothelium in preeclampsia.</p><p><strong>Methods: </strong>Conditioned media from human umbilical vein endothelial cells derived from normal and preeclamptic pregnancies were used to treat human (human cerebral microvascular endothelial cell line) and murine brain endothelial cells. Proteomic analysis of umbilical cord serum identified differentially expressed proteins, and TSP-1 was validated by Western blot. TSP-1 expression was investigated in umbilical endothelial cells (EA.hy926) exposed to umbilical cord serum TSP-1 depletion and antibody-mediated blockade were used to evaluate its role in angiogenesis and downstream signaling pathways.</p><p><strong>Results: </strong>Conditioned media from fetal endothelial cells of preeclamptic pregnancies reduced angiogenesis (<i>P</i><0.05), migration, and invasion of brain endothelial cells and disrupted cytoskeletal organization. These effects were associated with decreased signaling via vascular endothelial growth factor receptor 2 (<i>P</i><0.05). TSP-1 was elevated in serum and conditioned medium from preeclampsia (<i>P</i><0.05). Exposure of EA.hy926 to serum from preeclamptic pregnancies significantly increased TSP-1 protein levels compared with normal pregnancy serum. Antibody-mediated blockade of TSP-1 restored angiogenesis (<i>P</i><0.001) and rescued vascular endothelial growth factor receptor 2 signaling in brain endothelial cells exposed to conditioned media from preeclampsia.</p><p><strong>Conclusions: </strong>Our findings support TSP-1 as a key contributor to placenta-brain vascular communication in preeclampsia, in which it impairs angiogenic signaling and reduces fetal brain angiogenesis. This mechanism may contribute to acute and long-term cerebrovascular dysfunction in offspring of preeclampsia.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e27749"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148827751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemia, Insulin Sensitivity Markers and Arterial Stiffness: The Framingham Heart Study.","authors":"Steve R Noumegni, Stephen P Juraschek, Jordana B Cohen, Justin B Echouffo-Tcheugui","doi":"10.1161/HYPERTENSIONAHA.125.26375","DOIUrl":"10.1161/HYPERTENSIONAHA.125.26375","url":null,"abstract":"<p><strong>Background: </strong>There is limited data on the associations of (glycated hemoglobin A1C [HbA_1C], fasting plasma glucose, and 2-hour postload glucose) and insulin resistance (fasting plasma insulin, insulin-to-glucose ratio, homeostasis model assessment of insulin resistance, and quantitative insulin sensitivity check index) markers with arterial stiffness.</p><p><strong>Methods: </strong>We included 6617 Framingham Heart Study participants (53.8% women; 6.9% diabetes, mean age: 48±14 years). Arterial stiffness measures included natural log (Ln)-transformed carotid-femoral pulse wave velocity, augmentation index (AIx), central pulse pressure, carotid-brachial pulse wave velocity, carotid-radial pulse wave velocity, and brachial pulse pressure. Estimates of associations were adjusted for several clinical characteristics.</p><p><strong>Results: </strong>Adjusted means of log (Ln)-transformed carotid-femoral pulse wave velocity, AIx, and carotid-brachial pulse wave velocity were increasingly abnormal with higher HbA_1C (all <i>P</i><0.05). Each 1% higher HbA_1C was associated with elevated CFPWV (odds ratio [OR], 1.24 [95% CI, 1.11-1.39]) and lower AIx (OR, 0.86 [95% CI, 0.78-0.95]). Each 10-mg/dL higher fasting plasma glucose was associated with elevated CFPWV (OR, 1.09 [95% CI, 1.05-1.13]), but lower AIx (OR, 0.91 [95% CI, 0.87-0.94]). Each 10-mg/dL higher 2-hour postload glucose was associated with elevated CFPWV (OR, 1.04 [95% CI, 1.01-1.07]), central pulse pressure (OR, 1.04 [95% CI, 1.02-1.06]), brachial pulse pressure (OR, 1.04 [95% CI, 1.02-1.06]), but lower AIx (OR, 0.94 [95% CI, 0.91-0.96]). Higher fasting plasma insulin, insulin-to-glucose ratio, homeostasis model assessment of insulin resistance, and lower quantitative insulin sensitivity check index were associated with higher CFPWV and lower AIx (all <i>P</i><0.05).</p><p><strong>Conclusions: </strong>In community-dwelling individuals, worse glycemia and insulin sensitivity were associated with abnormal arterial stiffness.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e26375"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression of Left Ventricular Hypertrophy in Primary Aldosteronism.","authors":"Jessica Goi, Jacopo Burrello, Holger Schneider, Erik Johann Petersenn, Stephanie Zopp, Virginia Capuzzo, Ana María García Cano, Laura Caja Guayerbas, Elena Mena Ribas, Alicia Sanmartín Sánchez, Paola Parra Ramírez, Patricia Martín Rojas-Marcos, Miguel Paja Fano, Patricia Díaz Guardiola, Ángel Rebollo Román, Eva María Moya Mateo, Jorge Gabriel Ruiz-Sanchez, Marga González-Boillos, Fernando Jaén Aguila, Carolina María Perdomo, Cristina Robles Lázaro, Mònica Recasens, Rebeca Barahona San Millan, Emilia Gómez-Hoyos, María José Picón César, Sonsoles Gutiérrez-Medina, Cristina Lamas, Anna Casteras, Paolo Mulatero, Martin Reincke, Marta Araujo-Castro","doi":"10.1161/HYPERTENSIONAHA.126.26909","DOIUrl":"10.1161/HYPERTENSIONAHA.126.26909","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist (MRA) therapy, identified determinants of LVH regression, and evaluated the relationship between patients' outcomes and cardiac remodeling.</p><p><strong>Methods: </strong>We retrospectively analyzed an international cohort of patients with primary aldosteronism from 36 referral centers in Spain, Italy, and Germany. Echocardiographic recordings were included at baseline and after at least 1 year of targeted treatment. Regression models were applied to identify parameters associated with LVH regression and changes in left ventricular mass index.</p><p><strong>Results: </strong>Among 1454 patients (mean age, 51 years; 58.7% men) with primary aldosteronism, baseline LVH prevalence was 49.4%. Aldosterone, blood pressure, male sex, number of antihypertensive medications, and diabetes were associated with LVH. Of 473 patients with follow-up echocardiography, 33.6% underwent adrenalectomy, 61.7% received MRA, and 4.7% were taking MRA postsurgery. After a median follow-up of 51 months, LVH regression was observed in 54.2% of patients (61.9% after adrenalectomy versus 48.6% with MRA treatment; <i>P</i>=0.043), and left ventricular mass index significantly decreased after both surgery and medical therapy. Higher pretreatment blood pressure and aldosterone levels were associated with a lower likelihood of LVH regression, regardless of treatment modality. Complete biochemical success was associated with greater left ventricular mass index reduction at follow-up.</p><p><strong>Conclusions: </strong>LVH regressed in over half the patients after targeted treatment, with left ventricular mass index decreasing after both adrenalectomy and MRA therapy. Baseline aldosterone levels were associated with LVH regression, independently of blood pressure load.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e26909"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Orthostatic Blood Pressure Changes and Its Association With Orthostatic Symptoms and Falls at Very Old Ages: Findings From the ARIC Study.","authors":"Md Marufuzzaman Khan, Fredrick Larbi Kwapong, Hannah Col, Dhrumil Patil, Mingyu Zhang, Ruth-Alma N Turkson-Ocran, Long H Ngo, Jennifer L Cluett, Kenneth J Mukamal, Elizabeth Selvin, Pamela L Lutsey, B Gwen Windham, Thomas H Mosley, Timothy M Hughes, Lewis A Lipsitz, Arielle Valint, Stephen P Juraschek","doi":"10.1161/HYPERTENSIONAHA.126.27053","DOIUrl":"10.1161/HYPERTENSIONAHA.126.27053","url":null,"abstract":"<p><strong>Background: </strong>Assessment and treatment of orthostatic hypotension (OH) are recommended to prevent falls in older adults. However, the optimal timing of standing blood pressure (BP) assessments to identify clinically relevant OH remains unclear.</p><p><strong>Methods: </strong>We measured 3 supine BP readings after 5 minutes of rest at 30-second intervals and 6 standing BP readings (timed at 0, 1, 2, 3, 4, and 5 minutes after standing) during the ARIC study (Atherosclerosis Risk in Communities) visit 10. OH was defined as a drop in BP (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) upon standing from the supine position. We quantified the prevalence and predictors of initial OH (immediately after standing), early OH (within 3 minutes), late OH (after 3 minutes), and sustained OH (all 6 minutes). We examined their associations with orthostatic symptoms and falls using logistic regression and negative binomial models, respectively.</p><p><strong>Results: </strong>Of the 863 participants (mean age, 83.7 years), 41.3% had initial OH. Participants on antihypertensive medications had higher odds of all types of OH irrespective of controlled (<130/80 mm Hg) or uncontrolled (≥130/80 mm Hg) hypertension compared with those without hypertension (<130/80 mm Hg) and no antihypertensive use. Initial and early OH were strongly associated with orthostatic symptoms in the process of standing from the supine position (odds ratio, 2.34 [95% CI, 1.42-3.86]; odds ratio, 1.82 [95% CI, 1.11-2.98], respectively). Finally, participants with initial OH had higher fall rates (rate ratio, 1.45 [95% CI, 1.02-2.06]) than those without OH.</p><p><strong>Conclusions: </strong>Measuring BP within 3 minutes of standing, particularly the first BP measurement immediately after standing, may provide clinicians with important information on falls risk and orthostatic symptoms.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e27053"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining Variance in Pulse Wave Velocity in Youth: The Youth Vascular Consortium.","authors":"Vimarsha Kodithuwakku, Monique Breslin, Yanina Zocalo, Daniel Bia, Peter M Nilsson, Giacomo Pucci, Gaetano Vaudo, Marco D'abbondanza, Francesca Battista, Andrea Kelly, Manish Sinha, Piotr Skrzypczyk, Michał Szyszka, Christopher J A Pugh, Barry J McDonnell, Vikas Dharnidharka, Nazia Kulsum-Mecci, Iván Cavero-Redondo, Celia Alvarez-Bueno, Pierre Boutouyrie, Rosa-Maria Bruno, Elaine M Urbina, Seana Gall, Rachel E Climie","doi":"10.1161/HYPERTENSIONAHA.126.26866","DOIUrl":"10.1161/HYPERTENSIONAHA.126.26866","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease is a leading cause of global mortality. Carotid-femoral pulse wave velocity (cfPWV) is the gold-standard noninvasive measure of arterial stiffness and is commonly used to assess early vascular aging, as it predicts future cardiovascular events. Although the influence of cardiovascular risk factors on cfPWV is well studied in adults, evidence in youth is limited. This study aimed to identify common cardiovascular risk factors that best explain variation in cfPWV among young people.</p><p><strong>Methods: </strong>This study included 6763 participants aged 5 to 40 years with cfPWV measured using the SphygmoCor device, drawn from the Youth Vascular Consortium. Analyses were conducted across 5 subsets based on data completeness. Multiple linear regression models, stratified by sex and age (≤19 and >19 years), were developed to identify cardiovascular risk factors explaining cfPWV variation. Model selection was guided by Akaike information criterion and adjusted R².</p><p><strong>Results: </strong>Age and systolic blood pressure were consistent predictors, explaining <40% of cfPWV variance in cfPWV. Heart rate and waist circumference also emerged as key predictors of cfPWV, although lipids contributed modestly only in young adults. Waist circumference was the strongest anthropometric predictor in most groups.</p><p><strong>Conclusions: </strong>Age, systolic blood pressure, and heart rate were the strong contributors among traditional risk factors, yet explained <40% of variance in cfPWV in most groups. These findings highlight the role of hemodynamic load in shaping arterial stiffness even in childhood and adolescence, when structural changes are evolving. A large proportion of variance remains unexplained, suggesting that genetic, prenatal, environmental, and behavioral factors warrant investigation.</p>","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"e26866"},"PeriodicalIF":9.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}