Hypertension最新文献_第2页

In Memoriam: Stevo Julius, MD, ScD. 纪念：史蒂夫·朱利叶斯，医学博士，理学博士。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.125.25152

Sverre E Kjeldsen,Murray Esler,Kenneth A Jamerson,Brent Egan,Giuseppe Mancia

引用次数: 0

Vascular Assessment Stratifying Preeclampsia Risk in Overweight/Obese Women. 超重/肥胖妇女子痫前期风险分层血管评估

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.124.24394

Christos Chatzakis,Laura A Magee,Renata Castello,Gerardo Miranda,Peter von Dadelszen,Kypros H Nicolaides,Marietta Charakida

{"title":"Vascular Assessment Stratifying Preeclampsia Risk in Overweight/Obese Women.","authors":"Christos Chatzakis,Laura A Magee,Renata Castello,Gerardo Miranda,Peter von Dadelszen,Kypros H Nicolaides,Marietta Charakida","doi":"10.1161/hypertensionaha.124.24394","DOIUrl":"https://doi.org/10.1161/hypertensionaha.124.24394","url":null,"abstract":"BACKGROUNDOverweight and obesity greatly increase the risk of preeclampsia. There is a need to better risk-stratify these women in pregnancy and channel resources to those who can benefit most.METHODSProspective observational study of 11 962 women with singleton pregnancies attending a routine assessment at 35+0 to 36+6 weeks' gestation at King's College Hospital, London, United Kingdom. Women were categorized by their body mass index at 11 to 13 weeks' gestation as normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), or obese (≥30 kg/m2). We recorded maternal demographics, assessed uterine artery pulsatility index and ophthalmic artery peak systolic velocity ratio, and measured carotid-to-femoral pulse-wave velocity. Preeclampsia development was retrieved from medical records. Multivariable logistic regression was undertaken to examine determinants of preeclampsia. Mediation analysis was performed to assess causal relationships.RESULTSIn this cohort, 28.4% were overweight and 17.9% were obese. Preeclampsia developed more often in overweight/obese (versus normal weight) women (6.0% versus 1.7%, respectively; P<0.001); women of Black and South Asian ethnicity were at particularly increased risk (P=0.02 and 0.004, respectively). Determinants of preeclampsia development did not differ by body mass index. Mediation analysis suggested that the effect of overweight/obesity on preeclampsia development may be mediated partly by changes in maternal cardiovascular indices, particularly aortic stiffness (as reflected by carotid-to-femoral pulse-wave velocity, proportion mediated=72.6%).CONCLUSIONSRisk factors for term preeclampsia are largely similar between overweight/obese and normal-weight women, except for Black and South Asian women, who face a particularly high risk within the overweight/obese group. Maternal vascular assessment may serve as a valuable tool for stratifying the risk for term preeclampsia in these populations.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"12 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Cardiovascular Health Starts in the Womb. 修正：心血管健康始于子宫。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hyp.0000000000000245

Bonita Falkner,Barbara T Alexander,Anne-Monique Nuyt,Andrew M South,Julie Ingelfinger

引用次数: 0

Early Vascular Aging Requires Early Action. 早期血管老化需要早期行动。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.125.25115

Andrea Grillo,Paolo Salvi

引用次数: 0

CTRH as Biomarker of Drug Efficacy: In-Depth Assessment of Real-World Evidence. CTRH作为药物疗效的生物标志物：真实世界证据的深度评估。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.124.24523

Farzin Khosrow-Khavar,Reinhold Kreutz,Antonios Douros

{"title":"CTRH as Biomarker of Drug Efficacy: In-Depth Assessment of Real-World Evidence.","authors":"Farzin Khosrow-Khavar,Reinhold Kreutz,Antonios Douros","doi":"10.1161/hypertensionaha.124.24523","DOIUrl":"https://doi.org/10.1161/hypertensionaha.124.24523","url":null,"abstract":"BACKGROUNDObservational studies have suggested that cancer treatment-related hypertension (CTRH) is associated with improved survival and could possibly serve as a biomarker of drug efficacy. Our review aimed to provide an in-depth assessment of the methodological quality of available observational studies.METHODSWe systematically searched MEDLINE/PubMed from inception to January 2025 for observational studies that assessed the potential association between the development of CTRH and the risk of cancer-related outcomes, including progression-free survival and overall survival. We assessed the methodological quality of the identified studies using the Risk of Bias in Nonrandomized Studies of Interventions tool.RESULTSWe identified 25 observational studies with a total of 6364 patients treated for different cancer types that assessed the potential association between CTRH and the risk of progression-free survival and overall survival. All studies examined CTRH related to the use of vascular endothelial growth factor inhibitors. CTRH was mostly associated with improved progression-free survival and overall survival across cancer types with up to 79% decreased risks. Based on the Risk of Bias in Nonrandomized Studies of Interventions, 8 studies were at critical, 13 studies were at serious, and 4 studies were at moderate risk of bias. Major biases included important residual confounding, reverse causality, immortal time bias, and exposure misclassification. In studies at moderate risk of bias, the survival benefits associated with CTRH disappeared or were attenuated significantly.CONCLUSIONSObservational studies alluding to CTRH being a marker of drug efficacy have major, potentially conclusion-altering biases. Therefore, the findings of our review do not support CTRH as a biomarker of drug efficacy.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"11 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sympathetic Overactivation in the Resistant Hypertensive Phenotype: A Meta-Analysis of Published Studies. 交感神经过度激活在顽固性高血压表型：一项已发表研究的荟萃分析。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.125.24749

Guido Grassi,Fosca Quarti-Trevano,Cesare Cuspidi,Elias Sanidas,Giuseppe Mancia,Costas Thomopoulos

{"title":"Sympathetic Overactivation in the Resistant Hypertensive Phenotype: A Meta-Analysis of Published Studies.","authors":"Guido Grassi,Fosca Quarti-Trevano,Cesare Cuspidi,Elias Sanidas,Giuseppe Mancia,Costas Thomopoulos","doi":"10.1161/hypertensionaha.125.24749","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.24749","url":null,"abstract":"BACKGROUNDIndirect and direct approaches to assess sympathetic cardiovascular drive have shown that patients with essential hypertension responsive to the blood pressure-lowering effects of antihypertensive drugs are characterized by a pronounced adrenergic overactivity. Whether an emerging clinical hypertensive phenotype such as drug-resistant hypertension (RHT) is also characterized by sympathetic activation and whether its magnitude and underlying pathophysiological mechanisms differ from those of non-RHT is undefined.METHODSAmong the 54 studies identified providing information in RHT on muscle sympathetic nerve traffic (MSNA), 12 were eligible (508 patients) and meta-analyzed, grouping them based on clinically relevant questions: (1) Is MSNA increased in RHT? (2) Does the magnitude of the sympathetic activation differ from that observed in non-RHT? (3) Are heart rate and plasma norepinephrine valuable surrogate markers of MSNA in RHT? and (4) Is baroreflex-MSNA control impaired?RESULTSMSNA was significantly greater in patients with RHT than in normotensive patients (73.2±6.6 versus 46.1±11.1 bursts/100 heartbeats, means±SD; P<0.0001) and this was the case also when data were compared with patients with non-RHT (59.8±8.4 bursts/100 heartbeats; P<0.001), despite the greater number of antihypertensive drugs. At variance from non-RHT, in RHT, elevated MSNA was unrelated to heart rate and plasma venous norepinephrine. Similar to non-RHT, MSNA in RHT was inversely related to the baroreflex function.CONCLUSIONSRHT is characterized by a sustained sympathetic overdrive, significantly greater in magnitude than the 1 detected in non-RHT. Neither heart rate nor norepinephrine are capable of reflecting the marked adrenergic overdrive seen in this condition via MSNA recordings.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"8 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Letters and Editorials in Hypertension. 高血压研究通讯和社论。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.125.24750

David G Harrison,Rhian M Touyz

引用次数: 0

Calcium Aspirin Preeclampsia Early Prevention and Response (CASPER) Trial in Blantyre, Malawi: A Double-Blinded Cluster Randomized Trial. 钙阿司匹林先兆子痫早期预防和反应（CASPER）试验在马拉维布兰太尔：双盲集群随机试验。

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-09 DOI: 10.1161/HYPERTENSIONAHA.125.24675

Memory M Ngwira, Angela Makris, Renuka Shanmugalingam, John L Mbotwa, Josiah Mayani, Luis A Gadama, Annemarie Hennessy

{"title":"Calcium Aspirin Preeclampsia Early Prevention and Response (CASPER) Trial in Blantyre, Malawi: A Double-Blinded Cluster Randomized Trial.","authors":"Memory M Ngwira, Angela Makris, Renuka Shanmugalingam, John L Mbotwa, Josiah Mayani, Luis A Gadama, Annemarie Hennessy","doi":"10.1161/HYPERTENSIONAHA.125.24675","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24675","url":null,"abstract":"Background: Preeclampsia remains one of the major causes of maternal and neonatal mortality and morbidity, and yet it is uncertain whether aspirin combined with calcium would reduce the burden of preeclampsia in Malawian women, as elsewhere. This study assessed the efficacy of early low-dose aspirin in preventing in women given calcium to prevent preeclampsia/eclampsia in Blantyre, Malawi.Methods: This was a pragmatic, double-blind, cluster randomized controlled trial conducted in 4 urban health centers and Queen Elizabeth Central Hospital in Blantyre. A total of 306 women at high risk of preeclampsia were assigned to low-dose aspirin (150 mg/day) or placebo from 12 to 16 weeks until 34 weeks of gestation in clusters. All women were given calcium 1 g/day. The intention-to-treat analysis and adherence analysis were conducted with the primary end point of preeclampsia.Results: A total of 39 women were lost to follow-up, and 1 withdrew consent. Data for 266 women were available for analysis. Overall, preeclampsia occurred in 15.8% (42/266) and eclampsia in 2.3% (6/266) of all women. There was no statistically significant difference in the rate of preeclampsia between the low-dose aspirin group 19.3% (26/135) and placebo group (12.2% 16/131; adjusted odds ratio, 1.16 [95% CI, 0.41-3.41]; P=0.781). No statistically significant difference was observed in the secondary maternal and neonatal outcomes. The overall adherence was 69%.Conclusions: In high-risk women treated with calcium, additional low-dose aspirin resulted in no difference in the rate of preeclampsia, cesarean section rates, or important neonatal outcomes in Malawi.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension in Pregnancy Linked to Cerebral Small Vessel Disease 15 Years Later. 妊娠期高血压与15年后脑血管疾病相关

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-09 DOI: 10.1161/HYPERTENSIONAHA.124.24544

Rowina F Hussainali, Maria C Adank, Sander Lamballais, Meike W Vernooij, M Arfan Ikram, Eric A P Steegers, Eliza C Miller, Sarah Schalekamp-Timmermans

{"title":"Hypertension in Pregnancy Linked to Cerebral Small Vessel Disease 15 Years Later.","authors":"Rowina F Hussainali, Maria C Adank, Sander Lamballais, Meike W Vernooij, M Arfan Ikram, Eric A P Steegers, Eliza C Miller, Sarah Schalekamp-Timmermans","doi":"10.1161/HYPERTENSIONAHA.124.24544","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.124.24544","url":null,"abstract":"Background: Substantial evidence suggests an association between hypertensive disorders of pregnancy and long-term cerebrovascular health. We aimed to determine the associations between hypertensive disorders of pregnancy and markers of cerebral small vessel disease 15 years after pregnancy.Methods: This was a nested cohort study embedded in a population-based prospective cohort followed from early pregnancy. We included 538 women, 445 (82.8%) with normotensive index pregnancies, and 93 (17.2%) with hypertensive disorders in the index pregnancy. Fifteen years after the index pregnancy (median, 14.6 years; 90% range, 14.0-15.7 years), women underwent magnetic resonance imaging to assess brain tissue and white matter hyperintensity volume, lacunar infarcts, and cerebral microhemorrhages as markers of cerebral small vessel disease.Results: Women with prior hypertensive disorders of pregnancy had higher white matter hyperintensity volume compared with women with previous normotensive pregnancy (adjusted β, 0.32 [95% CI, 0.08-0.56]). This association was driven by women with gestational hypertension, who had higher white matter hyperintensity volume compared with women with previous normotensive pregnancy (adjusted β, 0.39 [95% CI, 0.10-0.67]). The effect was larger in those with gestational hypertension who developed chronic hypertension after the index pregnancy. No differences were found in infarcts or cerebral microhemorrhages.Conclusions: In a prospective cohort of midlife Dutch women, those with a history of hypertensive disorders of pregnancy, particularly gestational hypertension, showed some signs of cerebral small vessel disease, compared with those with normotensive pregnancies. These results support epidemiological data suggesting that not only preeclampsia but also gestational hypertension is associated with long-term cerebrovascular risk.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP. 心衰大鼠PVN中nNOS的降解：CHIP的作用

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-03 DOI: 10.1161/HYPERTENSIONAHA.125.24896

Tapan A Patel, Kenichi Katsurada, Hong Zheng, Kaushik P Patel

{"title":"Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP.","authors":"Tapan A Patel, Kenichi Katsurada, Hong Zheng, Kaushik P Patel","doi":"10.1161/HYPERTENSIONAHA.125.24896","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24896","url":null,"abstract":"Background: One salient feature of congestive heart failure (CHF) is the exaggerated sympathetic drive. Reduced nNOS (neuronal nitric oxide synthase) within the paraventricular nucleus (PVN) is primarily responsible for the enhanced sympathetic tone in CHF. Here, we examined the role of CHIP (C-terminus of heat shock cognate protein 70-interacting protein) as a key regulator of nNOS in the PVN.Methods: CHF in rats was induced by left coronary artery ligation. Alterations in the expression of nNOS, CHIP, HSP70 (heat shock protein 70), and HSP90 (heat shock protein 90) in the PVN of CHF rats were evaluated by Western blot and immunofluorescence techniques. Neuronal NG108-15 cells were used to analyze the effect of CHIP overexpression (using the pCMV3-CHIP-GFP spark plasmid) on nNOS expression in vitro. CHIP overexpression was achieved by viral injections in the PVN of normal rats.Results: CHIP (50%) and HSP70 (33%) were significantly upregulated in the PVN of rats with CHF. Overexpression of CHIP in neuronal NG108-15 cells showed an ≈74% increase in CHIP with a concomitant decrease in nNOS expression (≈49%). Overexpression of CHIP significantly increased ubiquitination of nNOS (46%) in NG108-15 cells. Overexpression of CHIP in the PVN of normal control rats significantly reduced NO-mediated inhibition of renal sympathetic nerve activity, blood pressure, and heart rate.Conclusions: Overall, these studies identify overexpression of CHIP, which triggers ubiquitination and proteasomal degradation of nNOS in the PVN results in reduced inhibitory sympathetic tone in CHF.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0