Hypertension最新文献_第3页

CTRH as Biomarker of Drug Efficacy: In-Depth Assessment of Real-World Evidence. CTRH作为药物疗效的生物标志物：真实世界证据的深度评估。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.124.24523

Farzin Khosrow-Khavar,Reinhold Kreutz,Antonios Douros

{"title":"CTRH as Biomarker of Drug Efficacy: In-Depth Assessment of Real-World Evidence.","authors":"Farzin Khosrow-Khavar,Reinhold Kreutz,Antonios Douros","doi":"10.1161/hypertensionaha.124.24523","DOIUrl":"https://doi.org/10.1161/hypertensionaha.124.24523","url":null,"abstract":"BACKGROUNDObservational studies have suggested that cancer treatment-related hypertension (CTRH) is associated with improved survival and could possibly serve as a biomarker of drug efficacy. Our review aimed to provide an in-depth assessment of the methodological quality of available observational studies.METHODSWe systematically searched MEDLINE/PubMed from inception to January 2025 for observational studies that assessed the potential association between the development of CTRH and the risk of cancer-related outcomes, including progression-free survival and overall survival. We assessed the methodological quality of the identified studies using the Risk of Bias in Nonrandomized Studies of Interventions tool.RESULTSWe identified 25 observational studies with a total of 6364 patients treated for different cancer types that assessed the potential association between CTRH and the risk of progression-free survival and overall survival. All studies examined CTRH related to the use of vascular endothelial growth factor inhibitors. CTRH was mostly associated with improved progression-free survival and overall survival across cancer types with up to 79% decreased risks. Based on the Risk of Bias in Nonrandomized Studies of Interventions, 8 studies were at critical, 13 studies were at serious, and 4 studies were at moderate risk of bias. Major biases included important residual confounding, reverse causality, immortal time bias, and exposure misclassification. In studies at moderate risk of bias, the survival benefits associated with CTRH disappeared or were attenuated significantly.CONCLUSIONSObservational studies alluding to CTRH being a marker of drug efficacy have major, potentially conclusion-altering biases. Therefore, the findings of our review do not support CTRH as a biomarker of drug efficacy.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"11 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sympathetic Overactivation in the Resistant Hypertensive Phenotype: A Meta-Analysis of Published Studies. 交感神经过度激活在顽固性高血压表型：一项已发表研究的荟萃分析。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.125.24749

Guido Grassi,Fosca Quarti-Trevano,Cesare Cuspidi,Elias Sanidas,Giuseppe Mancia,Costas Thomopoulos

{"title":"Sympathetic Overactivation in the Resistant Hypertensive Phenotype: A Meta-Analysis of Published Studies.","authors":"Guido Grassi,Fosca Quarti-Trevano,Cesare Cuspidi,Elias Sanidas,Giuseppe Mancia,Costas Thomopoulos","doi":"10.1161/hypertensionaha.125.24749","DOIUrl":"https://doi.org/10.1161/hypertensionaha.125.24749","url":null,"abstract":"BACKGROUNDIndirect and direct approaches to assess sympathetic cardiovascular drive have shown that patients with essential hypertension responsive to the blood pressure-lowering effects of antihypertensive drugs are characterized by a pronounced adrenergic overactivity. Whether an emerging clinical hypertensive phenotype such as drug-resistant hypertension (RHT) is also characterized by sympathetic activation and whether its magnitude and underlying pathophysiological mechanisms differ from those of non-RHT is undefined.METHODSAmong the 54 studies identified providing information in RHT on muscle sympathetic nerve traffic (MSNA), 12 were eligible (508 patients) and meta-analyzed, grouping them based on clinically relevant questions: (1) Is MSNA increased in RHT? (2) Does the magnitude of the sympathetic activation differ from that observed in non-RHT? (3) Are heart rate and plasma norepinephrine valuable surrogate markers of MSNA in RHT? and (4) Is baroreflex-MSNA control impaired?RESULTSMSNA was significantly greater in patients with RHT than in normotensive patients (73.2±6.6 versus 46.1±11.1 bursts/100 heartbeats, means±SD; P<0.0001) and this was the case also when data were compared with patients with non-RHT (59.8±8.4 bursts/100 heartbeats; P<0.001), despite the greater number of antihypertensive drugs. At variance from non-RHT, in RHT, elevated MSNA was unrelated to heart rate and plasma venous norepinephrine. Similar to non-RHT, MSNA in RHT was inversely related to the baroreflex function.CONCLUSIONSRHT is characterized by a sustained sympathetic overdrive, significantly greater in magnitude than the 1 detected in non-RHT. Neither heart rate nor norepinephrine are capable of reflecting the marked adrenergic overdrive seen in this condition via MSNA recordings.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":"8 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Letters and Editorials in Hypertension. 高血压研究通讯和社论。

IF 8.3 1区医学

Hypertension Pub Date : 2025-06-18 DOI: 10.1161/hypertensionaha.125.24750

David G Harrison,Rhian M Touyz

引用次数: 0

Calcium Aspirin Preeclampsia Early Prevention and Response (CASPER) Trial in Blantyre, Malawi: A Double-Blinded Cluster Randomized Trial. 钙阿司匹林先兆子痫早期预防和反应（CASPER）试验在马拉维布兰太尔：双盲集群随机试验。

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-09 DOI: 10.1161/HYPERTENSIONAHA.125.24675

Memory M Ngwira, Angela Makris, Renuka Shanmugalingam, John L Mbotwa, Josiah Mayani, Luis A Gadama, Annemarie Hennessy

{"title":"Calcium Aspirin Preeclampsia Early Prevention and Response (CASPER) Trial in Blantyre, Malawi: A Double-Blinded Cluster Randomized Trial.","authors":"Memory M Ngwira, Angela Makris, Renuka Shanmugalingam, John L Mbotwa, Josiah Mayani, Luis A Gadama, Annemarie Hennessy","doi":"10.1161/HYPERTENSIONAHA.125.24675","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24675","url":null,"abstract":"Background: Preeclampsia remains one of the major causes of maternal and neonatal mortality and morbidity, and yet it is uncertain whether aspirin combined with calcium would reduce the burden of preeclampsia in Malawian women, as elsewhere. This study assessed the efficacy of early low-dose aspirin in preventing in women given calcium to prevent preeclampsia/eclampsia in Blantyre, Malawi.Methods: This was a pragmatic, double-blind, cluster randomized controlled trial conducted in 4 urban health centers and Queen Elizabeth Central Hospital in Blantyre. A total of 306 women at high risk of preeclampsia were assigned to low-dose aspirin (150 mg/day) or placebo from 12 to 16 weeks until 34 weeks of gestation in clusters. All women were given calcium 1 g/day. The intention-to-treat analysis and adherence analysis were conducted with the primary end point of preeclampsia.Results: A total of 39 women were lost to follow-up, and 1 withdrew consent. Data for 266 women were available for analysis. Overall, preeclampsia occurred in 15.8% (42/266) and eclampsia in 2.3% (6/266) of all women. There was no statistically significant difference in the rate of preeclampsia between the low-dose aspirin group 19.3% (26/135) and placebo group (12.2% 16/131; adjusted odds ratio, 1.16 [95% CI, 0.41-3.41]; P=0.781). No statistically significant difference was observed in the secondary maternal and neonatal outcomes. The overall adherence was 69%.Conclusions: In high-risk women treated with calcium, additional low-dose aspirin resulted in no difference in the rate of preeclampsia, cesarean section rates, or important neonatal outcomes in Malawi.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension in Pregnancy Linked to Cerebral Small Vessel Disease 15 Years Later. 妊娠期高血压与15年后脑血管疾病相关

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-09 DOI: 10.1161/HYPERTENSIONAHA.124.24544

Rowina F Hussainali, Maria C Adank, Sander Lamballais, Meike W Vernooij, M Arfan Ikram, Eric A P Steegers, Eliza C Miller, Sarah Schalekamp-Timmermans

{"title":"Hypertension in Pregnancy Linked to Cerebral Small Vessel Disease 15 Years Later.","authors":"Rowina F Hussainali, Maria C Adank, Sander Lamballais, Meike W Vernooij, M Arfan Ikram, Eric A P Steegers, Eliza C Miller, Sarah Schalekamp-Timmermans","doi":"10.1161/HYPERTENSIONAHA.124.24544","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.124.24544","url":null,"abstract":"Background: Substantial evidence suggests an association between hypertensive disorders of pregnancy and long-term cerebrovascular health. We aimed to determine the associations between hypertensive disorders of pregnancy and markers of cerebral small vessel disease 15 years after pregnancy.Methods: This was a nested cohort study embedded in a population-based prospective cohort followed from early pregnancy. We included 538 women, 445 (82.8%) with normotensive index pregnancies, and 93 (17.2%) with hypertensive disorders in the index pregnancy. Fifteen years after the index pregnancy (median, 14.6 years; 90% range, 14.0-15.7 years), women underwent magnetic resonance imaging to assess brain tissue and white matter hyperintensity volume, lacunar infarcts, and cerebral microhemorrhages as markers of cerebral small vessel disease.Results: Women with prior hypertensive disorders of pregnancy had higher white matter hyperintensity volume compared with women with previous normotensive pregnancy (adjusted β, 0.32 [95% CI, 0.08-0.56]). This association was driven by women with gestational hypertension, who had higher white matter hyperintensity volume compared with women with previous normotensive pregnancy (adjusted β, 0.39 [95% CI, 0.10-0.67]). The effect was larger in those with gestational hypertension who developed chronic hypertension after the index pregnancy. No differences were found in infarcts or cerebral microhemorrhages.Conclusions: In a prospective cohort of midlife Dutch women, those with a history of hypertensive disorders of pregnancy, particularly gestational hypertension, showed some signs of cerebral small vessel disease, compared with those with normotensive pregnancies. These results support epidemiological data suggesting that not only preeclampsia but also gestational hypertension is associated with long-term cerebrovascular risk.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP. 心衰大鼠PVN中nNOS的降解：CHIP的作用

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-03 DOI: 10.1161/HYPERTENSIONAHA.125.24896

Tapan A Patel, Kenichi Katsurada, Hong Zheng, Kaushik P Patel

{"title":"Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP.","authors":"Tapan A Patel, Kenichi Katsurada, Hong Zheng, Kaushik P Patel","doi":"10.1161/HYPERTENSIONAHA.125.24896","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24896","url":null,"abstract":"Background: One salient feature of congestive heart failure (CHF) is the exaggerated sympathetic drive. Reduced nNOS (neuronal nitric oxide synthase) within the paraventricular nucleus (PVN) is primarily responsible for the enhanced sympathetic tone in CHF. Here, we examined the role of CHIP (C-terminus of heat shock cognate protein 70-interacting protein) as a key regulator of nNOS in the PVN.Methods: CHF in rats was induced by left coronary artery ligation. Alterations in the expression of nNOS, CHIP, HSP70 (heat shock protein 70), and HSP90 (heat shock protein 90) in the PVN of CHF rats were evaluated by Western blot and immunofluorescence techniques. Neuronal NG108-15 cells were used to analyze the effect of CHIP overexpression (using the pCMV3-CHIP-GFP spark plasmid) on nNOS expression in vitro. CHIP overexpression was achieved by viral injections in the PVN of normal rats.Results: CHIP (50%) and HSP70 (33%) were significantly upregulated in the PVN of rats with CHF. Overexpression of CHIP in neuronal NG108-15 cells showed an ≈74% increase in CHIP with a concomitant decrease in nNOS expression (≈49%). Overexpression of CHIP significantly increased ubiquitination of nNOS (46%) in NG108-15 cells. Overexpression of CHIP in the PVN of normal control rats significantly reduced NO-mediated inhibition of renal sympathetic nerve activity, blood pressure, and heart rate.Conclusions: Overall, these studies identify overexpression of CHIP, which triggers ubiquitination and proteasomal degradation of nNOS in the PVN results in reduced inhibitory sympathetic tone in CHF.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Aspirin Affect Extracellular Vesicles Involved in the Pathogenesis of Preeclampsia? A Systematic Review and Meta-Analysis. 阿司匹林是否影响细胞外囊泡参与子痫前期发病？系统回顾和荟萃分析。

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-02 DOI: 10.1161/HYPERTENSIONAHA.125.24826

Angel Nilesh D'Crus, Soumyalekshmi Nair, Jessica Jellins, Fabricio Da Silva Costa, Jon Hyett, Carlos Salomon

{"title":"Does Aspirin Affect Extracellular Vesicles Involved in the Pathogenesis of Preeclampsia? A Systematic Review and Meta-Analysis.","authors":"Angel Nilesh D'Crus, Soumyalekshmi Nair, Jessica Jellins, Fabricio Da Silva Costa, Jon Hyett, Carlos Salomon","doi":"10.1161/HYPERTENSIONAHA.125.24826","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24826","url":null,"abstract":"Background: Preeclampsia is a challenging pregnancy disorder to treat, and current preventive measures are not always effective. Aspirin is prescribed as a preventive agent for pregnant women who are at high risk of developing preeclampsia although there is no definitive conclusion for its mechanism of action or efficacy. Extracellular vesicles (EVs) provide a picture of the physiological state of the cells from which they originate and have been implicated in both normal and pathological pregnancies. This study reviewed the potential effects of aspirin on EVs when prescribed for prevention of preeclampsia.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used to identify published studies from the CENTRAL, The Cochrane Library (Cochrane Central Register of Controlled Trials), MEDLINE on PubMed, CINAHL, Web of Science, and Embase from inception to March 2024.Results: Sixty-three studies met the inclusion criteria and were grouped as studies on aspirin-mediated prevention of preeclampsia (n=31), studies on EVs in the pathogenesis of preeclampsia (n=28), and studies on the effects of aspirin on EVs in preeclampsia (n=4). Meta-analysis of randomized control trials showed that the odds of preeclampsia occurrence is 36% less likely in the aspirin treatment group (odds ratio, 0.64 [95% CI, 0.47-0.87]; P<0.01). EVs are involved in the pathogenesis of preeclampsia, and aspirin effectively reduced the negative effects of EVs in both in vitro and in vivo studies.Conclusions: Aspirin has an inhibitory effect on EVs in preeclampsia. However, further studies are needed to understand and confirm the mechanisms involved.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-Citrulline Improves IGF-1 Signaling Pathway in Preeclampsia via Polyamines. l -瓜氨酸通过多胺改善子痫前期IGF-1信号通路。

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-02 DOI: 10.1161/HYPERTENSIONAHA.125.24785

Andy W C Man, Joscha Steetskamp, Josche van der Ven, Gisela Reifenberg, Annette Hasenburg, Andreas Daiber, Ning Xia, Huige Li

{"title":"L-Citrulline Improves IGF-1 Signaling Pathway in Preeclampsia via Polyamines.","authors":"Andy W C Man, Joscha Steetskamp, Josche van der Ven, Gisela Reifenberg, Annette Hasenburg, Andreas Daiber, Ning Xia, Huige Li","doi":"10.1161/HYPERTENSIONAHA.125.24785","DOIUrl":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24785","url":null,"abstract":"Background: Preeclampsia is a severe pregnancy complication with no effective pharmacological therapy available. We previously demonstrated that L-citrulline supplementation improves preeclampsia phenotypes in Dahl salt-sensitive rats, an animal model of imposed preeclampsia. This study aimed to investigate the underlying molecular mechanisms.Methods: Pregnant Dahl salt-sensitive rats were treated with L-citrulline. In addition, patients with preeclampsia were recruited to donate placenta and serum samples.Results: In patients with preeclampsia, the placental IGF-1 (insulin-like growth factor 1) expression was significantly reduced compared with healthy pregnancy, associated with a downregulation of ZEB1 (zinc finger E-box binding homeobox 1) and an upregulation of miR-486-5p and miR-210. L-citrulline supplementation in preeclampsia rats significantly increased the placental expression of IGF-1 and ZEB1 and reduced the expression of miR-486-5p and miR-210. Total serum polyamine level was reduced in patients with preeclampsia and pregnant Dahl salt-sensitive rats, while L-citrulline treatment maintained the serum polyamine level in Dahl salt-sensitive rats during pregnancy. Placental IGF-1 expression was positively correlated to serum polyamine levels. Moreover, both L-citrulline and polyamines normalized the expression of IGF-1 and some antiangiogenic markers in cultured human placental vascular endothelial cells treated with preeclampsia serum. Results from IGF-1 siRNA experiments indicate that part of the L-citrulline effects on gene expression was dependent on IGF-1.Conclusions: L-citrulline supplementation improves the IGF-1 signaling pathway in preeclampsia, at least partly, via polyamine production. Maternal supplementation with L-citrulline or polyamine may represent a safe and effective therapeutic strategy for preeclampsia.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Morbidity of Pediatric Hypertension. 儿童高血压的发病率。

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-01 Epub Date: 2025-05-14 DOI: 10.1161/HYPERTENSIONAHA.124.24299

Cynthia S Bell, Samuel S Gidding

引用次数: 0

Hypertension Prevention and Healthy Life Expectancy in Black Adults: The Jackson Heart Study. 黑人成年人的高血压预防和健康寿命：杰克逊心脏研究

IF 6.9 1区医学

Hypertension Pub Date : 2025-06-01 Epub Date: 2025-02-26 DOI: 10.1161/HYPERTENSIONAHA.124.23702

Kathryn Foti, Yiyi Zhang, Susan E Hennessy, Lisandro D Colantonio, Lama Ghazi, Shakia T Hardy, Milla E Arabadjian, Rushelle L Byfield, Valy Fontil, Cora E Lewis, Daichi Shimbo, Paul Muntner, Brandon K Bellows

{"title":"Hypertension Prevention and Healthy Life Expectancy in Black Adults: The Jackson Heart Study.","authors":"Kathryn Foti, Yiyi Zhang, Susan E Hennessy, Lisandro D Colantonio, Lama Ghazi, Shakia T Hardy, Milla E Arabadjian, Rushelle L Byfield, Valy Fontil, Cora E Lewis, Daichi Shimbo, Paul Muntner, Brandon K Bellows","doi":"10.1161/HYPERTENSIONAHA.124.23702","DOIUrl":"10.1161/HYPERTENSIONAHA.124.23702","url":null,"abstract":"Background: The impact of preventing hypertension and maintaining normal blood pressure (BP) on life expectancy and healthy life expectancy (HLE) among Black adults, who are disproportionately affected by hypertension, has not been quantified.Methods: We used a discrete event simulation to estimate life expectancy and HLE among a cohort of Black adults from the Jackson Heart Study (n=4933) from age 20 to 100 years or until death. We modeled preventing hypertension as having BP <130/80 mm Hg and maintaining normal BP as having BP <120/80 mm Hg across the lifespan. In the primary analysis, we assumed that lowering BP decreased the risk of cardiovascular disease events, resulting in life expectancy and HLE gains. In a secondary analysis, we assumed that preventing hypertension and maintaining normal BP directly reduced both cardiovascular disease and mortality risk.Results: At age 20 years, the projected average life expectancy was age 80.8 (95% uncertainty interval [UI], 80.6-81.1) years, and HLE was 70.5 (95% UI, 70.3-70.7) healthy life years. In the primary analysis, preventing hypertension and maintaining normal BP added 0.9 (95% UI, 0.8-1.1) and 1.1 (95% UI, 0.9-1.3) years to life expectancy, respectively, and 2.7 (95% UI, 2.6-2.9) and 2.9 (95% UI, 2.7-3.1) healthy life years to HLE, respectively. In the secondary analysis, preventing hypertension and maintaining normal BP added 4.5 (95% UI, 4.3-4.6) and 4.6 (95% UI, 4.4-4.8) years to life expectancy, respectively, and 5.7 (95% UI, 5.6-5.8) and 5.9 (95% UI, 5.7-6.0) healthy life years to HLE, respectively.Conclusions: Preventing hypertension and maintaining normal BP were projected to increase life expectancy and HLE among Black adults.","PeriodicalId":13042,"journal":{"name":"Hypertension","volume":" ","pages":"1095-1105"},"PeriodicalIF":6.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0