建立青少年脉搏波速度参考值。

IF 6.9 1区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Vimarsha Kodithuwakku,Monique Breslin,Jeanne Hersant,Rosa-Maria Bruno,Pierre Boutouyrie,Elaine M Urbina,Seana Gall,Rachel E Climie,
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引用次数: 0

摘要

主动脉脉搏波速度(PWV)是血管老化的一个指标,已被证明是成人心血管风险评估的有效指标。为了在年轻人中使用它来识别那些可能有心血管疾病风险增加的人,需要确定参考值。青年血管联盟是一个大型的国际数据库,旨在研究青少年血管老化。使用来自青年血管协会的数据,本研究旨在建立健康年轻人主动脉PWV的参考值。方法本研究为回顾性、多中心研究。对1岁至40岁参与者的人口统计学、人体测量学、生化和血管老化测量数据进行了统一。使用广义加性模型推导PWV的百分位数曲线,并根据性别、大洲和设备报告年龄预测百分位数。结果纳入19 930名参与者(平均年龄17岁,51%女性,71%欧洲人)的数据,根据血压、体重指数、血清葡萄糖和胆固醇水平分类为健康,以构建参考值。使用6个装置评估主动脉PWV (29% sphygmoor)。构建了主动脉PWV的器械特异性百分位数曲线,发现随着年龄的增长,男女PWV均呈上升趋势。结论本研究为健康青年按年龄、性别分别使用6种仪器评估主动脉PWV提供了参考值。这些百分位数可以在临床上用于识别血管老化受损的年轻人,因此,那些可能在未来发展为明显心血管疾病的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Establishing Reference Values for Pulse Wave Velocity in Young People.
BACKGROUND Aortic pulse wave velocity (PWV) is an indicator of vascular aging and has proven to be effective in adult cardiovascular risk assessment. To use it in young people to identify those who may be at increased cardiovascular disease risk, reference values need to be determined. The Youth Vascular Consortium is a large, international database which was established to investigate vascular aging in youth. Using data from the Youth Vascular Consortium, this study aimed to develop reference values for aortic PWV in healthy young people. METHODS This is a retrospective, multicenter study. Data on demographics, anthropometric, biochemical, and vascular aging measures from participants aged 1 year to 40 years were harmonized. Generalized additive models were used to derive percentile curves for PWV and predicted percentiles at years of age were reported by sex, continent, and device. RESULTS Data from 19 930 participants (mean age=17 years, 51% female, 71% European), classified as healthy based on blood pressure, body mass index, serum glucose, and cholesterol levels, were included to construct the reference values. Six devices were used to assess aortic PWV (29% SphygmoCor). Device-specific percentile curves for aortic PWV were constructed, and an increasing trend was identified for both sexes with age. CONCLUSIONS This study provided reference values for aortic PWV assessed with 6 devices for healthy young people by age and sex. These percentiles may be applied clinically to identify youth with impaired vascular aging and, thus, those who may be at risk of developing overt cardiovascular disease in the future.
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来源期刊
Hypertension
Hypertension 医学-外周血管病
CiteScore
15.90
自引率
4.80%
发文量
1006
审稿时长
1 months
期刊介绍: Hypertension presents top-tier articles on high blood pressure in each monthly release. These articles delve into basic science, clinical treatment, and prevention of hypertension and associated cardiovascular, metabolic, and renal conditions. Renowned for their lasting significance, these papers contribute to advancing our understanding and management of hypertension-related issues.
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